PT1212300E - Inibidores de serina-protease de azacicloalcanona - Google Patents

Inibidores de serina-protease de azacicloalcanona

Info

Publication number
PT1212300E
PT1212300E PT00963388T PT00963388T PT1212300E PT 1212300 E PT1212300 E PT 1212300E PT 00963388 T PT00963388 T PT 00963388T PT 00963388 T PT00963388 T PT 00963388T PT 1212300 E PT1212300 E PT 1212300E
Authority
PT
Portugal
Prior art keywords
sup
sub
methylene
ethylene
alkyl
Prior art date
Application number
PT00963388T
Other languages
English (en)
Inventor
Scott C Miller
Juan Jose Marug N S Nchez
Kristin D Haslow
Jonathan P Hall
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of PT1212300E publication Critical patent/PT1212300E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PT00963388T 1999-09-13 2000-09-13 Inibidores de serina-protease de azacicloalcanona PT1212300E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15323699P 1999-09-13 1999-09-13

Publications (1)

Publication Number Publication Date
PT1212300E true PT1212300E (pt) 2004-03-31

Family

ID=22546339

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00963388T PT1212300E (pt) 1999-09-13 2000-09-13 Inibidores de serina-protease de azacicloalcanona

Country Status (20)

Country Link
US (2) US6469029B1 (pt)
EP (1) EP1212300B1 (pt)
JP (1) JP2003509409A (pt)
KR (1) KR20020027639A (pt)
CN (1) CN1373755A (pt)
AT (1) ATE253558T1 (pt)
AU (1) AU7480800A (pt)
BR (1) BR0013926A (pt)
CA (1) CA2384247A1 (pt)
DE (1) DE60006407T2 (pt)
DK (1) DK1212300T3 (pt)
ES (1) ES2209987T3 (pt)
HK (1) HK1050005A1 (pt)
IL (1) IL148358A0 (pt)
MX (1) MXPA02002657A (pt)
NO (1) NO322753B1 (pt)
NZ (1) NZ517603A (pt)
PL (1) PL354265A1 (pt)
PT (1) PT1212300E (pt)
WO (1) WO2001019795A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
CA2436774A1 (en) 2001-01-30 2002-08-08 R. Michael Lawrence Sulfonamide lactam inhibitors of factor xa
EP1395560A1 (en) 2001-05-23 2004-03-10 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
GB0127568D0 (en) 2001-11-16 2002-01-09 Glaxo Group Ltd Chemical compounds
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
US20070191306A1 (en) * 2005-08-17 2007-08-16 Bristol-Myers Squibb Company FACTOR Xa INHIBITOR FORMULATION AND METHOD
WO2009096198A1 (ja) * 2008-02-01 2009-08-06 Pharma Ip Limited Liability Intermediary Corporations 新規ビアリール誘導体
CN103910688B (zh) * 2013-01-04 2016-05-25 陈春麟 2-丙基-4-氯喹唑啉衍生物及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5385885A (en) 1988-01-15 1995-01-31 Gasic; Gregory P. Inhibition of smooth muscle cell proliferation by antistasin and tick anticoagulant peptide
DE4121947A1 (de) * 1991-07-03 1993-01-07 Basf Ag 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
WO1994020535A1 (en) 1992-12-11 1994-09-15 Corvas International, Inc. ECOTIN AS A FACTOR Xa, XIa, AND XIIa INHIBITOR
WO1995035311A1 (en) * 1994-06-17 1995-12-28 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
US5703208A (en) 1994-06-17 1997-12-30 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
JPH09165370A (ja) 1995-10-13 1997-06-24 Fuji Yakuhin Kogyo Kk ラクタム誘導体およびその塩
KR19990082424A (ko) 1996-02-13 1999-11-25 이.에이치. 리링크 세린 프로테아제 억제제
JP2000512616A (ja) 1996-02-22 2000-09-26 メルク エンド カンパニー インコーポレーテッド ピリジノントロンビンインヒビター
US5891909A (en) 1996-03-29 1999-04-06 3-Dimensional Pharmaceuticals, Inc. Amidinohydrazones as protease inhibitors
CA2268281A1 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. Selective factor xa inhibitors
CA2300478A1 (en) 1997-08-11 1999-02-18 Cor Therapeutics, Inc. Selective factor xa inhibitors
CA2299610A1 (en) 1997-08-11 1999-02-18 Cor Therapeutics, Inc. Selective factor xa inhibitors
AU751412B2 (en) 1997-11-26 2002-08-15 3-Dimensional Pharmaceuticals, Inc. Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors

