IL124994A - Taxoids preparation thereof and pharmaceutical compositions containing same - Google Patents

Taxoids preparation thereof and pharmaceutical compositions containing same

Info

Publication number
IL124994A
IL124994A IL12499496A IL12499496A IL124994A IL 124994 A IL124994 A IL 124994A IL 12499496 A IL12499496 A IL 12499496A IL 12499496 A IL12499496 A IL 12499496A IL 124994 A IL124994 A IL 124994A
Authority
IL
Israel
Prior art keywords
taxoids
preparation
pharmaceutical compositions
compositions containing
containing same
Prior art date
Application number
IL12499496A
Other languages
English (en)
Other versions
IL124994A0 (en
Original Assignee
Rhone Poulenc Rorer Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Gmbh filed Critical Rhone Poulenc Rorer Gmbh
Publication of IL124994A0 publication Critical patent/IL124994A0/xx
Publication of IL124994A publication Critical patent/IL124994A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IL12499496A 1995-12-22 1996-12-19 Taxoids preparation thereof and pharmaceutical compositions containing same IL124994A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
IL124994A0 IL124994A0 (en) 1999-01-26
IL124994A true IL124994A (en) 2000-12-06

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12499496A IL124994A (en) 1995-12-22 1996-12-19 Taxoids preparation thereof and pharmaceutical compositions containing same

Country Status (41)

Country Link
US (1) US5728849A (de)
EP (1) EP0876362B1 (de)
JP (1) JP3953106B2 (de)
KR (1) KR100500351B1 (de)
CN (1) CN1103766C (de)
AR (1) AR005197A1 (de)
AT (1) ATE250593T1 (de)
AU (1) AU712597B2 (de)
BG (1) BG63204B1 (de)
BR (1) BR9612135A (de)
CA (1) CA2238884C (de)
CO (1) CO4520184A1 (de)
CZ (1) CZ294972B6 (de)
DE (1) DE69630145T2 (de)
DK (1) DK0876362T3 (de)
DZ (1) DZ2149A1 (de)
EA (1) EA001533B1 (de)
ES (1) ES2202490T3 (de)
FR (1) FR2742751B1 (de)
HK (1) HK1017895A1 (de)
HU (1) HU225032B1 (de)
IL (1) IL124994A (de)
IN (4) IN186768B (de)
MA (1) MA26412A1 (de)
MX (1) MX9804688A (de)
MY (1) MY113934A (de)
NO (1) NO317358B1 (de)
NZ (1) NZ324337A (de)
OA (1) OA10700A (de)
PE (1) PE25198A1 (de)
PL (1) PL189311B1 (de)
PT (1) PT876362E (de)
RO (1) RO116194B1 (de)
SK (1) SK282835B6 (de)
TN (1) TNSN96169A1 (de)
TR (1) TR199801179T2 (de)
TW (1) TW371659B (de)
UA (1) UA48205C2 (de)
UY (1) UY24386A1 (de)
WO (1) WO1997023473A1 (de)
ZA (1) ZA9610737B (de)

Families Citing this family (39)

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GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
JP2003522171A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
PT1368349E (pt) * 2001-02-24 2007-04-30 Boehringer Ingelheim Pharma Derivados de xantina, sua preparação e sua utilização como medicamento
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
CA2526278A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (de) 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxische Wirkstoffen auf Basis von neuen Taxanen
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
MX2008014024A (es) 2006-05-04 2008-11-14 Boehringer Ingelheim Int Formas poliformas.
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP1852108A1 (de) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Zusammensetzungen von DPP-IV-Inhibitoren
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
US20110112069A1 (en) * 2007-08-17 2011-05-12 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
WO2010018217A2 (en) * 2008-08-15 2010-02-18 Boehringer Ingelheim International Gmbh Organic compounds for wound healing
US8513264B2 (en) 2008-09-10 2013-08-20 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN107011345A (zh) 2008-12-23 2017-08-04 勃林格殷格翰国际有限公司 有机化合物的盐形式
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
EP3646859A1 (de) 2009-11-27 2020-05-06 Boehringer Ingelheim International GmbH Behandlung von genotypisierten diabetes-patienten mit dpp-iv-hemmern wie etwa linagliptin
AU2011249722B2 (en) 2010-05-05 2015-09-17 Boehringer Ingelheim International Gmbh Combination therapy
BR112012032579B1 (pt) 2010-06-24 2021-05-11 Boehringer Ingelheim International Gmbh uso de linagliptina e composição farmacêutica compreendendo linagliptina e insulina basal de longa duração
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
HUE043540T2 (hu) 2011-07-15 2019-08-28 Boehringer Ingelheim Int Szubsztituált dimer kinazolin-származék, elõállítása, valamint alkalmazása 1-es és 2-es típusú cukorbetegség kezelésére szolgáló gyógyászati készítményekben
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP3685839A1 (de) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin zur verwendung in der behandlung von albuminuria und nierenbedingten erkrankungen
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
US10464955B2 (en) 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
CN113350518A (zh) 2015-07-12 2021-09-07 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
BR112018072401A2 (pt) 2016-06-10 2019-02-19 Boehringer Ingelheim International Gmbh combinações de linagliptina e metformina
NZ752394A (en) 2016-11-14 2021-07-30 Hangzhou Dac Biotech Co Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
DE69325454T2 (de) * 1992-04-17 2000-01-20 Abbott Lab Taxol-derivate
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them

Also Published As

Publication number Publication date
PE25198A1 (es) 1998-05-10
AR005197A1 (es) 1999-04-14
AU1180997A (en) 1997-07-17
TNSN96169A1 (fr) 2005-03-15
ATE250593T1 (de) 2003-10-15
NO982580L (no) 1998-06-05
PL327405A1 (en) 1998-12-07
UY24386A1 (es) 2001-08-27
DE69630145D1 (de) 2003-10-30
KR19990076680A (ko) 1999-10-15
WO1997023473A1 (fr) 1997-07-03
OA10700A (fr) 2002-11-27
IN188680B (de) 2002-10-26
HK1017895A1 (en) 1999-12-03
JP3953106B2 (ja) 2007-08-08
MA26412A1 (fr) 2004-12-20
EA199800588A1 (ru) 1998-12-24
KR100500351B1 (ko) 2005-12-21
MY113934A (en) 2002-06-29
CZ294972B6 (cs) 2005-04-13
HUP9904046A1 (hu) 2001-04-28
BG63204B1 (bg) 2001-06-29
EA001533B1 (ru) 2001-04-23
DZ2149A1 (fr) 2002-10-23
TR199801179T2 (xx) 1998-10-21
FR2742751A1 (fr) 1997-06-27
EP0876362A1 (de) 1998-11-11
PL189311B1 (pl) 2005-07-29
CN1205697A (zh) 1999-01-20
CO4520184A1 (es) 1997-10-15
DE69630145T2 (de) 2004-07-15
PT876362E (pt) 2004-02-27
BG102569A (en) 1999-04-30
CA2238884C (fr) 2007-02-06
BR9612135A (pt) 1999-07-13
IN188470B (de) 2002-09-28
NO982580D0 (no) 1998-06-05
ZA9610737B (en) 1997-06-27
EP0876362B1 (de) 2003-09-24
DK0876362T3 (da) 2004-02-02
NO317358B1 (no) 2004-10-18
ES2202490T3 (es) 2004-04-01
CA2238884A1 (fr) 1997-07-03
CZ196198A3 (cs) 1998-09-16
UA48205C2 (uk) 2002-08-15
TW371659B (en) 1999-10-11
IN186768B (de) 2001-11-03
HUP9904046A3 (en) 2001-08-28
IL124994A0 (en) 1999-01-26
JP2000502671A (ja) 2000-03-07
US5728849A (en) 1998-03-17
AU712597B2 (en) 1999-11-11
SK282835B6 (sk) 2002-12-03
SK85398A3 (en) 1998-11-04
IN188469B (de) 2002-09-28
MX9804688A (es) 1998-10-31
CN1103766C (zh) 2003-03-26
RO116194B1 (ro) 2000-11-30
NZ324337A (en) 2000-03-27
FR2742751B1 (fr) 1998-01-30
HU225032B1 (en) 2006-05-29

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Legal Events

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FF Patent granted
KB Patent renewed
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MM9K Patent not in force due to non-payment of renewal fees