IL136044A - 2-aminoacetamide derivatives and pharmaceutical compositions containing the same - Google Patents
2-aminoacetamide derivatives and pharmaceutical compositions containing the sameInfo
- Publication number
- IL136044A IL136044A IL13604498A IL13604498A IL136044A IL 136044 A IL136044 A IL 136044A IL 13604498 A IL13604498 A IL 13604498A IL 13604498 A IL13604498 A IL 13604498A IL 136044 A IL136044 A IL 136044A
- Authority
- IL
- Israel
- Prior art keywords
- same
- pharmaceutical compositions
- compositions containing
- aminoacetamide
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrane Compounds (AREA)
- Quinoline Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6670797P | 1997-11-21 | 1997-11-21 | |
PCT/US1998/024965 WO1999026614A1 (fr) | 1997-11-21 | 1998-11-20 | 2-aminoacetamides substitues et leur utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
IL136044A0 IL136044A0 (en) | 2001-05-20 |
IL136044A true IL136044A (en) | 2005-08-31 |
Family
ID=22071190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13604498A IL136044A (en) | 1997-11-21 | 1998-11-20 | 2-aminoacetamide derivatives and pharmaceutical compositions containing the same |
Country Status (10)
Country | Link |
---|---|
US (7) | US6479484B1 (fr) |
EP (3) | EP2201945B1 (fr) |
JP (3) | JP4070955B2 (fr) |
AU (1) | AU749214C (fr) |
CA (1) | CA2310664C (fr) |
DE (1) | DE69842004D1 (fr) |
ES (2) | ES2402104T3 (fr) |
IL (1) | IL136044A (fr) |
MX (1) | MXPA00004919A (fr) |
WO (1) | WO1999026614A1 (fr) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
US6455734B1 (en) * | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
CA2370030C (fr) | 1999-04-09 | 2007-08-14 | Euro-Celtique S.A. | Composition de blocage du canal sodique et leur utilisation |
EP1341414B1 (fr) * | 2000-11-16 | 2013-01-02 | The Regents of The University of California | Taxon d'actinomycete marin utilise pour la decouverte de medicaments et de produits de fermentation |
US8084447B2 (en) | 2001-09-03 | 2011-12-27 | Newron Pharmaceuticals S.P.A. | Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use |
US6667327B2 (en) | 2002-02-04 | 2003-12-23 | Hoffmann-La Roche Inc. | Pyridine amido derivatives |
US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US20050227974A9 (en) * | 2002-08-01 | 2005-10-13 | Euro-Celtique S.A. | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers |
US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
DE60316688T2 (de) * | 2002-08-02 | 2008-07-17 | Nereus Pharmaceuticals, Inc., San Diego | Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon |
AU2003296908A1 (en) * | 2002-09-27 | 2004-05-04 | Nereus Pharmaceuticals, Inc. | Macrocyclic lactams |
EP1438956A1 (fr) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Dérivés alpha-aminoamides en tant qu'agents antimigraine |
WO2004087125A1 (fr) * | 2003-04-02 | 2004-10-14 | Ionix Pharmaceuticals Limited | Derives d'acides amines en tant qu'inhibiteurs des canaux sodiques de mammiferes |
EP2441767B1 (fr) * | 2003-06-20 | 2015-06-10 | The Regents of The University of California | Salinosporamides et leurs procédés d'utilisation |
KR20060026052A (ko) * | 2003-06-20 | 2006-03-22 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법 |
WO2005000309A2 (fr) * | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Composes chimiques |
ATE411027T1 (de) | 2003-10-23 | 2008-10-15 | Hoffmann La Roche | Benzazepin-derivate als mao-b-hemmer |
EP1557166A1 (fr) | 2004-01-21 | 2005-07-27 | Newron Pharmaceuticals S.p.A. | Derives d'alpha-aminoamides pour le traitement des désordres de l'appareil urinaire inférieur |
KR20060132698A (ko) * | 2004-01-23 | 2006-12-21 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 항균제로 유용한 비스-인돌 피롤 |
US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
EP2025679A3 (fr) | 2004-04-30 | 2009-07-08 | Nereus Pharmaceuticals, Inc. | Composés hétérocycliques [3.2.0] et leurs procédés d'utilisation |
CA2577408C (fr) * | 2004-09-10 | 2013-07-09 | Elena Barbanti | Utilisation de (halobenzyloxy)benzylamino-propanamides pour la fabrication de medicaments actifs comme modulateurs selectifs des canaux sodiques et/ou calciques |
CN103230394B (zh) * | 2004-12-03 | 2016-04-20 | 达纳-法伯癌症研究公司 | 治疗肿瘤性疾病的化合物及其用途 |
JP4911365B2 (ja) * | 2005-03-18 | 2012-04-04 | 株式会社安川電機 | ロボットに用いるティーチングボックスおよびカスタマイズ方法とこれらを用いたロボットシステム |
WO2007047397A2 (fr) | 2005-10-13 | 2007-04-26 | Smithkline Beecham Corporation | Nouveaux composes heterocycliques |
US9005974B2 (en) * | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
PT1963280E (pt) * | 2005-12-22 | 2016-02-02 | Newron Pharm Spa | Derivados de 2-feniletilamino como cálcio e/ou moduladores do canal de sódio |
NZ596653A (en) | 2006-04-06 | 2012-10-26 | Nereus Pharmaceuticals Inc | Total synthesis of salinosporamide a and analogs thereof |
EP1870097A1 (fr) * | 2006-06-15 | 2007-12-26 | Newron Pharmaceuticals S.p.A. | Dérivés d'alpha-aminoamide pour le traitement de troubles cognitifs |
PE20080540A1 (es) * | 2006-08-10 | 2008-06-08 | Glaxo Group Ltd | Compuestos 4-fenil-2-piridinil-metil sustituidos como moduladores de los canales de sodio con apertura por voltaje |
US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
WO2008095195A2 (fr) * | 2007-02-02 | 2008-08-07 | Nereus Pharmaceuticals, Inc. | Formulations lyophilisées de salinosporamide a |
US8394816B2 (en) | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
ES2878063T3 (es) | 2007-12-19 | 2021-11-18 | Newron Pharm Spa | Derivados de la alfa-aminoamida para el tratamiento de trastornos psiquiátricos |
KR20110011645A (ko) | 2008-05-12 | 2011-02-08 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 프로테아좀 저해제로서의 살리노스포라마이드 유도체 |
JP2013530180A (ja) | 2010-06-16 | 2013-07-25 | パーデュー、ファーマ、リミテッド、パートナーシップ | アリール置換インドールおよびその使用 |
WO2012007836A1 (fr) | 2010-07-16 | 2012-01-19 | Purdue Pharma .Lp. | Composés pyridines comme bloqueurs des canaux sodiques |
CA2811479A1 (fr) | 2010-09-17 | 2012-03-22 | Purdue Pharma L.P. | Composes de pyridine et ses utilisations |
CN103168033A (zh) | 2010-10-05 | 2013-06-19 | 普渡制药公司 | 作为钠通道阻断剂的喹唑啉化合物 |
JP2014500303A (ja) | 2010-12-22 | 2014-01-09 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としての置換ピリジン |
ME02873B (fr) | 2011-09-02 | 2018-04-20 | Purdue Pharma Lp | Pyrimidines utilisées comme bloqueurs de canaux sodiques |
US9388137B2 (en) | 2011-10-31 | 2016-07-12 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
AU2012324010A1 (en) | 2011-10-31 | 2013-05-16 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
US9133131B2 (en) | 2011-11-15 | 2015-09-15 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
WO2013123658A1 (fr) | 2012-02-23 | 2013-08-29 | Empire Technology Development Llc | Composés azobenzéniques avec groupe cholestérol et compositions antisolaires associées |
WO2013136170A1 (fr) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Pyridines substituées en tant que bloqueurs des canaux sodiques |
CN103804341B (zh) * | 2012-11-13 | 2018-04-10 | 中国人民解放军军事医学科学院毒物药物研究所 | 酰胺衍生物及其医药用途 |
EP2935257B1 (fr) | 2012-12-20 | 2018-02-07 | Purdue Pharma LP | Sulfonamides cycliques en tant que bloquants des canaux sodiques |
US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
WO2014135955A1 (fr) | 2013-03-04 | 2014-09-12 | Purdue Pharma L.P. | Pyrimidine carboxamides à titre de bloqueurs des canaux sodiques |
CA2939549C (fr) | 2013-03-15 | 2020-08-18 | Purdue Pharma L.P. | Derives de carboxamide et leur utilisation |
US9359330B2 (en) | 2013-08-26 | 2016-06-07 | Purdue Pharma L.P. | Substituted piperidines as sodium channel blockers |
JP6422498B2 (ja) | 2013-08-26 | 2018-11-14 | パーデュー、ファーマ、リミテッド、パートナーシップ | アザスピロ[4.5]デカン誘導体及びその使用 |
US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
US9745287B2 (en) | 2013-12-20 | 2017-08-29 | Purdue Pharma L.P. | Pyrimidines and use thereof |
US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
JP6337124B2 (ja) | 2013-12-23 | 2018-06-06 | パーデュー、ファーマ、リミテッド、パートナーシップ | インダゾール及びその使用 |
EP3089978B1 (fr) | 2013-12-30 | 2018-08-29 | Purdue Pharma L.P. | Analogues de morphinane pyridone-sulfones utilisés comme ligands de récepteurs opioïdes |
KR101591772B1 (ko) * | 2013-12-30 | 2016-02-05 | 이화여자대학교 산학협력단 | 신규한 아민 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 t-형 또는 n-형 칼슘 채널 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
CN104761531B (zh) * | 2014-01-03 | 2017-12-01 | 中国人民解放军军事医学科学院毒物药物研究所 | 镇痛活性化合物及其医药用途 |
WO2015112801A1 (fr) | 2014-01-24 | 2015-07-30 | Purdue Pharma L.P. | Pyridines et pyrimidines, et leur utilisation |
CN106103422B (zh) | 2014-02-12 | 2020-09-18 | 普渡制药公司 | 异喹啉衍生物及其用途 |
US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
US9975854B2 (en) | 2014-05-06 | 2018-05-22 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
WO2015192053A1 (fr) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Dérivés d'azamophinan et leur utilisation |
JP2017521488A (ja) | 2014-06-13 | 2017-08-03 | パーデュー、ファーマ、リミテッド、パートナーシップ | 複素環式モルフィナン誘導体及びその使用 |
EP3193872A4 (fr) | 2014-09-14 | 2018-02-28 | Avanir Pharmaceuticals, Inc. | Compositions pharmaceutiques comprenant un composé dextrométhorphane et de la quinidine permettant le traitement de l'agitation dans le cadre d'une démence |
SG10202008673WA (en) | 2015-03-06 | 2020-10-29 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
MY194341A (en) | 2015-03-06 | 2022-11-29 | Beyondspring Pharmaceuticals Inc | Method of treating a brain tumor |
JP6969848B2 (ja) | 2015-07-13 | 2021-11-24 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | プリナブリン組成物 |
NZ744854A (en) | 2016-02-08 | 2020-01-31 | Beyondspring Pharmaceuticals Inc | Compositions containing tucaresol or its analogs |
RU2760348C2 (ru) | 2016-06-06 | 2021-11-24 | Бейондспринг Фармасьютикалс, Инк. | Способ уменьшения нейтропении |
CN107522647B (zh) * | 2016-06-21 | 2022-03-22 | 中国人民解放军军事医学科学院毒物药物研究所 | 含吲哚基团的α-氨基酰胺衍生物及其医药用途 |
US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
CN110431135A (zh) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | 微管蛋白结合化合物及其治疗用途 |
KR20190109479A (ko) | 2017-02-01 | 2019-09-25 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증의 감소 방법 |
AU2019212118A1 (en) | 2018-01-24 | 2020-09-03 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing thrombocytopenia via the administration of plinabulin |
CN111217776A (zh) * | 2020-01-19 | 2020-06-02 | 中国人民解放军军事科学院军事医学研究院 | 含苯并杂环结构的酰胺衍生物、组合物和应用 |
CN117603079B (zh) * | 2023-11-27 | 2024-07-05 | 山东绿叶制药有限公司 | 一种治疗疼痛的化合物和组合物 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH480308A (de) | 1966-08-11 | 1969-10-31 | Ciba Geigy | Verfahren zur Herstellung von Thiosemicarbazid-Verbindungen |
EP0144853B1 (fr) | 1983-11-21 | 1990-09-26 | Fujisawa Pharmaceutical Co., Ltd. | Dérivés semicarbazides, procédé pour leur préparation et compositions pharmaceutiques les contenant |
GB2216515A (en) * | 1988-03-04 | 1989-10-11 | Nippon Shinyaku Co Ltd | Acylphenol derivatives |
IL94466A (en) * | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
DE4239151A1 (de) | 1992-11-20 | 1994-05-26 | Thomae Gmbh Dr K | N,N-Disubstituierte Arylcycloalkylamine, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
GB9306899D0 (en) | 1993-04-01 | 1993-05-26 | Erba Carlo Spa | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation |
GB9306886D0 (en) | 1993-04-01 | 1993-05-26 | Erba Carlo Spa | Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation |
US5475007A (en) * | 1993-05-28 | 1995-12-12 | The Regents Of The University Of California | 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof |
PT757677E (pt) | 1994-04-26 | 2003-11-28 | Syntex Llc | Derivados de benzociclohexilimidazoletiona |
DE4421582A1 (de) | 1994-06-21 | 1996-01-04 | Thomae Gmbh Dr K | Basisch substituierte Phenylcyclohexylketone und deren Enolether, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
US5482964A (en) * | 1994-10-11 | 1996-01-09 | Warner-Lambert Company | Substituted phenoxyhydroxypropyl amines as central nervous system agents |
IL117659A (en) * | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
US5849737A (en) * | 1995-04-14 | 1998-12-15 | The Regents Of The University Of California | Compositions and methods for treating pain |
JPH11505524A (ja) * | 1995-05-01 | 1999-05-21 | 藤沢薬品工業株式会社 | イミダゾ1,2−aピリジンおよびイミダゾ1,2−aピリデジン誘導体、および骨吸収阻害剤としてのその用途 |
US5741818A (en) | 1995-06-07 | 1998-04-21 | University Of Saskatchewan | Semicarbazones having CNS activity and pharmaceutical preparations containing same |
GB9515412D0 (en) * | 1995-07-27 | 1995-09-27 | Pharmacia Spa | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives |
US5849373A (en) * | 1996-02-05 | 1998-12-15 | Sandia Corporation | Process for the synthesis of nanophase dispersion-strengthened aluminum alloy |
TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
GB9706730D0 (en) * | 1997-04-03 | 1997-05-21 | Pharmacia & Upjohn Spa | 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives |
EP0986540B1 (fr) | 1997-04-22 | 2005-02-16 | Euro-Celtique S.A. | L'utilisation des semicarbazones et thiosemicarbazones carbocycliques et heterocycliques substitues comme agents bloquants du canal sodique |
GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
AU754681B2 (en) | 1998-02-04 | 2002-11-21 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
-
1998
- 1998-11-20 EP EP10160063A patent/EP2201945B1/fr not_active Expired - Lifetime
- 1998-11-20 AU AU14215/99A patent/AU749214C/en not_active Ceased
- 1998-11-20 MX MXPA00004919A patent/MXPA00004919A/es active IP Right Grant
- 1998-11-20 ES ES10160063T patent/ES2402104T3/es not_active Expired - Lifetime
- 1998-11-20 US US09/554,739 patent/US6479484B1/en not_active Expired - Lifetime
- 1998-11-20 CA CA002310664A patent/CA2310664C/fr not_active Expired - Fee Related
- 1998-11-20 WO PCT/US1998/024965 patent/WO1999026614A1/fr active IP Right Grant
- 1998-11-20 JP JP2000521816A patent/JP4070955B2/ja not_active Expired - Fee Related
- 1998-11-20 DE DE69842004T patent/DE69842004D1/de not_active Expired - Lifetime
- 1998-11-20 EP EP98958114A patent/EP1032377B1/fr not_active Expired - Lifetime
- 1998-11-20 EP EP10160059A patent/EP2201944B1/fr not_active Expired - Lifetime
- 1998-11-20 ES ES98958114T patent/ES2352739T3/es not_active Expired - Lifetime
- 1998-11-20 IL IL13604498A patent/IL136044A/xx not_active IP Right Cessation
-
2001
- 2001-08-21 US US09/933,203 patent/US6500825B2/en not_active Expired - Lifetime
-
2002
- 2002-12-02 US US10/307,473 patent/US7091210B2/en not_active Expired - Fee Related
-
2006
- 2006-05-31 US US11/443,174 patent/US7541465B2/en not_active Expired - Fee Related
-
2007
- 2007-08-08 JP JP2007207280A patent/JP2008019263A/ja active Pending
-
2009
- 2009-05-28 US US12/473,887 patent/US7872127B2/en not_active Expired - Fee Related
-
2011
- 2011-01-07 US US12/986,587 patent/US8426431B2/en not_active Expired - Fee Related
- 2011-04-06 JP JP2011084727A patent/JP2011157387A/ja not_active Withdrawn
-
2013
- 2013-04-22 US US13/867,626 patent/US20130303568A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL136044A (en) | 2-aminoacetamide derivatives and pharmaceutical compositions containing the same | |
HK1026909A1 (en) | Substituted phenyl derivatives, their preparation and use | |
MY132671A (en) | Substituted 6,6-hetero-bicyclic derivatives | |
GR3032311T3 (en) | Stilbene derivatives and pharmaceutical compositions containing them | |
MY133473A (en) | Haterocyclic glycyl beta-alanine derivatives. | |
AP9701041A0 (en) | Pyridylpyrrole compounds. | |
AP9701019A0 (en) | Phenylamino-substituted tricycle derivatives. | |
BG103945A (en) | Derivatives of 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a | |
BG103947A (en) | Derivatives of 9-oxymerythromycin | |
HU9600834D0 (en) | Quinazoline derivatives | |
MX9503529A (es) | Derivados de glicinamida, procedimiento para su preparacion y medicamentos que los contienen. | |
EP0807633A3 (fr) | (5,6)-Pyrimidin-4-ones condensées à hétéroaryle, substituées en 2,3 | |
GEP20032953B (en) | Antitumor Agents | |
WO1998046576A3 (fr) | Promedicaments haloalcoxycarbonyles | |
SG64906A1 (en) | New bis-naphthalimides for the treatment of cancer | |
ZA941464B (en) | Use of pregnane derivative | |
MY114282A (en) | Anthracycline derivatives | |
TW252979B (fr) | ||
EP0855398A4 (fr) | Derives de sesquiterpene a activite antivirale | |
IL114646A0 (en) | Method of inhibiting leukotriene biosynthesis | |
MXPA99003849A (es) | Derivados 9a, 11b-deshidro de 9-oxima-3-ceto-6-0-metileritromicina. | |
ES2062940A1 (es) | Agente gastrocinetico, proceso para su preparacion y composiciones farmaceuticas que lo contengan. | |
RO116896B1 (ro) | Derivaţi pseudocarbaciclinici şi procedeu pentru prepararea acestora |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |