ATE204331T1 - Verfahren und system zur molekularbiologischen diagnose - Google Patents

Verfahren und system zur molekularbiologischen diagnose

Info

Publication number
ATE204331T1
ATE204331T1 AT93915067T AT93915067T ATE204331T1 AT E204331 T1 ATE204331 T1 AT E204331T1 AT 93915067 T AT93915067 T AT 93915067T AT 93915067 T AT93915067 T AT 93915067T AT E204331 T1 ATE204331 T1 AT E204331T1
Authority
AT
Austria
Prior art keywords
solid phase
dna
rna
pct
receptacles
Prior art date
Application number
AT93915067T
Other languages
English (en)
Inventor
Per Lindstroem
Original Assignee
Apbiotech Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apbiotech Aktiebolag filed Critical Apbiotech Aktiebolag
Application granted granted Critical
Publication of ATE204331T1 publication Critical patent/ATE204331T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT93915067T 1992-06-23 1993-06-23 Verfahren und system zur molekularbiologischen diagnose ATE204331T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9201929A SE9201929D0 (sv) 1992-06-23 1992-06-23 Method and system for molecular-biological diagnostics
PCT/SE1993/000557 WO1994000597A1 (en) 1992-06-23 1993-06-23 Method and system for molecular-biological diagnostics

Publications (1)

Publication Number Publication Date
ATE204331T1 true ATE204331T1 (de) 2001-09-15

Family

ID=20386582

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93915067T ATE204331T1 (de) 1992-06-23 1993-06-23 Verfahren und system zur molekularbiologischen diagnose

Country Status (7)

Country Link
US (1) US5618671A (de)
EP (1) EP0647278B1 (de)
JP (1) JPH07508407A (de)
AT (1) ATE204331T1 (de)
DE (1) DE69330604T2 (de)
SE (1) SE9201929D0 (de)
WO (1) WO1994000597A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9503808D0 (en) * 1995-02-24 1995-04-12 Univ Nottingham Detection assay
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
SE9802951D0 (sv) * 1998-09-02 1998-09-02 Amersham Pharm Biotech Ab Metod för screening samt verktyg att använda i metoden
US6461812B2 (en) 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
GB2373500B (en) * 2000-02-04 2004-12-15 Aeomica Inc Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
CN104673905B (zh) 2005-06-20 2016-09-07 领先细胞医疗诊断有限公司 检测单个细胞中的核酸和鉴定异质大细胞群中罕见细胞的方法
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
DE102006056790B3 (de) * 2006-12-01 2008-01-17 IfP Privates Institut für Produktqualität GmbH Laboreinmalartikel für Analyse und Diagnosik
CN107365847A (zh) 2010-10-21 2017-11-21 领先细胞医疗诊断有限公司 用于原位检测核酸的超灵敏方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4891319A (en) * 1985-07-09 1990-01-02 Quadrant Bioresources Limited Protection of proteins and the like
US4707235A (en) * 1985-10-16 1987-11-17 Pharmacia, Inc. Electrophoresis method and apparatus having continuous detection means
US4998617A (en) * 1986-09-15 1991-03-12 Laura Lupton Inc Facial cosmetic liquid make up kit
GB8627123D0 (en) * 1986-11-13 1986-12-10 Amersham Int Plc Dna sequence
GB8716279D0 (en) * 1987-07-10 1987-08-19 Amersham Int Plc Performing nucleic acid reactions
JP2589729B2 (ja) * 1988-01-30 1997-03-12 極東製薬工業株式会社 染色体ｄｎａを用いた細菌の同定方法および該同定用キット
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
CA2044591C (en) * 1989-02-13 2002-08-13 James Langham Dale Detection of a nucleic acid sequence or a change therein
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
WO1991008308A1 (en) * 1989-11-30 1991-06-13 Pharmacia Genetic Engineering, Inc. A new method for detecting a specific nucleic acid sequence in a sample of cells
WO1991009964A1 (en) * 1990-01-04 1991-07-11 The Johns Hopkins University Gene deleted in colorectal cancer of humans
SE9002579D0 (sv) * 1990-08-07 1990-08-07 Pharmacia Ab Method and apparatus for carrying out biochemical reactions
SE9203320D0 (sv) * 1992-11-06 1992-11-06 Pharmacia Lkb Biotech A method of processing nucleic acid samples

Also Published As

Publication number Publication date
US5618671A (en) 1997-04-08
DE69330604D1 (de) 2001-09-20
DE69330604T2 (de) 2002-07-04
EP0647278B1 (de) 2001-08-16
SE9201929D0 (sv) 1992-06-23
WO1994000597A1 (en) 1994-01-06
EP0647278A1 (de) 1995-04-12
JPH07508407A (ja) 1995-09-21

Similar Documents

Publication Publication Date Title
IL126842A0 (en) Artificial mismatch hybridization
US6372434B1 (en) Methods for reducing the complexity of DNA sequences
EP0427073A2 (de) Nukleinsäure-Amplifikation unter Verwendung von ligierter Haarnadelsonde und Transkription
Fortina et al. Detection of the most common mutations causing beta-thalassemia in Mediterraneans using a multiplex amplification refractory mutation system (MARMS).
KR870009024A (ko) 폴리뉴클레오티드의 생산 방법
KR950704508A (ko) 비-포스포디에스테르 누클레오티드간 결합을 함유하는 합성 올리고누클레오티드의 서열화 방법(methods for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkages)
Maskos et al. A novel method for the parallel analysis of multiple mutations in multiple samples.
JP2003052383A (ja) ゲノム分析方法
Zou et al. MICA allele-level typing by sequence-based typing with computerized assignment of polymorphic sites and short tandem repeats within the transmembrane region
ATE204331T1 (de) Verfahren und system zur molekularbiologischen diagnose
EP0986650A1 (de) Auf klasse-i basierende typisierung von hla-a, -b, -c allelen durch direkte dns sequenzierung
EP3638812A2 (de) Detektion seltener nukleinsäuren
Smith et al. A sequence-tagged site map of human chromosome 11
Novick et al. The Mobile Genetic Element" Alu" in the Human Genome
Zhang et al. Study of MICA alleles in 201 African Americans by multiplexed single nucleotide extension (MSNE) typing
KR20000075538A (ko) 선택적 결찰 및 증폭 방법
TW329476B (en) Method for detecting contaminant DNA in a protein product and kits used for the same purpose
Steube et al. A simple method using β-globin polymerase chain reaction for the species identification of animal cell lines—a progress report
Lawrance et al. Molecular approaches to the characterization of megabase regions of DNA: applications to the human major histocompatibility complex
Bergstrom et al. An expanded collection of mouse Y chromosome RDA clones
Chia et al. A new simplified method of gene typing
Stolz et al. Multiplex PCR reaction for the detection and identification of immunoglobulin kappa deleting element rearrangements in B‐lineage leukaemias
Timmers et al. Diversity of immunoglobulin χ light chain gene rearrangements and evidence for somatic mutation in VχIV family gene segments in X‐linked agammaglobulinemia
Kralovics et al. DNA curvature of the tobacco GRS repetitive sequence family and its relation to nucleosome positioning
Kurnit et al. Transcription patterns of sequences on human chromosome 21

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties