HRP970567A2 - Nicotinic agents in addiction therapy - Google Patents
Nicotinic agents in addiction therapyInfo
- Publication number
- HRP970567A2 HRP970567A2 HR60/028,804A HRP970567A HRP970567A2 HR P970567 A2 HRP970567 A2 HR P970567A2 HR P970567 A HRP970567 A HR P970567A HR P970567 A2 HRP970567 A2 HR P970567A2
- Authority
- HR
- Croatia
- Prior art keywords
- pyrido
- hexahydro
- methane
- diazocin
- boc
- Prior art date
Links
- 206010012335 Dependence Diseases 0.000 title claims description 9
- 238000002560 therapeutic procedure Methods 0.000 title description 6
- 239000000181 nicotinic agonist Substances 0.000 title 1
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- 150000001875 compounds Chemical class 0.000 claims description 102
- 239000000203 mixture Substances 0.000 claims description 60
- -1 hydroxy, hydroxymethyl Chemical group 0.000 claims description 57
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- 239000001257 hydrogen Substances 0.000 claims description 35
- 125000003118 aryl group Chemical group 0.000 claims description 30
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- 229910052794 bromium Inorganic materials 0.000 claims description 25
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
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- 201000000980 schizophrenia Diseases 0.000 claims description 4
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Chemical class OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
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- QIWRFOJWQSSRJZ-UHFFFAOYSA-N tributyl(ethenyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C=C QIWRFOJWQSSRJZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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Landscapes
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- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
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| US2880496P | 1996-10-30 | 1996-10-30 |
Publications (1)
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| HRP970567A2 true HRP970567A2 (en) | 1998-10-31 |
Family
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Family Applications (1)
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| HR60/028,804A HRP970567A2 (en) | 1996-10-30 | 1997-10-24 | Nicotinic agents in addiction therapy |
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| EP (1) | EP0937077B1 (es) |
| JP (2) | JP3621707B2 (es) |
| AP (1) | AP9701125A0 (es) |
| AR (1) | AR008901A1 (es) |
| AT (1) | ATE326468T1 (es) |
| AU (1) | AU4394897A (es) |
| DE (1) | DE69735891T2 (es) |
| ES (1) | ES2264169T3 (es) |
| GT (1) | GT199700115A (es) |
| HR (1) | HRP970567A2 (es) |
| ID (1) | ID18741A (es) |
| MA (1) | MA26445A1 (es) |
| PA (1) | PA8440201A1 (es) |
| TN (1) | TNSN97168A1 (es) |
| WO (1) | WO1998018798A1 (es) |
| ZA (1) | ZA979706B (es) |
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| US6717030B2 (en) * | 1998-07-06 | 2004-04-06 | The Regents Of The University Of California | Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse |
| IL137937A0 (en) * | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| US20010036943A1 (en) * | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| US20020010192A1 (en) * | 2000-06-02 | 2002-01-24 | Coe Jotham Wadsworth | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| US20020016334A1 (en) * | 2000-07-31 | 2002-02-07 | Coe Jotham Wadsworth | Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD) |
| PL369886A1 (en) | 2001-11-30 | 2005-05-02 | Pfizer Products Inc. | Aryl fused azapolycyclic compounds |
| SE0104463D0 (sv) * | 2001-12-29 | 2001-12-29 | Carlbiotech Ltd As | Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister |
| US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
| US20040224962A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| US20040224963A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| US8030300B2 (en) | 2003-06-10 | 2011-10-04 | Georgetown University | Ligands for nicotinic acetylcholine receptors, and methods of making and using them |
| DE602004023299D1 (de) | 2003-07-21 | 2009-11-05 | Pfizer Prod Inc | Nikotin abhängigkeit reduzierende heteroaryl kondensierte azapolycyclische verbindungen |
| US20050234024A1 (en) * | 2004-04-14 | 2005-10-20 | Clarke David E | Materials and methods for the treatment of ulcerative colitis |
| US7135933B2 (en) * | 2004-09-29 | 2006-11-14 | Intelliserv, Inc. | System for adjusting frequency of electrical output pulses derived from an oscillator |
| CA2591330A1 (en) * | 2004-12-07 | 2006-06-15 | Pfizer Products Inc. | 1, 2, 3, 3a, 8, 8a-hexahydro-2, 7a-diada-cyclopenta [a] inden-7-one derivatives which bind to neuronal nicotinic acetylcholine specific receptor sites and are useful in modulatingcholinergic function and in the treatment of addictive disorders |
| US20060211649A1 (en) * | 2005-03-21 | 2006-09-21 | Eric Marchewitz | Use of cytisine for enhancing physical performance |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| US20090318491A1 (en) * | 2006-01-27 | 2009-12-24 | Yale Univeristy | Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders |
| WO2007115092A2 (en) * | 2006-03-29 | 2007-10-11 | Georgetown University | 10-substituted cytisine derivatives and methods of use thereof |
| US7404725B2 (en) * | 2006-07-03 | 2008-07-29 | Hall David R | Wiper for tool string direct electrical connection |
| US8061443B2 (en) * | 2008-04-24 | 2011-11-22 | Schlumberger Technology Corporation | Downhole sample rate system |
| MX368365B (es) | 2009-12-22 | 2019-09-30 | Avon Prod Inc | Composiciones estimuladoras de paxilina y usos cosmeticos de las mismas. |
| US20110159125A1 (en) | 2009-12-29 | 2011-06-30 | Avon Products, Inc. | CGRP Compositions and Uses Thereof |
| FR2992315B1 (fr) * | 2012-06-25 | 2014-08-08 | Pf Medicament | Derives utiles dans le traitement de maladies du systeme nerveux central |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| CN102952134B (zh) * | 2012-12-05 | 2015-01-07 | 苏州药明康德检测检验有限责任公司 | 含二氟甲基的金雀花碱衍生物及制备方法和抗癌作用研究 |
| RU2630958C2 (ru) * | 2015-12-29 | 2017-09-15 | федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" (МФТИ) | Новые макроциклические соединения, содержащие природное 3,7-диазабицикло[3.3.1]нонановое ядро и способ их получения |
| GB201602145D0 (en) | 2016-02-05 | 2016-03-23 | Achieve Pharma Uk Ltd | Salt |
| CN110088106A (zh) | 2016-08-19 | 2019-08-02 | 布里斯托大学 | 化合物 |
| CA3070055A1 (en) * | 2017-07-24 | 2019-01-31 | Achieve Pharma Uk Limited | Cytisine salts |
| US11083715B2 (en) * | 2019-09-12 | 2021-08-10 | Achieve Life Sciences, Inc. | Compositions comprising cytisine in the treatment and/or prevention of addiction in subjects in need thereof |
Family Cites Families (5)
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|---|---|---|---|---|
| DE3332429T1 (de) * | 1982-02-22 | 1984-01-26 | Belorusskij naučno-issledovatel'skij sanitarno-gigieničeskij institut, 220012 Minsk | Arzneipraeparat mit antinikotinwirkung und verfahren zu seiner herstellung |
| US4835162A (en) * | 1987-02-12 | 1989-05-30 | Abood Leo G | Agonists and antagonists to nicotine as smoking deterents |
| US5242916A (en) * | 1992-07-07 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| TW261531B (es) * | 1993-10-28 | 1995-11-01 | Dynagen Inc | |
| JPH11512443A (ja) * | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
-
1997
- 1997-10-15 EP EP97942166A patent/EP0937077B1/en not_active Expired - Lifetime
- 1997-10-15 JP JP52022898A patent/JP3621707B2/ja not_active Expired - Fee Related
- 1997-10-15 ES ES97942166T patent/ES2264169T3/es not_active Expired - Lifetime
- 1997-10-15 AU AU43948/97A patent/AU4394897A/en not_active Abandoned
- 1997-10-15 US US09/297,109 patent/US6235734B1/en not_active Expired - Fee Related
- 1997-10-15 AT AT97942166T patent/ATE326468T1/de not_active IP Right Cessation
- 1997-10-15 DE DE69735891T patent/DE69735891T2/de not_active Expired - Fee Related
- 1997-10-15 WO PCT/IB1997/001282 patent/WO1998018798A1/en active IP Right Grant
- 1997-10-23 AP APAP/P/1997/001125A patent/AP9701125A0/en unknown
- 1997-10-24 HR HR60/028,804A patent/HRP970567A2/hr not_active Application Discontinuation
- 1997-10-24 PA PA19978440201A patent/PA8440201A1/es unknown
- 1997-10-27 GT GT199700115A patent/GT199700115A/es unknown
- 1997-10-28 ID IDP973538A patent/ID18741A/id unknown
- 1997-10-28 AR ARP970104980A patent/AR008901A1/es unknown
- 1997-10-29 ZA ZA979706A patent/ZA979706B/xx unknown
- 1997-10-29 TN TNTNSN97168A patent/TNSN97168A1/fr unknown
- 1997-10-29 MA MA24849A patent/MA26445A1/fr unknown
-
2001
- 2001-02-14 US US09/783,443 patent/US6630467B2/en not_active Expired - Fee Related
-
2004
- 2004-09-21 JP JP2004273910A patent/JP2005060403A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AP9701125A0 (en) | 1997-10-31 |
| US6630467B2 (en) | 2003-10-07 |
| ZA979706B (en) | 1999-04-29 |
| JP2000505809A (ja) | 2000-05-16 |
| US20030065173A1 (en) | 2003-04-03 |
| PA8440201A1 (es) | 2000-05-24 |
| JP3621707B2 (ja) | 2005-02-16 |
| ID18741A (id) | 1998-05-07 |
| TNSN97168A1 (fr) | 2005-03-15 |
| EP0937077A1 (en) | 1999-08-25 |
| GT199700115A (es) | 1999-04-20 |
| DE69735891D1 (de) | 2006-06-22 |
| JP2005060403A (ja) | 2005-03-10 |
| AR008901A1 (es) | 2000-02-23 |
| AU4394897A (en) | 1998-05-22 |
| ATE326468T1 (de) | 2006-06-15 |
| US6235734B1 (en) | 2001-05-22 |
| MA26445A1 (fr) | 2004-12-20 |
| WO1998018798A1 (en) | 1998-05-07 |
| ES2264169T3 (es) | 2006-12-16 |
| EP0937077B1 (en) | 2006-05-17 |
| DE69735891T2 (de) | 2006-12-14 |
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