IL121275A - Controlled release formulation for poorly soluble basic drugs - Google Patents
Controlled release formulation for poorly soluble basic drugsInfo
- Publication number
- IL121275A IL121275A IL12127596A IL12127596A IL121275A IL 121275 A IL121275 A IL 121275A IL 12127596 A IL12127596 A IL 12127596A IL 12127596 A IL12127596 A IL 12127596A IL 121275 A IL121275 A IL 121275A
- Authority
- IL
- Israel
- Prior art keywords
- controlled release
- release formulation
- poorly soluble
- soluble basic
- basic drugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/574,877 US5705190A (en) | 1995-12-19 | 1995-12-19 | Controlled release formulation for poorly soluble basic drugs |
PCT/US1996/018960 WO1997022335A1 (fr) | 1995-12-19 | 1996-11-25 | Formulation a liberation controlee pour medicaments basiques peu solubles |
Publications (2)
Publication Number | Publication Date |
---|---|
IL121275A0 IL121275A0 (en) | 1998-01-04 |
IL121275A true IL121275A (en) | 2003-10-31 |
Family
ID=24298013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12127596A IL121275A (en) | 1995-12-19 | 1996-11-25 | Controlled release formulation for poorly soluble basic drugs |
Country Status (27)
Country | Link |
---|---|
US (1) | US5705190A (fr) |
EP (1) | EP0799028B1 (fr) |
JP (1) | JP3292732B2 (fr) |
KR (1) | KR100632187B1 (fr) |
CN (1) | CN1131027C (fr) |
AR (1) | AR004391A1 (fr) |
AT (2) | ATE170744T1 (fr) |
AU (1) | AU701268B2 (fr) |
CA (1) | CA2209714C (fr) |
CZ (1) | CZ289158B6 (fr) |
DE (2) | DE69600620T2 (fr) |
DK (1) | DK0799028T3 (fr) |
ES (1) | ES2122810T3 (fr) |
HK (1) | HK1016873A1 (fr) |
HU (1) | HUP9800516A3 (fr) |
IL (1) | IL121275A (fr) |
IT (1) | ITMI20050383U1 (fr) |
NZ (1) | NZ323332A (fr) |
PL (1) | PL186696B1 (fr) |
PT (1) | PT103379B (fr) |
RO (1) | RO117501B1 (fr) |
RU (1) | RU2142793C1 (fr) |
TR (1) | TR199800777T2 (fr) |
TW (1) | TW429154B (fr) |
UA (1) | UA40663C2 (fr) |
WO (1) | WO1997022335A1 (fr) |
ZA (1) | ZA9610110B (fr) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1096862C (zh) | 1994-05-06 | 2002-12-25 | 辉瑞大药厂 | 阿齐霉素的控释剂型 |
TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
US6010718A (en) * | 1997-04-11 | 2000-01-04 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
US6551616B1 (en) * | 1997-04-11 | 2003-04-22 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
US20050064033A1 (en) * | 1997-04-11 | 2005-03-24 | Notario Gerard F. | Extended release formulations of erythromycin derivatives |
SK282427B6 (sk) * | 1997-06-11 | 2002-01-07 | Abbott Laboratories | Pevná farmaceutická kompozícia s riadeným uvoľňovaním |
US6156771A (en) * | 1997-08-28 | 2000-12-05 | Rubin; Walter | Method for alleviation of lower gastrointestinal disorders in a human patient |
DK2198858T3 (da) * | 1998-03-26 | 2011-10-03 | Astellas Pharma Inc | Præparat med opretholdt frigivelse af en makrolidforbindelse såsom tacrolimus |
ES2257869T3 (es) * | 1998-08-21 | 2006-08-01 | Novartis Ag | Nueva formulacion oral para agonistas o antagonistas de 5-ht4. |
IT1313610B1 (it) * | 1999-08-09 | 2002-09-09 | S I F I Societa Ind Farmaceuti | Processo per la preparazione di formulazioni acquose per uso oftalmico |
TR200000054A2 (tr) * | 2000-01-05 | 2001-08-21 | Sanovel İlaç San. Ve Ti̇c. Anoni̇m Şi̇rketi̇ | Klaritromisin içeren sürekli salım sağlayan tablet formülasyonları. |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
EP1313486A1 (fr) * | 2000-02-29 | 2003-05-28 | Teva Pharmaceutical Industries Ltd. | Procedes de preparation de la clarithromycine et d'un intermediaire de la clarithromycine, notamment la clarithromycine exempte d'oxime, et composition pharmaceutique correspondante |
BR0109544A (pt) * | 2000-03-28 | 2003-06-10 | Biochemie Gmbh | Partìculas granuladas com sabor ocultado |
DE10031043A1 (de) * | 2000-06-26 | 2002-02-14 | Bayer Ag | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
