IL148358A0 - Azacycloalkanone derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Azacycloalkanone derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL148358A0
IL148358A0 IL14835800A IL14835800A IL148358A0 IL 148358 A0 IL148358 A0 IL 148358A0 IL 14835800 A IL14835800 A IL 14835800A IL 14835800 A IL14835800 A IL 14835800A IL 148358 A0 IL148358 A0 IL 148358A0
Authority
IL
Israel
Prior art keywords
sup
sub
methylene
processes
preparation
Prior art date
Application number
IL14835800A
Other languages
English (en)
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of IL148358A0 publication Critical patent/IL148358A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14835800A 1999-09-13 2000-09-13 Azacycloalkanone derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same IL148358A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15323699P 1999-09-13 1999-09-13
PCT/US2000/025006 WO2001019795A1 (en) 1999-09-13 2000-09-13 Azacycloalkanone serine protease inhibitors

Publications (1)

Publication Number Publication Date
IL148358A0 true IL148358A0 (en) 2002-09-12

Family

ID=22546339

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14835800A IL148358A0 (en) 1999-09-13 2000-09-13 Azacycloalkanone derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (20)

Country Link
US (2) US6469029B1 (de)
EP (1) EP1212300B1 (de)
JP (1) JP2003509409A (de)
KR (1) KR20020027639A (de)
CN (1) CN1373755A (de)
AT (1) ATE253558T1 (de)
AU (1) AU7480800A (de)
BR (1) BR0013926A (de)
CA (1) CA2384247A1 (de)
DE (1) DE60006407T2 (de)
DK (1) DK1212300T3 (de)
ES (1) ES2209987T3 (de)
HK (1) HK1050005A1 (de)
IL (1) IL148358A0 (de)
MX (1) MXPA02002657A (de)
NO (1) NO322753B1 (de)
NZ (1) NZ517603A (de)
PL (1) PL354265A1 (de)
PT (1) PT1212300E (de)
WO (1) WO2001019795A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
JP2004518688A (ja) 2001-01-30 2004-06-24 ブリストル−マイヤーズ　スクイブ　カンパニー ファクターＸａ阻害剤のスルホンアミドラクタムおよびその方法
WO2002094787A1 (en) 2001-05-23 2002-11-28 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
WO2003000657A1 (en) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
GB0127568D0 (en) * 2001-11-16 2002-01-09 Glaxo Group Ltd Chemical compounds
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US20070191306A1 (en) * 2005-08-17 2007-08-16 Bristol-Myers Squibb Company FACTOR Xa INHIBITOR FORMULATION AND METHOD
WO2009096198A1 (ja) * 2008-02-01 2009-08-06 Pharma Ip Limited Liability Intermediary Corporations 新規ビアリール誘導体
CN103910688B (zh) * 2013-01-04 2016-05-25 陈春麟 2-丙基-4-氯喹唑啉衍生物及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5385885A (en) 1988-01-15 1995-01-31 Gasic; Gregory P. Inhibition of smooth muscle cell proliferation by antistasin and tick anticoagulant peptide
DE4121947A1 (de) 1991-07-03 1993-01-07 Basf Ag 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
WO1994020535A1 (en) 1992-12-11 1994-09-15 Corvas International, Inc. ECOTIN AS A FACTOR Xa, XIa, AND XIIa INHIBITOR
WO1995035311A1 (en) 1994-06-17 1995-12-28 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
US5703208A (en) 1994-06-17 1997-12-30 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
CA2224437A1 (en) 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
JPH09165370A (ja) 1995-10-13 1997-06-24 Fuji Yakuhin Kogyo Kk ラクタム誘導体およびその塩
CZ291690B6 (cs) 1996-02-13 2003-05-14 Akzo Nobel N. V. Inhibitory serinové proteázy a farmaceutický prostředek
EP0923372A4 (de) 1996-02-22 2001-09-05 Merck & Co Inc Inhibitoren von pyridinone thrombin
CA2250426C (en) 1996-03-29 2006-05-02 3-Dimensional Pharmaceuticals, Inc. Amidinohydrazones as protease inhibitors
JP2001504810A (ja) * 1996-10-11 2001-04-10 シーオーアール・セラピューティックス・インコーポレーテッド 選択的第Ｘａ因子阻害剤
JP2001512742A (ja) 1997-08-11 2001-08-28 シーオーアール セラピューティクス インコーポレイテッド 選択的Ｘａ因子阻害剤
CA2299610A1 (en) 1997-08-11 1999-02-18 Cor Therapeutics, Inc. Selective factor xa inhibitors
WO1999026926A1 (en) 1997-11-26 1999-06-03 3-Dimensional Pharmaceuticals, Inc. Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors

