AR007963A1 - Amidas de alfa-aminoacidos, los procesos para su preparacion, composiciones farmaceuticas que las contienen y su uso para preparar medicamentos. - Google Patents
Amidas de alfa-aminoacidos, los procesos para su preparacion, composiciones farmaceuticas que las contienen y su uso para preparar medicamentos.Info
- Publication number
- AR007963A1 AR007963A1 ARP970103300A ARP970103300A AR007963A1 AR 007963 A1 AR007963 A1 AR 007963A1 AR P970103300 A ARP970103300 A AR P970103300A AR P970103300 A ARP970103300 A AR P970103300A AR 007963 A1 AR007963 A1 AR 007963A1
- Authority
- AR
- Argentina
- Prior art keywords
- disease
- alpha
- amino acid
- processes
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se refiere a amidas de alfa-aminoácidos, los procesos para su preparación, composiciones farmacéuticas que las contienen y su uso parapreparar medicamentos. Más precisamente, se refiere a derivados de serinamida,glicinamid a, alaninamida y fenilalaninamida de fórmula (I), dondeR, R, R1 y R2 son como se han definido en la memoria. Los compuestos pueden tener la forma de sales de adición de ácido orgánico o inorgánico. Más aún,pueden tener uno o más átomosde carbono asimétricos, por lo tanto pueden usuarse tanto en la forma de mezclas que contienen más diastereoisómeros encualquier relación, como en la forma de mezclas racémicas que contienen pares de enantiómeros en relaciones iguales odiferentes, y en la forma de compuestosópticamente puros. Los compuestos pueden usarse en el tratamiento de enfermedades neurodegenerativas crónicas, como por ejemplo, la enfermedad deAlzheimer, varias formas de demencia, enfermedad deParkinson, enfermed ad de Huntigdon o trastornos neurodegenerativos agudos como por ejemplo,infartos o danos cerebrales; en el tratamiento de la epilepsia y depresión.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI001544A IT1283489B1 (it) | 1996-07-23 | 1996-07-23 | Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR007963A1 true AR007963A1 (es) | 1999-11-24 |
Family
ID=11374651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103300A AR007963A1 (es) | 1996-07-23 | 1997-07-22 | Amidas de alfa-aminoacidos, los procesos para su preparacion, composiciones farmaceuticas que las contienen y su uso para preparar medicamentos. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6114391A (es) |
| EP (1) | EP0951465B1 (es) |
| JP (1) | JP4542208B2 (es) |
| CN (1) | CN1211351C (es) |
| AR (1) | AR007963A1 (es) |
| AT (1) | ATE237584T1 (es) |
| AU (1) | AU729176B2 (es) |
| CA (1) | CA2261259C (es) |
| CZ (1) | CZ295824B6 (es) |
| DE (1) | DE69721052T2 (es) |
| DK (1) | DK0951465T3 (es) |
| ES (1) | ES2195158T3 (es) |
| HU (1) | HU225623B1 (es) |
| ID (1) | ID17999A (es) |
| IL (1) | IL128020A (es) |
| IT (1) | IT1283489B1 (es) |
| MY (1) | MY118244A (es) |
| NO (1) | NO326826B3 (es) |
| NZ (1) | NZ333869A (es) |
| PT (1) | PT951465E (es) |
| RU (1) | RU2174511C2 (es) |
| SI (1) | SI0951465T1 (es) |
| TR (1) | TR199900087T2 (es) |
| TW (1) | TW557291B (es) |
| WO (1) | WO1998003472A1 (es) |
| ZA (1) | ZA976479B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672746A (en) | 1994-08-30 | 1997-09-30 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
| PL345364A1 (en) | 1998-06-22 | 2001-12-17 | American Biogenetic Sciences | The use of valproic acid analog for the treatment and prevention of migraine and affective illness |
| US20030035784A1 (en) * | 2001-03-05 | 2003-02-20 | Kao Corporation | Hair cosmetic, aminocarboxylic acid amide and method for producing the same |
| ES2270947T3 (es) * | 2001-12-21 | 2007-04-16 | Chiesi Farmaceutici S.P.A. | Derivados de 2-indanilamino para la terapia de dolor cronico, agudo o inflamatorio. |
| FR2843590B1 (fr) * | 2002-08-14 | 2007-10-05 | Prestwick Scient Capital Inc | Derives de l'acide r(+)-2-amino-3-hydroxypropanoique a action glycinergique |
| US20040082543A1 (en) * | 2002-10-29 | 2004-04-29 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain |
| WO2006016219A2 (en) * | 2004-08-03 | 2006-02-16 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases |
| US9475757B2 (en) | 2013-05-03 | 2016-10-25 | Council Of Scientific & Industrial Research | Synthesis of anti-Parkinson agent |
| CN105646252A (zh) * | 2016-02-25 | 2016-06-08 | 吉尔生化（上海）有限公司 | 一种丝氨酸酰胺盐酸盐的合成方法 |
| HUE067087T2 (hu) * | 2019-06-25 | 2024-09-28 | Amtixbio Co Ltd | Származék-vegyület új aminoalkánsavba beépítettett bifenilcsoporttal, és ezt tartalmazó gombaellenes gyógyszerészeti készítmény |
| CA3218884A1 (en) * | 2021-05-11 | 2022-11-17 | David Nutt | Therapeutic aminoindane compounds and compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3010599A1 (de) * | 1979-03-22 | 1980-10-09 | Continental Pharma | Derivate von glycinamid, deren herstellung und verwendung |
| DE3718317A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte basische 2-aminotetraline |
| ATE212027T1 (de) * | 1988-03-16 | 2002-02-15 | Eisai Co Ltd | Cephemderivate und verfahren zu ihrer herstellung |
| IL94466A (en) * | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| US5198547A (en) * | 1992-03-16 | 1993-03-30 | South Alabama Medical Science Foundation, Usa | Process for N5-formylating tetrahydropteridines |
| GB9306899D0 (en) * | 1993-04-01 | 1993-05-26 | Erba Carlo Spa | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation |
| GB9306886D0 (en) * | 1993-04-01 | 1993-05-26 | Erba Carlo Spa | Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation |
| US5332840A (en) * | 1993-05-27 | 1994-07-26 | Bristol-Myers Squibb Company | Method for preparing a benzaldehyde intermediate |
-
1996
- 1996-07-23 IT IT96MI001544A patent/IT1283489B1/it active IP Right Grant
-
1997
- 1997-07-15 AT AT97933680T patent/ATE237584T1/de not_active IP Right Cessation
- 1997-07-15 CN CNB971966044A patent/CN1211351C/zh not_active Expired - Fee Related
- 1997-07-15 NZ NZ333869A patent/NZ333869A/xx not_active IP Right Cessation
- 1997-07-15 IL IL12802097A patent/IL128020A/en not_active IP Right Cessation
- 1997-07-15 CZ CZ1999182A patent/CZ295824B6/cs not_active IP Right Cessation
- 1997-07-15 DE DE69721052T patent/DE69721052T2/de not_active Expired - Lifetime
- 1997-07-15 TR TR1999/00087T patent/TR199900087T2/xx unknown
- 1997-07-15 HU HU9902992A patent/HU225623B1/hu not_active IP Right Cessation
- 1997-07-15 WO PCT/EP1997/003773 patent/WO1998003472A1/en active IP Right Grant
- 1997-07-15 US US09/147,553 patent/US6114391A/en not_active Expired - Fee Related
- 1997-07-15 EP EP97933680A patent/EP0951465B1/en not_active Expired - Lifetime
- 1997-07-15 JP JP50542498A patent/JP4542208B2/ja not_active Expired - Fee Related
- 1997-07-15 PT PT97933680T patent/PT951465E/pt unknown
- 1997-07-15 RU RU99103681/04A patent/RU2174511C2/ru not_active IP Right Cessation
- 1997-07-15 AU AU36952/97A patent/AU729176B2/en not_active Ceased
- 1997-07-15 CA CA002261259A patent/CA2261259C/en not_active Expired - Fee Related
- 1997-07-15 SI SI9730515T patent/SI0951465T1/xx unknown
- 1997-07-15 ES ES97933680T patent/ES2195158T3/es not_active Expired - Lifetime
- 1997-07-15 DK DK97933680T patent/DK0951465T3/da active
- 1997-07-21 ID IDP972516A patent/ID17999A/id unknown
- 1997-07-22 AR ARP970103300A patent/AR007963A1/es active IP Right Grant
- 1997-07-22 ZA ZA9706479A patent/ZA976479B/xx unknown
- 1997-07-22 MY MYPI97003309A patent/MY118244A/en unknown
- 1997-09-10 TW TW086113174A patent/TW557291B/zh active
-
1999
- 1999-01-22 NO NO19990300A patent/NO326826B3/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR007963A1 (es) | Amidas de alfa-aminoacidos, los procesos para su preparacion, composiciones farmaceuticas que las contienen y su uso para preparar medicamentos. | |
| AR038045A1 (es) | Agentes terapeuticos | |
| CO5570667A2 (es) | Compuestos azabiciclico sustituidos condensados con heteroarilo para el tratamiento de enfermedades | |
| ATE284208T1 (de) | R-enantiomer des n-propargyl-1-aminoindan zur behandlung verschiedener krankheiten und mesylat, esylat und sulfat davon | |
| DOP2006000205A (es) | Derivados de fenil-1,2,4-oxadiazolona con grupo fenilo, procedimientos para su preparacion y su uso como productos farmaceuticos. | |
| BRPI0410477A (pt) | composto ou um sal farmaceuticamente aceitável do mesmo, método para a profilaxia ou tratamento de uma condição quiral em um mamìfero, formulação farmacêutica, combinação, uso de um composto, e, processo para preparar um composto | |
| DE69937198D1 (de) | Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo | |
| AR008901A1 (es) | Compuesto azabiciclico condensado con piridona, y composiciones que los contiene e intermediarios | |
| BR0314299A (pt) | Derivados de pirrolidona como inibidores de mao-b | |
| ATE383853T1 (de) | Arylessigsäuren und verwandte verbindungen zur behandlung von alzheimer-krankheit | |
| BRPI0406827A (pt) | Processo para a modificação da formação de cristal de droga | |
| UY29790A1 (es) | Sales de diariloimidazola-4-carboxamidas, composiciones que las contienen, procesos de preparación y aplicaciones | |
| SE9702564D0 (sv) | New compounds | |
| UY27700A1 (es) | Compuestos oxo - azabiclícos. | |
| UY28098A1 (es) | Derivados de anilinopirazol útiles en el tratamiento de la diabetes | |
| BRPI0415203A (pt) | pentanóis reestruturados, um processo para sua produção e seu uso como agentes antiinflamatórios | |
| UY29741A1 (es) | Sales de 1,5- diaril pirazol-3-carboxamidas, procesos de preparación, composeciones farmacéuticas que las contienen, aplicaciones y métodos de uso. | |
| GT200700097A (es) | Nuevos derivados de fenilpiridinilpiperazina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| DE69815306D1 (de) | Valnoctamid-stereoisomere, eine methode zu ihrer herstellung und abtrennung und ihre anwendungen | |
| ES2101373T3 (es) | Tetrahidrociclopent(b)indol-metaminas y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos. | |
| GEP20063815B (en) | Novel benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | |
| EA200702295A1 (ru) | Применение азитромицина для изготовления лекарственного средства для лечения глазных инфекций | |
| ES2191350T3 (es) | Mitogenos especificos de osteoblastos y medicamentos que contienen estos compuestos. | |
| UY28676A1 (es) | Nuevos compuestos | |
| UY28368A1 (es) | Agentes terapéuticos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |