DE60017110D1 - Biphenylderivate als neurokinin-1 antagonisten - Google Patents

Biphenylderivate als neurokinin-1 antagonisten

Info

Publication number
DE60017110D1
DE60017110D1 DE60017110T DE60017110T DE60017110D1 DE 60017110 D1 DE60017110 D1 DE 60017110D1 DE 60017110 T DE60017110 T DE 60017110T DE 60017110 T DE60017110 T DE 60017110T DE 60017110 D1 DE60017110 D1 DE 60017110D1
Authority
DE
Germany
Prior art keywords
neurokinin
antagonists
biphenyl derivatives
biphenyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017110T
Other languages
English (en)
Other versions
DE60017110T2 (de
Inventor
Michael Boes
Guido Galley
Thierry Godel
Torsten Hoffmann
Walter Hunkeler
Patrick Schnider
Heinz Stadler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60017110D1 publication Critical patent/DE60017110D1/de
Publication of DE60017110T2 publication Critical patent/DE60017110T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/44—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60017110T 1999-03-09 2000-02-28 Biphenylderivate als neurokinin-1 antagonisten Expired - Lifetime DE60017110T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99104626 1999-03-09
EP99104626 1999-03-09
PCT/EP2000/001668 WO2000053572A1 (en) 1999-03-09 2000-02-28 Biphenyl derivatives as antagonists of the neurokinine-1 receptor

Publications (2)

Publication Number Publication Date
DE60017110D1 true DE60017110D1 (de) 2005-02-03
DE60017110T2 DE60017110T2 (de) 2006-01-26

Family

ID=8237723

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017110T Expired - Lifetime DE60017110T2 (de) 1999-03-09 2000-02-28 Biphenylderivate als neurokinin-1 antagonisten

Country Status (33)

Country Link
US (2) US6291465B1 (de)
EP (1) EP1171419B1 (de)
JP (1) JP3839668B2 (de)
KR (1) KR100473247B1 (de)
CN (1) CN1152006C (de)
AR (1) AR043273A1 (de)
AT (1) ATE286018T1 (de)
AU (1) AU767449B2 (de)
BR (1) BR0008862A (de)
CA (1) CA2366205C (de)
CO (1) CO5160261A1 (de)
CZ (1) CZ20013190A3 (de)
DE (1) DE60017110T2 (de)
ES (1) ES2233338T3 (de)
HK (1) HK1045684B (de)
HR (1) HRP20010629A2 (de)
HU (1) HUP0201710A3 (de)
IL (2) IL145166A0 (de)
JO (1) JO2235B1 (de)
MA (1) MA26778A1 (de)
MY (1) MY121145A (de)
NO (1) NO20014356L (de)
NZ (1) NZ513824A (de)
PE (1) PE20001549A1 (de)
PL (1) PL201681B1 (de)
PT (1) PT1171419E (de)
RU (1) RU2238266C2 (de)
SI (1) SI1171419T1 (de)
TR (1) TR200102585T2 (de)
UY (1) UY26051A1 (de)
WO (1) WO2000053572A1 (de)
YU (1) YU64901A (de)
ZA (1) ZA200107259B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200102490T2 (tr) 1999-02-24 2001-12-21 F.Hoffmann-La Roche Ag Fenil ve piridinil türevleri
AUPQ514600A0 (en) 2000-01-18 2000-02-10 James Cook University Brain injury treatment
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
US6642226B2 (en) 2001-02-06 2003-11-04 Hoffman-La Roche Inc. Substituted phenyl-piperidine methanone compounds
US6531597B2 (en) * 2001-02-13 2003-03-11 Hoffmann-La Roche Inc. Process for preparation of 2-phenyl acetic acid derivatives
NZ535366A (en) 2002-03-13 2007-07-27 Univ Tennessee Res Foundation Substituted tetrahydroisoquinoline compounds, methods of making, and their use
EP1888549A2 (de) * 2005-05-19 2008-02-20 Vertex Pharmaceuticals, Inc. Als modulatoren von ionenkanälen geeignete biaryle
JP5388574B2 (ja) 2005-05-31 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なヘテロ環式類
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
US10975049B2 (en) 2016-05-23 2021-04-13 Institute Of Materia Medica, Chinese Academy Of Medical Sciences Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
AU2019223237A1 (en) 2018-02-26 2020-09-03 Ospedale San Raffaele S.R.L. NK-1 antagonists for use in the treatment of ocular pain
WO2021180885A1 (en) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency
CN115466195B (zh) * 2022-09-15 2024-04-19 中国科学院成都生物研究所 一类联苯类酰胺化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06227913A (ja) * 1993-02-03 1994-08-16 Sumitomo Chem Co Ltd 安息香酸誘導体を有効成分とする植物病害防除剤
IL111960A (en) 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
BR9408442A (pt) 1993-12-29 1997-08-05 Merck Sharp & Dohme Composto composição farmacêutica processos para tratamento ou prevenção de distúrbios fisiológicos associados com um excesso de taquiquininas e para a preparação do composto e de uso do composto
TW385308B (en) 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
JP3839518B2 (ja) * 1996-03-27 2006-11-01 ポーラ化成工業株式会社 抗真菌剤
CN1252792A (zh) 1997-04-18 2000-05-10 辉瑞大药厂 制备4'－三氟甲基－联苯基－2－羧酸(1,2,3,4－四氢－异喹啉－6－基)酰胺的方法和中间体
US5972938A (en) 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
ATE496032T1 (de) * 1999-02-24 2011-02-15 Hoffmann La Roche 4-phenylpyridinderivate und deren verwendung als nk-1 rezeptorantagonisten

Also Published As

Publication number Publication date
TR200102585T2 (tr) 2002-01-21
BR0008862A (pt) 2002-01-02
WO2000053572A1 (en) 2000-09-14
ZA200107259B (en) 2002-12-02
HUP0201710A2 (en) 2002-10-28
UY26051A1 (es) 2000-09-29
YU64901A (sh) 2005-07-19
JO2235B1 (en) 2004-10-07
IL145166A0 (en) 2002-06-30
CO5160261A1 (es) 2002-05-30
EP1171419A1 (de) 2002-01-16
CZ20013190A3 (cs) 2002-02-13
NO20014356D0 (no) 2001-09-07
ES2233338T3 (es) 2005-06-16
PT1171419E (pt) 2005-04-29
NO20014356L (no) 2001-09-07
NZ513824A (en) 2004-01-30
KR100473247B1 (ko) 2005-03-08
US6552088B2 (en) 2003-04-22
KR20010111271A (ko) 2001-12-17
HRP20010629A2 (en) 2002-08-31
PE20001549A1 (es) 2001-01-09
ATE286018T1 (de) 2005-01-15
PL350536A1 (en) 2002-12-16
CA2366205C (en) 2008-09-09
JP2002539112A (ja) 2002-11-19
MY121145A (en) 2005-12-30
RU2238266C2 (ru) 2004-10-20
DE60017110T2 (de) 2006-01-26
AR043273A1 (es) 2005-07-27
CN1152006C (zh) 2004-06-02
AU3161200A (en) 2000-09-28
HUP0201710A3 (en) 2002-11-28
CN1343197A (zh) 2002-04-03
PL201681B1 (pl) 2009-04-30
US20020040060A1 (en) 2002-04-04
AU767449B2 (en) 2003-11-13
SI1171419T1 (en) 2005-06-30
HK1045684B (zh) 2004-11-26
IL145166A (en) 2006-10-05
MA26778A1 (fr) 2004-12-20
HK1045684A1 (en) 2002-12-06
US6291465B1 (en) 2001-09-18
JP3839668B2 (ja) 2006-11-01
EP1171419B1 (de) 2004-12-29
CA2366205A1 (en) 2000-09-14

Similar Documents

Publication Publication Date Title
DE60120419D1 (de) 4-phenyl-pyridin-derivate verwendbar als neurokinin-1 rezeptor antagonisten
DE60205100D1 (de) DIHYDRO-BENZO (b) (1,4) DIAZEPIN-2-ON-DERIVATE ALS MGLUR2 ANTAGONISTEN
DE60032601D1 (de) Als antikrebsmittel verwendbare heterocyklische derivate
ATE330954T1 (de) Quinazolin-derivate als vegf-hemmer
ATE299865T1 (de) Piperazinderivate verwendbar als ccr5 antagonisten
NO20023424L (no) Kortikotropin-frigjörende faktorantagonister
DE60008262D1 (de) Piperazinderivate als 5-ht1b antagonisten
ATE384053T1 (de) Triazolderivate als tachykininrezeptor- antagonisten
DE60218340D1 (de) 5,6-diaryl-pyrazineamidderivate als cb1 antagonisten
DE60202761D1 (de) Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten
DE60110844D1 (de) Chinazolone derivate als alfa 1a/b adrenozeptor antagonisten
ATE322496T1 (de) 4-phenylpyridin-derivate als neurokinin-1- rezeptor-antagonisten
DE60018989D1 (de) N-carbamoyloxyalkyl-substituierte azolium-verbindungen
NO20032142L (no) Substituerte 2-fenylaminoimidazolin-fenylketon-derivater som IP-antagonister
DE60114852D1 (de) Chinazolin-derivate als alpha-1 adrenerge antagonisten
ATE286018T1 (de) Biphenylderivate als neurokinin-1 antagonisten
ID29914A (id) Senyawa benzensulfonamida heterosiklik sebagai antagonis bradikinin
ATE254621T1 (de) Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten
ATE244716T1 (de) Neue n-triazolylmethyl-piperazinderivate als neurokininrezeptor-antagonisten
DE60207399D1 (de) Alkoxycarbonylaminobenzoesäure- oder alkoxycarbonylaminotetrazolylphenylderivate als ip-antagonisten
DE60003072D1 (de) Thiazolidindion-derivate als antidiabetika
NO20025659L (no) Heterocykliske forbindelser
DE60210058D1 (de) Alkoxycarbonylamino-heteroaryl-carbonsäurederivate als ip-antagonisten
DE50005743D1 (de) Substituierte benzoylcyclohexandione als herbizide
ATE280161T1 (de) Imidazolverbindungen als alpha2-adrenorezeptoren antagonisten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition