ATE221052T1 - Tetrahydrochinolinderivate als eaa antagonisten - Google Patents

Tetrahydrochinolinderivate als eaa antagonisten

Info

Publication number
ATE221052T1
ATE221052T1 AT97943809T AT97943809T ATE221052T1 AT E221052 T1 ATE221052 T1 AT E221052T1 AT 97943809 T AT97943809 T AT 97943809T AT 97943809 T AT97943809 T AT 97943809T AT E221052 T1 ATE221052 T1 AT E221052T1
Authority
AT
Austria
Prior art keywords
eaa antagonists
tetrahydrochinoline
derivatives
tetrahydrochinoline derivatives
eaa
Prior art date
Application number
AT97943809T
Other languages
English (en)
Inventor
Romano Di-Fabio
Alessandra Pasquarello
Fabio Maria Sabbatini
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Application granted granted Critical
Publication of ATE221052T1 publication Critical patent/ATE221052T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT97943809T 1996-08-17 1997-08-14 Tetrahydrochinolinderivate als eaa antagonisten ATE221052T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9617305.9A GB9617305D0 (en) 1996-08-17 1996-08-17 Heterocyclic compounds
PCT/EP1997/004440 WO1998007704A1 (en) 1996-08-17 1997-08-14 Tetrahydroquinoline derivatives as eaa antagonists

Publications (1)

Publication Number Publication Date
ATE221052T1 true ATE221052T1 (de) 2002-08-15

Family

ID=10798623

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97943809T ATE221052T1 (de) 1996-08-17 1997-08-14 Tetrahydrochinolinderivate als eaa antagonisten

Country Status (34)

Country Link
US (1) US6479488B1 (de)
EP (1) EP0922034B1 (de)
JP (1) JP4108129B2 (de)
KR (1) KR100552864B1 (de)
CN (1) CN1131214C (de)
AP (1) AP877A (de)
AR (1) AR008296A1 (de)
AT (1) ATE221052T1 (de)
AU (1) AU724473B2 (de)
BR (1) BR9711311B1 (de)
CA (1) CA2264118C (de)
CO (1) CO4900066A1 (de)
CZ (1) CZ296250B6 (de)
DE (1) DE69714265T2 (de)
DK (1) DK0922034T3 (de)
EA (1) EA001704B1 (de)
ES (1) ES2181030T3 (de)
GB (1) GB9617305D0 (de)
HU (1) HU225797B1 (de)
ID (1) ID18095A (de)
IL (1) IL128141A0 (de)
IS (1) IS4953A (de)
MY (1) MY116952A (de)
NO (1) NO312241B1 (de)
NZ (1) NZ333812A (de)
PE (1) PE107098A1 (de)
PL (1) PL194532B1 (de)
PT (1) PT922034E (de)
SI (1) SI0922034T1 (de)
TR (1) TR199900336T2 (de)
TW (1) TW449582B (de)
WO (1) WO1998007704A1 (de)
YU (1) YU6799A (de)
ZA (1) ZA977326B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
US6455734B1 (en) 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
GB9929037D0 (en) * 1999-12-08 2000-02-02 Glaxo Wellcome Spa Heterocyclic derivatives
DE10132725A1 (de) 2001-07-05 2006-08-03 Grünenthal GmbH Substituierte γ-Lactonverbindungen
ES2251624T3 (es) * 2001-12-28 2006-05-01 Acadia Pharmaceuticals Inc. Analogos de la tetrahidroquinolina como los agonistas muscarinicos.
JP2006515628A (ja) * 2003-01-23 2006-06-01 アカディア ファーマシューティカルズ，インコーポレーテッド ヒト神経精神疾患を処置するためのｎ−デスメチルクロザピンの使用
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
WO2004073639A2 (en) * 2003-02-19 2004-09-02 Merck & Co. Inc. Treatment of psychosis with a muscarinic m1 receptor ectopic activator
ES2324713T3 (es) * 2003-12-22 2009-08-13 Acadia Pharmaceuticals Inc. Analogos de diaril(a,d)ciclohepteno amino-sustituidos como agonistas muscarinicos y metodos de tratamiento de trastornos neuropsiquiatricos.
CN1950346A (zh) * 2004-04-01 2007-04-18 阿卡蒂亚药品公司 N－去甲基氯氮平的晶形
WO2007010383A1 (ja) 2005-07-22 2007-01-25 Mochida Pharmaceutical Co., Ltd. 新規なヘテロシクリデンアセトアミド誘導体
RU2451014C2 (ru) * 2005-07-22 2012-05-20 Мотида Фармасьютикал Ко., Лтд. Новое производное гетероциклиден ацетамида
WO2007033180A1 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
US9427419B2 (en) 2005-09-12 2016-08-30 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (DMSO)
US7955418B2 (en) 2005-09-12 2011-06-07 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated with same
WO2007053618A1 (en) * 2005-10-31 2007-05-10 Acadia Pharmaceuticals Inc. Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
BRPI0921494A2 (pt) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
JP5947721B2 (ja) 2009-10-30 2016-07-06 アベラ ファーマスーティカルズ インコーポレイテッド 変形性関節症を治療するためのジメチルスルホキシド（ｄｍｓｏ）およびメチルスルホニルメタン（ｍｓｍ）製剤
WO2013055386A2 (en) 2011-10-03 2013-04-18 The University Of Utah Research Foundation Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386839B1 (de) * 1989-03-08 1997-01-15 Merck Sharp & Dohme Ltd. Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten
BR9610733A (pt) * 1995-09-29 1999-07-13 Glaxo Wellcome Spa Composto processos para a preparação do mesmo e para o tratamento de um mamífero composição farmacêutica e utilização de um composto

Also Published As

Publication number Publication date
NO990723L (no) 1999-04-14
ZA977326B (en) 1999-02-15
AR008296A1 (es) 1999-12-29
SI0922034T1 (en) 2003-02-28
KR100552864B1 (ko) 2006-02-20
CA2264118A1 (en) 1998-02-26
AP9901459A0 (en) 1999-03-31
AP877A (en) 2000-09-27
CA2264118C (en) 2008-06-17
CZ296250B6 (cs) 2006-02-15
EP0922034B1 (de) 2002-07-24
CN1131214C (zh) 2003-12-17
DE69714265D1 (de) 2002-08-29
HU225797B1 (en) 2007-09-28
JP2001508031A (ja) 2001-06-19
US6479488B1 (en) 2002-11-12
ID18095A (id) 1998-02-26
GB9617305D0 (en) 1996-09-25
AU4551897A (en) 1998-03-06
PE107098A1 (es) 1999-01-15
CZ52999A3 (cs) 1999-07-14
TR199900336T2 (xx) 1999-04-21
BR9711311A (pt) 1999-08-17
PT922034E (pt) 2002-12-31
TW449582B (en) 2001-08-11
KR20000068172A (ko) 2000-11-25
NZ333812A (en) 2000-07-28
IL128141A0 (en) 1999-11-30
DE69714265T2 (de) 2003-03-06
PL194532B1 (pl) 2007-06-29
CN1227544A (zh) 1999-09-01
HUP9903108A3 (en) 2004-04-28
EA001704B1 (ru) 2001-06-25
MY116952A (en) 2004-04-30
YU6799A (sh) 2000-03-21
NO312241B1 (no) 2002-04-15
ES2181030T3 (es) 2003-02-16
EA199900121A1 (ru) 1999-10-28
BR9711311B1 (pt) 2009-01-13
DK0922034T3 (da) 2002-11-18
AU724473B2 (en) 2000-09-21
PL331562A1 (en) 1999-07-19
EP0922034A1 (de) 1999-06-16
NO990723D0 (no) 1999-02-16
JP4108129B2 (ja) 2008-06-25
CO4900066A1 (es) 2000-03-27
IS4953A (is) 1999-01-22
WO1998007704A1 (en) 1998-02-26

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