HUP0302562A2 - Benzoil-piridazinok, ezeket tartalmazó gyógyszerkészítmények és eljárás az előállításaikra - Google Patents
Benzoil-piridazinok, ezeket tartalmazó gyógyszerkészítmények és eljárás az előállításaikraInfo
- Publication number
- HUP0302562A2 HUP0302562A2 HU0302562A HUP0302562A HUP0302562A2 HU P0302562 A2 HUP0302562 A2 HU P0302562A2 HU 0302562 A HU0302562 A HU 0302562A HU P0302562 A HUP0302562 A HU P0302562A HU P0302562 A2 HUP0302562 A2 HU P0302562A2
- Authority
- HU
- Hungary
- Prior art keywords
- hal
- cycloalkyl
- benzoylpyridazines
- groups
- nhcoa1
- Prior art date
Links
- VDWSVBMVZLRATD-UHFFFAOYSA-N phenyl(pyridazin-3-yl)methanone Chemical class C=1C=CN=NC=1C(=O)C1=CC=CC=C1 VDWSVBMVZLRATD-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- -1 COOA1 Chemical group 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 101100533888 Hypocrea jecorina (strain QM6a) sor4 gene Proteins 0.000 abstract 1
- 101100533877 Hypocrea jecorina (strain QM6a) sor8 gene Proteins 0.000 abstract 1
- 108010044467 Isoenzymes Proteins 0.000 abstract 1
- 108091006662 SLC9B1 Proteins 0.000 abstract 1
- 102100022894 Sodium/hydrogen exchanger 9B1 Human genes 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
Abstract
A találmány tárgya (I) általános képletű benzoil-piridazinok, ahol R1és R2 jelentése egymástól függetlenül H, OH, OR4, SR4, SOR4, SO2R4vagy Hal, ahol R1 és R2 együtt -O-CH2-O-t is 10 jelenthet, R3jelentése Hal, OH, OA, NO2, NH2, NHA1, NA1A2, CN, COOH, COOA1, CONH2,CONHA1, CONA1A2, NHCOA1, NHSO2A1, NHCOOA1, (a), (b), (c), (d), (e),(f) vagy (g) képletű csoport, R4 jelentése A1 vagy 3-7 szénatomoscikloalkil-, 4-8 szénatomos alkilén-cikloalkil- vagy 2-8 szénatomosalkenilcsoport, A1 és A2 egymástól függetlenül lehet 1-12 szénatomosalkilcsoport, amely szubsztituálva lehet 1-5 fluor- és/vagyklóratommal vagy hidroxilcsoporttal, ahol A1 és A2 együtt alternatívlehet cikloalkil- vagy cikloalkiléncsoport, amelyek 3-7 gyűrűtagottartalmaznak, és amelyekben egy vagy több metiléncsoportot -S-, -O-, -NH-, -NA1-, -NHCOA1- vagy -NCOOA1- helyettesíthet, X jelentése H vagyHal, Hal jelentése fluor-, klór-, bróm- vagy jódatom, és Q jelentése1-15 szénatomos alkil- vagy alkenilcsoport, amelyben 1-5metiléncsoportot a következő csoportok helyettesítetnek: -O-, -S-, -SO2-, -CH(Hal)-, -C(Hal)2-, -CHA1-, -CA1A2-, -NH- vagy -NA1-. Atalálmány szerinti vegyületek PDE IV izozim gátló hatásúak. Atalálmány kiterjed a vegyületek előállítására és ezeket tartalmazógyógyszerkészítményre is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10064997A DE10064997A1 (de) | 2000-12-23 | 2000-12-23 | Benzoylpyridazine |
| PCT/EP2001/015070 WO2002051814A1 (en) | 2000-12-23 | 2001-12-19 | Benzoylpyridazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0302562A2 true HUP0302562A2 (hu) | 2003-11-28 |
Family
ID=7668970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302562A HUP0302562A2 (hu) | 2000-12-23 | 2001-12-19 | Benzoil-piridazinok, ezeket tartalmazó gyógyszerkészítmények és eljárás az előállításaikra |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7312328B2 (hu) |
| EP (1) | EP1343769B1 (hu) |
| JP (1) | JP4532071B2 (hu) |
| KR (1) | KR20030065564A (hu) |
| CN (1) | CN1483026A (hu) |
| AR (1) | AR032010A1 (hu) |
| AT (1) | ATE476423T1 (hu) |
| BR (1) | BR0116304A (hu) |
| CA (1) | CA2432568C (hu) |
| CZ (1) | CZ20031860A3 (hu) |
| DE (2) | DE10064997A1 (hu) |
| ES (1) | ES2349622T3 (hu) |
| HU (1) | HUP0302562A2 (hu) |
| MX (1) | MXPA03005494A (hu) |
| NO (1) | NO20032862D0 (hu) |
| PL (1) | PL364229A1 (hu) |
| RU (1) | RU2003122188A (hu) |
| SK (1) | SK8662003A3 (hu) |
| WO (1) | WO2002051814A1 (hu) |
| ZA (1) | ZA200305661B (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| AR049384A1 (es) * | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| ES2628219T3 (es) * | 2009-05-19 | 2017-08-02 | Vivia Biotech S.L. | Métodos para proporcionar ensayos de medicina personalizada ex vivo para neoplasias hematológicas |
| US10806711B2 (en) | 2011-08-12 | 2020-10-20 | University Of Cincinnati | Method of treating acute decompensated heart failure with probenecid |
| EP2968238A1 (en) | 2013-03-13 | 2016-01-20 | University of Cincinnati | Treatment of a diastolic cardiac dysfunction with a trpv2 receptor agonist |
| EP3268085A4 (en) | 2015-03-13 | 2018-10-31 | The Board of Trustees of The Leland Stanford Junior University | Ltb4 inhibition to prevent and treat human lymphedema |
| CN105175283A (zh) * | 2015-09-23 | 2015-12-23 | 蚌埠中实化学技术有限公司 | 一种3-乙氧基-4-甲氧基苯腈的制备方法 |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2139307A1 (en) * | 1992-07-01 | 1994-01-20 | Donald W. Combs | 1-arylsulphonyl, arylcarbonyl and 1-arylphosphonyl-3-phenyl-1,4,5,6-tetrahydropyridazines |
| DE69433594T2 (de) | 1993-12-22 | 2004-08-05 | Celltech R&D Ltd., Slough | Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe |
| US5786354A (en) | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| GB9412672D0 (en) | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| DE19514568A1 (de) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
| DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| GB9525262D0 (en) | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
| DE19632549A1 (de) | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19826841A1 (de) * | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19850701A1 (de) * | 1998-11-04 | 2000-05-11 | Merck Patent Gmbh | Benzoylpyridazine |
-
2000
- 2000-12-23 DE DE10064997A patent/DE10064997A1/de not_active Withdrawn
-
2001
- 2001-12-19 AT AT01272031T patent/ATE476423T1/de not_active IP Right Cessation
- 2001-12-19 JP JP2002552911A patent/JP4532071B2/ja not_active Expired - Fee Related
- 2001-12-19 AR ARP010105890A patent/AR032010A1/es unknown
- 2001-12-19 MX MXPA03005494A patent/MXPA03005494A/es unknown
- 2001-12-19 CZ CZ20031860A patent/CZ20031860A3/cs unknown
- 2001-12-19 US US10/451,393 patent/US7312328B2/en not_active Expired - Fee Related
- 2001-12-19 DE DE60142749T patent/DE60142749D1/de not_active Expired - Lifetime
- 2001-12-19 RU RU2003122188/04A patent/RU2003122188A/ru not_active Application Discontinuation
- 2001-12-19 BR BR0116304-3A patent/BR0116304A/pt not_active Application Discontinuation
- 2001-12-19 KR KR10-2003-7008423A patent/KR20030065564A/ko not_active Application Discontinuation
- 2001-12-19 SK SK866-2003A patent/SK8662003A3/sk unknown
- 2001-12-19 CA CA2432568A patent/CA2432568C/en not_active Expired - Fee Related
- 2001-12-19 EP EP01272031A patent/EP1343769B1/en not_active Expired - Lifetime
- 2001-12-19 PL PL01364229A patent/PL364229A1/xx unknown
- 2001-12-19 ES ES01272031T patent/ES2349622T3/es not_active Expired - Lifetime
- 2001-12-19 HU HU0302562A patent/HUP0302562A2/hu unknown
- 2001-12-19 WO PCT/EP2001/015070 patent/WO2002051814A1/en not_active Application Discontinuation
- 2001-12-19 CN CNA018211763A patent/CN1483026A/zh active Pending
-
2003
- 2003-06-20 NO NO20032862A patent/NO20032862D0/no not_active Application Discontinuation
- 2003-07-22 ZA ZA200305661A patent/ZA200305661B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7312328B2 (en) | 2007-12-25 |
| CZ20031860A3 (cs) | 2003-10-15 |
| DE60142749D1 (de) | 2010-09-16 |
| NO20032862L (no) | 2003-06-20 |
| EP1343769B1 (en) | 2010-08-04 |
| ES2349622T3 (es) | 2011-01-07 |
| WO2002051814A1 (en) | 2002-07-04 |
| JP4532071B2 (ja) | 2010-08-25 |
| DE10064997A1 (de) | 2002-06-27 |
| PL364229A1 (en) | 2004-12-13 |
| ZA200305661B (en) | 2004-10-22 |
| CN1483026A (zh) | 2004-03-17 |
| ATE476423T1 (de) | 2010-08-15 |
| RU2003122188A (ru) | 2005-02-27 |
| BR0116304A (pt) | 2003-09-30 |
| AR032010A1 (es) | 2003-10-22 |
| NO20032862D0 (no) | 2003-06-20 |
| JP2004519450A (ja) | 2004-07-02 |
| MXPA03005494A (es) | 2003-10-06 |
| SK8662003A3 (en) | 2003-12-02 |
| CA2432568C (en) | 2011-08-09 |
| CA2432568A1 (en) | 2002-07-04 |
| EP1343769A1 (en) | 2003-09-17 |
| KR20030065564A (ko) | 2003-08-06 |
| US20040067954A1 (en) | 2004-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0300207A2 (en) | 1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes | |
| CY1106237T1 (el) | Ετepοκυκλικα παραγωγα με 5 μελη στο δακτυλιο και εφαρμογη αυτων ως παρεμποδιστων της μονοαμινο οξυδασης | |
| HUP0001760A2 (hu) | Aril-acil-piridazin-származékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és a vegyületek alkalmazása gyógyszerkészítmények előállítására | |
| HUP0401564A2 (hu) | Diaril-cikloalkil-származékok, PPAR aktivátorként történő alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP0401982A2 (hu) | Indolizinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
| CA2475432A1 (en) | 2,4,6-triamino-1,3,5-triazine derivative | |
| HK1039316A1 (zh) | 具有一氧化氮合成酶抑制作用的苯胺衍生物 | |
| HUP0203288A2 (hu) | Foszfodiészteráz VII inhibitor hatású pirrolszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0303756A2 (hu) | 1-Aril- vagy 1-alkilszulfonil-heterociklobenzazolok és eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0001848A2 (hu) | NOS gátló 6-fenil-piridil-2-amin származékok | |
| HUP0302562A2 (hu) | Benzoil-piridazinok, ezeket tartalmazó gyógyszerkészítmények és eljárás az előállításaikra | |
| HUP0103096A2 (hu) | 2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények | |
| HUP0300080A2 (hu) | Új malonsavszármazékok, eljárás előállításukra, ezek alkalmazása Xa faktor inhibitorként és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0000980A2 (hu) | Akril-nitril-vegyületek, eljárás előállításukra, valamint akril-nitril- vegyületeket tartalmazó peszticidek | |
| MY139027A (en) | N-acylamino benzyl ether derivatives | |
| HUP0104033A2 (hu) | Benzoilpiridazin-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás az előállításukra és alkalmazásuk | |
| HUP0004731A2 (hu) | 2-Aril-benzo[b]tiofének alkalmazása ösztrogén elvonási szindróma kezelésére alkalmas gyógyszerkészítmények előállítására | |
| HUP0203526A2 (hu) | D4-antagonistákként alkalmazható tienoizoxazolil- és tienilpirazolil-fenoxi-helyettesített propilszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0401699A2 (hu) | Szerves szilíciumvegyületek és alkalmazásuk | |
| HUP9800865A2 (hu) | Kondenzált piperidinszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP0302538A2 (hu) | 3,7-diaza-biciklo[3.3.0]oktán-vegyületek, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és felhasználásuk szívritmus-zavarok kezelésére | |
| HUP0400772A2 (hu) | Eljárás piperazinszármazékok mezilátjainak előállítására és ezen vegyületek | |
| HUP0301587A2 (hu) | Foszfodiészteráz V gátló hatású 5-amino-alkil-pirazolo[4,3-d]pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárások az elżállításaikra | |
| HUP0004413A2 (hu) | 2-Aril-3-aroil-benzo[b]tiofének alkalmazása ösztrogén elvonási szindróma kezelésére alkalmas gyógyszerkészítmények előállítására | |
| HUP0303593A2 (hu) | Biguanidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |