IL144995A0 - Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders - Google Patents

Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders

Info

Publication number
IL144995A0
IL144995A0 IL14499500A IL14499500A IL144995A0 IL 144995 A0 IL144995 A0 IL 144995A0 IL 14499500 A IL14499500 A IL 14499500A IL 14499500 A IL14499500 A IL 14499500A IL 144995 A0 IL144995 A0 IL 144995A0
Authority
IL
Israel
Prior art keywords
recombinant
treatment
mediated disorders
antagonists useful
antagonists
Prior art date
Application number
IL14499500A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Smithkline Beecham Plc filed Critical Smithkline Beecham Corp
Publication of IL144995A0 publication Critical patent/IL144995A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL14499500A 1999-03-19 2000-03-17 Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders IL144995A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12529999P 1999-03-19 1999-03-19
PCT/US2000/007349 WO2000056771A1 (en) 1999-03-19 2000-03-17 Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders

Publications (1)

Publication Number Publication Date
IL144995A0 true IL144995A0 (en) 2002-06-30

Family

ID=22419067

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14499500A IL144995A0 (en) 1999-03-19 2000-03-17 Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders

Country Status (28)

Country Link
US (2) US6706487B1 (cs)
EP (2) EP1961768A1 (cs)
JP (1) JP2002542769A (cs)
KR (1) KR100697120B1 (cs)
CN (1) CN1246335C (cs)
AR (1) AR022952A1 (cs)
AT (1) ATE402191T1 (cs)
AU (1) AU764622B2 (cs)
BR (1) BR0008688A (cs)
CA (1) CA2368965C (cs)
CO (1) CO5470287A1 (cs)
CY (1) CY1108387T1 (cs)
CZ (1) CZ303704B6 (cs)
DE (1) DE60039589D1 (cs)
DK (1) DK1163271T3 (cs)
ES (1) ES2308974T3 (cs)
HK (1) HK1043798B (cs)
HU (1) HU228931B1 (cs)
IL (1) IL144995A0 (cs)
MY (1) MY124219A (cs)
NO (1) NO330391B1 (cs)
NZ (1) NZ513699A (cs)
PL (1) PL202396B1 (cs)
PT (1) PT1163271E (cs)
SI (1) SI1163271T1 (cs)
TR (3) TR200102733T2 (cs)
WO (1) WO2000056771A1 (cs)
ZA (1) ZA200107639B (cs)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852266A (en) * 1993-07-14 1998-12-22 Hitachi, Ltd. Vacuum circuit breaker as well as vacuum valve and electric contact used in same
US7704944B2 (en) 1997-08-14 2010-04-27 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
US7220717B2 (en) 1997-08-14 2007-05-22 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
AR022952A1 (es) * 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
US7229619B1 (en) 2000-11-28 2007-06-12 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
ES2349348T3 (es) * 2000-01-27 2010-12-30 Medimmune, Llc Anticuerpos neutralizantes de rsv de ultra alta afinidad.
TW201305214A (zh) * 2000-02-10 2013-02-01 Abbott Gmbh & Co Kg 與人類間白素－１８結合之抗體，及其製法及用途
KR20020086540A (ko) * 2000-02-21 2002-11-18 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. Ｉｌ-18 저해물질의 용도
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
US7179900B2 (en) 2000-11-28 2007-02-20 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US20040018195A1 (en) * 2002-03-26 2004-01-29 Griswold Don Edgar Diabetes-related immunoglobulin derived proteins, compositions, methods and uses
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
AU2002343870A1 (en) 2002-11-07 2004-06-07 Kumamoto Technology And Industry Foundation Transgenic mammal carrying ganp and utilization thereof
WO2004097019A1 (ja) 2003-04-30 2004-11-11 Japan Science And Technology Agency ヒト抗ヒトインターロイキン－１８抗体およびその断片、並びにそれらの利用方法
US20050100965A1 (en) * 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
AU2011224023C1 (en) * 2003-11-12 2013-08-29 Abbvie Inc. IL-18 binding proteins
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
US7141382B1 (en) 2004-10-12 2006-11-28 Parikh Chirag R Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality
JP5006330B2 (ja) 2005-10-21 2012-08-22 ノバルティス アーゲー Ｉｌ１３に対するヒト抗体および治療的使用
GB0610438D0 (en) * 2006-05-25 2006-07-05 Glaxo Group Ltd Immunoglobulins
MY157173A (en) * 2006-05-25 2016-05-13 Glaxo Group Ltd Modified humanised anti-interleukin-18
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
KR20100115340A (ko) * 2007-10-19 2010-10-27 이무나스 파마 가부시키가이샤 Ａβ 올리고머에 특이적으로 결합하는 항체 및 그의 이용
US20100291071A1 (en) * 2008-08-01 2010-11-18 Immunas Pharma, Inc. Antibody Specific Binding to A-Beta Oligomer and the Use
CN102936287B (zh) * 2008-02-08 2015-09-09 伊缪纳斯制药株式会社 能够特异性结合Aβ寡聚体的抗体及其应用
US20110189093A1 (en) * 2008-04-14 2011-08-04 Proscan Rx Pharma Prostate specific membrane antigen antibodies and antigen binding fragments
US9085614B2 (en) 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
JP2012500242A (ja) * 2008-08-18 2012-01-05 グラクソ グループ リミテッド Ｉｌ−１８アンタゴニストを用いる自己免疫疾患の治療
WO2010040736A2 (en) * 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
US8168165B2 (en) * 2008-12-23 2012-05-01 Abbott Laboratories Alkylated interleukin-18 compositions
JP5812418B2 (ja) 2009-04-17 2015-11-11 イムナス・ファーマ株式会社 Ａβオリゴマーに特異的に結合する抗体およびその利用
EP2377583A1 (en) * 2009-06-30 2011-10-19 Gosen Co., Ltd. Racket string, method for manufacturing same, and racket strung with same
DK2462162T3 (en) 2009-08-06 2017-01-16 Immunas Pharma Inc Antibodies that specifically bind to A-beta oligomers and their use
ES2624835T3 (es) 2009-08-06 2017-07-17 Immunas Pharma, Inc. Anticuerpos que se unen específicamente a los oligómeros A beta y uso de los mismos
MX2012002605A (es) 2009-08-29 2012-04-02 Abbott Lab Proteinas terapeutico de union a dll4.
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
WO2011098424A2 (en) * 2010-02-09 2011-08-18 Glaxo Group Limited Treatment of a metabolic disorder
EP2538965B1 (en) * 2010-02-25 2017-04-12 Schepens Eye Research Institute Therapeutic compositions for the treatment of dry eye disease
BR112012021941A2 (pt) * 2010-03-02 2022-02-01 Abbvie Inc Proteínas terapêuticas de ligação a dll4
US20130109107A1 (en) * 2010-05-25 2013-05-02 The Regents Of The University Of Colorado Diagnosis and treatment of autoimmune disease
JP6081356B2 (ja) 2010-07-30 2017-02-15 エーシー イミューン エス．エー． 安全で機能的なヒト化抗βアミロイド抗体
MX2013007067A (es) 2010-12-20 2013-11-01 Medimmune Ltd Anticuerpos anti-il-18 y sus usos.
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
US10570199B2 (en) 2012-11-21 2020-02-25 Km Biologics Co., Ltd. Human antibody against IL-18
SG11201706879UA (en) * 2015-03-05 2017-09-28 Ab2 Bio Sa Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases
JP2023530489A (ja) * 2020-06-18 2023-07-18 ネクストキュア インコーポレイテッド Ｆｌｒｔ３媒介性シグナル伝達を調節するための組成物及び方法
EP4371573A1 (en) 2021-07-13 2024-05-22 National University Corporation Tokai National Higher Education and Research System Medicinal composition for treating inflammatory bowel disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22545A1 (es) * 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
ES2145004T3 (es) 1991-08-21 2000-07-01 Novartis Ag Derivados de anticuerpos.
GB9125979D0 (en) * 1991-12-06 1992-02-05 Wellcome Found Antibody
TW581771B (en) 1994-11-15 2004-04-01 Hayashibara Biochem Lab Recombinant production of a polypeptide for inducing interferon-gamma production, and monoclonal antibody against the polypeptide
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
FR2767697B1 (fr) 1997-09-01 2000-05-05 Boots Co Plc Composition dermatologique permettant d'eviter l'apparition de symptomes d'hypersensibilite et d'intolerance cutanee
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
AR022952A1 (es) * 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL

Also Published As

Publication number Publication date
NO20014524D0 (no) 2001-09-18
EP1163271A4 (en) 2003-04-09
ZA200107639B (en) 2002-09-17
AU3901600A (en) 2000-10-09
DE60039589D1 (de) 2008-09-04
HUP0200502A3 (en) 2003-12-29
CY1108387T1 (el) 2014-02-12
CN1246335C (zh) 2006-03-22
TR200202253T2 (tr) 2002-12-23
JP2002542769A (ja) 2002-12-17
CZ303704B6 (cs) 2013-03-27
NO330391B1 (no) 2011-04-04
PL202396B1 (pl) 2009-06-30
AR022952A1 (es) 2002-09-04
CA2368965A1 (en) 2000-09-28
CZ20013362A3 (cs) 2002-03-13
WO2000056771A1 (en) 2000-09-28
KR100697120B1 (ko) 2007-03-20
NZ513699A (en) 2004-02-27
CN1352650A (zh) 2002-06-05
CA2368965C (en) 2010-05-18
NO20014524L (no) 2001-11-14
ES2308974T3 (es) 2008-12-16
TR200202254T2 (tr) 2002-12-23
CO5470287A1 (es) 2004-12-30
DK1163271T3 (da) 2008-11-10
TR200102733T2 (tr) 2002-04-22
US20040141964A1 (en) 2004-07-22
HU228931B1 (en) 2013-06-28
AU764622B2 (en) 2003-08-28
PL350460A1 (en) 2002-12-16
KR20020008130A (ko) 2002-01-29
SI1163271T1 (sl) 2008-10-31
EP1961768A1 (en) 2008-08-27
PT1163271E (pt) 2008-09-16
US6706487B1 (en) 2004-03-16
MY124219A (en) 2006-06-30
HUP0200502A2 (en) 2002-06-29
ATE402191T1 (de) 2008-08-15
BR0008688A (pt) 2002-01-08
HK1043798B (zh) 2009-04-09
HK1043798A1 (en) 2002-09-27
EP1163271A1 (en) 2001-12-19
EP1163271B1 (en) 2008-07-23

Similar Documents

Publication Publication Date Title
HUP0200502A2 (en) Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders
HUS1500070I1 (hu) IL-5-Mediált rendellenességek kezelésére használható rekombináns IL-5 antagonisták
HK1109867A1 (en) Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders
HK1152243A1 (en) Vegf for use in the treatment of central nervous system disorders vegf
HK1068885A1 (en) N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases n--
IL153565A0 (en) 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat vcam-1 mediated disorders
HK1079203A1 (en) Substituted amine derivatives and methods of use in the treatment of angiogenesis related disorders
IL144954A0 (en) Quinazolines and therapeutic use thereof
IL157365A0 (en) Mch antagonists and their use in the treatment of obesity
GB0007193D0 (en) Treatment of movrmrnt disorders
EP1404343A4 (en) THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF HORMONE DEFICIENCIES
IL149496A0 (en) Pharmaceutical combinations and their use in treating gastrointestinal disorders
IL161267A0 (en) Combinations for the treatment of immunoinflammatory disorders
IL156781A0 (en) (diazolo-pyridinyl)-pyrimidines for use in teatment of cns disorders and diabetes
EP1416957A4 (en) TREATMENT OF IMMUNE DISEASES AND B-CELL DISEASES
PL369822A1 (en) Use of endothelin receptor antagonists in the treatment of tumour diseases
HUP0301553A3 (en) Pharmaceutical compositions and their use for treating neurological disorders
AU2003250831A8 (en) Use of hec1 antagonists in the treatment of proliferative disorders and cancer
PL351554A1 (en) Osanetant in the treatment of mood disorders
HUP0202339A3 (en) Use of cortisol antagonists in the treatment of heat failure
PL347976A1 (en) Isonipecotamides for the treatment of integrin−mediated disorders
AU2002210763A1 (en) Use of 1-ebio in the treatment of bipolar disorders
AU6330300A (en) Use of interleukin-6 in treatment of obesity and/or obesity associated disorders
IL160551A0 (en) Plaster for the treatment of dysfunctions and disorders of nails
AU2002229091A1 (en) Secreted polypeptide and their use in the treatment of bone disorders

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired