IL142093A - Transfer hydrogenation process - Google Patents

Transfer hydrogenation process

Info

Publication number
IL142093A
IL142093A IL14209399A IL14209399A IL142093A IL 142093 A IL142093 A IL 142093A IL 14209399 A IL14209399 A IL 14209399A IL 14209399 A IL14209399 A IL 14209399A IL 142093 A IL142093 A IL 142093A
Authority
IL
Israel
Prior art keywords
hydrogenation process
transfer hydrogenation
bidentate ligands
employed
transfer
Prior art date
Application number
IL14209399A
Other languages
English (en)
Other versions
IL142093A0 (en
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Publication of IL142093A0 publication Critical patent/IL142093A0/xx
Publication of IL142093A publication Critical patent/IL142093A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
IL14209399A 1998-09-29 1999-09-22 Transfer hydrogenation process IL142093A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9821067.7A GB9821067D0 (en) 1998-09-29 1998-09-29 Transfer hydrogenation process
PCT/GB1999/003176 WO2000018708A1 (en) 1998-09-29 1999-09-22 Transfer hydrogenation process

Publications (2)

Publication Number Publication Date
IL142093A0 IL142093A0 (en) 2002-03-10
IL142093A true IL142093A (en) 2005-11-20

Family

ID=10839587

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14209399A IL142093A (en) 1998-09-29 1999-09-22 Transfer hydrogenation process

Country Status (19)

Country Link
US (1) US6509467B1 (ko)
EP (1) EP1117627B1 (ko)
JP (1) JP2002525342A (ko)
KR (1) KR100674631B1 (ko)
CN (1) CN1231433C (ko)
AT (1) ATE241578T1 (ko)
AU (1) AU764996B2 (ko)
CA (1) CA2343088C (ko)
CZ (1) CZ299368B6 (ko)
DE (1) DE69908390T2 (ko)
DK (1) DK1117627T3 (ko)
ES (1) ES2201780T3 (ko)
GB (1) GB9821067D0 (ko)
HK (1) HK1042887B (ko)
HU (1) HU225492B1 (ko)
IL (1) IL142093A (ko)
NO (1) NO325921B1 (ko)
PT (1) PT1117627E (ko)
WO (1) WO2000018708A1 (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6353112B1 (en) 1998-07-17 2002-03-05 The University Of Tennessee Research Corporation Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions
US6562850B1 (en) 1998-07-17 2003-05-13 The University Of Tennessee Research Corporation Methods of synthesizing sultams and anti-viral compositions
US6458962B1 (en) 1999-03-25 2002-10-01 The University Of Tennesseee Research Corporation Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams
GB0029356D0 (en) * 2000-12-01 2001-01-17 Avecia Ltd Transfer hydrogenation
US6743921B2 (en) 2002-01-24 2004-06-01 Dsm Catalytica Pharmaceuticals, Inc. Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
CA2565130C (en) * 2003-05-02 2011-03-15 Kamaluddin Abdur-Rashid Transfer hydrogenation processes and catalysts
WO2008080138A1 (en) 2006-12-22 2008-07-03 Richmond Chemical Corporation Stereoinversion of amino acids
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
DE602008004245D1 (de) * 2007-05-04 2011-02-10 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten
US8729266B2 (en) * 2007-07-17 2014-05-20 Mallinckrodt Llc Preparation of N-alkylated opiates by reductive amination
CN101917853B (zh) 2007-12-27 2014-03-19 无限药品股份有限公司 立体选择性还原的方法
WO2010039222A2 (en) * 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the selective amination of ketomorphinans
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
ES2598496T3 (es) * 2009-06-11 2017-01-27 Mallinckrodt Llc Preparación de 6-alfa-amino morfinanos N-sustituidos por transferencia de hidrógeno catalítico
CN102459274B (zh) * 2009-06-11 2015-07-15 马林克罗特有限公司 6-酮基去甲吗啡喃通过催化氢转移的还原胺化
WO2011001373A1 (en) * 2009-06-30 2011-01-06 Actelion Pharmaceuticals Ltd Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative
EP2462115B1 (en) 2009-08-05 2016-01-06 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
US9394313B2 (en) 2010-09-14 2016-07-19 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
ES2698408T3 (es) 2011-06-09 2019-02-04 SpecGx LLC Aminación reductora de 6-ceto morfinanos por transferencia de hidrógeno catalítico
WO2013036729A1 (en) 2011-09-08 2013-03-14 Mallinckrodt Llc Production of alkaloids without the isolation of intermediates
CA2988289C (en) 2015-06-04 2023-12-05 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT333764B (de) * 1972-06-20 1976-12-10 Fujisawa Pharmaceutical Co Verfahren zur herstellung von neuen 1,2,3,4-tetrahydroisochinolinen und deren salzen
JPS553349B2 (ko) * 1972-06-20 1980-01-24
JP3149989B2 (ja) * 1992-04-28 2001-03-26 広栄化学工業株式会社 ２−クロロ−５−置換アミノメチルピリジン類の製法
GB9706321D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Catalytic hydrogenation

Also Published As

Publication number Publication date
DE69908390T2 (de) 2004-04-22
HUP0103510A2 (hu) 2002-01-28
CN1321140A (zh) 2001-11-07
EP1117627A1 (en) 2001-07-25
NO20011573D0 (no) 2001-03-28
EP1117627B1 (en) 2003-05-28
US6509467B1 (en) 2003-01-21
HUP0103510A3 (en) 2002-04-29
KR100674631B1 (ko) 2007-01-25
CA2343088C (en) 2009-02-24
CN1231433C (zh) 2005-12-14
NO20011573L (no) 2001-03-28
GB9821067D0 (en) 1998-11-18
NO325921B1 (no) 2008-08-18
CA2343088A1 (en) 2000-04-06
WO2000018708A1 (en) 2000-04-06
DE69908390D1 (de) 2003-07-03
DK1117627T3 (da) 2003-09-15
PT1117627E (pt) 2003-10-31
ES2201780T3 (es) 2004-03-16
JP2002525342A (ja) 2002-08-13
CZ299368B6 (cs) 2008-07-02
HU225492B1 (en) 2007-01-29
HK1042887B (zh) 2006-08-18
AU6212599A (en) 2000-04-17
CZ20011110A3 (cs) 2001-08-15
AU764996B2 (en) 2003-09-04
ATE241578T1 (de) 2003-06-15
HK1042887A1 (en) 2002-08-30
IL142093A0 (en) 2002-03-10
KR20010075408A (ko) 2001-08-09

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Legal Events

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FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees