PE20001549A1 - Derivados de bifenilo como antagonistas del receptor de neuroquinina 1 - Google Patents
Derivados de bifenilo como antagonistas del receptor de neuroquinina 1Info
- Publication number
- PE20001549A1 PE20001549A1 PE2000000177A PE0001772000A PE20001549A1 PE 20001549 A1 PE20001549 A1 PE 20001549A1 PE 2000000177 A PE2000000177 A PE 2000000177A PE 0001772000 A PE0001772000 A PE 0001772000A PE 20001549 A1 PE20001549 A1 PE 20001549A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- alkyl
- biphenyl
- neuroquinin
- trifluoromethyl
- Prior art date
Links
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- -1 AMINO Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 150000003512 tertiary amines Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/44—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE BIFENILO DE FORMULA I, DONDE: R ES H, ALQUILO, ALCOXI, HALOGENO, AMINO, -N(R6)2, TRIFLUOROMETILO; R1 ES H, ALCOXI, HALOGENO; R Y R1 JUNTOS SON -CH=CH-CH=CH-; R2 ES HALOGENO, ALQUILO, TRIFLUOROMETILO; R3 ES H, ALQUILO; R4 ES H, AMINA TERCIARIA CICLICA SUSTITUIDA CON ALQUILO; R5 ES H, NITRO, AMINO, N(R6)2, R6 ES H, ALQUILO; X ES CONR6, (CH2)nO, (CH2)nNR6, NR6CO, NR6(CH2)n; n ES 1-2. SON COMPUESTOS PREFERIDOS ACIDO 2`-METIL-BIFENIL-2-CARBOXILICO-(3,5-BIS-TRIFLUOROMETIL-BENCIL)METIL-AMIDA, ACIDO 2'-METIL-5-(4-METIL-PIPERAZIN-1-IL)-BIFENIL-2-CARBOXILICO-(3,5-BISTRIFLUOROMETILO-BENCIL)METIL-AMIDA, ACIDO 2'-CLORO-5-(4-METIL-PIPERAZIN-1-IL)-BIFENIL-2-CARBOXILICO-(3,5-BISTRIFLUOROMETIL-BENCIL)METIL-AMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN ANTAGONISTA DEL RECEPTOR DE NEUROQUININA 1 (NK-1) POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DEL DOLOR, CEFALEA, MIGRANA, ENFERMEDAD DE ALZHEIMER, ESCLEROSIS MULTIPLE, EDEMA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99104626 | 1999-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20001549A1 true PE20001549A1 (es) | 2001-01-09 |
Family
ID=8237723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000177A PE20001549A1 (es) | 1999-03-09 | 2000-03-03 | Derivados de bifenilo como antagonistas del receptor de neuroquinina 1 |
Country Status (33)
Country | Link |
---|---|
US (2) | US6291465B1 (es) |
EP (1) | EP1171419B1 (es) |
JP (1) | JP3839668B2 (es) |
KR (1) | KR100473247B1 (es) |
CN (1) | CN1152006C (es) |
AR (1) | AR043273A1 (es) |
AT (1) | ATE286018T1 (es) |
AU (1) | AU767449B2 (es) |
BR (1) | BR0008862A (es) |
CA (1) | CA2366205C (es) |
CO (1) | CO5160261A1 (es) |
CZ (1) | CZ20013190A3 (es) |
DE (1) | DE60017110T2 (es) |
ES (1) | ES2233338T3 (es) |
HK (1) | HK1045684B (es) |
HR (1) | HRP20010629A2 (es) |
HU (1) | HUP0201710A3 (es) |
IL (2) | IL145166A0 (es) |
JO (1) | JO2235B1 (es) |
MA (1) | MA26778A1 (es) |
MY (1) | MY121145A (es) |
NO (1) | NO20014356L (es) |
NZ (1) | NZ513824A (es) |
PE (1) | PE20001549A1 (es) |
PL (1) | PL201681B1 (es) |
PT (1) | PT1171419E (es) |
RU (1) | RU2238266C2 (es) |
SI (1) | SI1171419T1 (es) |
TR (1) | TR200102585T2 (es) |
UY (1) | UY26051A1 (es) |
WO (1) | WO2000053572A1 (es) |
YU (1) | YU64901A (es) |
ZA (1) | ZA200107259B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2238264C2 (ru) | 1999-02-24 | 2004-10-20 | Ф.Хоффманн-Ля Рош Аг | Производные бензола или пиридина и фармацевтическая композиция на их основе |
AUPQ514600A0 (en) | 2000-01-18 | 2000-02-10 | James Cook University | Brain injury treatment |
TWI287003B (en) * | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
US6642226B2 (en) | 2001-02-06 | 2003-11-04 | Hoffman-La Roche Inc. | Substituted phenyl-piperidine methanone compounds |
US6531597B2 (en) * | 2001-02-13 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for preparation of 2-phenyl acetic acid derivatives |
US7241774B2 (en) | 2002-03-13 | 2007-07-10 | University Of Tennessee Research Foundation | Substituted tetrahydroisoquinoline compounds, methods of making, and their use |
JP2008540665A (ja) * | 2005-05-19 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なビアリール |
EP1904491A2 (en) | 2005-05-31 | 2008-04-02 | Vertex Pharmaceuticals Incorporated | Heterocycles useful as modulators of ion channels |
DK2729147T3 (en) | 2011-07-04 | 2017-12-18 | Irbm - Science Park S P A | NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA |
US10975049B2 (en) | 2016-05-23 | 2021-04-13 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof |
RU2020131446A (ru) | 2018-02-26 | 2022-03-28 | Оспедале Сан Раффаэле С.Р.Л. | Антагонисты nk-1 для применения в лечении глазной боли |
EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
CN115466195B (zh) * | 2022-09-15 | 2024-04-19 | 中国科学院成都生物研究所 | 一类联苯类酰胺化合物及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06227913A (ja) * | 1993-02-03 | 1994-08-16 | Sumitomo Chem Co Ltd | 安息香酸誘導体を有効成分とする植物病害防除剤 |
IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
SG52217A1 (en) | 1993-12-29 | 1998-09-28 | Merck Sharp & Dohme | Substituted morpholine derivatives and their use as therapeutic agents |
IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
JP3839518B2 (ja) * | 1996-03-27 | 2006-11-01 | ポーラ化成工業株式会社 | 抗真菌剤 |
WO1998047875A1 (en) | 1997-04-18 | 1998-10-29 | Pfizer Inc. | Process and intermediates for the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide |
US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
PT1394150E (pt) * | 1999-02-24 | 2011-02-17 | Hoffmann La Roche | Derivados de 4-fenilpiridina e a sua utilização como antagonistas dos receptores de nc-1 |
-
2000
- 2000-02-25 US US09/513,147 patent/US6291465B1/en not_active Expired - Fee Related
- 2000-02-28 RU RU2001126547A patent/RU2238266C2/ru not_active IP Right Cessation
- 2000-02-28 EP EP00909264A patent/EP1171419B1/en not_active Expired - Lifetime
- 2000-02-28 YU YU64901A patent/YU64901A/sh unknown
- 2000-02-28 SI SI200030598T patent/SI1171419T1/xx unknown
- 2000-02-28 KR KR10-2001-7011407A patent/KR100473247B1/ko not_active IP Right Cessation
- 2000-02-28 TR TR2001/02585T patent/TR200102585T2/xx unknown
- 2000-02-28 CN CNB008047812A patent/CN1152006C/zh not_active Expired - Fee Related
- 2000-02-28 IL IL14516600A patent/IL145166A0/xx active IP Right Grant
- 2000-02-28 PL PL350536A patent/PL201681B1/pl not_active IP Right Cessation
- 2000-02-28 JP JP2000604013A patent/JP3839668B2/ja not_active Expired - Fee Related
- 2000-02-28 DE DE60017110T patent/DE60017110T2/de not_active Expired - Lifetime
- 2000-02-28 CA CA002366205A patent/CA2366205C/en not_active Expired - Fee Related
- 2000-02-28 HU HU0201710A patent/HUP0201710A3/hu unknown
- 2000-02-28 BR BR0008862-5A patent/BR0008862A/pt not_active Application Discontinuation
- 2000-02-28 WO PCT/EP2000/001668 patent/WO2000053572A1/en active IP Right Grant
- 2000-02-28 ES ES00909264T patent/ES2233338T3/es not_active Expired - Lifetime
- 2000-02-28 NZ NZ513824A patent/NZ513824A/xx unknown
- 2000-02-28 CZ CZ20013190A patent/CZ20013190A3/cs unknown
- 2000-02-28 AU AU31612/00A patent/AU767449B2/en not_active Ceased
- 2000-02-28 AT AT00909264T patent/ATE286018T1/de not_active IP Right Cessation
- 2000-02-28 PT PT00909264T patent/PT1171419E/pt unknown
- 2000-03-02 JO JO200017A patent/JO2235B1/en active
- 2000-03-03 PE PE2000000177A patent/PE20001549A1/es not_active Application Discontinuation
- 2000-03-06 MY MYPI20000864A patent/MY121145A/en unknown
- 2000-03-06 CO CO00016011A patent/CO5160261A1/es unknown
- 2000-03-07 AR ARP000101001A patent/AR043273A1/es not_active Application Discontinuation
- 2000-03-08 UY UY26051A patent/UY26051A1/es unknown
-
2001
- 2001-06-21 US US09/886,669 patent/US6552088B2/en not_active Expired - Fee Related
- 2001-08-28 IL IL145166A patent/IL145166A/en not_active IP Right Cessation
- 2001-08-28 HR HR20010629A patent/HRP20010629A2/hr not_active Application Discontinuation
- 2001-08-31 ZA ZA200107259A patent/ZA200107259B/en unknown
- 2001-09-07 MA MA26322A patent/MA26778A1/fr unknown
- 2001-09-07 NO NO20014356A patent/NO20014356L/no not_active Application Discontinuation
-
2002
- 2002-09-26 HK HK02107102.8A patent/HK1045684B/zh not_active IP Right Cessation
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