IL128020A - Alpha-amino acid amides, preparation thereof and pharmaceutical compositions containing them - Google Patents

Alpha-amino acid amides, preparation thereof and pharmaceutical compositions containing them

Info

Publication number
IL128020A
IL128020A IL12802097A IL12802097A IL128020A IL 128020 A IL128020 A IL 128020A IL 12802097 A IL12802097 A IL 12802097A IL 12802097 A IL12802097 A IL 12802097A IL 128020 A IL128020 A IL 128020A
Authority
IL
Israel
Prior art keywords
compounds
formula
hydrogen
chf
alkyl
Prior art date
Application number
IL12802097A
Other languages
English (en)
Other versions
IL128020A0 (en
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of IL128020A0 publication Critical patent/IL128020A0/xx
Publication of IL128020A publication Critical patent/IL128020A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL12802097A 1996-07-23 1997-07-15 Alpha-amino acid amides, preparation thereof and pharmaceutical compositions containing them IL128020A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001544A IT1283489B1 (it) 1996-07-23 1996-07-23 Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico
PCT/EP1997/003773 WO1998003472A1 (fr) 1996-07-23 1997-07-15 Amides d'acide alpha-amino, leur preparation et leur utilisation therapeutique

Publications (2)

Publication Number Publication Date
IL128020A0 IL128020A0 (en) 1999-11-30
IL128020A true IL128020A (en) 2002-04-21

Family

ID=11374651

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12802097A IL128020A (en) 1996-07-23 1997-07-15 Alpha-amino acid amides, preparation thereof and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (1) US6114391A (fr)
EP (1) EP0951465B1 (fr)
JP (1) JP4542208B2 (fr)
CN (1) CN1211351C (fr)
AR (1) AR007963A1 (fr)
AT (1) ATE237584T1 (fr)
AU (1) AU729176B2 (fr)
CA (1) CA2261259C (fr)
CZ (1) CZ295824B6 (fr)
DE (1) DE69721052T2 (fr)
DK (1) DK0951465T3 (fr)
ES (1) ES2195158T3 (fr)
HU (1) HU225623B1 (fr)
ID (1) ID17999A (fr)
IL (1) IL128020A (fr)
IT (1) IT1283489B1 (fr)
MY (1) MY118244A (fr)
NO (1) NO326826B3 (fr)
NZ (1) NZ333869A (fr)
PT (1) PT951465E (fr)
RU (1) RU2174511C2 (fr)
SI (1) SI0951465T1 (fr)
TR (1) TR199900087T2 (fr)
TW (1) TW557291B (fr)
WO (1) WO1998003472A1 (fr)
ZA (1) ZA976479B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672746A (en) 1994-08-30 1997-09-30 American Biogenetic Sciences, Inc. Antiproliferative and neurotrophic molecules
JP2002518442A (ja) 1998-06-22 2002-06-25 アメリカン・バイオジェネティック・サイエンシズ・インコーポレーテッド 偏頭痛及び情動病の治療及び予防用バルプロ酸類似物の用法
US20030035784A1 (en) 2001-03-05 2003-02-20 Kao Corporation Hair cosmetic, aminocarboxylic acid amide and method for producing the same
DE60122541T2 (de) * 2001-12-21 2007-09-13 Chiesi Farmaceutici S.P.A. 2-Indanylaminoderivate zur Therapie von chronischen, akuten oder entzündlichen Schmerzen
FR2843590B1 (fr) * 2002-08-14 2007-10-05 Prestwick Scient Capital Inc Derives de l'acide r(+)-2-amino-3-hydroxypropanoique a action glycinergique
US20040082543A1 (en) * 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
DE602005007912D1 (de) * 2004-08-03 2008-08-14 Chiesi Farma Spa Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten
WO2014178083A1 (fr) 2013-05-03 2014-11-06 Council Of Scientific & Industrial Research Synthèse améliorée d'agent antiparkinsonien
CN105646252A (zh) * 2016-02-25 2016-06-08 吉尔生化（上海）有限公司 一种丝氨酸酰胺盐酸盐的合成方法
JP7290361B2 (ja) * 2019-06-25 2023-06-13 エムティックスバイオ カンパニー リミテッド 新規なアミノアルカン酸にビフェニル基を導入した誘導体化合物、およびこれを含む抗真菌薬学的組成物
EP4337316A1 (fr) * 2021-05-11 2024-03-20 Awakn Ls Europe Holdings Limited Composés et compositions thérapeutiques à base d'aminoindane

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3050800C2 (fr) * 1979-03-22 1989-06-22 Continental Pharma Inc., Bruessel/Bruxelles, Be
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
CA1339738C (fr) * 1988-03-16 1998-03-17 Takashi Kamiya Methode de preparation de derives de cephemes; produits intermediaires utiles a cette fin
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
US5332840A (en) * 1993-05-27 1994-07-26 Bristol-Myers Squibb Company Method for preparing a benzaldehyde intermediate

Also Published As

Publication number Publication date
CZ18299A3 (cs) 1999-06-16
HU225623B1 (en) 2007-05-02
ES2195158T3 (es) 2003-12-01
ITMI961544A1 (it) 1998-01-23
CA2261259C (fr) 2006-10-03
MY118244A (en) 2004-09-30
IT1283489B1 (it) 1998-04-21
AU729176B2 (en) 2001-01-25
PT951465E (pt) 2003-08-29
CN1211351C (zh) 2005-07-20
RU2174511C2 (ru) 2001-10-10
ATE237584T1 (de) 2003-05-15
JP2001506577A (ja) 2001-05-22
EP0951465A1 (fr) 1999-10-27
WO1998003472A1 (fr) 1998-01-29
JP4542208B2 (ja) 2010-09-08
CN1225625A (zh) 1999-08-11
AU3695297A (en) 1998-02-10
TR199900087T2 (xx) 1999-03-22
AR007963A1 (es) 1999-11-24
DE69721052T2 (de) 2004-02-05
HUP9902992A3 (en) 2004-04-28
US6114391A (en) 2000-09-05
CZ295824B6 (cs) 2005-11-16
TW557291B (en) 2003-10-11
NO990300L (no) 1999-01-22
CA2261259A1 (fr) 1998-01-29
EP0951465B1 (fr) 2003-04-16
ITMI961544A0 (fr) 1996-07-23
ZA976479B (en) 1998-03-02
DE69721052D1 (de) 2003-05-22
ID17999A (id) 1998-02-19
SI0951465T1 (en) 2003-08-31
NO326826B1 (no) 2009-02-23
NZ333869A (en) 2000-05-26
DK0951465T3 (da) 2003-08-11
IL128020A0 (en) 1999-11-30
NO990300D0 (no) 1999-01-22
NO326826B3 (no) 2010-06-07

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IL128020A (en) Alpha-amino acid amides, preparation thereof and pharmaceutical compositions containing them
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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees