IL123898A - The history of compressed tropane, their preparation and the pharmaceutical preparations containing them - Google Patents

The history of compressed tropane, their preparation and the pharmaceutical preparations containing them

Info

Publication number
IL123898A
IL123898A IL12389896A IL12389896A IL123898A IL 123898 A IL123898 A IL 123898A IL 12389896 A IL12389896 A IL 12389896A IL 12389896 A IL12389896 A IL 12389896A IL 123898 A IL123898 A IL 123898A
Authority
IL
Israel
Prior art keywords
azatricyclo
dichlorophenyl
decan
oxime
alkyl
Prior art date
Application number
IL12389896A
Other languages
English (en)
Hebrew (he)
Other versions
IL123898A0 (en
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of IL123898A0 publication Critical patent/IL123898A0/xx
Publication of IL123898A publication Critical patent/IL123898A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Exhaust Gas After Treatment (AREA)
IL12389896A 1995-11-02 1996-11-04 The history of compressed tropane, their preparation and the pharmaceutical preparations containing them IL123898A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK122395 1995-11-02
DK14696 1996-02-13
PCT/EP1996/004793 WO1997016451A1 (en) 1995-11-02 1996-11-04 Fused tropane-derivatives as neurotransmitter reuptake inhibitors

Publications (2)

Publication Number Publication Date
IL123898A0 IL123898A0 (en) 1998-10-30
IL123898A true IL123898A (en) 2001-08-08

Family

ID=26063395

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12389896A IL123898A (en) 1995-11-02 1996-11-04 The history of compressed tropane, their preparation and the pharmaceutical preparations containing them

Country Status (25)

Country Link
US (1) US5998405A (pt)
EP (1) EP0858461B1 (pt)
JP (1) JP3157839B2 (pt)
KR (1) KR100277482B1 (pt)
CN (1) CN1060775C (pt)
AT (1) ATE224392T1 (pt)
AU (1) AU702720B2 (pt)
BR (1) BR9611300A (pt)
CA (1) CA2236707C (pt)
CZ (1) CZ285571B6 (pt)
DE (1) DE69623799T2 (pt)
DK (1) DK0858461T3 (pt)
EE (1) EE03566B1 (pt)
HK (1) HK1016984A1 (pt)
HU (1) HUP9802534A3 (pt)
IL (1) IL123898A (pt)
IS (1) IS4708A (pt)
NO (1) NO309569B1 (pt)
NZ (1) NZ321970A (pt)
PL (1) PL184843B1 (pt)
RU (1) RU2162469C2 (pt)
SK (1) SK282944B6 (pt)
TR (1) TR199800780T2 (pt)
UA (1) UA47442C2 (pt)
WO (1) WO1997016451A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706880B2 (en) 1990-08-09 2004-03-16 Research Triangle Institute Cocaine receptor binding ligands
US6329520B1 (en) 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
US6150376A (en) * 1998-08-05 2000-11-21 Georgetown University Bi- and tri-cyclic aza compounds and their uses
NZ509762A (en) * 1998-08-18 2002-12-20 Ucb S 5-Azatricyclo[3.3.1.1<3,7>]decane derivatives, pharmaceuticals thereof, and their use as cholinergic receptor agonists and antagonists
CA2384692A1 (en) * 1999-09-27 2001-04-05 Alan P. Kozikowski Novel tropane analogs
US6479509B1 (en) 2000-05-22 2002-11-12 Research Triangle Institute Method of promoting smoking cessation
WO2002002559A1 (en) * 2000-07-04 2002-01-10 Neurosearch A/S Steric isomers of fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
DE60231386D1 (de) 2001-04-09 2009-04-16 Neurosearch As Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
WO2002094827A1 (en) * 2001-05-23 2002-11-28 Neurosearch A/S Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AR035898A1 (es) 2001-05-25 2004-07-21 Wyeth Corp Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
ATE345135T1 (de) * 2001-11-30 2006-12-15 Neurosearch As Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen
JP2006517567A (ja) 2003-02-12 2006-07-27 ニューロサーチ、アクティーゼルスカブ 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
JP2006517568A (ja) 2003-02-12 2006-07-27 ニューロサーチ、アクティーゼルスカブ ８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
EP2272847A1 (en) 2005-04-08 2011-01-12 NeuroSearch A/S Enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
EP1917264B1 (en) 2005-06-28 2010-11-17 NeuroSearch A/S Novel 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US8093388B2 (en) 2005-06-28 2012-01-10 Neurosearch A/S 3-aza spiro[5,5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW200800980A (en) 2006-02-17 2008-01-01 Neurosearch As Novel compounds
AU2010247514A1 (en) 2009-05-15 2011-11-17 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2010145208A1 (en) * 2009-06-19 2010-12-23 Abbott Laboratories Diazahomoadamantane derivatives and methods of use thereof
WO2011032903A1 (en) 2009-09-21 2011-03-24 Neurosearch A/S Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011092061A1 (en) 2010-01-29 2011-08-04 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en) 2010-03-25 2011-09-29 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
WO2012000881A1 (en) 2010-07-02 2012-01-05 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP6052524B1 (ja) * 2015-07-30 2016-12-27 秋夫 湯田 持ち運び設置が容易な手提げハンドルの付いた薪ストーブ。
TW202409027A (zh) 2022-07-08 2024-03-01 丹麥商創始人製藥股份有限公司 用於女性性功能障礙的治療之化合物
WO2024089247A1 (en) 2022-10-28 2024-05-02 Initiator Pharma A/S Compound for treatment of pain
WO2024146892A1 (en) 2023-01-03 2024-07-11 Initiator Pharma A/S Compound for treatment of erectile dysfunction

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
DK0756596T3 (da) * 1994-04-19 2002-12-23 Neurosearch As Tropan-2-aldoximderivater som neurotransmitter-genoptagelsesinhibitorer

Also Published As

Publication number Publication date
EE9800100A (et) 1998-10-15
DK0858461T3 (da) 2003-01-27
IL123898A0 (en) 1998-10-30
CN1060775C (zh) 2001-01-17
NO309569B1 (no) 2001-02-19
IS4708A (is) 1998-03-31
MX9803554A (es) 1998-09-30
PL184843B1 (pl) 2002-12-31
US5998405A (en) 1999-12-07
JP3157839B2 (ja) 2001-04-16
SK282944B6 (sk) 2003-01-09
SK42298A3 (en) 1998-10-07
NZ321970A (en) 2000-02-28
AU7563196A (en) 1997-05-22
CA2236707C (en) 2002-08-06
BR9611300A (pt) 1999-06-15
TR199800780T2 (xx) 1998-07-21
KR100277482B1 (ko) 2001-01-15
HUP9802534A2 (hu) 1999-04-28
HK1016984A1 (en) 1999-11-12
CZ285571B6 (cs) 1999-09-15
RU2162469C2 (ru) 2001-01-27
DE69623799D1 (de) 2002-10-24
CZ113898A3 (cs) 1998-07-15
EP0858461B1 (en) 2002-09-18
WO1997016451A1 (en) 1997-05-09
ATE224392T1 (de) 2002-10-15
DE69623799T2 (de) 2003-01-30
EP0858461A1 (en) 1998-08-19
UA47442C2 (uk) 2002-07-15
KR19990064111A (ko) 1999-07-26
AU702720B2 (en) 1999-03-04
CN1201461A (zh) 1998-12-09
HUP9802534A3 (en) 1999-06-28
CA2236707A1 (en) 1997-05-09
NO981609L (no) 1998-06-26
JPH11514638A (ja) 1999-12-14
PL326448A1 (en) 1998-09-28
EE03566B1 (et) 2001-12-17
NO981609D0 (no) 1998-04-07

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Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees