IL133784A - Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer - Google Patents

Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer

Info

Publication number
IL133784A
IL133784A IL13378498A IL13378498A IL133784A IL 133784 A IL133784 A IL 133784A IL 13378498 A IL13378498 A IL 13378498A IL 13378498 A IL13378498 A IL 13378498A IL 133784 A IL133784 A IL 133784A
Authority
IL
Israel
Prior art keywords
dolastatin
medicaments
derivatives
pharmaceutical compositions
treating cancer
Prior art date
Application number
IL13378498A
Other languages
English (en)
Other versions
IL133784A0 (en
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of IL133784A0 publication Critical patent/IL133784A0/xx
Publication of IL133784A publication Critical patent/IL133784A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13378498A 1997-07-18 1998-07-07 Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer IL133784A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives
PCT/US1998/013901 WO1999003879A1 (en) 1997-07-18 1998-07-07 Dolastatin 15 derivatives

Publications (2)

Publication Number Publication Date
IL133784A0 IL133784A0 (en) 2001-04-30
IL133784A true IL133784A (en) 2005-09-25

Family

ID=25406130

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13378498A IL133784A (en) 1997-07-18 1998-07-07 Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer

Country Status (33)

Country Link
US (6) US6143721A (zh)
EP (1) EP0991658B1 (zh)
JP (4) JP4508413B2 (zh)
KR (1) KR100579748B1 (zh)
CN (1) CN1268636C (zh)
AR (1) AR018501A1 (zh)
AT (1) ATE314387T1 (zh)
AU (1) AU750120B2 (zh)
BG (1) BG65212B1 (zh)
BR (1) BR9810911A (zh)
CA (1) CA2296036C (zh)
CO (1) CO4990967A1 (zh)
CY (1) CY1107047T1 (zh)
CZ (1) CZ303045B6 (zh)
DE (1) DE69832982T2 (zh)
DK (1) DK0991658T3 (zh)
ES (1) ES2258819T3 (zh)
HK (1) HK1029125A1 (zh)
HR (1) HRP980397A2 (zh)
HU (1) HU228996B1 (zh)
ID (1) ID24669A (zh)
IL (1) IL133784A (zh)
MY (1) MY135057A (zh)
NO (1) NO326827B1 (zh)
NZ (1) NZ502296A (zh)
PL (1) PL197884B1 (zh)
PT (1) PT991658E (zh)
RU (1) RU2195462C2 (zh)
SK (1) SK286581B6 (zh)
TR (2) TR200000132T2 (zh)
TW (1) TW533217B (zh)
WO (1) WO1999003879A1 (zh)
ZA (1) ZA986358B (zh)

Families Citing this family (26)

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US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
WO2001058928A1 (en) * 2000-02-08 2001-08-16 Nagasawa Herbert T N-terminal d(-)-penicillamine peptides as aldehyde sequestration agents
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
IL163868A0 (en) 2002-03-22 2005-12-18 Eisai Co Ltd Hermiasterlin derivatives and uses thereof
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
AU2003263964C1 (en) 2002-07-31 2010-08-19 Seagen Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
PT1725249E (pt) 2003-11-06 2014-04-10 Seattle Genetics Inc Compostos de monometilvalina capazes de conjugação a ligandos
JP2008522624A (ja) * 2004-12-09 2008-07-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘミアスタリン(hemiasterlin)アナログを使用する癌治療におけるチューブリンのアイソタイプのスクリーニング
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Birドメイン結合化合物
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
TW200918089A (en) 2007-07-16 2009-05-01 Genentech Inc Humanized anti-CD79b antibodies and immunoconjugates and methods of use
WO2009012268A1 (en) 2007-07-16 2009-01-22 Genentech, Inc. Anti-cd79b antibodies and immunoconjugates and methods of use
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
ES2587392T3 (es) 2008-01-31 2016-10-24 Genentech, Inc. Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso
BR112012014899A2 (pt) 2009-12-18 2017-03-14 Idenix Pharmaceuticals Inc composto, composição farmacêutica, método para tratar ou prevenir uma infecção por vírus de hepatite c em um sujeito, método para tratar , prevenir ou melhorar um ou mais sintomas de uma doença hepática ou distúrbio associado a uma infecção por vírus de hepatite c em um sujeito, método para inibir a replicação de um vírus em um hospedeiro, método para inibir a replicação de um vírus
CN105001334A (zh) 2010-02-10 2015-10-28 伊缪诺金公司 Cd20抗体及其用途
EP2534170B1 (en) 2010-02-12 2017-04-19 Pharmascience Inc. Iap bir domain binding compounds
CN105849086B (zh) 2012-11-24 2018-07-31 杭州多禧生物科技有限公司 亲水性链接体及其在药物分子和细胞结合分子共轭反应上的应用
AU2014384434B2 (en) 2014-02-28 2016-11-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
HUE049175T2 (hu) 2014-09-23 2020-09-28 Hoffmann La Roche Eljárás anti-CD79b immunkonjugátumok alkalmazására
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220147721A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
WO2023033129A1 (ja) 2021-09-03 2023-03-09 東レ株式会社 癌の治療及び/又は予防用医薬組成物

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
WO1993003054A1 (en) * 1991-08-09 1993-02-18 Teikoku Hormone Mfg. Co., Ltd. Novel tetrapeptide derivative
AU3777593A (en) 1992-02-26 1993-09-13 Paul C. Clark System for protecting computers via intelligent tokens or smart cards
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
UA45304C2 (uk) * 1992-05-20 2002-04-15 Басф Аг Похідні пептиду або їх солі, фармацевтична композиція
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
HUT72067A (en) * 1992-12-16 1996-03-28 Basf Ag Dolostatin analog
US5554993A (en) 1994-01-04 1996-09-10 Panasonic Technologies, Inc. Global position determining system and method
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
WO1998030297A1 (en) 1997-01-10 1998-07-16 Silicon Gaming, Inc. Method and apparatus for providing authenticated, secure on-line communication between remote locations
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
JP2009137967A (ja) 2009-06-25
DE69832982T2 (de) 2006-08-24
JP5122429B2 (ja) 2013-01-16
JP2009137968A (ja) 2009-06-25
HRP980397A2 (en) 1999-04-30
US6143721A (en) 2000-11-07
US20030153505A1 (en) 2003-08-14
NO20000231D0 (no) 2000-01-17
US20060270606A1 (en) 2006-11-30
CZ2000176A3 (en) 2001-06-13
JP2001515010A (ja) 2001-09-18
TR200000132T2 (tr) 2000-05-22
CZ303045B6 (cs) 2012-03-07
ES2258819T3 (es) 2006-09-01
SK187999A3 (en) 2000-09-12
NZ502296A (en) 2002-02-01
DE69832982D1 (de) 2006-02-02
CY1107047T1 (el) 2012-09-26
EP0991658B1 (en) 2005-12-28
JP5047935B2 (ja) 2012-10-10
AU750120B2 (en) 2002-07-11
CO4990967A1 (es) 2000-12-26
BG65212B1 (bg) 2007-07-31
ZA986358B (en) 2000-01-17
BR9810911A (pt) 2000-08-01
NO326827B1 (no) 2009-02-23
JP2012211164A (ja) 2012-11-01
EP0991658A1 (en) 2000-04-12
CA2296036A1 (en) 1999-01-28
DK0991658T3 (da) 2006-05-15
CN1264388A (zh) 2000-08-23
US7662786B2 (en) 2010-02-16
US8163698B2 (en) 2012-04-24
ATE314387T1 (de) 2006-01-15
PT991658E (pt) 2006-05-31
MY135057A (en) 2008-01-31
CN1268636C (zh) 2006-08-09
IL133784A0 (en) 2001-04-30
KR100579748B1 (ko) 2006-05-15
US20100099843A1 (en) 2010-04-22
PL338144A1 (en) 2000-09-25
JP4508413B2 (ja) 2010-07-21
NO20000231L (no) 2000-01-17
HU228996B1 (hu) 2013-07-29
WO1999003879A1 (en) 1999-01-28
TR200103545T2 (tr) 2002-06-21
ID24669A (id) 2000-07-27
HUP0004234A2 (hu) 2001-05-28
HUP0004234A3 (en) 2001-08-28
CA2296036C (en) 2007-05-01
HK1029125A1 (en) 2001-03-23
BG104089A (en) 2000-12-29
RU2195462C2 (ru) 2002-12-27
TW533217B (en) 2003-05-21
SK286581B6 (sk) 2009-01-07
US7084110B2 (en) 2006-08-01
PL197884B1 (pl) 2008-05-30
AU8475898A (en) 1999-02-10
KR20010021998A (ko) 2001-03-15
US20130046077A1 (en) 2013-02-21
US6458765B1 (en) 2002-10-01
AR018501A1 (es) 2001-11-28

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Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees