PE107098A1 - Derivados de tetrahidroquinolina - Google Patents

Derivados de tetrahidroquinolina

Info

Publication number
PE107098A1
PE107098A1 PE1997000718A PE00071897A PE107098A1 PE 107098 A1 PE107098 A1 PE 107098A1 PE 1997000718 A PE1997000718 A PE 1997000718A PE 00071897 A PE00071897 A PE 00071897A PE 107098 A1 PE107098 A1 PE 107098A1
Authority
PE
Peru
Prior art keywords
alkyl
amino
alcoxy
compounds
heterocicle
Prior art date
Application number
PE1997000718A
Other languages
English (en)
Inventor
Romano Di-Fabio
Alessandra Pasquarello
Fabio Maria Sabbatini
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Publication of PE107098A1 publication Critical patent/PE107098A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: R ES HALOGENO, ALQUILO, ALCOXI, AMINO, ALQUILAMINO, DIALQUILAMINO, OH, CF3, OCF3, NITRO, CN, SO2R2 o COR2, DE PREFERENCIA EN LA POSICION 5 Y/O 7; R1 ES (CH2)nCN, -CH=CHR3, (CH2)nNHCOCH2R4, o O(CH2)pNR5R6; R2 ES OH, OCH3, AMINO, ALQUILAMINO o DIALQUILAMINO; R3 ES CN o COR7; R4 ES ALCOXI o NHCOR8; R5 Y R6 ES H o ALQUILO o R5 Y R6 JUNTOS CON EL NITROGENO FORMAN UN GRUPO HETEROCICLO o R5 ES H Y R6 ES COR9; R7 ES ALCOXI, AMINO o OH; R8 ES H, ALQUILO, ALCOXI, FENILO o HETEROCICLO SUSTITUIDO OPCIONALMENTE; R9 ES R8 o NR10R11; R10 ES H o ALQUILO; R11 ES ALQUILO, FENILO, HETEROCICLO o CICLOALQUILO; m ES O; 1 o 2; n ES 0; 1; 2; 3 o 4; p ES 2; 3 o 4. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I). LOS COMPUESTOS OBTENIDOS ACTUAN COMO ANTAGONISTAS DE AMINOACIDOS EXCITATORIOS EN EL SITIO DE UNION DE LA GLICINA INSENSIBLE A LA ESTRICNINA PRESENTE EN EL COMPLEJO RECEPTOR N-METIL-D-ASPARTATO (NMDA) SIENDO UTILES EN EL TRATAMIENTO o PREVENCION DE DANOS NEUROTOXICOS (COMO RESULTADO DE ATAQUES CEREBRALES, ISQUEMIA) Y DE ENFERMEDADES NEURODEGENERATIVAS CRONICAS (COMO LA ENFERMEDAD DE HUNTINGTON o DE ALZHEIMER) O INDUCIDAS POR INFECCION VIRAL (COMO POR SIDA), ENTRE OTROS
PE1997000718A 1996-08-17 1997-08-14 Derivados de tetrahidroquinolina PE107098A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9617305.9A GB9617305D0 (en) 1996-08-17 1996-08-17 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
PE107098A1 true PE107098A1 (es) 1999-01-15

Family

ID=10798623

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000718A PE107098A1 (es) 1996-08-17 1997-08-14 Derivados de tetrahidroquinolina

Country Status (34)

Country Link
US (1) US6479488B1 (es)
EP (1) EP0922034B1 (es)
JP (1) JP4108129B2 (es)
KR (1) KR100552864B1 (es)
CN (1) CN1131214C (es)
AP (1) AP877A (es)
AR (1) AR008296A1 (es)
AT (1) ATE221052T1 (es)
AU (1) AU724473B2 (es)
BR (1) BR9711311B1 (es)
CA (1) CA2264118C (es)
CO (1) CO4900066A1 (es)
CZ (1) CZ296250B6 (es)
DE (1) DE69714265T2 (es)
DK (1) DK0922034T3 (es)
EA (1) EA001704B1 (es)
ES (1) ES2181030T3 (es)
GB (1) GB9617305D0 (es)
HU (1) HU225797B1 (es)
ID (1) ID18095A (es)
IL (1) IL128141A0 (es)
IS (1) IS4953A (es)
MY (1) MY116952A (es)
NO (1) NO312241B1 (es)
NZ (1) NZ333812A (es)
PE (1) PE107098A1 (es)
PL (1) PL194532B1 (es)
PT (1) PT922034E (es)
SI (1) SI0922034T1 (es)
TR (1) TR199900336T2 (es)
TW (1) TW449582B (es)
WO (1) WO1998007704A1 (es)
YU (1) YU6799A (es)
ZA (1) ZA977326B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
US6455734B1 (en) 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
GB9929037D0 (en) * 1999-12-08 2000-02-02 Glaxo Wellcome Spa Heterocyclic derivatives
DE10132725A1 (de) 2001-07-05 2006-08-03 Grünenthal GmbH Substituierte γ-Lactonverbindungen
BR0215430A (pt) * 2001-12-28 2004-12-14 Acadia Pharm Inc Composto e seus usos, composição, método de tratamento, método de aumento d atividade de um receptor colinérgico, método de tratamento e prevenção ou redução dos sintomas associados à disfunção em mamìferos
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
MXPA05007784A (es) * 2003-01-23 2005-09-30 Acadia Pharm Inc Empleo de la n-desmetilclozapina para tratar las enfermedades neuropsiquiatricas humanas.
EP1596867A4 (en) * 2003-02-19 2006-03-22 Merck & Co Inc TREATMENT OF PSYCHOSIS WITH ECTOPIC ACTIVATOR OF M1 MUSCARINIC RECEPTOR
PL1696931T3 (pl) * 2003-12-22 2009-10-30 Acadia Pharm Inc Aminopodstawione analogi diarylo[A,D]cykloheptenowe jako agoniści receptorów muskarynowych i sposoby leczenia chorób neuropsychiatrycznych
MXPA06011320A (es) * 2004-04-01 2007-03-21 Acadia Pharm Inc Metodo de sintesis y aislamiento de n-desmetilclozapina solida y sus formas cristalinas.
CA2616079C (en) * 2005-07-22 2012-09-25 Mochida Pharmaceutical Co., Ltd. Novel heterocyclidene acetamide derivative
RU2451014C2 (ru) * 2005-07-22 2012-05-20 Мотида Фармасьютикал Ко., Лтд. Новое производное гетероциклиден ацетамида
WO2007033082A2 (en) * 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (dmso)
WO2007033180A1 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
JP5399072B2 (ja) 2005-09-12 2014-01-29 アベラ ファーマスーティカルズ インコーポレイテッド ジメチルスルホキシド（ｄｍｓｏ）若しくは関連化合物、又はそれに関連する臭気を除去するシステム
WO2007053618A1 (en) * 2005-10-31 2007-05-10 Acadia Pharmaceuticals Inc. Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
BRPI0921494A2 (pt) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
EP2493314B1 (en) 2009-10-30 2020-04-08 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (dmso) and methylsulfonylmethane (msm) formulations to treat osteoarthritis
EP2763676B1 (en) 2011-10-03 2019-12-25 The University of Utah Research Foundation Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386839B1 (en) 1989-03-08 1997-01-15 Merck Sharp & Dohme Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
EA000875B1 (ru) 1995-09-29 2000-06-26 ГЛАКСО ВЕЛЛКАМ С.п.А. Тетрагидрохинолины в качестве антагонистов nmda (n-метил-d-аспарагиновой кислоты)

Also Published As

Publication number Publication date
TW449582B (en) 2001-08-11
HUP9903108A3 (en) 2004-04-28
KR20000068172A (ko) 2000-11-25
EP0922034B1 (en) 2002-07-24
BR9711311B1 (pt) 2009-01-13
ID18095A (id) 1998-02-26
TR199900336T2 (xx) 1999-04-21
CN1131214C (zh) 2003-12-17
DE69714265D1 (de) 2002-08-29
EA199900121A1 (ru) 1999-10-28
NZ333812A (en) 2000-07-28
AP877A (en) 2000-09-27
NO990723L (no) 1999-04-14
GB9617305D0 (en) 1996-09-25
US6479488B1 (en) 2002-11-12
CZ296250B6 (cs) 2006-02-15
JP2001508031A (ja) 2001-06-19
EA001704B1 (ru) 2001-06-25
MY116952A (en) 2004-04-30
PT922034E (pt) 2002-12-31
HU225797B1 (en) 2007-09-28
AP9901459A0 (en) 1999-03-31
DE69714265T2 (de) 2003-03-06
IL128141A0 (en) 1999-11-30
EP0922034A1 (en) 1999-06-16
CO4900066A1 (es) 2000-03-27
AU4551897A (en) 1998-03-06
BR9711311A (pt) 1999-08-17
CN1227544A (zh) 1999-09-01
WO1998007704A1 (en) 1998-02-26
NO990723D0 (no) 1999-02-16
AR008296A1 (es) 1999-12-29
IS4953A (is) 1999-01-22
DK0922034T3 (da) 2002-11-18
SI0922034T1 (en) 2003-02-28
YU6799A (sh) 2000-03-21
KR100552864B1 (ko) 2006-02-20
ES2181030T3 (es) 2003-02-16
CA2264118C (en) 2008-06-17
JP4108129B2 (ja) 2008-06-25
CZ52999A3 (cs) 1999-07-14
PL194532B1 (pl) 2007-06-29
ATE221052T1 (de) 2002-08-15
AU724473B2 (en) 2000-09-21
ZA977326B (en) 1999-02-15
PL331562A1 (en) 1999-07-19
CA2264118A1 (en) 1998-02-26
NO312241B1 (no) 2002-04-15

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FD Application declared void or lapsed