IL146025A0 - Improved pharmaceutical formulations comprising at least one hiv protease inhibiting compound - Google Patents

Improved pharmaceutical formulations comprising at least one hiv protease inhibiting compound

Info

Publication number
IL146025A0
IL146025A0 IL14602500A IL14602500A IL146025A0 IL 146025 A0 IL146025 A0 IL 146025A0 IL 14602500 A IL14602500 A IL 14602500A IL 14602500 A IL14602500 A IL 14602500A IL 146025 A0 IL146025 A0 IL 146025A0
Authority
IL
Israel
Prior art keywords
pharmaceutical formulations
hiv protease
inhibiting compound
improved pharmaceutical
protease inhibiting
Prior art date
Application number
IL14602500A
Other languages
English (en)
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23269615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL146025(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of IL146025A0 publication Critical patent/IL146025A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
IL14602500A 1999-06-04 2000-05-25 Improved pharmaceutical formulations comprising at least one hiv protease inhibiting compound IL146025A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32582699A 1999-06-04 1999-06-04
PCT/US2000/014342 WO2000074677A2 (en) 1999-06-04 2000-05-25 Improved pharmaceutical formulations

Publications (1)

Publication Number Publication Date
IL146025A0 true IL146025A0 (en) 2002-07-25

Family

ID=23269615

Family Applications (3)

Application Number Title Priority Date Filing Date
IL14602500A IL146025A0 (en) 1999-06-04 2000-05-25 Improved pharmaceutical formulations comprising at least one hiv protease inhibiting compound
IL146025A IL146025A (en) 1999-06-04 2001-10-18 Dissolving drug containing ritonavir and organic solvent containing a mixture of long-chain fatty acids ethanol and water
IL216686A IL216686A (en) 1999-06-04 2011-11-29 Ritonavir-containing drug solution and organic solvent containing a mixture of long fatty acids and water

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL146025A IL146025A (en) 1999-06-04 2001-10-18 Dissolving drug containing ritonavir and organic solvent containing a mixture of long-chain fatty acids ethanol and water
IL216686A IL216686A (en) 1999-06-04 2011-11-29 Ritonavir-containing drug solution and organic solvent containing a mixture of long fatty acids and water

Country Status (33)

Country Link
EP (2) EP1183026B1 (xx)
JP (1) JP4753511B2 (xx)
KR (1) KR100815412B1 (xx)
CN (2) CN100418527C (xx)
AR (2) AR032586A1 (xx)
AT (2) ATE429224T1 (xx)
AU (1) AU778198B2 (xx)
BG (1) BG65445B1 (xx)
BR (1) BR0007294A (xx)
CA (1) CA2371109C (xx)
CL (1) CL2008003491A1 (xx)
CO (1) CO5160323A1 (xx)
CY (2) CY1105237T1 (xx)
CZ (1) CZ301308B6 (xx)
DE (2) DE60029219T2 (xx)
DK (2) DK1733725T4 (xx)
ES (2) ES2324549T5 (xx)
HK (1) HK1045804A1 (xx)
HU (1) HU229501B1 (xx)
IL (3) IL146025A0 (xx)
MX (1) MXPA01012478A (xx)
MY (1) MY127908A (xx)
NO (1) NO328968B1 (xx)
NZ (1) NZ515016A (xx)
PL (1) PL197671B1 (xx)
PT (2) PT1733725E (xx)
SA (1) SA00210237B1 (xx)
SI (2) SI1183026T1 (xx)
SK (2) SK287185B6 (xx)
TR (1) TR200103488T2 (xx)
TW (1) TWI244390B (xx)
WO (1) WO2000074677A2 (xx)
ZA (1) ZA200108641B (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5090830A1 (es) * 1998-07-20 2001-10-30 Abbott Lab Poliformo de un agente farmaceutico
CA2371109C (en) * 1999-06-04 2011-04-26 Laman A. Alani Improved pharmaceutical formulations
US7141593B1 (en) 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
DE60028754T2 (de) 1999-11-12 2007-05-31 Abbott Laboratories, Abbott Park Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
ES2304990T3 (es) * 2000-01-19 2008-11-01 Abbott Laboratories Formulaciones farmaceuticas de inhibidores de la proteasa del vih mejoradas.
MXPA03010771A (es) * 2001-05-25 2004-07-01 Abbott Lab Capsulas elasticas blandas que comprenden ritonavir y/o lopinavir.
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
SG170795A1 (en) * 2005-12-30 2011-05-30 Gilead Sciences Inc Methods for improving the pharmacokinetics of hiv integrase inhibitors
AU2015258296B2 (en) * 2006-07-07 2017-08-17 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
AU2013204805C1 (en) * 2006-07-07 2017-03-09 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
EP3696171A1 (en) 2006-07-07 2020-08-19 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
NO347119B1 (no) * 2006-07-07 2023-05-15 Gilead Sciences Inc Modulatorer av farmakokinetikkegenskaper til terapeutika
AU2015234299B2 (en) * 2006-07-07 2017-03-09 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
EP2112925A4 (en) 2006-11-15 2013-01-09 Abbott Lab SOLID PHARMACEUTICAL DOSAGE FORMULATIONS
AU2015204378B2 (en) * 2007-02-23 2017-03-09 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
AU2013204817B2 (en) * 2007-02-23 2015-05-07 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
SI2487162T1 (sl) 2007-02-23 2016-12-30 Gilead Sciences, Inc. Modulatorji farmakokinetičnih lastnosti terapevtskih sredstev
EP3150586B1 (en) * 2007-02-23 2020-01-08 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
CN101796040A (zh) 2007-07-06 2010-08-04 吉里德科学公司 治疗剂的药代动力学特性调节剂
PT2231628E (pt) 2008-01-04 2015-12-29 Gilead Sciences Inc Inibidores de citocromo p450
UA108738C2 (uk) * 2009-04-03 2015-06-10 Спосіб одержання інгібітора цитохром р450 монооксигенази та залучені проміжні сполуки

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696270A (en) * 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
IL110752A (en) † 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
IL111991A (en) † 1994-01-28 2000-07-26 Abbott Lab Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
JP4157969B2 (ja) * 1994-03-18 2008-10-01 スパーナス ファーマシューティカルズ インコーポレイテッド 乳化薬物送達システム
DE4431489A1 (de) * 1994-09-03 1996-03-07 Heidelberger Baustofftech Gmbh Schnellhärtende aminosilanvernetzende Silikonmassen
US5567823A (en) * 1995-06-06 1996-10-22 Abbott Laboratories Process for the preparation of an HIV protease inhibiting compound
US6037157A (en) * 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
WO1997021683A1 (en) * 1995-12-13 1997-06-19 Abbott Laboratories Retroviral protease inhibiting compounds
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
CO5090830A1 (es) * 1998-07-20 2001-10-30 Abbott Lab Poliformo de un agente farmaceutico
CA2371109C (en) * 1999-06-04 2011-04-26 Laman A. Alani Improved pharmaceutical formulations

Also Published As

Publication number Publication date
JP4753511B2 (ja) 2011-08-24
ATE429224T1 (de) 2009-05-15
EP1183026B1 (en) 2006-07-05
PL351943A1 (en) 2003-07-14
IL216686A0 (en) 2012-01-31
BG65445B1 (bg) 2008-08-29
CA2371109C (en) 2011-04-26
SA00210237B1 (ar) 2006-11-07
CZ20014293A3 (cs) 2002-03-13
ATE332132T1 (de) 2006-07-15
WO2000074677A3 (en) 2001-02-22
IL146025A (en) 2012-04-30
PT1183026E (pt) 2006-11-30
SK286305B6 (en) 2008-07-07
SK287185B6 (sk) 2010-02-08
TR200103488T2 (tr) 2002-04-22
CL2008003491A1 (es) 2009-03-06
DK1733725T3 (da) 2009-08-03
HUP0201591A3 (en) 2002-10-28
AR032586A1 (es) 2003-11-19
ZA200108641B (en) 2003-01-20
CN101361723B (zh) 2013-11-06
EP1733725A1 (en) 2006-12-20
MY127908A (en) 2006-12-29
PT1733725E (pt) 2009-06-30
AU778198B2 (en) 2004-11-25
EP1733725B2 (en) 2012-08-08
AU5287700A (en) 2000-12-28
NO328968B1 (no) 2010-06-28
EP1733725B1 (en) 2009-04-22
EP1183026A2 (en) 2002-03-06
ES2265946T3 (es) 2007-03-01
SK17202001A3 (sk) 2002-03-05
CY1109135T1 (el) 2014-07-02
DE60042092D1 (de) 2009-06-04
DE60029219D1 (de) 2006-08-17
CZ301308B6 (cs) 2010-01-06
DE60029219T2 (de) 2007-06-28
ES2324549T5 (es) 2012-10-31
HUP0201591A2 (en) 2002-09-28
AR064309A2 (es) 2009-03-25
NO20015670D0 (no) 2001-11-20
SI1733725T2 (sl) 2012-10-30
BG106239A (en) 2002-08-30
NZ515016A (en) 2004-02-27
CA2371109A1 (en) 2000-12-14
CY1105237T1 (el) 2010-03-03
IL216686A (en) 2014-01-30
CO5160323A1 (es) 2002-05-30
DK1183026T3 (da) 2006-11-06
CN100418527C (zh) 2008-09-17
SI1733725T1 (sl) 2009-08-31
TWI244390B (en) 2005-12-01
HK1045804A1 (en) 2002-12-13
CN101361723A (zh) 2009-02-11
KR20020011994A (ko) 2002-02-09
SI1183026T1 (sl) 2006-10-31
CN1353607A (zh) 2002-06-12
PL197671B1 (pl) 2008-04-30
NO20015670L (no) 2001-11-20
BR0007294A (pt) 2002-08-27
KR100815412B1 (ko) 2008-03-20
ES2324549T3 (es) 2009-08-10
WO2000074677A2 (en) 2000-12-14
HU229501B1 (hu) 2014-01-28
DK1733725T4 (da) 2012-09-17
MXPA01012478A (es) 2003-10-14
JP2003501386A (ja) 2003-01-14

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