IL148050A0 - Crystals of the sodium salt of pravastatin - Google Patents
Crystals of the sodium salt of pravastatinInfo
- Publication number
- IL148050A0 IL148050A0 IL14805000A IL14805000A IL148050A0 IL 148050 A0 IL148050 A0 IL 148050A0 IL 14805000 A IL14805000 A IL 14805000A IL 14805000 A IL14805000 A IL 14805000A IL 148050 A0 IL148050 A0 IL 148050A0
- Authority
- IL
- Israel
- Prior art keywords
- pravastatin
- sodium salt
- crystalline form
- cervastatin
- fluvastatin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9900191A SI20305A (sl) | 1999-08-06 | 1999-08-06 | Kristali natrijeve soli pravastatina |
PCT/IB2000/001103 WO2001010813A1 (fr) | 1999-08-06 | 2000-08-04 | Cristaux de sel de sodium de pravastatine |
Publications (1)
Publication Number | Publication Date |
---|---|
IL148050A0 true IL148050A0 (en) | 2002-09-12 |
Family
ID=20432515
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14805000A IL148050A0 (en) | 1999-08-06 | 2000-08-04 | Crystals of the sodium salt of pravastatin |
IL148050A IL148050A (en) | 1999-08-06 | 2002-02-06 | Crystals of pravastatin sodium salt |
IL187261A IL187261A0 (en) | 1999-08-06 | 2007-11-08 | Crystals of the sodium salt of pravastatin |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL148050A IL148050A (en) | 1999-08-06 | 2002-02-06 | Crystals of pravastatin sodium salt |
IL187261A IL187261A0 (en) | 1999-08-06 | 2007-11-08 | Crystals of the sodium salt of pravastatin |
Country Status (24)
Country | Link |
---|---|
US (3) | US7078558B1 (fr) |
EP (1) | EP1200385B2 (fr) |
JP (1) | JP2003506424A (fr) |
KR (2) | KR100766928B1 (fr) |
CN (1) | CN1205172C (fr) |
AT (1) | ATE287389T1 (fr) |
BG (1) | BG65368B1 (fr) |
CA (1) | CA2379335A1 (fr) |
CZ (1) | CZ2002414A3 (fr) |
DE (1) | DE60017568T2 (fr) |
DK (1) | DK1200385T3 (fr) |
ES (1) | ES2235911T5 (fr) |
HR (1) | HRP20020106A2 (fr) |
HU (1) | HUP0202536A3 (fr) |
IL (3) | IL148050A0 (fr) |
NZ (1) | NZ516685A (fr) |
PL (1) | PL365850A1 (fr) |
PT (1) | PT1200385E (fr) |
RU (1) | RU2247711C2 (fr) |
SI (2) | SI20305A (fr) |
SK (1) | SK1742002A3 (fr) |
WO (1) | WO2001010813A1 (fr) |
YU (1) | YU5402A (fr) |
ZA (1) | ZA200200437B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
US7001919B2 (en) | 1999-12-14 | 2006-02-21 | Teva Gyogyszergyar Reszvenytarsasag | Forms of pravastatin sodium |
JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
JP2002121172A (ja) * | 2000-10-16 | 2002-04-23 | Sankyo Co Ltd | プラバスタチン又はその薬理上許容される塩の精製方法 |
WO2002057229A1 (fr) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORME V CRISTALLINE DE SEL HEMICALCIQUE D'ACIDE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIQUE (ATORVASTATINE) |
US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
JP4308021B2 (ja) * | 2002-03-18 | 2009-08-05 | バイオコン・リミテッド | 望ましい粒子サイズのアモルファスHMG−CoAレダクターゼ阻害剤 |
JP4622855B2 (ja) * | 2003-06-10 | 2011-02-02 | 大正製薬株式会社 | 放射球状晶析物およびその製造方法並びにこれを利用するドライパウダー製剤 |
CN1293874C (zh) * | 2003-08-18 | 2007-01-10 | 李朝晖 | 以洛伐他汀盐为主要活性成分的中药红曲及其制剂 |
CA2546377A1 (fr) | 2003-11-24 | 2005-06-09 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Procede de purification de pravastatine |
US20080242725A1 (en) * | 2004-03-01 | 2008-10-02 | Janez Kerc | Pharmaceutical Composition |
US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
BRPI0513082A (pt) * | 2004-08-06 | 2008-04-22 | Transform Pharmaceuticals Inc | formulações de fenofibrato e métodos de tratamento relacionados |
US7642287B2 (en) | 2004-08-06 | 2010-01-05 | Transform Pharmaceuticals, Inc. | Statin pharmaceutical compositions and related methods of treatment |
TW200640854A (en) * | 2005-02-09 | 2006-12-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Methods of making pravastatin sodium |
JP4895510B2 (ja) * | 2005-02-23 | 2012-03-14 | 株式会社トクヤマ | バリオールアミンの製造方法 |
JP4813841B2 (ja) * | 2005-07-25 | 2011-11-09 | キユーピー株式会社 | プラバスタチンナトリウムの製造方法 |
