DK1183026T3 - Forbedrede farmaceutiske formuleringer omfattende ritonavir - Google Patents

Forbedrede farmaceutiske formuleringer omfattende ritonavir

Info

Publication number
DK1183026T3
DK1183026T3 DK00937743T DK00937743T DK1183026T3 DK 1183026 T3 DK1183026 T3 DK 1183026T3 DK 00937743 T DK00937743 T DK 00937743T DK 00937743 T DK00937743 T DK 00937743T DK 1183026 T3 DK1183026 T3 DK 1183026T3
Authority
DK
Denmark
Prior art keywords
ritonavir
pharmaceutical formulations
improved pharmaceutical
improved
formulations
Prior art date
Application number
DK00937743T
Other languages
English (en)
Inventor
Laman A Alani
Soumojeet Ghosh
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23269615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1183026(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1183026T3 publication Critical patent/DK1183026T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/63Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK00937743T 1999-06-04 2000-05-25 Forbedrede farmaceutiske formuleringer omfattende ritonavir DK1183026T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32582699A 1999-06-04 1999-06-04

Publications (1)

Publication Number Publication Date
DK1183026T3 true DK1183026T3 (da) 2006-11-06

Family

ID=23269615

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00937743T DK1183026T3 (da) 1999-06-04 2000-05-25 Forbedrede farmaceutiske formuleringer omfattende ritonavir
DK06114684.1T DK1733725T4 (da) 1999-06-04 2000-05-25 Farmaceutiske formuleringer omfattende mindst én HIV-proteaseinhiberende forbindelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK06114684.1T DK1733725T4 (da) 1999-06-04 2000-05-25 Farmaceutiske formuleringer omfattende mindst én HIV-proteaseinhiberende forbindelse

Country Status (33)

Country Link
EP (2) EP1733725B2 (da)
JP (1) JP4753511B2 (da)
KR (1) KR100815412B1 (da)
CN (2) CN101361723B (da)
AR (2) AR032586A1 (da)
AT (2) ATE332132T1 (da)
AU (1) AU778198B2 (da)
BG (1) BG65445B1 (da)
BR (1) BR0007294A (da)
CA (1) CA2371109C (da)
CL (1) CL2008003491A1 (da)
CO (1) CO5160323A1 (da)
CY (2) CY1105237T1 (da)
CZ (1) CZ301308B6 (da)
DE (2) DE60029219T2 (da)
DK (2) DK1183026T3 (da)
ES (2) ES2324549T5 (da)
HK (1) HK1045804A1 (da)
HU (1) HU229501B1 (da)
IL (3) IL146025A0 (da)
MX (1) MXPA01012478A (da)
MY (1) MY127908A (da)
NO (1) NO328968B1 (da)
NZ (1) NZ515016A (da)
PL (1) PL197671B1 (da)
PT (2) PT1183026E (da)
SA (1) SA00210237B1 (da)
SI (2) SI1733725T2 (da)
SK (2) SK286305B6 (da)
TR (1) TR200103488T2 (da)
TW (1) TWI244390B (da)
WO (1) WO2000074677A2 (da)
ZA (1) ZA200108641B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145265A (en) * 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
US7141593B1 (en) 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
EP1733725B2 (en) * 1999-06-04 2012-08-08 Abbott Laboratories Pharmaceutical solution comprising ritonavir, a solvent (long chain fatty acid) and water
WO2001034119A2 (en) 1999-11-12 2001-05-17 Abbott Laboratories Inhibitors of crystallization in a solid dispersion
BR0011864A (pt) * 2000-01-19 2004-07-20 Abbott Lab Formulações farmacêuticas
CA2448438A1 (en) * 2001-05-25 2002-12-05 Abbott Laboratories Soft elastic capsules comprising ritonavir and/or lopinavir
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
EP2308490A1 (en) * 2005-12-30 2011-04-13 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
EP3696171A1 (en) * 2006-07-07 2020-08-19 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
NO345893B1 (no) * 2006-07-07 2021-09-27 Gilead Sciences Inc Modulatorer av farmakokinetikkegenskaper til terapeutika
AU2015258296B2 (en) * 2006-07-07 2017-08-17 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
AU2013204805C1 (en) * 2006-07-07 2017-03-09 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
AU2015234299B2 (en) * 2006-07-07 2017-03-09 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US20080181948A1 (en) 2006-11-15 2008-07-31 Abbott Laboratories Solid pharmaceutical dosage formulations
DK2487161T4 (da) 2007-02-23 2024-06-24 Gilead Sciences Inc Modulatorer af farmakokinetiske egenskaber af terapeutika
ES2603617T3 (es) 2007-02-23 2017-02-28 Gilead Sciences, Inc. Moduladores de propiedades farmacocinéticas de la terapéutica
AU2013204815B2 (en) * 2007-02-23 2015-05-07 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
AU2015204378B2 (en) * 2007-02-23 2017-03-09 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
JP5393665B2 (ja) 2007-07-06 2014-01-22 ギリアード サイエンシーズ, インコーポレイテッド 治療剤の薬物動態特性の調整剤
EP2231628B1 (en) 2008-01-04 2015-10-28 Gilead Sciences, Inc. Inhibitors of cytochrome p450
UA108738C2 (uk) * 2009-04-03 2015-06-10 Спосіб одержання інгібітора цитохром р450 монооксигенази та залучені проміжні сполуки

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552558A (en) * 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
IL111991A (en) 1994-01-28 2000-07-26 Abbott Lab Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
ES2270426T3 (es) * 1994-03-18 2007-04-01 Supernus Pharmaceuticals, Inc. Sistema de suministros de farmacos emulsionados.
DE4431489A1 (de) * 1994-09-03 1996-03-07 Heidelberger Baustofftech Gmbh Schnellhärtende aminosilanvernetzende Silikonmassen
US5567823A (en) * 1995-06-06 1996-10-22 Abbott Laboratories Process for the preparation of an HIV protease inhibiting compound
US6037157A (en) * 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
EP1295874A3 (en) * 1995-12-13 2003-04-02 Abbott Laboratories Retroviral protease inhibiting compounds
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
MY145265A (en) * 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
EP1733725B2 (en) * 1999-06-04 2012-08-08 Abbott Laboratories Pharmaceutical solution comprising ritonavir, a solvent (long chain fatty acid) and water

Also Published As

Publication number Publication date
NO20015670D0 (no) 2001-11-20
HUP0201591A2 (en) 2002-09-28
IL216686A0 (en) 2012-01-31
JP2003501386A (ja) 2003-01-14
NZ515016A (en) 2004-02-27
ATE429224T1 (de) 2009-05-15
MXPA01012478A (es) 2003-10-14
CN101361723A (zh) 2009-02-11
DE60029219T2 (de) 2007-06-28
HU229501B1 (hu) 2014-01-28
ZA200108641B (en) 2003-01-20
ES2324549T3 (es) 2009-08-10
SK287185B6 (sk) 2010-02-08
IL146025A0 (en) 2002-07-25
IL216686A (en) 2014-01-30
ATE332132T1 (de) 2006-07-15
SI1733725T2 (sl) 2012-10-30
DE60042092D1 (de) 2009-06-04
CA2371109A1 (en) 2000-12-14
CY1109135T1 (el) 2014-07-02
EP1183026A2 (en) 2002-03-06
JP4753511B2 (ja) 2011-08-24
CN101361723B (zh) 2013-11-06
TR200103488T2 (tr) 2002-04-22
BG65445B1 (bg) 2008-08-29
KR20020011994A (ko) 2002-02-09
SK17202001A3 (sk) 2002-03-05
SA00210237B1 (ar) 2006-11-07
BR0007294A (pt) 2002-08-27
WO2000074677A2 (en) 2000-12-14
KR100815412B1 (ko) 2008-03-20
HK1045804A1 (en) 2002-12-13
DK1733725T3 (da) 2009-08-03
HUP0201591A3 (en) 2002-10-28
DE60029219D1 (de) 2006-08-17
NO328968B1 (no) 2010-06-28
AR032586A1 (es) 2003-11-19
PT1733725E (pt) 2009-06-30
TWI244390B (en) 2005-12-01
CA2371109C (en) 2011-04-26
ES2265946T3 (es) 2007-03-01
CL2008003491A1 (es) 2009-03-06
DK1733725T4 (da) 2012-09-17
CN1353607A (zh) 2002-06-12
SK286305B6 (en) 2008-07-07
PT1183026E (pt) 2006-11-30
AU778198B2 (en) 2004-11-25
AU5287700A (en) 2000-12-28
NO20015670L (no) 2001-11-20
CO5160323A1 (es) 2002-05-30
SI1733725T1 (sl) 2009-08-31
SI1183026T1 (sl) 2006-10-31
CZ20014293A3 (cs) 2002-03-13
EP1733725B2 (en) 2012-08-08
CY1105237T1 (el) 2010-03-03
CN100418527C (zh) 2008-09-17
IL146025A (en) 2012-04-30
EP1733725B1 (en) 2009-04-22
MY127908A (en) 2006-12-29
WO2000074677A3 (en) 2001-02-22
ES2324549T5 (es) 2012-10-31
BG106239A (en) 2002-08-30
PL351943A1 (en) 2003-07-14
PL197671B1 (pl) 2008-04-30
EP1733725A1 (en) 2006-12-20
CZ301308B6 (cs) 2010-01-06
EP1183026B1 (en) 2006-07-05
AR064309A2 (es) 2009-03-25

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