IL148910A0 - Novel thiazolo (4,5-d) pyrimidine compounds - Google Patents

Novel thiazolo (4,5-d) pyrimidine compounds

Info

Publication number
IL148910A0
IL148910A0 IL14891000A IL14891000A IL148910A0 IL 148910 A0 IL148910 A0 IL 148910A0 IL 14891000 A IL14891000 A IL 14891000A IL 14891000 A IL14891000 A IL 14891000A IL 148910 A0 IL148910 A0 IL 148910A0
Authority
IL
Israel
Prior art keywords
pyrimidine compounds
solvate
chem
therapy
processes
Prior art date
Application number
IL14891000A
Other languages
English (en)
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of IL148910A0 publication Critical patent/IL148910A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL14891000A 1999-10-01 2000-09-26 Novel thiazolo (4,5-d) pyrimidine compounds IL148910A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903544A SE9903544D0 (sv) 1999-10-01 1999-10-01 Novel compounds
PCT/GB2000/003692 WO2001025242A1 (en) 1999-10-01 2000-09-26 Novel thiazolo(4,5-d)pyrimidine compounds

Publications (1)

Publication Number Publication Date
IL148910A0 true IL148910A0 (en) 2002-09-12

Family

ID=20417218

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14891000A IL148910A0 (en) 1999-10-01 2000-09-26 Novel thiazolo (4,5-d) pyrimidine compounds
IL148910A IL148910A (en) 1999-10-01 2002-03-26 7 - Amino - Thiazole (D – 5,4) Pyrimidine - 2 - (N3) - Converted lobes in position 5, their preparation, pharmaceutical preparations containing them and a number of their intermediates

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148910A IL148910A (en) 1999-10-01 2002-03-26 7 - Amino - Thiazole (D – 5,4) Pyrimidine - 2 - (N3) - Converted lobes in position 5, their preparation, pharmaceutical preparations containing them and a number of their intermediates

Country Status (27)

Country Link
US (3) US6790850B1 (et)
EP (2) EP1222195B1 (et)
JP (1) JP4824889B2 (et)
KR (1) KR100765051B1 (et)
CN (1) CN1210279C (et)
AT (2) ATE257838T1 (et)
AU (1) AU777872B2 (et)
BR (1) BR0014334A (et)
CA (1) CA2385269C (et)
CZ (1) CZ20021113A3 (et)
DE (2) DE60007768T2 (et)
DK (1) DK1222195T3 (et)
EE (1) EE05037B1 (et)
ES (2) ES2298451T3 (et)
HK (1) HK1052009A1 (et)
HU (1) HUP0204246A3 (et)
IL (2) IL148910A0 (et)
IS (1) IS2229B (et)
MX (1) MXPA02003263A (et)
NO (1) NO327706B1 (et)
NZ (1) NZ517880A (et)
PT (1) PT1222195E (et)
SE (1) SE9903544D0 (et)
TW (1) TWI260324B (et)
UA (1) UA73521C2 (et)
WO (1) WO2001025242A1 (et)
ZA (1) ZA200202380B (et)

Families Citing this family (33)

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SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
DE60101372T2 (de) * 2000-02-11 2004-10-14 Astrazeneca Ab Pyrimidinverbindungen und ihre verwendung als modulatoren der chemokin-rezeptor-aktivität
GB2359081A (en) * 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359551A (en) * 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
SE0101322D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
WO2003049679A2 (en) 2001-12-06 2003-06-19 Merck & Co., Inc. Mitotic kinesin inhibitors
DE60232994D1 (de) 2001-12-06 2009-08-27 Merck & Co Inc Inhibitoren von mitotischem kinesin
GB0217431D0 (en) 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
EP1537112B1 (en) 2002-08-06 2006-04-19 Astrazeneca AB Condensed pyridines and pyrimidines with tie2 (tek) activity
JP4694963B2 (ja) 2002-08-24 2011-06-08 アストラゼネカ・アクチエボラーグ ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
MXPA06003792A (es) * 2003-10-07 2006-06-14 Astrazeneca Ab Nuevas 4-amino-tiazolo[4,5-d]-pirimidinas 2-sustituidas, utiles como antagonistas del receptor de quimiocina, especialmente cx3cr1.
GB0328243D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Methods
PT1809624E (pt) 2004-08-28 2014-01-14 Astrazeneca Ab Derivados de pirimidina sulfonamida como moduladores do recetor de quimiocina
EP1844054A2 (en) * 2004-12-17 2007-10-17 AstraZeneca AB Thiazolopyrimidine compounds for the modulation of chemokine receptor activity
TW200700727A (en) * 2005-03-23 2007-01-01 Astrazeneca Ab Screen
AR053347A1 (es) * 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
UA90707C2 (en) * 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
TW200820973A (en) * 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
AR071036A1 (es) * 2008-03-26 2010-05-19 Astrazeneca Ab Derivados 5, 7-disustituidos de [1, 3]tiazolo[4, 5-d]pirimidin-2 (3h)-ona, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor cx3cr1.
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
CN101899058B (zh) * 2010-05-24 2012-05-23 中国人民解放军第四军医大学 一种噻唑并嘧啶化合物及其制备方法和应用
EP3011012B1 (en) 2013-06-18 2018-09-12 New York University Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets
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MX359556B (es) * 2013-08-02 2018-10-02 Syntrix Biosystems Inc Acido 2-[5-[n-(4-fluorofenil)carbamoíl]pirimidin-2-ilsulfanilmetil ]-4-(trifluorometoxi)fenil]borónico.
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
WO2018073248A1 (en) 2016-10-17 2018-04-26 Icm (Institut Du Cerveau Et De La Moelle Épinière) Prognosis of demyelinating diseases patients and treatment thereof
CN110172067B (zh) * 2019-04-11 2021-06-15 河南科技大学第一附属医院 一种具有杀菌活性的噻唑类药物分子及其制备方法

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Also Published As

Publication number Publication date
CN1210279C (zh) 2005-07-13
EP1348709A3 (en) 2003-11-19
WO2001025242A1 (en) 2001-04-12
US20040224961A1 (en) 2004-11-11
SE9903544D0 (sv) 1999-10-01
IL148910A (en) 2006-10-31
KR100765051B1 (ko) 2007-10-09
ES2298451T3 (es) 2008-05-16
NZ517880A (en) 2003-09-26
IS2229B (is) 2007-04-15
DE60037836T2 (de) 2009-01-15
HK1052009A1 (en) 2003-08-29
CN1402730A (zh) 2003-03-12
IS6306A (is) 2002-03-18
CA2385269A1 (en) 2001-04-12
CA2385269C (en) 2010-08-17
UA73521C2 (en) 2005-08-15
ATE257838T1 (de) 2004-01-15
US8143261B2 (en) 2012-03-27
NO327706B1 (no) 2009-09-14
ES2213043T3 (es) 2004-08-16
ZA200202380B (en) 2003-10-29
EP1348709A2 (en) 2003-10-01
US6790850B1 (en) 2004-09-14
EP1348709B1 (en) 2008-01-16
PL365778A1 (en) 2005-01-10
EE05037B1 (et) 2008-06-16
AU777872B2 (en) 2004-11-04
MXPA02003263A (es) 2002-09-30
TWI260324B (en) 2006-08-21
DE60007768T2 (de) 2004-12-02
DE60037836D1 (de) 2008-03-06
HUP0204246A3 (en) 2006-01-30
CZ20021113A3 (cs) 2002-06-12
EE200200174A (et) 2003-04-15
AU7304900A (en) 2001-05-10
EP1222195B1 (en) 2004-01-14
PT1222195E (pt) 2004-05-31
ATE384068T1 (de) 2008-02-15
HUP0204246A2 (hu) 2003-04-28
JP4824889B2 (ja) 2011-11-30
US20090281123A1 (en) 2009-11-12
EP1222195A1 (en) 2002-07-17
DE60007768D1 (de) 2004-02-19
NO20021448D0 (no) 2002-03-22
NO20021448L (no) 2002-05-22
JP2003511384A (ja) 2003-03-25
KR20020032635A (ko) 2002-05-03
BR0014334A (pt) 2002-06-11
DK1222195T3 (da) 2004-04-19

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