WO2009148709A1 (fr) * | 2008-04-16 | 2009-12-10 | University Of Utah Research Foundation | Ciblage pharmacologique de malformation vasculaire |
CN101348476B (zh) * | 2008-09-05 | 2011-05-11 | 丽珠集团新北江制药股份有限公司 | 一种制备4,5,6,7-四氢普伐他汀及其钠盐的方法和固体结晶形式 |
CN101648867B (zh) * | 2009-09-04 | 2012-07-11 | 天津大学 | 一种普伐他汀钠晶型及其制备方法和应用 |
EP2343054A1 (fr) | 2010-01-04 | 2011-07-13 | LEK Pharmaceuticals d.d. | Granules et microparticules de sodium de pravastatine et leur procédé de fabrication |
CN102533893A (zh) * | 2010-12-09 | 2012-07-04 | 浙江海正药业股份有限公司 | 一种制备莫那可林j的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
JPS572240A (en) * | 1980-06-06 | 1982-01-07 | Sankyo Co Ltd | Ml-236b derivative |
JPS5889191A (ja) * | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | 3−ヒドロキシ−ml−236b誘導体の製造法 |
CA2040865C (fr) | 1990-05-15 | 2002-07-23 | James L. Bergey | Methode visant a prevenir, stabiliser ou reduire l'atherosclerose et reposant sur l'utilisation conjointe d'un medicament a effet hypocholesterolemiant et d'un inhibiteur de l'enzyme de conversion |
KR100210482B1 (ko) * | 1997-04-10 | 1999-07-15 | 김종인 | 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 |
US6098031A (en) | 1998-03-05 | 2000-08-01 | Gsi Lumonics, Inc. | Versatile method and system for high speed, 3D imaging of microscopic targets |
SI20070A (sl) | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
KR100648541B1 (ko) † | 1999-02-03 | 2006-11-24 | 인스티튜트 포 드럭 리서치 리미티드 | 프라바스타틴을 제조하기 위한 미생물학적인 방법 |
-
1999
- 1999-08-06 SI SI9900191A patent/SI20305A/sl not_active IP Right Cessation
-
2000
- 2000-08-04 RU RU2002102862/04A patent/RU2247711C2/ru not_active IP Right Cessation
- 2000-08-04 PL PL00365850A patent/PL365850A1/xx not_active Application Discontinuation
- 2000-08-04 IL IL14805000A patent/IL148050A0/xx unknown
- 2000-08-04 US US10/049,093 patent/US7078558B1/en not_active Expired - Fee Related
- 2000-08-04 DK DK00946239T patent/DK1200385T3/da active
- 2000-08-04 ES ES00946239T patent/ES2235911T5/es not_active Expired - Lifetime
- 2000-08-04 SK SK174-2002A patent/SK1742002A3/sk not_active Application Discontinuation
- 2000-08-04 NZ NZ516685A patent/NZ516685A/en not_active IP Right Cessation
- 2000-08-04 EP EP00946239A patent/EP1200385B2/fr not_active Expired - Lifetime
- 2000-08-04 KR KR1020027001231A patent/KR100766928B1/ko not_active IP Right Cessation
- 2000-08-04 JP JP2001515281A patent/JP2003506424A/ja active Pending
- 2000-08-04 CZ CZ2002414A patent/CZ2002414A3/cs unknown
- 2000-08-04 AT AT00946239T patent/ATE287389T1/de not_active IP Right Cessation
- 2000-08-04 KR KR1020077015051A patent/KR20070086847A/ko not_active Application Discontinuation
- 2000-08-04 WO PCT/IB2000/001103 patent/WO2001010813A1/fr active Application Filing
- 2000-08-04 HU HU0202536A patent/HUP0202536A3/hu unknown
- 2000-08-04 SI SI200030653T patent/SI1200385T2/sl unknown
- 2000-08-04 DE DE60017568T patent/DE60017568T2/de not_active Expired - Lifetime
- 2000-08-04 PT PT00946239T patent/PT1200385E/pt unknown
- 2000-08-04 YU YU5402A patent/YU5402A/sh unknown
- 2000-08-04 CA CA002379335A patent/CA2379335A1/fr not_active Abandoned
- 2000-08-04 CN CNB008113653A patent/CN1205172C/zh not_active Expired - Fee Related
-
2002
- 2002-01-17 ZA ZA200200437A patent/ZA200200437B/en unknown
- 2002-02-04 HR HR20020106A patent/HRP20020106A2/hr not_active Application Discontinuation
- 2002-02-05 BG BG106389A patent/BG65368B1/bg unknown
- 2002-02-06 IL IL148050A patent/IL148050A/en not_active IP Right Cessation
-
2003
- 2003-04-04 US US10/408,012 patent/US6740775B1/en not_active Expired - Fee Related
-
2006
- 2006-04-10 US US11/400,872 patent/US20060183929A1/en not_active Abandoned
-
2007
- 2007-11-08 IL IL187261A patent/IL187261A0/en unknown
Also Published As
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