IL128942A - Ingredients of dihydragonias hydroxysteroid - type b17 type 5 and pharmaceutical preparations containing them - Google Patents

Ingredients of dihydragonias hydroxysteroid - type b17 type 5 and pharmaceutical preparations containing them

Info

Publication number
IL128942A
IL128942A IL12894299A IL12894299A IL128942A IL 128942 A IL128942 A IL 128942A IL 12894299 A IL12894299 A IL 12894299A IL 12894299 A IL12894299 A IL 12894299A IL 128942 A IL128942 A IL 128942A
Authority
IL
Israel
Prior art keywords
inhibitor
type
hydroxysteroid dehydrogenase
effective amount
therapeutically effective
Prior art date
Application number
IL12894299A
Other languages
English (en)
Hebrew (he)
Other versions
IL128942A0 (en
Original Assignee
Endorech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endorech Inc filed Critical Endorech Inc
Publication of IL128942A0 publication Critical patent/IL128942A0/xx
Publication of IL128942A publication Critical patent/IL128942A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
IL12894299A 1998-03-11 1999-03-11 Ingredients of dihydragonias hydroxysteroid - type b17 type 5 and pharmaceutical preparations containing them IL128942A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7751098P 1998-03-11 1998-03-11
US9562398P 1998-08-07 1998-08-07

Publications (2)

Publication Number Publication Date
IL128942A0 IL128942A0 (en) 2000-02-17
IL128942A true IL128942A (en) 2004-07-25

Family

ID=26759352

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12894299A IL128942A (en) 1998-03-11 1999-03-11 Ingredients of dihydragonias hydroxysteroid - type b17 type 5 and pharmaceutical preparations containing them

Country Status (15)

Country Link
US (2) US6541463B1 (xx)
EP (1) EP1094798A2 (xx)
JP (1) JP2002506077A (xx)
CN (1) CN1429104A (xx)
AU (1) AU2707999A (xx)
BR (1) BR9908592A (xx)
CA (1) CA2323089A1 (xx)
HK (1) HK1053054A1 (xx)
HU (1) HUP0101809A3 (xx)
IL (1) IL128942A (xx)
MX (1) MXPA00008868A (xx)
PL (1) PL343862A1 (xx)
RU (1) RU2000125533A (xx)
TR (1) TR200002784T2 (xx)
WO (1) WO1999046279A2 (xx)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19825591A1 (de) * 1998-06-09 1999-12-23 Jenapharm Gmbh Pharmazeutische Kombinationen zum Ausgleich eines Testosteron-Defizits beim Mann mit gleichzeitigem Schutz der Prostata
JP2002522380A (ja) * 1998-08-07 2002-07-23 アンドルシェルシュ・インコーポレイテッド タイプ３３α−ヒドロキシステロイドデヒドロゲナーゼの阻害
RU2340632C2 (ru) * 2002-01-22 2008-12-10 Биоматера Инк. Способ высушивания способных к биологическому разрушению полимеров
PE20040750A1 (es) 2002-11-18 2004-11-06 Schering Corp Derivados de n-(1-acetilpiperidin-4-il)-4-benzidril-2-isopropilpiperazin-1-carboxamida como inhibidores de 17beta-hidroxiesteroide deshidrogenasa de tipo 3
US7053091B2 (en) 2002-12-17 2006-05-30 Schering Corporation 17 β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
US20040224935A1 (en) * 2003-04-07 2004-11-11 Endorecherche, Inc. Topical antiandrogenic steroids
US7754709B2 (en) * 2003-06-10 2010-07-13 Solvay Pharmaceuticals Bv Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds
US7465739B2 (en) * 2003-06-10 2008-12-16 Solvay Pharmaceuticals B.V. Compounds and their use in therapy
CN102358750B (zh) 2004-01-07 2015-11-25 恩多研究公司 螺旋12定向的甾族药品
US7138246B2 (en) 2004-03-01 2006-11-21 Bristol-Myers Squibb Company Methods for identifying or screening for agents that modulate 17β-HSD3
US7417040B2 (en) 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
DE102004032673A1 (de) * 2004-07-02 2006-01-26 Schering Ag Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1
DE102004032674A1 (de) * 2004-07-02 2006-01-26 Schering Ag Neue 2-substituierte Estra-1,3,5(10)-trien-17-one als Inhibitoren der 17β-Hydroxysteroiddehydrogenase Typ 1
US7419972B2 (en) 2004-07-02 2008-09-02 Schering Ag 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US20060073099A1 (en) * 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
US7569725B2 (en) 2004-10-21 2009-08-04 Britsol-Myers Squibb Company Anthranilic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
GB0513702D0 (en) 2005-07-04 2005-08-10 Sterix Ltd Compound
EP1990335A4 (en) * 2006-03-02 2009-11-11 Astellas Pharma Inc 17-BETA-HSD-type-5 INHIBITOR
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
CA2671075A1 (en) * 2006-11-30 2008-06-05 Solvay Pharmaceuticals Gmbh Substituted estratrien derivatives as 17beta hsd inhibitors
US8288367B2 (en) * 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
US9284345B2 (en) 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
JP5251876B2 (ja) 2007-07-24 2013-07-31 アステラス製薬株式会社 ベンズイミダゾール誘導体
ES2392120T3 (es) * 2007-08-31 2012-12-04 Astellas Pharma Inc. Derivado de piperidina
GB0722779D0 (en) 2007-11-20 2008-01-02 Sterix Ltd Compound
JPWO2010087319A1 (ja) 2009-01-27 2012-08-02 アステラス製薬株式会社 前立腺癌治療剤として有効な物質のスクリーニング方法
JP5609150B2 (ja) * 2009-02-27 2014-10-22 アステラス製薬株式会社 ピペリジン誘導体
JP2011057643A (ja) * 2009-09-14 2011-03-24 Sumitomo Chemical Co Ltd ３型１７β−ヒドロキシステロイドデヒドロゲナーゼを阻害するための化合物の使用およびそのための医薬組成物
JP2011057644A (ja) * 2009-09-14 2011-03-24 Sumitomo Chemical Co Ltd ３型１７β−ヒドロキシステロイドデヒドロゲナーゼを阻害するための化合物の使用およびそのための医薬組成物
CN102134265B (zh) * 2009-12-29 2013-04-03 黄云生 一种合成6-甲基-17α-乙酰氧基-19-去甲孕甾-4,6-二烯-3,20-二酮的方法
CN102952169B (zh) * 2011-08-16 2015-11-11 黄云生 6-甲基-17α-乙酰氧基-19-去甲孕甾-4,6-二烯-3,20-二酮合成方法
DE102011083725A1 (de) 2011-09-29 2013-04-04 Bayer Pharma AG Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
AP2014008179A0 (en) * 2012-07-10 2014-12-31 Bayer Pharma AG 3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments
AU2014220800A1 (en) * 2013-02-21 2015-08-27 Bayer Pharma Aktiengesellschaft Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1 C3)
WO2014207309A1 (en) 2013-06-25 2014-12-31 Forendo Pharma Ltd Therapeutically active estratrienthiazole derivatives as inhibitors of 17 b-hydroxysteroid dehydrogenase, type 1
AU2014300894A1 (en) 2013-06-25 2016-01-28 Forendo Pharma Ltd Therapeutically active 17-nitrogen substituted estratrienthiazole derivatives as inhibitors of 17.beta.-hydroxysteroid dehydrogenase
WO2014207311A1 (en) 2013-06-25 2014-12-31 Forendo Pharma Ltd Therapeutically active estratrienthiazole derivatives as inhibitors of 17.beta.-hydroxy-steroid dehydrogenase, type 1
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
EP3237431B1 (en) 2014-12-23 2019-03-20 Forendo Pharma Ltd Prodrugs of 17.beta.-hsd1 -inhibitors
EP3237430B1 (en) 2014-12-23 2019-03-20 Forendo Pharma Ltd PRODRUGS OF 17ß -HSD1 -INHIBITORS
US10167293B2 (en) 2016-05-26 2019-01-01 Bayer Pharma Aktiengesellschaft [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs) 2016-06-07 2018-08-22 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
TW201825478A (zh) 2016-12-19 2018-07-16 德商拜耳製藥公司 ［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮
US20200085791A1 (en) 2016-12-19 2020-03-19 Bayer Pharma Aktiengesellschaft [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
CA3047191A1 (en) 2016-12-19 2018-06-28 Bayer Pharma Aktiengesellschaft [4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones
KR102619197B1 (ko) 2017-01-23 2024-01-03 리제너론 파마슈티칼스 인코포레이티드 Hsd17b13 변종 및 이것의 용도
AU2018250727A1 (en) 2017-04-11 2019-10-31 Regeneron Pharmaceuticals, Inc. Assays for screening activity of modulators of members of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) family
NZ760155A (en) 2017-06-08 2022-09-30 Forendo Pharma Ltd 15.beta.-[3-propanamido]-substituted estra-1,3,5
EP3421483A1 (en) * 2017-06-29 2019-01-02 Bayer Pharma Aktiengesellschaft Novel steroidal 17-beta heteroaryl compounds as inhibitors of akr1c3
EP3695012B1 (en) 2017-10-11 2023-03-08 Regeneron Pharmaceuticals, Inc. Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation
EP3891167A1 (en) 2018-12-05 2021-10-13 Forendo Pharma Ltd Estra-1,3,5(10)-triene compounds condensed in position 16(17) with a pyrazole ring as inhibitors of 17-hsd1
CN114057821B (zh) * 2021-11-30 2022-12-09 黑龙江中医药大学 用于围绝经期综合征的醋酸甲羟孕酮的制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2875199A (en) * 1958-04-22 1959-02-24 Searle & Co Lactones of 17-carboxyalkylated estra-1, 3, 5(10)-triene-3, 17-diols and 3-ethers
GB870286A (en) * 1958-11-04 1961-06-14 British Drug Houses Ltd Improvements in or relating to 6-methyl-3-oxo-í~-steroid compounds
FR1405214A (fr) * 1962-06-21 1965-07-09 Rhone Poulenc Sa Nouveaux stéroïdes de la série du prégnane et leur procédé de préparation
US3917657A (en) * 1970-03-04 1975-11-04 Philips Corp 16-Methylene-17-acyloxy-9{62 ,10-{60 -pregna-4,6-dinene-3,20 diones and methods of producing same
DE2059338C3 (de) * 1970-11-27 1980-01-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verwendung von Cyproteronacetat bei der Behandlung der Pubertas praecox
DE2817157A1 (de) * 1978-04-17 1979-10-25 Schering Ag Verwendung von antioestrogenen und antigonadotrop wirkenden antiandrogenen zur prophylaxe und therapie der prostatahyperplasie
DE3121152A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen "verwendung der kombination eines aromatase-hemmers mit einem antiandrogen zur prophylaxe und therapie der prostatahyperplasie"
ZA837859B (en) * 1982-10-21 1984-11-28 Christopher Harry Mortimer Treatment of male scalp hair loss
JPS6028926A (ja) * 1983-07-28 1985-02-14 Shiseido Co Ltd 皮膚外用剤
JPS60126214A (ja) * 1983-12-14 1985-07-05 Kazuoki Tsuchiya 養毛剤
US4684635A (en) * 1984-05-11 1987-08-04 Norman Orentreich Compositions and methods for inhibiting the action of androgens
US4666885A (en) 1985-02-08 1987-05-19 Fernand Labrie Combination therapy for treatment of female breast cancer
US4659695A (en) 1985-02-08 1987-04-21 Fernand Labrie Method of treatment of prostate cancer
AU594309B2 (en) 1984-08-02 1990-03-08 Fernand Labrie Pharmaceutical composition for combination therapy of hormonedependent cancers
WO1986001402A1 (en) 1984-09-05 1986-03-13 Schering Aktiengesellschaft Means for handling androgenization phenomena and use of antiandrogens for the production thereof
EP0462189B1 (en) 1989-03-10 1995-09-27 Endorecherche Inc. Combination therapy for treatment of estrogen sensitive diseases
CA2062973C (en) 1989-07-07 2003-09-23 Fernand Labrie Combination therapy for prophylaxsis and/or treatment of benign prostatic hyperplasia
DK0595796T3 (da) 1989-07-07 2003-05-05 Endorech Inc Fremgangsmåde til behandling af androgen-relaterede sygdomme
US5227375A (en) 1990-02-08 1993-07-13 Endorecherche, Inc. Aromatase inhibitors
JP2985007B2 (ja) * 1990-02-09 1999-11-29 武田薬品工業株式会社 血管新生阻害剤
HU222501B1 (hu) 1991-06-28 2003-07-28 Endorecherche Inc. MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
US6060503A (en) 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
HUT69408A (en) 1993-05-17 1995-09-28 Endorecherche Inc Androstane derivatives as antiandrogenes and pharmaceutical compositions containing them and intermediates
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
PT792152E (pt) 1994-11-22 2004-07-30 Balance Pharmaceuticals Inc Metodos de contracepcao
US6124115A (en) * 1995-09-22 2000-09-26 Endorecherche Inc. Production and use of isolated type 5 17β-hydroxysteroid dehydrogenase

Also Published As

Publication number Publication date
CA2323089A1 (en) 1999-09-16
CN1429104A (zh) 2003-07-09
BR9908592A (pt) 2001-04-24
EP1094798A2 (en) 2001-05-02
HUP0101809A2 (hu) 2001-12-28
RU2000125533A (ru) 2002-10-20
HK1053054A1 (zh) 2003-10-10
AU2707999A (en) 1999-09-27
US6541463B1 (en) 2003-04-01
TR200002784T2 (tr) 2000-12-21
US20040082556A1 (en) 2004-04-29
HUP0101809A3 (en) 2002-07-29
MXPA00008868A (es) 2003-04-25
WO1999046279A2 (en) 1999-09-16
IL128942A0 (en) 2000-02-17
JP2002506077A (ja) 2002-02-26
WO1999046279A3 (en) 2001-02-22
PL343862A1 (en) 2001-09-10

Similar Documents

Publication Publication Date Title
US6541463B1 (en) Inhibitors of type 5 and type 3 17β-hydroxysteroid dehydrogenase and methods for their use
JP4866740B2 (ja) へリックス１２指向ステロイド系医薬品
RU2142945C1 (ru) Производные бензопиперидина, бициклические соединения и фармацевтическая композиция на их основе
EP1102582A2 (en) Inhibitors of type 3 3alpha-hydroxysteroid dehydrogenase
US5763432A (en) Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
HU208150B (en) Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives
JP2001524487A (ja) アンドロゲンステロイド化合物並びにその調製法及び使用法
JP2014094952A (ja) 局所活性「ソフト」抗アンドロゲン剤
Jin et al. Role of corticotropin-releasing hormone family peptides in androgen receptor and vitamin D receptor expression and translocation in human breast cancer MCF-7 cells
US10265329B2 (en) Altering steroid metabolism for treatment of steroid-dependent disease
RU2141966C1 (ru) Антиандрогенные соединения, предшественник антиандрогенного соединения, фармацевтические композиции
EP1321146A2 (en) Inhibitors of type 5 and 3 17beta-hydroxysteroid dehydrogenase and methods for their use
JP2004524325A (ja) 良性及び／または悪性腫瘍の治療のためのステロイド誘導体の使用
AU2004200173A1 (en) Inhibitors of Type 5 and Type 3 17B-Hydroxysteroid Dehydrogenase and Methods for Their Use
JP2005511489A (ja) 骨同化化合物およびその使用方法
MXPA01001405A (en) INHIBITION OF TYPE 3 3&agr;-HYDROXYSTEROID DEHYDROGENASE
Brueggemeier Analogs and antagonists of male sex hormones
US20190330258A1 (en) 15beta-substituted estrone derivatives as selective inhibitors of 17beta-hydroxysteoid-dehydrogenases, method of preparation and use thereof
Wiren Androgens and Skeletal Biology: Basic Mechanisms
Vedeckis ANGELA MH BRODIE
BANTING et al. Oestrogen-Dependent Breast Cancer

Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees