PE20010995A1 - Dihidrobenzopiranos sustituidos y analogos de estos para el tratamiento de desordenes en los que interviene cox-2 - Google Patents

Dihidrobenzopiranos sustituidos y analogos de estos para el tratamiento de desordenes en los que interviene cox-2

Info

Publication number
PE20010995A1
PE20010995A1 PE2000001413A PE0014132000A PE20010995A1 PE 20010995 A1 PE20010995 A1 PE 20010995A1 PE 2000001413 A PE2000001413 A PE 2000001413A PE 0014132000 A PE0014132000 A PE 0014132000A PE 20010995 A1 PE20010995 A1 PE 20010995A1
Authority
PE
Peru
Prior art keywords
alkyl
dihydrobenzopyranes
treatment
hydride
analogs
Prior art date
Application number
PE2000001413A
Other languages
English (en)
Inventor
Jeffery S Carter
John J Talley
Rogier
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22635573&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20010995(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PE20010995A1 publication Critical patent/PE20010995A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A DIHIDROBENZOPIRANOS SUSTITUIDOS DE FORMULA I DONDE X ES O, S, CRcRb; NRa; Ra ES HIDRURO, ALQUILO C1-C3, FENIL ALQUILO C1-C3; Rb, Rc SON HIDRURO, ALQUILO C1-C3, ENTRE OTROS; R ES CARBOXILO, AMINOCARBONILO, ALQUILSULFONILCARBONILO C1-C6, ALCOXICARBONILO C1-C; R" ES HIDRURO, FENILO, TIENILALQUILO C1-C6, ALQUENILO C2-C6, R1 ES PERFLUOROALQUILO C1-C3, CLORO, ALQUILTIO C1-C6, ALCOXI C1-C6, NITRO, CIANO, ENTRE OTROS; R2 ES HIDRURO, HALO, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; A1, A2, A3, A4 DEL ANILLO A SON C, N; CON LA CONDICION QUE DOS SEAN C; R2 JUNTO CON EL ANILLO A ES NAFTILO, QUINOLILO, ISOQUINOLILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO REL-(2R,3S)-6,8-DICLORO-3,4-DIHIDRO-2-(TRIFLUOROMETIL)-2H-1-BENZOTIOPIRAN-3-CARBOXILICO; ACIDO (2S,3R)-6,8-DICLORO-3,4-DIHIDRO-2-TRIFLUOROMETIL)-2H-1-BENZOPIRAN-3-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO PUEDE SER UTIL PARA EL TRATAMIENTO DE DESORDENES EN LOS QUE INTERVIENE LA CICLOOXIGENASA 2
PE2000001413A 2000-01-03 2000-12-29 Dihidrobenzopiranos sustituidos y analogos de estos para el tratamiento de desordenes en los que interviene cox-2 PE20010995A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17428100P 2000-01-03 2000-01-03

Publications (1)

Publication Number Publication Date
PE20010995A1 true PE20010995A1 (es) 2001-09-21

Family

ID=22635573

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001413A PE20010995A1 (es) 2000-01-03 2000-12-29 Dihidrobenzopiranos sustituidos y analogos de estos para el tratamiento de desordenes en los que interviene cox-2

Country Status (16)

Country Link
US (2) US6822102B2 (es)
EP (1) EP1274700B1 (es)
JP (1) JP2003519221A (es)
AR (1) AR026784A1 (es)
AT (1) ATE282604T1 (es)
AU (1) AU2584001A (es)
CA (1) CA2395795A1 (es)
DE (1) DE60016047T2 (es)
EC (1) ECSP013867A (es)
ES (1) ES2231301T3 (es)
MX (1) MXPA02006617A (es)
PE (1) PE20010995A1 (es)
PT (1) PT1274700E (es)
TW (1) TWI227234B (es)
WO (1) WO2001049675A1 (es)
ZA (1) ZA200205098B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100594A1 (en) * 2001-08-10 2003-05-29 Pharmacia Corporation Carbonic anhydrase inhibitor
MXPA05003456A (es) 2002-10-04 2005-07-05 Millennium Pharm Inc Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias.
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
CA2424009A1 (en) 2003-03-28 2004-09-28 Ibm Canada Limited - Ibm Canada Limitee Context-sensitive attributes
GB0407908D0 (en) * 2004-04-07 2004-05-12 Univ York Ionic liquids
TW200603792A (en) * 2004-04-23 2006-02-01 Pharmacia & Upjohn Co Llc Monotherapy for the treatment of psoriasis with cyclooxygenase-2 selective inhibitors
US7122700B2 (en) 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes
WO2006040672A1 (en) * 2004-10-12 2006-04-20 Pharmacia & Upjohn Company Llc Substituted cyclopropyl chromene compounds for use in the treatment and prevention of inflammation related conditions
JP2008543726A (ja) 2005-02-24 2008-12-04 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 炎症性疾患の処置のためのｐｇｄ２受容体アンタゴニスト
US7999107B2 (en) 2007-01-31 2011-08-16 Merck Sharp & Dohme Corp. Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
SG186989A1 (en) 2010-07-14 2013-02-28 Novartis Ag Ip receptor agonist heterocyclic compounds
TW201335160A (zh) 2012-01-13 2013-09-01 Novartis Ag Ｉｐ受體激動劑之雜環化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008836A1 (fr) * 1996-08-27 1998-03-05 Shionogi & Co., Ltd. Derives de chromene-3-carboxylate
DE19638484A1 (de) * 1996-09-20 1998-03-26 Basf Ag Hetaroylderivate
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation

Also Published As

Publication number Publication date
PT1274700E (pt) 2005-02-28
DE60016047D1 (de) 2004-12-23
DE60016047T2 (de) 2005-11-03
US20030232844A1 (en) 2003-12-18
ZA200205098B (en) 2004-03-31
MXPA02006617A (es) 2004-09-10
TWI227234B (en) 2005-02-01
ATE282604T1 (de) 2004-12-15
EP1274700A1 (en) 2003-01-15
AU2584001A (en) 2001-07-16
US20050010050A1 (en) 2005-01-13
ES2231301T3 (es) 2005-05-16
CA2395795A1 (en) 2001-07-12
ECSP013867A (es) 2002-09-27
AR026784A1 (es) 2003-02-26
EP1274700B1 (en) 2004-11-17
WO2001049675A1 (en) 2001-07-12
US6822102B2 (en) 2004-11-23
JP2003519221A (ja) 2003-06-17

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