DE69729122D1 - KüNSTLICHE FEHLHYBRIDISIERUNG - Google Patents

KüNSTLICHE FEHLHYBRIDISIERUNG

Info

Publication number
DE69729122D1
DE69729122D1 DE69729122T DE69729122T DE69729122D1 DE 69729122 D1 DE69729122 D1 DE 69729122D1 DE 69729122 T DE69729122 T DE 69729122T DE 69729122 T DE69729122 T DE 69729122T DE 69729122 D1 DE69729122 D1 DE 69729122D1
Authority
DE
Germany
Prior art keywords
nucleic acid
hybridization
acid target
sequence variation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69729122T
Other languages
English (en)
Other versions
DE69729122T2 (de
Inventor
Zhen Guo
M Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of DE69729122D1 publication Critical patent/DE69729122D1/de
Application granted granted Critical
Publication of DE69729122T2 publication Critical patent/DE69729122T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
DE69729122T 1996-06-06 1997-06-05 KüNSTLICHE FEHLHYBRIDISIERUNG Expired - Lifetime DE69729122T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/659,605 US5780233A (en) 1996-06-06 1996-06-06 Artificial mismatch hybridization
US659605 1996-06-06
PCT/US1997/009780 WO1997046711A1 (en) 1996-06-06 1997-06-05 Artificial mismatch hybridization

Publications (2)

Publication Number Publication Date
DE69729122D1 true DE69729122D1 (de) 2004-06-17
DE69729122T2 DE69729122T2 (de) 2005-04-28

Family

ID=24646042

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69729122T Expired - Lifetime DE69729122T2 (de) 1996-06-06 1997-06-05 KüNSTLICHE FEHLHYBRIDISIERUNG

Country Status (11)

Country Link
US (1) US5780233A (de)
EP (1) EP0970240B1 (de)
JP (1) JP3816109B2 (de)
AT (1) ATE266737T1 (de)
AU (1) AU710204B2 (de)
CA (1) CA2254111C (de)
DE (1) DE69729122T2 (de)
DK (1) DK0970240T3 (de)
IL (1) IL126842A (de)
NZ (1) NZ332753A (de)
WO (1) WO1997046711A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
GB2333597B (en) 1996-10-29 2001-04-18 Univ Nebraska At Lincoln Method for detecting point mutations in dna utilizing fluorescence energy transfer
FR2766825B1 (fr) * 1997-08-04 2001-04-13 Pasteur Institut Oligonucleotide specifique de l'espece escherichia coli et procede de detection et de visualisation des bacteries de cette espece
US20030165888A1 (en) * 2001-07-18 2003-09-04 Brown Bob D. Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
US6518017B1 (en) * 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
AU1366299A (en) 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
EP1055001A1 (de) 1998-02-05 2000-11-29 Bavarian Nordic Research Institute A/S Quantifizierung durch inhibierung der amplifikation
US6174680B1 (en) * 1998-12-30 2001-01-16 Dana-Farber Cancer Institute, Inc. Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US6441152B1 (en) * 1998-12-08 2002-08-27 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
CN1348396A (zh) 1999-03-19 2002-05-08 金克克国际有限公司 用于高效筛选的多通孔测试板
KR20020013519A (ko) * 1999-04-08 2002-02-20 추후제출 보편적 및/또는 축퇴성 염기를 포함하는 안티센스올리고뉴클레오티드
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US20040009514A1 (en) * 2000-02-28 2004-01-15 Frutos Anthony G. Assembly for label-free detection of hybridized nucleic targets
US6579680B2 (en) 2000-02-28 2003-06-17 Corning Incorporated Method for label-free detection of hybridized DNA targets
WO2001090417A2 (en) * 2000-05-19 2001-11-29 Eragen Biosciences, Inc. Materials and methods for detection of nucleic acids
US6977161B2 (en) * 2000-10-14 2005-12-20 Eragen Biosciences, Inc. Solid support assay systems and methods utilizing non-standard bases
CN100385013C (zh) * 2000-10-14 2008-04-30 伊拉根生物科学公司 使用非标准碱基的固相支持体分析系统和方法
DE60213579T2 (de) 2001-04-30 2007-08-09 The Regents Of The University Of Michigan, Ann Arbor Isoretikuläre organometallische grundstrukturen, verfahren zu deren bildung und systematische entwicklung von deren porengrösse und funktionalität, mit anwendung für die gasspeicherung
EP1430150B1 (de) * 2001-09-24 2015-08-19 One Lambda, Inc. Diagnostisches sondennachweissystem
KR20040068122A (ko) * 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
JP2003180397A (ja) * 2001-12-13 2003-07-02 Nisshinbo Ind Inc ミトコンドリアdnaを用いたシロザケのハプロタイプ判定法
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
EP1608952B1 (de) 2002-12-20 2016-08-10 Life Technologies Corporation Assay vorrichtung und verfahren unter verwendung von mikrofluiden matrixstrukturen
ATE417129T1 (de) 2003-01-17 2008-12-15 Eragen Biosciences Inc Nukleinsäureamplifikation mit nichtstandardbasen
CA2521127C (en) 2003-04-01 2014-05-27 Eragen Biosciences, Inc. Polymerase inhibitor and method of using same
WO2004098386A2 (en) 2003-05-01 2004-11-18 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch
EP1633760B1 (de) 2003-05-09 2010-05-05 The Regents of The University of Michigan MOFs mit einer hohen Oberfläche und Methode zu deren Herstellung
EP1633893B1 (de) 2003-05-19 2012-01-25 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zur bestimmung des vorhandenseins von trichomonas vaginalis in einer testprobe
US7745117B2 (en) 2003-06-06 2010-06-29 The Regents Of The University Of Michigan Methods for incorporating non-perfectly matched oligonucleotides into target-specific hybridization sequences
US20070111213A1 (en) * 2003-10-28 2007-05-17 Lu Wang Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles
US20060078930A1 (en) * 2004-10-01 2006-04-13 Dynal Biotech Inc. Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles
US20050130213A1 (en) * 2003-12-10 2005-06-16 Tom Morrison Selective ligation and amplification assay
WO2005089945A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
GB0406864D0 (en) 2004-03-26 2004-04-28 Qiagen As Nucleic acid sequencing
US7618778B2 (en) * 2004-06-02 2009-11-17 Kaufman Joseph C Producing, cataloging and classifying sequence tags
EP1766089A1 (de) * 2004-06-30 2007-03-28 Applera Corporation Analogsondenkomplexe
WO2006093526A2 (en) * 2004-07-21 2006-09-08 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a modified or non-natural nucleobase
US7892731B2 (en) * 2004-10-01 2011-02-22 Radix Biosolutions, Ltd. System and method for inhibiting the decryption of a nucleic acid probe sequence used for the detection of a specific nucleic acid
JP5160893B2 (ja) 2004-10-22 2013-03-13 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 共有結合性有機骨格及び多面体
US20060292586A1 (en) * 2004-12-17 2006-12-28 Schroth Gary P ID-tag complexes, arrays, and methods of use thereof
KR100682923B1 (ko) * 2005-01-22 2007-02-15 삼성전자주식회사 허들 dna와 인공적인 미스매치가 도입된 프로브를이용한 단일 염기 미스매치에 대한 구별 향상 방법
WO2006101913A2 (en) 2005-03-18 2006-09-28 Eragen Biosciences, Inc. Methods for detecting multiple species and subspecies of neiserria
PT1874459E (pt) 2005-04-07 2016-02-08 Univ Michigan Alta adsorção de gás numa estrutura microporosa organometálica com locais metálicos abertos
CA2919210C (en) 2005-06-07 2019-03-05 Luminex Corporation Methods for detection and typing of nucleic acids
WO2007038508A2 (en) 2005-09-26 2007-04-05 The Regents Of The University Of Michigan Metal-organic frameworks with exceptionally high capacity for storage of carbon dioxide at room-temperature
US20070076001A1 (en) * 2005-09-30 2007-04-05 Brand Matthew E Method for selecting a low dimensional model from a set of low dimensional models representing high dimensional data based on the high dimensional data
CN100510105C (zh) * 2006-02-08 2009-07-08 博奥生物有限公司 一种序列特异性寡核苷酸探针及其应用
CN101432070A (zh) 2006-02-28 2009-05-13 密歇根大学董事会 官能化沸石骨架的制备
CN1896284B (zh) * 2006-06-30 2013-09-11 博奥生物有限公司 一种鉴别等位基因类型的方法
US9115389B2 (en) * 2006-06-30 2015-08-25 Rosetta Genomics Ltd. Method for detecting a target nucleic acid comprising two portions using probes having a first portion complementary to the first portion of the target nucleic acid and a second portion substantially complementary to the second portion of the target nucleic acid
KR100813263B1 (ko) 2006-08-17 2008-03-13 삼성전자주식회사 표적 서열 검출용 프로브 설계 방법 및 상기 프로브를이용한 표적 서열 검출 방법
US20090062138A1 (en) * 2007-08-31 2009-03-05 Curry Bo U Array-based method for performing SNP analysis
GB0821457D0 (en) * 2008-11-24 2008-12-31 Trillion Genomics Ltd Oligonucleotides
WO2010085542A2 (en) 2009-01-23 2010-07-29 Novartis Ag Biomarkers related to age-related macular degeneration (amd)
JP5756995B2 (ja) 2009-10-06 2015-07-29 国立研究開発法人理化学研究所 新規蛍光性人工塩基
CN102639712A (zh) * 2009-10-23 2012-08-15 卢米耐克斯公司 用于提高反应特异性的具有非标准碱基的扩增引物
WO2011091330A1 (en) 2010-01-22 2011-07-28 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
CA2849023C (en) * 2011-09-15 2022-07-19 David A. Shafer Probe:antiprobe compositions for high specificity dna or rna detection
JP5928906B2 (ja) * 2013-08-27 2016-06-01 横河電機株式会社 核酸配列計測方法、核酸配列計測用デバイス、核酸配列計測用デバイスの製造方法および核酸配列計測装置
US10385388B2 (en) 2013-12-06 2019-08-20 Swift Biosciences, Inc. Cleavable competitor polynucleotides
PT3408408T (pt) * 2016-01-27 2019-07-09 Devyser Holding Ab Amplificacao seletiva das regiqes do acido nucleico desejadas numa sequencia alvo
KR102494612B1 (ko) * 2017-12-20 2023-01-31 국립대학법인 도야마 다이가쿠 개량 Tm 매핑법
JP7066540B2 (ja) * 2018-06-14 2022-05-13 株式会社日立製作所 デジタルpcrの測定方法および測定装置
US20220282314A1 (en) * 2019-08-30 2022-09-08 Toyo Kohan Co., Ltd. Kit for evaluating a gene mutation related to myeloproliferative neoplasms

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438131A (en) * 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside

Also Published As

Publication number Publication date
EP0970240A4 (de) 2001-07-11
NZ332753A (en) 1999-11-29
DK0970240T3 (da) 2004-09-20
ATE266737T1 (de) 2004-05-15
AU3302997A (en) 1998-01-05
DE69729122T2 (de) 2005-04-28
EP0970240B1 (de) 2004-05-12
WO1997046711A1 (en) 1997-12-11
EP0970240A1 (de) 2000-01-12
IL126842A0 (en) 1999-09-22
JP3816109B2 (ja) 2006-08-30
US5780233A (en) 1998-07-14
IL126842A (en) 2004-03-28
AU710204B2 (en) 1999-09-16
JP2000511434A (ja) 2000-09-05
CA2254111A1 (en) 1997-12-11
CA2254111C (en) 2008-02-12

Similar Documents

Publication Publication Date Title
DE69729122D1 (de) KüNSTLICHE FEHLHYBRIDISIERUNG
DE3650679T3 (de) Oligonukleotide zur Amplifizierung von Nukleinsäuresequenzen und zur Anknüpfung einer Promotersequenz
ATE232242T1 (de) Universale primersequenz zur multiplex dna amplifikation
KR950704508A (ko) 비-포스포디에스테르 누클레오티드간 결합을 함유하는 합성 올리고누클레오티드의 서열화 방법(methods for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkages)
DE69638318D1 (de) Nukleinsäureliganden, die an DNA-Polymerasen binden und diese inhibieren
ATE239090T1 (de) Methode zum generieren von einzelsträngigen dna molekülen
ATE211769T1 (de) Oligonukleotide und verfahren zum nachweis von chlamydia trachomatis
NO176362C (no) Fremgangsmåte og reagenskombinasjon for bestemmelse av nukleotidsekvenser, samt anvendelse for bestemmelse av nukleotidvariasjon
ATE159762T1 (de) Verfahren zur dns-sequenzbestimmung mit dns- polymerase von thermus aquaticus
ATE244259T1 (de) Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
ATE209257T1 (de) Stoffen und verfahren zum nachweis von mycobakterium tuberculosis
ATE194391T1 (de) Amplifikationsoligonukleotide und sonden für borrelia, die mit lyme kranheit assoziiert sind
NO955119D0 (no) Salmonella identifisering ved polymerasekjedereaksjon
DE69518697T2 (de) Nachweis von Treponema Pallidum und Haemophilus Ducreyi
DE69616102D1 (de) Amplikationsprimern und Nukleinsäuresonden zum Nachweis von Coccidioides immites
ATE204331T1 (de) Verfahren und system zur molekularbiologischen diagnose
DE69636917D1 (de) Nucleinsäuresonden und Amplifizierungsoligonukleotide für Neisseria Spezies

Legal Events

Date Code Title Description
8364 No opposition during term of opposition