Also Published As

Publication number Publication date
NO20021224L (no) 2002-05-13
US20030109517A1 (en) 2003-06-12
JP2003509409A (ja) 2003-03-11
EP1212300A1 (en) 2002-06-12
US6469029B1 (en) 2002-10-22
DK1212300T3 (da) 2004-03-15
DE60006407D1 (de) 2003-12-11
US6962942B2 (en) 2005-11-08
IL148358A0 (en) 2002-09-12
NO322753B1 (no) 2006-12-04
ATE253558T1 (de) 2003-11-15
DE60006407T2 (de) 2004-09-09
KR20020027639A (ko) 2002-04-13
CN1373755A (zh) 2002-10-09
CA2384247A1 (en) 2001-03-22
AU7480800A (en) 2001-04-17
BR0013926A (pt) 2002-07-23
NO20021224D0 (no) 2002-03-12
WO2001019795A1 (en) 2001-03-22
NZ517603A (en) 2003-09-26
MXPA02002657A (es) 2002-10-28
PL354265A1 (en) 2003-12-29
EP1212300B1 (en) 2003-11-05
HK1050005A1 (zh) 2003-06-06
ES2209987T3 (es) 2004-07-01

Similar Documents

Publication Publication Date Title
EA199900591A1 (ru) АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха
DE69924135D1 (de) Heterozyklische kalium-kanal inhibitoren
NO20020214D0 (no) Substituerte oksozaheterocyklylforbindelser
WO2001019828A3 (en) Kinase inhibitors as therapeutic agents
MY127894A (en) Renin inhibitors
EA200300306A1 (ru) Спиропиримидин-2,4,6-трионовые ингибиторы металлопротеиназы
DE69919212D1 (de) Aromatische amiden
NO20055655D0 (no) Anvendelse av azetidinkarboksamidderivater i terapi
ATE241621T1 (de) Arylsulfonyle als faktor xa inhibitoren
ECSP045104A (es) Ligandos de los receptores de los cannabinoides
IL146851A0 (en) 1- (4-sulfamylaryl)- 3- substituted -5-ayl-2-pyrazolines as inhibitors of cyclooxygenase-2
DE60019347D1 (de) Inhibitoren der alpha-l beta-2 vermittelten zelladhäsion
PT1212300E (pt) Inibidores de serina-protease de azacicloalcanona
DE69937372D1 (de) Piperidin-indol derivate mit 5-ht6 affinität
DE69434888D1 (de) 5-ht4-rezeptor-antagonisten
ATE211740T1 (de) Substituierte indazolderivate
EA200000204A1 (ru) Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
ATE203905T1 (de) Thrombin inhibitor
SE9902267D0 (sv) New compounds
AU2002339158A1 (en) 2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors
BR9912374A (pt) Isoquinolinas como inibidores de urocinase
WO2003064378A3 (de) Verbindungen, die faktor xa-aktivität
ATE265453T1 (de) Diketopiperazinderivate als thrombininhibitoren
ATE233244T1 (de) Carboxylsäure substituierte heterocyclische verbindungen als metalloproteinase inhibitoren
FI940171A0 (fi) Ketorolaakkijohdannaisia, joiden gastrointestinaalinen ärsytys ja ulserointi ovat huomattavasti vähentyneet