DE69815306D1 - Valnoctamid-stereoisomere, eine methode zu ihrer herstellung und abtrennung und ihre anwendungen - Google Patents

Valnoctamid-stereoisomere, eine methode zu ihrer herstellung und abtrennung und ihre anwendungen

Info

Publication number
DE69815306D1
DE69815306D1 DE69815306T DE69815306T DE69815306D1 DE 69815306 D1 DE69815306 D1 DE 69815306D1 DE 69815306 T DE69815306 T DE 69815306T DE 69815306 T DE69815306 T DE 69815306T DE 69815306 D1 DE69815306 D1 DE 69815306D1
Authority
DE
Germany
Prior art keywords
stereoisomers
present
valnoctamide
separation
vcd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69815306T
Other languages
English (en)
Other versions
DE69815306T2 (de
Inventor
Meir Bialer
Boris Yagen
Ofer Spiegelstein
Michael Roeder
Volker Schurig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Application granted granted Critical
Publication of DE69815306D1 publication Critical patent/DE69815306D1/de
Publication of DE69815306T2 publication Critical patent/DE69815306T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69815306T 1997-01-14 1998-01-14 Valnoctamid-stereoisomere, eine methode zu ihrer herstellung und abtrennung und ihre anwendungen Expired - Lifetime DE69815306T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL12000697 1997-01-14
IL12000697A IL120006A (en) 1997-01-14 1997-01-14 Valnoctamide stereoisomers and a method for their synthesis and separation
PCT/IL1998/000015 WO1998030536A1 (en) 1997-01-14 1998-01-14 Valnoctamide stereoisomers, a method for their synthesis and separation and uses thereof

Publications (2)

Publication Number Publication Date
DE69815306D1 true DE69815306D1 (de) 2003-07-10
DE69815306T2 DE69815306T2 (de) 2004-04-29

Family

ID=11069694

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69815306T Expired - Lifetime DE69815306T2 (de) 1997-01-14 1998-01-14 Valnoctamid-stereoisomere, eine methode zu ihrer herstellung und abtrennung und ihre anwendungen

Country Status (8)

Country Link
US (1) US6417399B1 (de)
EP (1) EP0966429B1 (de)
AT (1) ATE242200T1 (de)
AU (1) AU5494598A (de)
DE (1) DE69815306T2 (de)
ES (1) ES2201433T3 (de)
IL (1) IL120006A (de)
WO (1) WO1998030536A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL124118A (en) * 1998-04-16 2007-09-20 Yissum Res Dev Co Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, method for their synthesis and pharmaceutical compositions containing them
US6969732B2 (en) 1999-04-12 2005-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them
IL147953A (en) * 2002-02-01 2008-04-13 Meir Bialer Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl-
IL157751A0 (en) * 2003-02-28 2004-03-28 Yissum Res Dev Co New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them
US20060004098A1 (en) * 2003-07-28 2006-01-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compounds useful for treating neurological disorders
EP1653937B1 (de) * 2003-07-28 2010-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Verbindungen zur behandlung von neuropathischen schmerzen und migräne
US20060025477A1 (en) * 2004-07-22 2006-02-02 Artman Linda D Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases
WO2013132490A1 (en) * 2012-03-06 2013-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods of treatment of status epilepticus
CN102875407A (zh) * 2012-09-28 2013-01-16 湖北大学 戊诺酰胺立体异构体的非对映选择性合成方法
US20190125701A1 (en) * 2016-05-06 2019-05-02 Yale University Compositions and Methods for Treating Viral Infection in Mammals

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3056726A (en) * 1960-03-22 1962-10-02 Mcneilab Inc alpha-ethyl-beta-methylvaleramide for mental hyperirritability
US5360938A (en) * 1991-08-21 1994-11-01 Union Carbide Chemicals & Plastics Technology Corporation Asymmetric syntheses
US5256293A (en) * 1991-09-20 1993-10-26 Research Corporation Technologies, Inc. Separation of enantiomers of non-steroidal anti-inflammatory drugs and chiral selector therefor
US5506268A (en) * 1993-06-11 1996-04-09 Nps Pharmaceuticals, Inc. Use of isovaleramide as a mild anxiolytic and sedative agent

Also Published As

Publication number Publication date
US6417399B1 (en) 2002-07-09
DE69815306T2 (de) 2004-04-29
ES2201433T3 (es) 2004-03-16
EP0966429B1 (de) 2003-06-04
IL120006A (en) 2000-12-06
EP0966429A1 (de) 1999-12-29
WO1998030536A1 (en) 1998-07-16
IL120006A0 (en) 1997-04-15
ATE242200T1 (de) 2003-06-15
AU5494598A (en) 1998-08-03

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Legal Events

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