IL125732A - Crystalline modification of the compound -1 (-6,2 difluorobenzyl) 1H- - 1, 2, 3 - triazole-4-carboxamide and a medicinal product for the treatment of epilepsy containing it - Google Patents

Crystalline modification of the compound -1 (-6,2 difluorobenzyl) 1H- - 1, 2, 3 - triazole-4-carboxamide and a medicinal product for the treatment of epilepsy containing it

Info

Publication number
IL125732A
IL125732A IL12573298A IL12573298A IL125732A IL 125732 A IL125732 A IL 125732A IL 12573298 A IL12573298 A IL 12573298A IL 12573298 A IL12573298 A IL 12573298A IL 125732 A IL125732 A IL 125732A
Authority
IL
Israel
Prior art keywords
weak
modification
medium
triazole
carboxamide
Prior art date
Application number
IL12573298A
Other languages
English (en)
Hebrew (he)
Other versions
IL125732A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL125732(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL125732A0 publication Critical patent/IL125732A0/xx
Publication of IL125732A publication Critical patent/IL125732A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12573298A 1997-06-10 1998-06-08 Crystalline modification of the compound -1 (-6,2 difluorobenzyl) 1H- - 1, 2, 3 - triazole-4-carboxamide and a medicinal product for the treatment of epilepsy containing it IL125732A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (2)

Publication Number Publication Date
IL125732A0 IL125732A0 (en) 1999-04-11
IL125732A true IL125732A (en) 2002-12-01

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
IL12573398A IL125733A (en) 1997-06-10 1998-06-08 Crystal modification of the compound -1 (-6,2 difluorobenzyl) - 1H- -3,2,1 triazole - 4 carboxamide and medicinal preparations for the treatment of epilepsy containing it
IL12573298A IL125732A (en) 1997-06-10 1998-06-08 Crystalline modification of the compound -1 (-6,2 difluorobenzyl) 1H- - 1, 2, 3 - triazole-4-carboxamide and a medicinal product for the treatment of epilepsy containing it

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL12573398A IL125733A (en) 1997-06-10 1998-06-08 Crystal modification of the compound -1 (-6,2 difluorobenzyl) - 1H- -3,2,1 triazole - 4 carboxamide and medicinal preparations for the treatment of epilepsy containing it

Country Status (37)

Country Link
US (6) US6740669B1 (nl)
EP (2) EP0994863B1 (nl)
JP (2) JP3672575B2 (nl)
KR (2) KR100425656B1 (nl)
CN (3) CN1159300C (nl)
AR (4) AR012946A1 (nl)
AT (2) ATE232852T1 (nl)
AU (2) AU725528B2 (nl)
BR (2) BR9804947A (nl)
CA (3) CA2614926C (nl)
CO (2) CO4940452A1 (nl)
CY (1) CY2007014I1 (nl)
CZ (2) CZ292481B6 (nl)
DE (3) DE69813560T2 (nl)
DK (2) DK0994864T3 (nl)
ES (2) ES2197485T3 (nl)
FR (1) FR07C0037I2 (nl)
HK (3) HK1028241A1 (nl)
HU (2) HU226107B1 (nl)
ID (2) ID21014A (nl)
IL (2) IL125733A (nl)
LU (1) LU91345I2 (nl)
MY (2) MY125854A (nl)
NL (1) NL300284I2 (nl)
NO (2) NO329315B1 (nl)
NZ (2) NZ331371A (nl)
PE (2) PE79799A1 (nl)
PL (2) PL192114B1 (nl)
PT (1) PT994864E (nl)
RU (2) RU2194041C2 (nl)
SI (2) SI0994864T1 (nl)
SK (2) SK283734B6 (nl)
TR (2) TR199801631T1 (nl)
TW (2) TW526195B (nl)
UY (1) UY25844A1 (nl)
WO (2) WO1998056772A1 (nl)
ZA (2) ZA984967B (nl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
JP2005529933A (ja) * 2002-05-31 2005-10-06 シェーリング　コーポレイション キサンチンホスホジエステラーゼｖインヒビター多形体
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
WO2010043849A1 (en) * 2008-10-13 2010-04-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
KR101597338B1 (ko) * 2009-09-04 2016-02-24 탁티칼 떼라페우틱스 인크. 5-아미노 또는 치환된 아미노 1,2,3-트리아졸 화합물 및 이의 오로트산염 제형들의 신규한 조성물들 및 이의 제조방법
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
EP2563766B1 (en) 2010-04-30 2014-06-25 Laboratorios Lesvi, S.L. Improved process for preparing rufinamide intermediate
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

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US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) * 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
WO1991001724A1 (en) 1989-07-27 1991-02-21 G.D. Searle & Co. Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
ES2150417T3 (es) 1990-11-06 2000-12-01 Yamanouchi Pharma Co Ltd Derivados de pirazina fusionados.
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
CA2213693C (en) 1995-02-22 2008-04-15 Hoechst Pharmaceuticals & Chemicals K.K. Amorphous piretanide, piretanide polymorphs, process for their preparation and their use
SK283990B6 (sk) * 1996-07-11 2004-07-07 Novartis Ag Spôsob prípravy 1-substituovaných 4-kyano-1,2,3-triazolov, 4-kyano-1-(2,6-difluórbenzyl)-1H-1,2,3-triazol
TW526195B (en) 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
AR061004A2 (es) 2008-07-30
CO4940452A1 (es) 2000-07-24
ZA984967B (en) 1999-01-11
KR100409168B1 (ko) 2004-01-31
NO983666D0 (no) 1998-08-11
NO329315B1 (no) 2010-09-27
SK109398A3 (en) 1998-12-02
KR19990087836A (ko) 1999-12-27
CA2256015C (en) 2008-06-03
PE80999A1 (es) 1999-09-06
CO4940448A1 (es) 2000-07-24
CA2614926A1 (en) 1998-12-17
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
ATE237599T1 (de) 2003-05-15
PL192114B1 (pl) 2006-08-31
CN1572789A (zh) 2005-02-02
LU91345I2 (fr) 2007-09-04
NO983666L (no) 1998-12-17
HUP0002113A3 (en) 2002-09-30
US20030125568A1 (en) 2003-07-03
IL125732A0 (en) 1999-04-11
SK283685B6 (sk) 2003-12-02
EP0994863B1 (en) 2003-02-19
EP0994864A1 (en) 2000-04-26
AR061005A2 (es) 2008-07-30
CN1132820C (zh) 2003-12-31
DE69811500T2 (de) 2004-04-01
ID21014A (id) 1999-04-08
NO983667L (no) 1998-12-17
CN1159300C (zh) 2004-07-28
JP3672575B2 (ja) 2005-07-20
KR19990087835A (ko) 1999-12-27
SI0994864T1 (en) 2003-10-31
HUP0002113A2 (hu) 2001-02-28
ATE232852T1 (de) 2003-03-15
NZ331371A (en) 2000-08-25
NO329314B1 (no) 2010-09-27
HUP0000798A3 (en) 2000-10-30
JP2000516259A (ja) 2000-12-05
FR07C0037I2 (nl) 2008-05-16
EP0994864B1 (en) 2003-04-16
AU8437298A (en) 1998-12-30
ID27660A (id) 2001-04-19
DE122007000051I1 (de) 2007-11-08
HK1028031A1 (en) 2001-02-02
MY125854A (en) 2006-08-30
JP3672574B2 (ja) 2005-07-20
JP2000516258A (ja) 2000-12-05
CY2007014I2 (el) 2009-11-04
TW403740B (en) 2000-09-01
CA2256013A1 (en) 1998-12-17
CA2256015A1 (en) 1998-12-17
CA2614926C (en) 2010-02-09
WO1998056772A1 (en) 1998-12-17
CZ253498A3 (cs) 1999-04-14
CN1259127A (zh) 2000-07-05
TR199801631T1 (xx) 1999-06-21
KR100425656B1 (ko) 2004-05-17
US20060116520A1 (en) 2006-06-01
DE122007000051I2 (de) 2009-02-19
AU725528B2 (en) 2000-10-12
CZ253398A3 (cs) 1999-04-14
AR012945A1 (es) 2000-11-22
AU725517B2 (en) 2000-10-12
US6455556B2 (en) 2002-09-24
PT994864E (pt) 2003-07-31
TW526195B (en) 2003-04-01
US20010037029A1 (en) 2001-11-01
EP0994863A1 (en) 2000-04-26
LU91345I9 (nl) 2018-12-31
DK0994863T3 (da) 2003-05-26
NL300284I2 (nl) 2007-11-01
US20040167186A1 (en) 2004-08-26
UY25844A1 (es) 2001-08-27
US6740669B1 (en) 2004-05-25
PE79799A1 (es) 1999-09-03
IL125733A0 (en) 1999-04-11
NZ331370A (en) 2000-08-25
CN1298708C (zh) 2007-02-07
ES2192779T3 (es) 2003-10-16
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
CZ292260B6 (cs) 2003-08-13
DE69811500D1 (de) 2003-03-27
CZ292481B6 (cs) 2003-09-17
US8076362B2 (en) 2011-12-13
RU2198167C2 (ru) 2003-02-10
IL125733A (en) 2002-12-01
SI0994863T1 (en) 2003-08-31
HU225153B1 (en) 2006-07-28
DE69813560D1 (de) 2003-05-22
FR07C0037I1 (nl) 2007-08-17
CA2256013C (en) 2007-10-16
US7750028B2 (en) 2010-07-06
DK0994864T3 (da) 2003-07-21
HK1028241A1 (en) 2001-02-09
US20100310655A1 (en) 2010-12-09
BR9804947A (pt) 1999-08-24
HU226107B1 (en) 2008-04-28
HK1028242A1 (en) 2001-02-09
BR9804946A (pt) 1999-08-24
PL191943B1 (pl) 2006-07-31
ZA984966B (en) 1999-01-11
PL330798A1 (en) 1999-06-07
ES2197485T3 (es) 2004-01-01
TR199801630T1 (xx) 1999-06-21
HUP0000798A2 (hu) 2000-10-30
MY120156A (en) 2005-09-30
PL330764A1 (en) 1999-05-24
SK109498A3 (en) 1998-12-02
RU2194041C2 (ru) 2002-12-10
DE69813560T2 (de) 2004-02-05
AR012946A1 (es) 2000-11-22
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
CN1217716A (zh) 1999-05-26

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