IL124747A - Process for producing captopril - Google Patents
Process for producing captoprilInfo
- Publication number
- IL124747A IL124747A IL12474797A IL12474797A IL124747A IL 124747 A IL124747 A IL 124747A IL 12474797 A IL12474797 A IL 12474797A IL 12474797 A IL12474797 A IL 12474797A IL 124747 A IL124747 A IL 124747A
- Authority
- IL
- Israel
- Prior art keywords
- aqueous medium
- hydrolysis reaction
- producing captopril
- captopril
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28934096A JP3980684B2 (ja) | 1996-10-11 | 1996-10-11 | 高品質カプトプリルの簡便な製造方法 |
| PCT/JP1997/003655 WO1998016509A1 (fr) | 1996-10-11 | 1997-10-13 | Procede simplifie pour produire du captotril de qualite superieure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124747A0 IL124747A0 (en) | 1999-01-26 |
| IL124747A true IL124747A (en) | 2003-05-29 |
Family
ID=17741941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12474797A IL124747A (en) | 1996-10-11 | 1997-10-13 | Process for producing captopril |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6187932B1 (de) |
| EP (1) | EP0889031B1 (de) |
| JP (1) | JP3980684B2 (de) |
| KR (1) | KR19990072045A (de) |
| AT (1) | ATE231125T1 (de) |
| CA (1) | CA2249543A1 (de) |
| DE (1) | DE69718450T2 (de) |
| ES (1) | ES2191200T3 (de) |
| HR (1) | HRP970536A2 (de) |
| HU (1) | HUP0000199A3 (de) |
| IL (1) | IL124747A (de) |
| IN (1) | IN183229B (de) |
| SI (1) | SI9720012A (de) |
| WO (1) | WO1998016509A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107652215A (zh) * | 2017-09-19 | 2018-02-02 | 重庆西南制药二厂有限责任公司 | 一种卡托普利的制备方法 |
| CN110950792A (zh) * | 2019-12-11 | 2020-04-03 | 华中药业股份有限公司 | 一种卡托普利的改进制备方法 |
| CN116655512A (zh) * | 2023-05-31 | 2023-08-29 | 江苏阿尔法药业股份有限公司 | 一种卡托普利的制备工艺 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5538363A (en) * | 1978-09-13 | 1980-03-17 | Yoshitomi Pharmaceut Ind Ltd | Preparation of optically active n-mercaptoacyl-imino acid |
| US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
| US5026873A (en) * | 1989-11-06 | 1991-06-25 | E. R. Squibb & Sons, Inc. | Process for direct isolation of captopril |
| JP2896818B2 (ja) * | 1991-04-02 | 1999-05-31 | 三菱レイヨン株式会社 | Ｌ−プロリン誘導体の製造法 |
| JPH05221966A (ja) * | 1992-02-18 | 1993-08-31 | Mitsubishi Rayon Co Ltd | Ｌ−プロリン誘導体の製造方法 |
| HU211101B (en) * | 1992-03-13 | 1995-10-30 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid |
| US5387697A (en) * | 1994-06-13 | 1995-02-07 | Merck & Co., Inc. | Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline |
| JPH09157251A (ja) | 1995-10-06 | 1997-06-17 | Kanegafuchi Chem Ind Co Ltd | Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリン及び該中間体の製造方法 |
-
1996
- 1996-10-11 JP JP28934096A patent/JP3980684B2/ja not_active Expired - Lifetime
-
1997
- 1997-10-07 IN IN1885CA1997 patent/IN183229B/en unknown
- 1997-10-08 HR HRHEI-8-289340A patent/HRP970536A2/hr not_active Application Discontinuation
- 1997-10-13 HU HU0000199A patent/HUP0000199A3/hu unknown
- 1997-10-13 KR KR1019980704339A patent/KR19990072045A/ko not_active Application Discontinuation
- 1997-10-13 WO PCT/JP1997/003655 patent/WO1998016509A1/ja not_active Application Discontinuation
- 1997-10-13 DE DE69718450T patent/DE69718450T2/de not_active Expired - Fee Related
- 1997-10-13 ES ES97943179T patent/ES2191200T3/es not_active Expired - Lifetime
- 1997-10-13 EP EP97943179A patent/EP0889031B1/de not_active Expired - Lifetime
- 1997-10-13 IL IL12474797A patent/IL124747A/xx not_active IP Right Cessation
- 1997-10-13 CA CA002249543A patent/CA2249543A1/en not_active Abandoned
- 1997-10-13 AT AT97943179T patent/ATE231125T1/de not_active IP Right Cessation
- 1997-10-13 US US09/077,747 patent/US6187932B1/en not_active Expired - Fee Related
- 1997-10-13 SI SI9720012A patent/SI9720012A/sl not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0889031A1 (de) | 1999-01-07 |
| CA2249543A1 (en) | 1998-04-23 |
| SI9720012A (sl) | 1998-12-31 |
| DE69718450D1 (de) | 2003-02-20 |
| ES2191200T3 (es) | 2003-09-01 |
| JPH10114740A (ja) | 1998-05-06 |
| DE69718450T2 (de) | 2003-11-20 |
| KR19990072045A (ko) | 1999-09-27 |
| EP0889031B1 (de) | 2003-01-15 |
| US6187932B1 (en) | 2001-02-13 |
| IL124747A0 (en) | 1999-01-26 |
| IN183229B (de) | 1999-10-09 |
| EP0889031A4 (de) | 2000-03-22 |
| HUP0000199A3 (en) | 2001-12-28 |
| HRP970536A2 (en) | 1998-08-31 |
| HUP0000199A2 (hu) | 2000-06-28 |
| WO1998016509A1 (fr) | 1998-04-23 |
| JP3980684B2 (ja) | 2007-09-26 |
| ATE231125T1 (de) | 2003-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1999036355A3 (en) | Method of preparing hydrophobic silica | |
| DE69517832D1 (de) | Ein Verfahren zur Herstellung von Tetrazolyl-Verbindungen | |
| ZA975425B (en) | A process for the preparation of tetraazamacrocycles. | |
| CA2134347A1 (en) | Thiazole or imidazole derivatives as maillard reaction inhibitors | |
| EP0464325A3 (en) | Process for the preparation of l-ornithine salts | |
| CA2239537A1 (en) | Process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms | |
| CA2244948A1 (en) | Waste stream treatment | |
| AU4457385A (en) | Synthesis of double stranded nucleic acids from single stranded nucleic acids | |
| ZA985023B (en) | A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof | |
| EP1046634A4 (de) | Verfahren zur herstellung von beta-halogen-alpha-amino-carbonsäuren, phenylcysteinderivaten und ihren zwischenprodukten | |
| TW272968B (de) | ||
| IL124747A (en) | Process for producing captopril | |
| AU7337598A (en) | Process for preparing and purifying complex esters | |
| DE3563858D1 (en) | Process for the preparation of l-alpha-aminoacids | |
| EP1193253A4 (de) | Verfahren zur herstellung von optisch aktiven azetidin-2-carbonsäuren | |
| PL311002A1 (en) | Method of obtaining aminomethanophosphonic acid | |
| HU9201412D0 (en) | Process for the enzymatic hydrolysis of carbonic acid derivatives | |
| EP0892044A3 (de) | Esterase und seine verwendung zur Herstellung von optisch aktiver Chroman-Verbindungen | |
| EP1092714A3 (de) | Verfahren zur Herstellung von Benzo[b]thiophenen | |
| AU2321900A (en) | Process for the preparation of alpha-aminoketones | |
| ES2193524T3 (es) | Procedimiento de preparacion de acido azetidino-2-carboxilico. | |
| DE59707269D1 (de) | Verfahren zur Herstellung von Z-L-Asparaginsäure-Dinatriumsalz aus Fumarsäure | |
| EP1035099A4 (de) | Verfahren zur herstellung von sorbinsäuren oder sorbinsäuresalzen | |
| EP0748799A4 (de) | Verfahren zur herstellung von 5,7 dichlor-4-hydroxychinolin | |
| EP1526127A3 (de) | Verfahren zur Herstellung von Eisen-alkalisalz der S,S-Ethylendiamin-N,N'-dibersteinsaäure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |