IL145166A0 - Biphenyl derivatives as antagonists of the neurokinine-1 receptor - Google Patents

Biphenyl derivatives as antagonists of the neurokinine-1 receptor

Info

Publication number
IL145166A0
IL145166A0 IL14516600A IL14516600A IL145166A0 IL 145166 A0 IL145166 A0 IL 145166A0 IL 14516600 A IL14516600 A IL 14516600A IL 14516600 A IL14516600 A IL 14516600A IL 145166 A0 IL145166 A0 IL 145166A0
Authority
IL
Israel
Prior art keywords
neurokinine
antagonists
receptor
biphenyl derivatives
biphenyl
Prior art date
Application number
IL14516600A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL145166A0 publication Critical patent/IL145166A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/44—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL14516600A 1999-03-09 2000-02-28 Biphenyl derivatives as antagonists of the neurokinine-1 receptor IL145166A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99104626 1999-03-09
PCT/EP2000/001668 WO2000053572A1 (en) 1999-03-09 2000-02-28 Biphenyl derivatives as antagonists of the neurokinine-1 receptor

Publications (1)

Publication Number Publication Date
IL145166A0 true IL145166A0 (en) 2002-06-30

Family

ID=8237723

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14516600A IL145166A0 (en) 1999-03-09 2000-02-28 Biphenyl derivatives as antagonists of the neurokinine-1 receptor
IL145166A IL145166A (en) 1999-03-09 2001-08-28 History of biphenyl used as neurokinin-1 receptor antagonists

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL145166A IL145166A (en) 1999-03-09 2001-08-28 History of biphenyl used as neurokinin-1 receptor antagonists

Country Status (33)

Country Link
US (2) US6291465B1 (ar)
EP (1) EP1171419B1 (ar)
JP (1) JP3839668B2 (ar)
KR (1) KR100473247B1 (ar)
CN (1) CN1152006C (ar)
AR (1) AR043273A1 (ar)
AT (1) ATE286018T1 (ar)
AU (1) AU767449B2 (ar)
BR (1) BR0008862A (ar)
CA (1) CA2366205C (ar)
CO (1) CO5160261A1 (ar)
CZ (1) CZ20013190A3 (ar)
DE (1) DE60017110T2 (ar)
ES (1) ES2233338T3 (ar)
HK (1) HK1045684B (ar)
HR (1) HRP20010629A2 (ar)
HU (1) HUP0201710A3 (ar)
IL (2) IL145166A0 (ar)
JO (1) JO2235B1 (ar)
MA (1) MA26778A1 (ar)
MY (1) MY121145A (ar)
NO (1) NO20014356D0 (ar)
NZ (1) NZ513824A (ar)
PE (1) PE20001549A1 (ar)
PL (1) PL201681B1 (ar)
PT (1) PT1171419E (ar)
RU (1) RU2238266C2 (ar)
SI (1) SI1171419T1 (ar)
TR (1) TR200102585T2 (ar)
UY (1) UY26051A1 (ar)
WO (1) WO2000053572A1 (ar)
YU (1) YU64901A (ar)
ZA (1) ZA200107259B (ar)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100514236B1 (ko) 1999-02-24 2005-09-13 에프. 호프만-라 로슈 아게 페닐 유도체 및 피리디닐 유도체
AUPQ514600A0 (en) 2000-01-18 2000-02-10 James Cook University Brain injury treatment
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
US6642226B2 (en) 2001-02-06 2003-11-04 Hoffman-La Roche Inc. Substituted phenyl-piperidine methanone compounds
US6531597B2 (en) * 2001-02-13 2003-03-11 Hoffmann-La Roche Inc. Process for preparation of 2-phenyl acetic acid derivatives
JP4542341B2 (ja) 2002-03-13 2010-09-15 ザ ユニバーシティ オブ テネシー リサーチ ファウンデイション 置換テトラヒドロイソキノリン化合物、調製方法、およびその使用
JP2008540665A (ja) 2005-05-19 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なビアリール
WO2006130493A2 (en) 2005-05-31 2006-12-07 Vertex Pharmaceuticals Incorporated Heterocycles useful as modulators of ion channels
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
CN109153670B (zh) * 2016-05-23 2022-03-15 中国医学科学院药物研究所 烟醇醚类衍生物、及其制法和药物组合物与用途
AU2019223237A1 (en) 2018-02-26 2020-09-03 Ospedale San Raffaele S.R.L. NK-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency
CN115466195B (zh) * 2022-09-15 2024-04-19 中国科学院成都生物研究所 一类联苯类酰胺化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06227913A (ja) * 1993-02-03 1994-08-16 Sumitomo Chem Co Ltd 安息香酸誘導体を有効成分とする植物病害防除剤
IL111960A (en) 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
ATE278687T1 (de) 1993-12-29 2004-10-15 Merck Sharp & Dohme Substituierte morpholinderivate und ihre verwendung als therapeutische mittel
IL112778A0 (en) 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
JP3839518B2 (ja) * 1996-03-27 2006-11-01 ポーラ化成工業株式会社 抗真菌剤
PL336481A1 (en) 1997-04-18 2000-06-19 Pfizer Method of obtaining (1,2,3,4- tetrahydroisoquinolin -6-yl) amide of 4'-trifluoromethylbiphenyl-2-carboxylic acid and intermediate compounds
US5972938A (en) 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
EP1035115B1 (en) * 1999-02-24 2004-09-29 F. Hoffmann-La Roche Ag 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists

Also Published As

Publication number Publication date
US6291465B1 (en) 2001-09-18
JO2235B1 (ar) 2004-10-07
JP3839668B2 (ja) 2006-11-01
CZ20013190A3 (cs) 2002-02-13
HRP20010629A2 (en) 2002-08-31
KR100473247B1 (ko) 2005-03-08
HK1045684B (zh) 2004-11-26
ES2233338T3 (es) 2005-06-16
JP2002539112A (ja) 2002-11-19
NZ513824A (en) 2004-01-30
AR043273A1 (es) 2005-07-27
CA2366205A1 (en) 2000-09-14
AU767449B2 (en) 2003-11-13
DE60017110D1 (de) 2005-02-03
MA26778A1 (fr) 2004-12-20
PL350536A1 (en) 2002-12-16
IL145166A (en) 2006-10-05
CN1343197A (zh) 2002-04-03
ATE286018T1 (de) 2005-01-15
PT1171419E (pt) 2005-04-29
PL201681B1 (pl) 2009-04-30
PE20001549A1 (es) 2001-01-09
CO5160261A1 (es) 2002-05-30
TR200102585T2 (tr) 2002-01-21
US6552088B2 (en) 2003-04-22
HUP0201710A2 (en) 2002-10-28
KR20010111271A (ko) 2001-12-17
NO20014356L (no) 2001-09-07
CA2366205C (en) 2008-09-09
HK1045684A1 (en) 2002-12-06
RU2238266C2 (ru) 2004-10-20
BR0008862A (pt) 2002-01-02
NO20014356D0 (no) 2001-09-07
SI1171419T1 (en) 2005-06-30
CN1152006C (zh) 2004-06-02
DE60017110T2 (de) 2006-01-26
EP1171419A1 (en) 2002-01-16
EP1171419B1 (en) 2004-12-29
US20020040060A1 (en) 2002-04-04
AU3161200A (en) 2000-09-28
YU64901A (sh) 2005-07-19
WO2000053572A1 (en) 2000-09-14
ZA200107259B (en) 2002-12-02
MY121145A (en) 2005-12-30
UY26051A1 (es) 2000-09-29
HUP0201710A3 (en) 2002-11-28

Similar Documents

Publication Publication Date Title
AP2001002223A0 (en) Substituted bicyclic derivatives useful as anticancer agents
SI1224175T1 (en) Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
PL357418A1 (en) Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
HK1076459A1 (en) 4-Phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
PL356990A1 (en) Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
IL152700A0 (en) Substituted 1-aminoalkyl-lactams and their use as muscarinc receptor antagonists
IL153837A0 (en) 4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
HUP0004851A3 (en) Cyclopentene derivatives useful as antagonists of the motilin receptor
PL350536A1 (en) Biphenyl derivatives as antagonists of the neurokinine-1 receptor
IL148623A0 (en) Thienoisoxazolyl-and thienylpyrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists
IL146151A0 (en) Human-g-protein receptor
PL352213A1 (en) Antagonistic compounds of the il-8 receptor
IL144299A0 (en) N-triazolymethyl-piperazine derivatives as neurokinin receptor antagonists
PL330708A1 (en) Derivatives of indolydine useful as antagonists of 5-ht-2c receptor
AU2001250820A1 (en) Novel cyclohexene derivatives useful as antagonists of the motilin receptor
PL338453A1 (en) 2-acylaminopropanoamines as antagonists of the tachykinin receptor
AU2001247357A1 (en) Novel cyclobutene derivatives useful as antagonists of the motilin receptor
AU2001249144A1 (en) Novel cyclopentene derivatives useful as antagonists of the motilin receptor
AU1100300A (en) Piperidyloxadiazoles as dopamine receptor antagonists
PL338456A1 (en) 2-acylaminopropanoamines as antagonists of the tachykinin receptor
AU2574801A (en) Selective iGLUR5 receptor antagonists
EP1169042A4 (en) DIBENZO-AZEPINE DERIVATIVES AS ANTAGONISTS OF THE ALPHA V INTEGRIN RECEPTOR
PL352222A1 (en) Antagonists of the il-8 receptor
AU2512800A (en) Alpha1-adrenergic receptor antagonists
AU2002313055A1 (en) 5-cyano-1h-indole derivatives as antagonists of the interleukine-8 receptors

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed