IL126842A - Hybridization with artificial matching material - Google Patents

Hybridization with artificial matching material

Info

Publication number
IL126842A
IL126842A IL12684297A IL12684297A IL126842A IL 126842 A IL126842 A IL 126842A IL 12684297 A IL12684297 A IL 12684297A IL 12684297 A IL12684297 A IL 12684297A IL 126842 A IL126842 A IL 126842A
Authority
IL
Israel
Prior art keywords
duplex
mismatch
oligonucleotide
target
nucleic acid
Prior art date
Application number
IL12684297A
Other languages
English (en)
Hebrew (he)
Other versions
IL126842A0 (en
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of IL126842A0 publication Critical patent/IL126842A0/xx
Publication of IL126842A publication Critical patent/IL126842A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12684297A 1996-06-06 1997-06-05 Hybridization with artificial matching material IL126842A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/659,605 US5780233A (en) 1996-06-06 1996-06-06 Artificial mismatch hybridization
PCT/US1997/009780 WO1997046711A1 (fr) 1996-06-06 1997-06-05 Hybridation par mesappariement artificiel

Publications (2)

Publication Number Publication Date
IL126842A0 IL126842A0 (en) 1999-09-22
IL126842A true IL126842A (en) 2004-03-28

Family

ID=24646042

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12684297A IL126842A (en) 1996-06-06 1997-06-05 Hybridization with artificial matching material

Country Status (11)

Country Link
US (1) US5780233A (fr)
EP (1) EP0970240B1 (fr)
JP (1) JP3816109B2 (fr)
AT (1) ATE266737T1 (fr)
AU (1) AU710204B2 (fr)
CA (1) CA2254111C (fr)
DE (1) DE69729122T2 (fr)
DK (1) DK0970240T3 (fr)
IL (1) IL126842A (fr)
NZ (1) NZ332753A (fr)
WO (1) WO1997046711A1 (fr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
GB2333597B (en) 1996-10-29 2001-04-18 Univ Nebraska At Lincoln Method for detecting point mutations in dna utilizing fluorescence energy transfer
FR2766825B1 (fr) * 1997-08-04 2001-04-13 Pasteur Institut Oligonucleotide specifique de l'espece escherichia coli et procede de detection et de visualisation des bacteries de cette espece
US20030165888A1 (en) * 2001-07-18 2003-09-04 Brown Bob D. Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
US6518017B1 (en) * 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
WO1999022018A2 (fr) 1997-10-27 1999-05-06 Boston Probes, Inc. Procedes, trousses et compositions ayant trait a des balises moleculaires de pna (acide nucleique peptidique)
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
EP1055001A1 (fr) * 1998-02-05 2000-11-29 Bavarian Nordic Research Institute A/S Quantification par inhibition de l'amplification
US6174680B1 (en) * 1998-12-30 2001-01-16 Dana-Farber Cancer Institute, Inc. Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof
US6361942B1 (en) * 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
WO2000034521A1 (fr) * 1998-12-08 2000-06-15 Boston Probes, Inc. Methodes, trousses et compositions aux fins de l'identification d'acide nucleiques fixes a des matrices par electricite statique
ATE526580T1 (de) * 1999-03-19 2011-10-15 Life Technologies Corp Methode zum sichten von mutierten zellen
JP2002541825A (ja) * 1999-04-08 2002-12-10 オアシス バイオサイエンシーズ インコーポレイティッド ユニバーサル及び/又は同義性塩基を含むアンチセンスオリゴヌクレオチド
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US6579680B2 (en) 2000-02-28 2003-06-17 Corning Incorporated Method for label-free detection of hybridized DNA targets
US20040009514A1 (en) * 2000-02-28 2004-01-15 Frutos Anthony G. Assembly for label-free detection of hybridized nucleic targets
ATE497018T1 (de) * 2000-05-19 2011-02-15 Eragen Biosciences Inc Materialien und methoden zum nachweis von nukleinsäuren
CN100385013C (zh) * 2000-10-14 2008-04-30 伊拉根生物科学公司 使用非标准碱基的固相支持体分析系统和方法
AU1317502A (en) 2000-10-14 2002-04-29 Eragen Biosciences Inc Solid support assay systems and methods utilizing non-standard bases
DE60213579T2 (de) 2001-04-30 2007-08-09 The Regents Of The University Of Michigan, Ann Arbor Isoretikuläre organometallische grundstrukturen, verfahren zu deren bildung und systematische entwicklung von deren porengrösse und funktionalität, mit anwendung für die gasspeicherung
EP2980222A1 (fr) * 2001-09-24 2016-02-03 One Lambda, Inc. Système de détection de sondes de diagnostic
ES2661167T3 (es) * 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
JP2003180397A (ja) * 2001-12-13 2003-07-02 Nisshinbo Ind Inc ミトコンドリアdnaを用いたシロザケのハプロタイプ判定法
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
EP1608952B1 (fr) 2002-12-20 2016-08-10 Life Technologies Corporation Appareil et procede de dosage utilisant des reseaux microfluidiques
ATE417129T1 (de) 2003-01-17 2008-12-15 Eragen Biosciences Inc Nukleinsäureamplifikation mit nichtstandardbasen
JP4567673B2 (ja) 2003-04-01 2010-10-20 エラジェン バイオサイエンシズ インコーポレイテッド ポリメラーゼ阻害剤およびその使用方法
CA2524572C (fr) 2003-05-01 2018-07-10 Gen-Probe Incorporated Oligonucleotides comprenant un systeme de commutation moleculaire ayant une sensibilite accrue a la presence d'un mesappariement
KR101186764B1 (ko) 2003-05-09 2012-09-28 더 리젠츠 오브 더 유니버시티 오브 미시간 결정들에서 우수한 수준의 표면적과 다공성의 성취를 위한 방법의 이행
AU2004276722B2 (en) 2003-05-19 2009-03-12 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
WO2004108950A2 (fr) * 2003-06-06 2004-12-16 The Regents Of The University Of Michigan Procedes permettant d'incorporer des oligonucleotides ne correspondant pas parfaitement, dans des sequences d'hybridation a specificite de cible
US20060078930A1 (en) * 2004-10-01 2006-04-13 Dynal Biotech Inc. Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles
US20070111213A1 (en) * 2003-10-28 2007-05-17 Lu Wang Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles
US20050130213A1 (en) * 2003-12-10 2005-06-16 Tom Morrison Selective ligation and amplification assay
US8105554B2 (en) 2004-03-12 2012-01-31 Life Technologies Corporation Nanoliter array loading
GB0406864D0 (en) 2004-03-26 2004-04-28 Qiagen As Nucleic acid sequencing
US7618778B2 (en) 2004-06-02 2009-11-17 Kaufman Joseph C Producing, cataloging and classifying sequence tags
WO2006016978A1 (fr) * 2004-06-30 2006-02-16 Applera Corporation Complexes sondes analogiques
AU2005328382C1 (en) * 2004-07-21 2013-01-24 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a modified or non-natural nucleobase
US7892731B2 (en) * 2004-10-01 2011-02-22 Radix Biosolutions, Ltd. System and method for inhibiting the decryption of a nucleic acid probe sequence used for the detection of a specific nucleic acid
CN101189244A (zh) 2004-10-22 2008-05-28 密歇根大学董事会 共价连接的有机骨架和多面体
US20060292586A1 (en) * 2004-12-17 2006-12-28 Schroth Gary P ID-tag complexes, arrays, and methods of use thereof
KR100682923B1 (ko) * 2005-01-22 2007-02-15 삼성전자주식회사 허들 dna와 인공적인 미스매치가 도입된 프로브를이용한 단일 염기 미스매치에 대한 구별 향상 방법
WO2006101913A2 (fr) 2005-03-18 2006-09-28 Eragen Biosciences, Inc. Procedes destines a detecter des especes et des sous-especes multiples de neiserria
ES2558536T3 (es) 2005-04-07 2016-02-05 The Regents Of The University Of Michigan Technology Management Wolverine Tower Office Adsorción elevada de gas en un marco metal-orgánico con sitios metálicos abiertos
CA2610863C (fr) 2005-06-07 2017-01-17 Eragen Biosciences, Inc. Methodes de detection et de typage d'acides nucleiques
WO2007038508A2 (fr) 2005-09-26 2007-04-05 The Regents Of The University Of Michigan Structures metallo-organiques a capacite exceptionnellement elevee pour le stockage de dioxyde de carbone a la temperature ambiante
US20070076001A1 (en) * 2005-09-30 2007-04-05 Brand Matthew E Method for selecting a low dimensional model from a set of low dimensional models representing high dimensional data based on the high dimensional data
CN100510105C (zh) * 2006-02-08 2009-07-08 博奥生物有限公司 一种序列特异性寡核苷酸探针及其应用
LT1988996T (lt) 2006-02-28 2017-10-25 The Regents Of The University Of Michigan Funkcionalizuotų ceolito struktūrų gavimas
JP2010500867A (ja) * 2006-06-30 2010-01-14 ロゼッタ ジノミクス リミテッド 核酸の検出方法
CN1896284B (zh) * 2006-06-30 2013-09-11 博奥生物有限公司 一种鉴别等位基因类型的方法
KR100813263B1 (ko) 2006-08-17 2008-03-13 삼성전자주식회사 표적 서열 검출용 프로브 설계 방법 및 상기 프로브를이용한 표적 서열 검출 방법
US20090062138A1 (en) * 2007-08-31 2009-03-05 Curry Bo U Array-based method for performing SNP analysis
GB0821457D0 (en) * 2008-11-24 2008-12-31 Trillion Genomics Ltd Oligonucleotides
WO2010085542A2 (fr) 2009-01-23 2010-07-29 Novartis Ag Biomarqueurs associés à la dégénérescence maculaire liée à l'âge (dmla)
EP2487180B1 (fr) 2009-10-06 2014-12-03 Riken Nouvelles bases fluorescentes artificielles
CN102639712A (zh) * 2009-10-23 2012-08-15 卢米耐克斯公司 用于提高反应特异性的具有非标准碱基的扩增引物
AU2011207406B2 (en) 2010-01-22 2015-01-15 Gen-Probe Incorporated Probes for detecting the presence of Trichomonas vaginalis in a sample
WO2013040491A2 (fr) * 2011-09-15 2013-03-21 Shafer David A Compositions sonde: anti-sonde pour une détection d'adn ou d'arn à spécificité élevée
JP5928906B2 (ja) * 2013-08-27 2016-06-01 横河電機株式会社 核酸配列計測方法、核酸配列計測用デバイス、核酸配列計測用デバイスの製造方法および核酸配列計測装置
WO2015085183A2 (fr) * 2013-12-06 2015-06-11 Swift Biosciences, Inc. Polynucléotides concurrents clivables
TR201908099T4 (tr) * 2016-01-27 2019-06-21 Devyser Holding Ab Bir hedef sekansta istenilen nükleik asit bölgelerinde seçici amplifikasyon.
JP7153358B2 (ja) * 2017-12-20 2022-10-14 国立大学法人富山大学 改良Tmマッピング法
JP7066540B2 (ja) * 2018-06-14 2022-05-13 株式会社日立製作所 デジタルpcrの測定方法および測定装置
JP7487040B2 (ja) 2019-09-27 2024-05-20 東洋鋼鈑株式会社 骨髄増殖性腫瘍に関連する遺伝子変異評価用キット
CN114302967A (zh) * 2019-08-30 2022-04-08 东洋钢钣株式会社 用于评价骨髓增殖性肿瘤相关基因突变的试剂盒

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438131A (en) * 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside

Also Published As

Publication number Publication date
IL126842A0 (en) 1999-09-22
EP0970240B1 (fr) 2004-05-12
AU710204B2 (en) 1999-09-16
NZ332753A (en) 1999-11-29
DE69729122T2 (de) 2005-04-28
ATE266737T1 (de) 2004-05-15
EP0970240A4 (fr) 2001-07-11
JP3816109B2 (ja) 2006-08-30
CA2254111C (fr) 2008-02-12
WO1997046711A1 (fr) 1997-12-11
US5780233A (en) 1998-07-14
JP2000511434A (ja) 2000-09-05
DE69729122D1 (de) 2004-06-17
CA2254111A1 (fr) 1997-12-11
AU3302997A (en) 1998-01-05
DK0970240T3 (da) 2004-09-20
EP0970240A1 (fr) 2000-01-12

Similar Documents

Publication Publication Date Title
AU710204B2 (en) Artificial mismatch hybridization
Guo et al. Enhanced discrimination of single nucleotide polymorphisms by artificial mismatch hybridization
US8206926B2 (en) Restriction endonuclease enhanced polymorphic sequence detection
US6090553A (en) Use of uracil-DNA glycosylase in genetic analysis
US7141371B2 (en) Methods for detecting and localizing DNA mutations by microarray
CA2680588A1 (fr) Detection de sequence polymorphe amplifiee par endonuclease de restriction
CA2366107C (fr) Compositions et methode d'analyse genetique
WO2005093101A1 (fr) Sequençage d'acide nucleique
EP1151136A1 (fr) Methode pour detecter des nucleotides alleliques par amplification multiplex arms
WO2001004357A2 (fr) Protocole generique sbe-fret
WO2002018659A2 (fr) Procede servant a determiner des alleles
EP2132338A1 (fr) Procédé de détermination de polymorphismes nucléotidiques simples et de mutations dans une séquence d'acide nucléique
EP1461458A2 (fr) Procedes multiplexes de detection de methylation
Igloi Single-nucleotide polymorphism detection using peptide nucleic acids
WO2005026389A2 (fr) Procede a base de ligature permettant l'analyse de polymorphismes simples nucleotides sur l'adn genomique
KR100466995B1 (ko) 인위적으로오결합시킨하이브리다이제이션
MXPA98009882A (en) Artificial hybridization by erro alignment
Hou et al. Detection of single nucleotide polymorphism by RNase H-cleavage mediated allele-specific extension method
US20040241697A1 (en) Compositions and methods to identify haplotypes
AU2002357968A1 (en) Method and integrated device for the detection of cytosine methylations
US20110257018A1 (en) Nucleic acid sequencing
WO2001032929A1 (fr) Procedes et compositions servant a analyser des polymorphismes a nucleotide unique et des sequences courtes repetees en tandems
WO2002024960A1 (fr) Detection de la variation d'adn
WO2009143590A2 (fr) Protocol de détection de séquence d'insertion

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired