AR008901A1 - Compuesto azabiciclico condensado con piridona, y composiciones que los contiene e intermediarios - Google Patents
Compuesto azabiciclico condensado con piridona, y composiciones que los contiene e intermediariosInfo
- Publication number
- AR008901A1 AR008901A1 ARP970104980A ARP970104980A AR008901A1 AR 008901 A1 AR008901 A1 AR 008901A1 AR P970104980 A ARP970104980 A AR P970104980A AR P970104980 A ARP970104980 A AR P970104980A AR 008901 A1 AR008901 A1 AR 008901A1
- Authority
- AR
- Argentina
- Prior art keywords
- neurological
- procedures
- formula
- azabicillic
- piridone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Compuestos azabicíclicos condensados con piridona de la formula (I) y sus sales y profármacos farmacéuticamente aceptables, en los que R1, R2 y R3 soncomo se definen en la memoria. Los intermedios y los procedimientos para su preparacion, las composiciones y los procedimiento para usar los compuestosde la formula (I) en el tratamiento de trastornos neurologicos y mentales relacionados con una disminucion de la funcion colinérgica, tales comoadicion a nicotina, Corea de Huntington, discinesia tardía, hipercinesia, manía, dislexia, esquizofrenia, analgesia, trastornos de déficit de atencion(ADD), demencia multi-infarto, descenso cognitivo relacionado con la edad, epilepsia, trastornos neurologicos y mentales relacionados con una disminucionde la funcion colinérgica, demencia senil de tipo Alzheimer, enfermedad de Parkinson, trastorno de hiperactividad de déficit de atencion (ADHD), ansiedad,obesidad, Síndrome de Tourette y colitis ulcerativa
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2880496P | 1996-10-30 | 1996-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR008901A1 true AR008901A1 (es) | 2000-02-23 |
Family
ID=21845528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970104980A AR008901A1 (es) | 1996-10-30 | 1997-10-28 | Compuesto azabiciclico condensado con piridona, y composiciones que los contiene e intermediarios |
Country Status (17)
Country | Link |
---|---|
US (2) | US6235734B1 (es) |
EP (1) | EP0937077B1 (es) |
JP (2) | JP3621707B2 (es) |
AP (1) | AP9701125A0 (es) |
AR (1) | AR008901A1 (es) |
AT (1) | ATE326468T1 (es) |
AU (1) | AU4394897A (es) |
DE (1) | DE69735891T2 (es) |
ES (1) | ES2264169T3 (es) |
GT (1) | GT199700115A (es) |
HR (1) | HRP970567A2 (es) |
ID (1) | ID18741A (es) |
MA (1) | MA26445A1 (es) |
PA (1) | PA8440201A1 (es) |
TN (1) | TNSN97168A1 (es) |
WO (1) | WO1998018798A1 (es) |
ZA (1) | ZA979706B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6717030B2 (en) * | 1998-07-06 | 2004-04-06 | The Regents Of The University Of California | Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse |
IL137937A0 (en) * | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
US20010036943A1 (en) * | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
US20020010192A1 (en) * | 2000-06-02 | 2002-01-24 | Coe Jotham Wadsworth | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
US20020016334A1 (en) * | 2000-07-31 | 2002-02-07 | Coe Jotham Wadsworth | Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD) |
IL161836A0 (en) | 2001-11-30 | 2005-11-20 | Pfizer Prod Inc | Aryl fused azapolycyclic compounds |
SE0104463D0 (sv) * | 2001-12-29 | 2001-12-29 | Carlbiotech Ltd As | Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister |
US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
US20040224963A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
US20040224962A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
US8030300B2 (en) | 2003-06-10 | 2011-10-04 | Georgetown University | Ligands for nicotinic acetylcholine receptors, and methods of making and using them |
DE602004023299D1 (de) | 2003-07-21 | 2009-11-05 | Pfizer Prod Inc | Nikotin abhängigkeit reduzierende heteroaryl kondensierte azapolycyclische verbindungen |
US20050234024A1 (en) * | 2004-04-14 | 2005-10-20 | Clarke David E | Materials and methods for the treatment of ulcerative colitis |
US7135933B2 (en) * | 2004-09-29 | 2006-11-14 | Intelliserv, Inc. | System for adjusting frequency of electrical output pulses derived from an oscillator |
US20090093512A1 (en) * | 2004-12-07 | 2009-04-09 | Pfizer Inc | 1, 2, 3, 3a, 8, 8a-hexahydro-2, 7a-diada-cyclopenta[a]inden-7-one derivatives which bind to neuronal nicotinic acetylcholine specific receptor sites and are useful in modulating cholinergic function and in the treatment of addictive disorders |
US20060211649A1 (en) * | 2005-03-21 | 2006-09-21 | Eric Marchewitz | Use of cytisine for enhancing physical performance |
US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
US20090318491A1 (en) * | 2006-01-27 | 2009-12-24 | Yale Univeristy | Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders |
US20100048606A1 (en) * | 2006-03-29 | 2010-02-25 | Georgetown University Office of Technology Commercialization | 10-Substituted Cytisine Derivatives and Methods of Use Thereof |
US7404725B2 (en) * | 2006-07-03 | 2008-07-29 | Hall David R | Wiper for tool string direct electrical connection |
US8061443B2 (en) * | 2008-04-24 | 2011-11-22 | Schlumberger Technology Corporation | Downhole sample rate system |
BR112012015446B1 (pt) * | 2009-12-22 | 2020-02-11 | Avon Products, Inc. | Composição tópica e método para conferir um benefício antienvelhecimento à pele |
US20110159125A1 (en) | 2009-12-29 | 2011-06-30 | Avon Products, Inc. | CGRP Compositions and Uses Thereof |
FR2992315B1 (fr) * | 2012-06-25 | 2014-08-08 | Pf Medicament | Derives utiles dans le traitement de maladies du systeme nerveux central |
EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA |
CN102952134B (zh) * | 2012-12-05 | 2015-01-07 | 苏州药明康德检测检验有限责任公司 | 含二氟甲基的金雀花碱衍生物及制备方法和抗癌作用研究 |
RU2630958C2 (ru) * | 2015-12-29 | 2017-09-15 | федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" (МФТИ) | Новые макроциклические соединения, содержащие природное 3,7-диазабицикло[3.3.1]нонановое ядро и способ их получения |
GB201602145D0 (en) | 2016-02-05 | 2016-03-23 | Achieve Pharma Uk Ltd | Salt |
HRP20221497T1 (hr) | 2016-08-19 | 2023-02-17 | The University Of Bristol | Derivati citizina za liječenje ovisnosti |
AU2018306520B2 (en) * | 2017-07-24 | 2022-07-21 | Achieve Pharma Uk Limited | Cytisine salts |
KR20220074895A (ko) * | 2019-09-12 | 2022-06-03 | 어치브 라이프 사이언시즈, 인크. | 필요로 하는 대상체의 중독 치료 및/또는 예방을 위한 시티신을 포함하는 조성물 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3332429T1 (de) * | 1982-02-22 | 1984-01-26 | Belorusskij naučno-issledovatel'skij sanitarno-gigieničeskij institut, 220012 Minsk | Arzneipraeparat mit antinikotinwirkung und verfahren zu seiner herstellung |
US4835162A (en) | 1987-02-12 | 1989-05-30 | Abood Leo G | Agonists and antagonists to nicotine as smoking deterents |
US5242916A (en) * | 1992-07-07 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
TW261531B (es) * | 1993-10-28 | 1995-11-01 | Dynagen Inc | |
JPH11512443A (ja) * | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
-
1997
- 1997-10-15 ES ES97942166T patent/ES2264169T3/es not_active Expired - Lifetime
- 1997-10-15 US US09/297,109 patent/US6235734B1/en not_active Expired - Fee Related
- 1997-10-15 AT AT97942166T patent/ATE326468T1/de not_active IP Right Cessation
- 1997-10-15 EP EP97942166A patent/EP0937077B1/en not_active Expired - Lifetime
- 1997-10-15 DE DE69735891T patent/DE69735891T2/de not_active Expired - Fee Related
- 1997-10-15 WO PCT/IB1997/001282 patent/WO1998018798A1/en active IP Right Grant
- 1997-10-15 JP JP52022898A patent/JP3621707B2/ja not_active Expired - Fee Related
- 1997-10-15 AU AU43948/97A patent/AU4394897A/en not_active Abandoned
- 1997-10-23 AP APAP/P/1997/001125A patent/AP9701125A0/en unknown
- 1997-10-24 HR HR60/028,804A patent/HRP970567A2/hr not_active Application Discontinuation
- 1997-10-24 PA PA19978440201A patent/PA8440201A1/es unknown
- 1997-10-27 GT GT199700115A patent/GT199700115A/es unknown
- 1997-10-28 ID IDP973538A patent/ID18741A/id unknown
- 1997-10-28 AR ARP970104980A patent/AR008901A1/es unknown
- 1997-10-29 TN TNTNSN97168A patent/TNSN97168A1/fr unknown
- 1997-10-29 ZA ZA979706A patent/ZA979706B/xx unknown
- 1997-10-29 MA MA24849A patent/MA26445A1/fr unknown
-
2001
- 2001-02-14 US US09/783,443 patent/US6630467B2/en not_active Expired - Fee Related
-
2004
- 2004-09-21 JP JP2004273910A patent/JP2005060403A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20030065173A1 (en) | 2003-04-03 |
JP3621707B2 (ja) | 2005-02-16 |
AP9701125A0 (en) | 1997-10-31 |
US6235734B1 (en) | 2001-05-22 |
JP2005060403A (ja) | 2005-03-10 |
AU4394897A (en) | 1998-05-22 |
HRP970567A2 (en) | 1998-10-31 |
ES2264169T3 (es) | 2006-12-16 |
WO1998018798A1 (en) | 1998-05-07 |
MA26445A1 (fr) | 2004-12-20 |
DE69735891D1 (de) | 2006-06-22 |
ATE326468T1 (de) | 2006-06-15 |
EP0937077A1 (en) | 1999-08-25 |
GT199700115A (es) | 1999-04-20 |
ZA979706B (en) | 1999-04-29 |
DE69735891T2 (de) | 2006-12-14 |
TNSN97168A1 (fr) | 2005-03-15 |
US6630467B2 (en) | 2003-10-07 |
EP0937077B1 (en) | 2006-05-17 |
ID18741A (id) | 1998-05-07 |
JP2000505809A (ja) | 2000-05-16 |
PA8440201A1 (es) | 2000-05-24 |
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