|
GB0109146D0
(en)
*
|
2001-04-11 |
2001-05-30 |
Ferring Bv |
Treatment of type 2 diabetes
|
|
US8048917B2
(en)
|
2005-04-06 |
2011-11-01 |
Xenoport, Inc. |
Prodrugs of GABA analogs, compositions and uses thereof
|
|
US7186855B2
(en)
|
2001-06-11 |
2007-03-06 |
Xenoport, Inc. |
Prodrugs of GABA analogs, compositions and uses thereof
|
|
US6818787B2
(en)
|
2001-06-11 |
2004-11-16 |
Xenoport, Inc. |
Prodrugs of GABA analogs, compositions and uses thereof
|
|
US7232924B2
(en)
|
2001-06-11 |
2007-06-19 |
Xenoport, Inc. |
Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
|
|
WO2003000180A2
(en)
*
|
2001-06-20 |
2003-01-03 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
|
|
EP1399420B1
(en)
*
|
2001-06-27 |
2007-12-05 |
SmithKline Beecham Corporation |
Pyrrolidines as dipeptidyl peptidase inhibitors
|
|
CZ20033521A3
(en)
|
2001-06-27 |
2004-05-12 |
Smithklineábeechamácorporation |
Fluoropyrrolidines as dipeptidyl peptidase inhibitors
|
|
DE10154689A1
(de)
*
|
2001-11-09 |
2003-05-22 |
Probiodrug Ag |
Substituierte Aminoketonverbindungen
|
|
JP4357293B2
(ja)
|
2001-06-27 |
2009-11-04 |
スミスクライン ビーチャム コーポレーション |
ジペプチジルペプチダーゼ阻害剤としてのフルオロピロリジン類
|
|
GB0125446D0
(en)
*
|
2001-10-23 |
2001-12-12 |
Ferring Bv |
Novel anti-diabetic agents
|
|
US6861440B2
(en)
|
2001-10-26 |
2005-03-01 |
Hoffmann-La Roche Inc. |
DPP IV inhibitors
|
|
WO2003068757A1
(en)
|
2002-02-13 |
2003-08-21 |
F. Hoffmann-La Roche Ag |
Novel pyridin- and pyrimidin-derivatives
|
|
CN1308311C
(zh)
|
2002-02-13 |
2007-04-04 |
霍夫曼-拉罗奇有限公司 |
新型吡啶-和喹啉-衍生物
|
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
|
CA2508487A1
(en)
*
|
2002-12-04 |
2004-06-17 |
Merck & Co., Inc. |
Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
|
WO2004087053A2
(en)
*
|
2003-03-25 |
2004-10-14 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
|
WO2004098591A2
(en)
|
2003-05-05 |
2004-11-18 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
|
|
AU2004237408C9
(en)
|
2003-05-05 |
2010-04-15 |
Probiodrug Ag |
Medical use of inhibitors of glutaminyl and glutamate cyclases
|
|
NZ572274A
(en)
|
2003-05-05 |
2009-06-26 |
Probiodrug Ag |
Use of effectors of glutaminyl and glutamate cyclases
|
|
US7638638B2
(en)
|
2003-05-14 |
2009-12-29 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
|
AU2004251829B2
(en)
|
2003-06-20 |
2009-12-17 |
F. Hoffmann-La Roche Ag |
Hexahydropyridoisoqinolines as DPP-IV inhibitors
|
|
DK1638970T3
(da)
|
2003-06-20 |
2011-01-03 |
Hoffmann La Roche |
Pyrid (2, 1-A)-isoquinolinderivater som DPP-IV-inhibitorer
|
|
US7678909B1
(en)
|
2003-08-13 |
2010-03-16 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US7723344B2
(en)
*
|
2003-08-13 |
2010-05-25 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
|
US7169926B1
(en)
|
2003-08-13 |
2007-01-30 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US7205409B2
(en)
|
2003-09-04 |
2007-04-17 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
|
WO2005030751A2
(en)
*
|
2003-09-08 |
2005-04-07 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
JP2007505121A
(ja)
*
|
2003-09-08 |
2007-03-08 |
武田薬品工業株式会社 |
ジペプチジルぺプチダーゼ阻害剤
|
|
KR101121882B1
(ko)
|
2003-10-15 |
2012-04-12 |
프로비오드룩 아게 |
글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도
|
|
JP2007509898A
(ja)
|
2003-11-03 |
2007-04-19 |
プロビオドルグ エージー |
神経障害治療に有用な組合せ
|
|
CA2545641A1
(en)
|
2003-11-17 |
2005-06-02 |
Novartis Ag |
Use of organic compounds
|
|
EP2165703A3
(en)
|
2004-01-20 |
2012-03-28 |
Novartis Pharma AG |
Direct compression formulation and process
|
|
AU2005210004B2
(en)
|
2004-02-05 |
2010-10-28 |
Probiodrug Ag |
Novel inhibitors of glutaminyl cyclase
|
|
US7501426B2
(en)
|
2004-02-18 |
2009-03-10 |
Boehringer Ingelheim International Gmbh |
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
|
|
US7732446B1
(en)
|
2004-03-11 |
2010-06-08 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
CN102127057A
(zh)
*
|
2004-03-15 |
2011-07-20 |
武田药品工业株式会社 |
二肽基肽酶抑制剂
|
|
JP2008501714A
(ja)
*
|
2004-06-04 |
2008-01-24 |
武田薬品工業株式会社 |
ジペプチジルペプチダーゼインヒビター
|
|
WO2006019965A2
(en)
|
2004-07-16 |
2006-02-23 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
|
EP1794120B1
(en)
|
2004-07-23 |
2012-04-11 |
Nuada, LLC |
Peptidase inhibitors
|
|
DE102004054054A1
(de)
|
2004-11-05 |
2006-05-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
|
|
US7411093B2
(en)
|
2004-12-20 |
2008-08-12 |
Hoffman-La Roche Inc. |
Aminocycloalkanes as DPP-IV inhibitors
|
|
WO2006066747A1
(en)
|
2004-12-20 |
2006-06-29 |
F. Hoffmann-La Roche Ag |
4-aminopiperidine derivatives
|
|
EP1828192B1
(en)
|
2004-12-21 |
2014-12-03 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
EP1829877A4
(en)
|
2004-12-24 |
2009-10-14 |
Dainippon Sumitomo Pharma Co |
BICYCLIC PYRROLE DERIVATIVES
|
|
CA2599419A1
(en)
|
2005-04-22 |
2006-11-02 |
Alantos Pharmaceuticals Holding, Inc. |
Dipeptidyl peptidase-iv inhibitors
|
|
US7399869B2
(en)
|
2005-05-19 |
2008-07-15 |
Genentech, Inc. |
Fibroblast activation protein inhibitor compounds and methods
|
|
US8106090B2
(en)
|
2005-07-20 |
2012-01-31 |
Eli Lilly And Company |
1-amino linked compounds
|
|
MX2008001799A
(es)
*
|
2005-08-11 |
2008-04-16 |
Hoffmann La Roche |
Composicion farmaceutica que comprende un inhibidor de dipeptidil peptidasa iv.
|
|
EP1760076A1
(en)
*
|
2005-09-02 |
2007-03-07 |
Ferring B.V. |
FAP Inhibitors
|
|
BRPI0616077B8
(pt)
*
|
2005-09-14 |
2021-05-25 |
Takeda Pharmaceuticals Co |
composição farmacêutica formulada em uma dose única, kit, artigo de manufatura, uso da composição farmacêutica e uso de um ou mais compostos antidiabéticos
|
|
CN101374523B
(zh)
*
|
2005-09-14 |
2012-04-11 |
武田药品工业株式会社 |
用于治疗糖尿病的二肽基肽酶抑制剂
|
|
TW200745079A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
|
|
TW200745080A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
|
|
CN101360723A
(zh)
|
2005-09-16 |
2009-02-04 |
武田药品工业株式会社 |
制备嘧啶二酮衍生物的方法
|
|
GB0525164D0
(en)
|
2005-12-09 |
2006-01-18 |
Xention Discovery Ltd |
Compounds
|
|
GB0526291D0
(en)
|
2005-12-23 |
2006-02-01 |
Prosidion Ltd |
Therapeutic method
|
|
WO2007112347A1
(en)
|
2006-03-28 |
2007-10-04 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US20100029941A1
(en)
*
|
2006-03-28 |
2010-02-04 |
Takeda Pharmaceutical Company Limited |
Preparation of (r)-3-aminopiperidine dihydrochloride
|
|
WO2007123686A2
(en)
*
|
2006-03-31 |
2007-11-01 |
Point Therapeutics, Inc. |
Dpp inhibitors and uses thereof
|
|
JP2009533393A
(ja)
|
2006-04-12 |
2009-09-17 |
プロビオドルグ エージー |
酵素阻害薬
|
|
PE20080251A1
(es)
|
2006-05-04 |
2008-04-25 |
Boehringer Ingelheim Int |
Usos de inhibidores de dpp iv
|
|
EP1852108A1
(en)
|
2006-05-04 |
2007-11-07 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
DPP IV inhibitor formulations
|
|
EA015687B1
(ru)
|
2006-05-04 |
2011-10-31 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Полиморфы
|
|
US8324383B2
(en)
|
2006-09-13 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
|
|
ES2370873T3
(es)
*
|
2006-09-13 |
2011-12-23 |
Takeda Pharmaceutical Company Limited |
Utilización del 2-6-(3-amino-piperidin-1-il)-3-metil-2,4-dioxo-3,4-dihidro-2h-pirimidin-1-ilmetil-4-fluoro-benzonitrilo para el tratamiento de la diabetes, el cáncer, los trastornos autoinmunitarios y la infección por el vih.
|
|
EP2089383B1
(en)
|
2006-11-09 |
2015-09-16 |
Probiodrug AG |
3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
|
|
TW200838536A
(en)
|
2006-11-29 |
2008-10-01 |
Takeda Pharmaceutical |
Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
|
|
WO2008065141A1
(en)
|
2006-11-30 |
2008-06-05 |
Probiodrug Ag |
Novel inhibitors of glutaminyl cyclase
|
|
US8093236B2
(en)
|
2007-03-13 |
2012-01-10 |
Takeda Pharmaceuticals Company Limited |
Weekly administration of dipeptidyl peptidase inhibitors
|
|
CN103330939A
(zh)
|
2007-04-03 |
2013-10-02 |
田边三菱制药株式会社 |
二肽基肽酶iv抑制化合物和甜味剂的并用
|
|
ES2533484T3
(es)
|
2007-04-18 |
2015-04-10 |
Probiodrug Ag |
Derivados de tiourea como inhibidores de la glutaminil ciclasa
|
|
GB2465132B
(en)
*
|
2007-09-21 |
2012-06-06 |
Lupin Ltd |
Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
|
|
CL2008003653A1
(es)
|
2008-01-17 |
2010-03-05 |
Mitsubishi Tanabe Pharma Corp |
Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
|
|
KR101634656B1
(ko)
*
|
2008-03-05 |
2016-06-29 |
내셔날 헬스 리서치 인스티튜트 |
피롤리딘 유도체
|
|
AR071175A1
(es)
|
2008-04-03 |
2010-06-02 |
Boehringer Ingelheim Int |
Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
|
|
KR20190016601A
(ko)
|
2008-08-06 |
2019-02-18 |
베링거 인겔하임 인터내셔날 게엠베하 |
메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
|
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
|
US20200155558A1
(en)
|
2018-11-20 |
2020-05-21 |
Boehringer Ingelheim International Gmbh |
Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
|
|
DE102008062136B4
(de)
|
2008-12-16 |
2012-05-03 |
Kamamed Ug |
Pharmazeutische Zusammensetzung auf Basis von Peptid aus Kamelmilch
|
|
CA2745037C
(en)
|
2008-12-23 |
2020-06-23 |
Boehringer Ingelheim International Gmbh |
Salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8(3-(r)-amino-piperidin-1-yl)-xanthine
|
|
AR074990A1
(es)
|
2009-01-07 |
2011-03-02 |
Boehringer Ingelheim Int |
Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
|
|
US8748457B2
(en)
|
2009-06-18 |
2014-06-10 |
Lupin Limited |
2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent DPP-IV inhibitors
|
|
SG178953A1
(en)
|
2009-09-11 |
2012-04-27 |
Probiodrug Ag |
Heterocylcic derivatives as inhibitors of glutaminyl cyclase
|
|
NZ599298A
(en)
|
2009-11-27 |
2014-11-28 |
Boehringer Ingelheim Int |
Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
|
|
ES2586231T3
(es)
|
2010-03-03 |
2016-10-13 |
Probiodrug Ag |
Inhibidores de glutaminil ciclasa
|
|
EA022420B1
(ru)
|
2010-03-10 |
2015-12-30 |
Пробиодруг Аг |
Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5)
|
|
EP2560953B1
(en)
|
2010-04-21 |
2016-01-06 |
Probiodrug AG |
Inhibitors of glutaminyl cyclase
|
|
EP2566469B1
(en)
|
2010-05-05 |
2022-12-21 |
Boehringer Ingelheim International GmbH |
Combination therapy
|
|
KR20220025926A
(ko)
|
2010-06-24 |
2022-03-03 |
베링거 인겔하임 인터내셔날 게엠베하 |
당뇨병 요법
|
|
AR083878A1
(es)
|
2010-11-15 |
2013-03-27 |
Boehringer Ingelheim Int |
Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
|
|
US8530670B2
(en)
|
2011-03-16 |
2013-09-10 |
Probiodrug Ag |
Inhibitors
|
|
CA2841552C
(en)
|
2011-07-15 |
2020-06-23 |
Boehringer Ingelheim International Gmbh |
Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
|
|
US9555001B2
(en)
|
2012-03-07 |
2017-01-31 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition and uses thereof
|
|
JP6224084B2
(ja)
|
2012-05-14 |
2017-11-01 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体
|
|
JP6218811B2
(ja)
|
2012-05-14 |
2017-10-25 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Sirs及び/又は敗血症の治療に用いるdpp−4阻害薬としてのキサンチン誘導体
|
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
|
EA021236B1
(ru)
*
|
2012-10-03 |
2015-05-29 |
Дафот Энтерпраизес Лимитед |
Nα-АЦИЛЬНЫЕ ПРОИЗВОДНЫЕ АМИНОАЦИЛ-2-ЦИАНОПИРРОЛИДИНА - ИНГИБИТОРЫ ПРОЛИЛЭНДОПЕПТИДАЗЫ И ДИПЕПТИДИЛПЕПТИДАЗЫ-IV, ОБЛАДАЮЩИЕ ГИПОГЛИКЕМИЧЕСКИМ, ПРОТИВОГИПОКСИЧЕСКИМ, НЕЙРОПРОТЕКТОРНЫМ И УЛУЧШАЮЩИМ КОГНИТИВНЫЕ ФУНКЦИИ ДЕЙСТВИЕМ
|
|
EP3110449B1
(en)
|
2014-02-28 |
2023-06-28 |
Boehringer Ingelheim International GmbH |
Medical use of a dpp-4 inhibitor
|
|
HK1249847A1
(zh)
|
2015-03-09 |
2018-11-16 |
Intekrin Therapeutics, Inc. |
用於治疗非酒精性脂肪肝疾病和/或脂肪营养不良的方法
|
|
CA3022202A1
(en)
|
2016-06-10 |
2017-12-14 |
Boehringer Ingelheim International Gmbh |
Combinations of linagliptin and metformin
|
|
WO2018162722A1
(en)
|
2017-03-09 |
2018-09-13 |
Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke |
Dpp-4 inhibitors for use in treating bone fractures
|
|
EP3606527A1
(en)
|
2017-04-03 |
2020-02-12 |
Coherus Biosciences, Inc. |
Ppar-gamma agonist for treatment of progressive supranuclear palsy
|
|
EP3461819B1
(en)
|
2017-09-29 |
2020-05-27 |
Probiodrug AG |
Inhibitors of glutaminyl cyclase
|
|
JP7622229B2
(ja)
*
|
2020-12-17 |
2025-01-27 |
アストラゼネカ・アクチエボラーグ |
N-(2-(4-シアノチアゾリジン-3-イル)-2-オキソエチル)-キノリン-4-カルボキサミド
|
|
CN115368344A
(zh)
*
|
2022-08-22 |
2022-11-22 |
湖北科技学院 |
组氨酸类衍生物及其制备方法和应用
|