PT1200385E - Cristais do sal de sodio de pravastatina - Google Patents
Cristais do sal de sodio de pravastatinaInfo
- Publication number
- PT1200385E PT1200385E PT00946239T PT00946239T PT1200385E PT 1200385 E PT1200385 E PT 1200385E PT 00946239 T PT00946239 T PT 00946239T PT 00946239 T PT00946239 T PT 00946239T PT 1200385 E PT1200385 E PT 1200385E
- Authority
- PT
- Portugal
- Prior art keywords
- sodium salt
- pravastatin
- crystalline form
- cervastatin
- fluvastatin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9900191A SI20305A (sl) | 1999-08-06 | 1999-08-06 | Kristali natrijeve soli pravastatina |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1200385E true PT1200385E (pt) | 2005-04-29 |
Family
ID=20432515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00946239T PT1200385E (pt) | 1999-08-06 | 2000-08-04 | Cristais do sal de sodio de pravastatina |
Country Status (24)
Country | Link |
---|---|
US (3) | US7078558B1 (pt) |
EP (1) | EP1200385B2 (pt) |
JP (1) | JP2003506424A (pt) |
KR (2) | KR100766928B1 (pt) |
CN (1) | CN1205172C (pt) |
AT (1) | ATE287389T1 (pt) |
BG (1) | BG65368B1 (pt) |
CA (1) | CA2379335A1 (pt) |
CZ (1) | CZ2002414A3 (pt) |
DE (1) | DE60017568T2 (pt) |
DK (1) | DK1200385T3 (pt) |
ES (1) | ES2235911T5 (pt) |
HR (1) | HRP20020106A2 (pt) |
HU (1) | HUP0202536A3 (pt) |
IL (3) | IL148050A0 (pt) |
NZ (1) | NZ516685A (pt) |
PL (1) | PL365850A1 (pt) |
PT (1) | PT1200385E (pt) |
RU (1) | RU2247711C2 (pt) |
SI (2) | SI20305A (pt) |
SK (1) | SK1742002A3 (pt) |
WO (1) | WO2001010813A1 (pt) |
YU (1) | YU5402A (pt) |
ZA (1) | ZA200200437B (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
SK8312002A3 (en) | 1999-12-14 | 2003-05-02 | Biogal Gyogyszergyar | Novel forms of pravastatin sodium |
JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
JP2002121172A (ja) * | 2000-10-16 | 2002-04-23 | Sankyo Co Ltd | プラバスタチン又はその薬理上許容される塩の精製方法 |
WO2002057229A1 (en) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
CZ2004943A3 (cs) * | 2002-03-18 | 2005-02-16 | Biocon Limited | Amorfní HMG-CoA inhibitory obsahující reduktázu s požadovanou velikostí částic |
WO2004110585A1 (ja) * | 2003-06-10 | 2004-12-23 | Taisho Pharmaceutical Co., Ltd. | 放射球状晶析物およびその製造方法並びにこれを利用するドライパウダー製剤 |
CN1293874C (zh) * | 2003-08-18 | 2007-01-10 | 李朝晖 | 以洛伐他汀盐为主要活性成分的中药红曲及其制剂 |
DE04811862T1 (de) | 2003-11-24 | 2006-03-02 | Teva Gyogyszergyar Reszvenytarsasag | Verfahren zur Reinigung von Pravastatin |
WO2005084669A1 (en) * | 2004-03-01 | 2005-09-15 | Lek Pharmaceuticals D.D. | Pharmaceutical composition |
KR20070038553A (ko) | 2004-08-06 | 2007-04-10 | 트렌스폼 파마수티컬스 인코퍼레이티드 | 신규한 스타틴 약제학적 조성물 및 관련된 치료방법 |
US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
SG155189A1 (en) * | 2004-08-06 | 2009-09-30 | Transform Pharmaceuticals Inc | Novel fenofibrate formulations and related methods of treatment |
EP1833780A1 (en) * | 2005-02-09 | 2007-09-19 | Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság | Methods of making pravastatin sodium |
JP4895510B2 (ja) * | 2005-02-23 | 2012-03-14 | 株式会社トクヤマ | バリオールアミンの製造方法 |
JP4813841B2 (ja) * | 2005-07-25 | 2011-11-09 | キユーピー株式会社 | プラバスタチンナトリウムの製造方法 |
US20110112053A1 (en) * | 2008-04-16 | 2011-05-12 | University Of Utah Research Foundation | Pharmacological targeting of vascular malformations |
CN101348476B (zh) * | 2008-09-05 | 2011-05-11 | 丽珠集团新北江制药股份有限公司 | 一种制备4,5,6,7-四氢普伐他汀及其钠盐的方法和固体结晶形式 |
CN101648867B (zh) * | 2009-09-04 | 2012-07-11 | 天津大学 | 一种普伐他汀钠晶型及其制备方法和应用 |
EP2343054A1 (en) | 2010-01-04 | 2011-07-13 | LEK Pharmaceuticals d.d. | Pellets and microparticles of pravastatin sodium and a process of making them |
CN102533893A (zh) * | 2010-12-09 | 2012-07-04 | 浙江海正药业股份有限公司 | 一种制备莫那可林j的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS572240A (en) * | 1980-06-06 | 1982-01-07 | Sankyo Co Ltd | Ml-236b derivative |
DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
JPS5889191A (ja) * | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | 3−ヒドロキシ−ml−236b誘導体の製造法 |
CA2040865C (en) | 1990-05-15 | 2002-07-23 | James L. Bergey | Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor |
KR100210482B1 (ko) * | 1997-04-10 | 1999-07-15 | 김종인 | 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 |
US6098031A (en) | 1998-03-05 | 2000-08-01 | Gsi Lumonics, Inc. | Versatile method and system for high speed, 3D imaging of microscopic targets |
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
TR200600009T2 (tr) † | 1999-02-03 | 2006-08-21 | Institute For Drug Research Ltd. | Pravastatinin hazırlanması için mikrobiyal işlem.@ |
-
1999
- 1999-08-06 SI SI9900191A patent/SI20305A/sl not_active IP Right Cessation
-
2000
- 2000-08-04 CZ CZ2002414A patent/CZ2002414A3/cs unknown
- 2000-08-04 WO PCT/IB2000/001103 patent/WO2001010813A1/en active Application Filing
- 2000-08-04 SK SK174-2002A patent/SK1742002A3/sk not_active Application Discontinuation
- 2000-08-04 ES ES00946239T patent/ES2235911T5/es not_active Expired - Lifetime
- 2000-08-04 KR KR1020027001231A patent/KR100766928B1/ko not_active IP Right Cessation
- 2000-08-04 DE DE60017568T patent/DE60017568T2/de not_active Expired - Lifetime
- 2000-08-04 DK DK00946239T patent/DK1200385T3/da active
- 2000-08-04 CA CA002379335A patent/CA2379335A1/en not_active Abandoned
- 2000-08-04 NZ NZ516685A patent/NZ516685A/en not_active IP Right Cessation
- 2000-08-04 HU HU0202536A patent/HUP0202536A3/hu unknown
- 2000-08-04 PT PT00946239T patent/PT1200385E/pt unknown
- 2000-08-04 EP EP00946239A patent/EP1200385B2/en not_active Expired - Lifetime
- 2000-08-04 KR KR1020077015051A patent/KR20070086847A/ko not_active Application Discontinuation
- 2000-08-04 YU YU5402A patent/YU5402A/sh unknown
- 2000-08-04 RU RU2002102862/04A patent/RU2247711C2/ru not_active IP Right Cessation
- 2000-08-04 JP JP2001515281A patent/JP2003506424A/ja active Pending
- 2000-08-04 US US10/049,093 patent/US7078558B1/en not_active Expired - Fee Related
- 2000-08-04 SI SI200030653T patent/SI1200385T2/sl unknown
- 2000-08-04 PL PL00365850A patent/PL365850A1/xx not_active Application Discontinuation
- 2000-08-04 CN CNB008113653A patent/CN1205172C/zh not_active Expired - Fee Related
- 2000-08-04 IL IL14805000A patent/IL148050A0/xx unknown
- 2000-08-04 AT AT00946239T patent/ATE287389T1/de not_active IP Right Cessation
-
2002
- 2002-01-17 ZA ZA200200437A patent/ZA200200437B/en unknown
- 2002-02-04 HR HR20020106A patent/HRP20020106A2/hr not_active Application Discontinuation
- 2002-02-05 BG BG106389A patent/BG65368B1/bg unknown
- 2002-02-06 IL IL148050A patent/IL148050A/en not_active IP Right Cessation
-
2003
- 2003-04-04 US US10/408,012 patent/US6740775B1/en not_active Expired - Fee Related
-
2006
- 2006-04-10 US US11/400,872 patent/US20060183929A1/en not_active Abandoned
-
2007
- 2007-11-08 IL IL187261A patent/IL187261A0/en unknown
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