Also Published As

Publication number Publication date
NZ517603A (en) 2003-09-26
PL354265A1 (en) 2003-12-29
KR20020027639A (ko) 2002-04-13
EP1212300B1 (de) 2003-11-05
PT1212300E (pt) 2004-03-31
BR0013926A (pt) 2002-07-23
US6962942B2 (en) 2005-11-08
ES2209987T3 (es) 2004-07-01
ATE253558T1 (de) 2003-11-15
AU7480800A (en) 2001-04-17
DE60006407D1 (de) 2003-12-11
EP1212300A1 (de) 2002-06-12
DK1212300T3 (da) 2004-03-15
WO2001019795A1 (en) 2001-03-22
NO20021224D0 (no) 2002-03-12
HK1050005A1 (zh) 2003-06-06
NO20021224L (no) 2002-05-13
DE60006407T2 (de) 2004-09-09
US20030109517A1 (en) 2003-06-12
NO322753B1 (no) 2006-12-04
JP2003509409A (ja) 2003-03-11
US6469029B1 (en) 2002-10-22
CN1373755A (zh) 2002-10-09
CA2384247A1 (en) 2001-03-22
MXPA02002657A (es) 2002-10-28

Similar Documents

Publication Publication Date Title
ATE272633T1 (de) Aromatische amiden
CA2272291A1 (en) Crf antagonistic quino- and quinazolines
HK1053831A1 (zh) 作为治疗药物的激酶抑制剂
IL148358A0 (en) Azacycloalkanone derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
WO2002089782A3 (en) Dioxanes and uses thereof
ATE211740T1 (de) Substituierte indazolderivate
ATE346850T1 (de) 5-ht4-rezeptor-antagonisten
NO20055655L (no) Anvendelse av azetidinkarboksamidderivater i terapi
NO984740L (no) Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midler
WO2001081316A3 (en) Substituted phenyl farnesyltransferase inhibitors
SE9902267D0 (sv) New compounds
DE69614392D1 (en) Thrombin inhibitor
IL160082A0 (en) Quinoline derivatives and use thereof as antitumor agents
BG104718A (en) Pde iv inhibiting pyridine derivatives
AU2002339158A1 (en) 2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors
WO2003064378A3 (de) Verbindungen, die faktor xa-aktivität
FI940171A0 (fi) Ketorolaakkijohdannaisia, joiden gastrointestinaalinen ärsytys ja ulserointi ovat huomattavasti vähentyneet
DK1049670T3 (da) Azetidincarboxamidderivater til behandling af CNS-lidelser
ATE265453T1 (de) Diketopiperazinderivate als thrombininhibitoren
TH64776A (th) สารประกอบไพราโซล, องค์ประกอบทางเภสัชกรรมและวิธีการสำหรับการปรับ และ/หรือ การยับยั้งการออกฤทธิ์ erab/hadh2
MX9709386A (es) Derivados del arilsulfonilaminobenceno y el uso de los mismos como inhibidores del factor xa.
AU2002254907A1 (en) Diamides which inhibit tryptase and factor xa activity