IN192748B (fr) * | 2000-08-29 | 2004-05-15 | Ranbaxy Lab Ltd | |
US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
PL368306A1 (en) * | 2001-08-29 | 2005-03-21 | Ranbaxy Laboratories Limited | Controlled release formulation of clarithromycin or tinidazol |
US6673369B2 (en) | 2001-08-29 | 2004-01-06 | Ranbaxy Laboratories Limited | Controlled release formulation |
US6642276B2 (en) * | 2001-10-01 | 2003-11-04 | M/S Ind-Swift Limited | Controlled release macrolide pharmaceutical formulations |
US20030091627A1 (en) * | 2001-10-31 | 2003-05-15 | Vinay Sharma | Rate-controlled delivery of macrolides |
WO2003037304A1 (fr) * | 2001-11-02 | 2003-05-08 | Wockhardt Limited | Compositions a liberation controlee pour agents antimicrobiens macrolides |
US20030181488A1 (en) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
WO2003077897A1 (fr) * | 2002-03-15 | 2003-09-25 | Cypress Bioscience, Inc. | Inhibiteurs de recaptage de 5-ht pour le traitement de syndromes de la douleur viscerale |
WO2003105810A1 (fr) * | 2002-06-14 | 2003-12-24 | Andrx Corporation | Compositions pharmaceutiques pour medicaments ayant une solubilite dependant du ph |
US20060083759A1 (en) * | 2002-07-17 | 2006-04-20 | Aleksander Resman | Stabilization of the profile of release of active substances from a formulation |
SI21300A (sl) * | 2002-10-08 | 2004-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Farmacevtske formulacije z alginati |
US20040132826A1 (en) * | 2002-10-25 | 2004-07-08 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
US20060003004A1 (en) * | 2002-10-25 | 2006-01-05 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
GB0230034D0 (en) * | 2002-12-23 | 2003-01-29 | Biochemie Gmbh | Organic compounds |
CA2513893A1 (fr) * | 2003-01-28 | 2004-08-12 | Collegium Pharmaceutical, Inc. | Compositions multiparticulaires de milnacipran destinees a etre administrees par voie orale |
US20040185097A1 (en) * | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
US8507000B2 (en) * | 2003-05-06 | 2013-08-13 | Nostrum Pharmaceuticals, Inc. | Controlled release formulation of erythromycin derivatives |
US7063862B2 (en) * | 2003-06-03 | 2006-06-20 | Biokey, Inc. | Pharmaceutical composition and method for treating |
EP2535042A1 (fr) * | 2003-06-16 | 2012-12-19 | ANDRX Pharmaceuticals LLC. | Composition à libération prolongée orale comprenant a macrolide |
US20050053658A1 (en) * | 2003-09-09 | 2005-03-10 | Venkatesh Gopi M. | Extended release systems for macrolide antibiotics |
JP2006528185A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
US8313776B2 (en) * | 2003-07-21 | 2012-11-20 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
JP2006528190A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
CA2535177A1 (fr) * | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Pastille robuste |
CA2535398C (fr) * | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotique, utilisation et formulation associees |
AU2004270170B2 (en) * | 2003-08-29 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
WO2005027877A1 (fr) * | 2003-09-15 | 2005-03-31 | Advancis Pharmaceutical Corporation | Antibiotique, son utilisation et sa formulation |
EP1670516A2 (fr) * | 2003-09-30 | 2006-06-21 | Solubest Ltd | Nanoparticules hydrosolubles et leur procede de production |
CA2547597A1 (fr) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Compositions multiparticulaires a stabilite amelioree |
US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
WO2005053652A1 (fr) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Compositions medicamenteuses cristallines multiparticulaires contenant un poloxamere et un glyceride |
WO2005053639A2 (fr) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Formes multiparticulaires a liberation controlee produites avec des optimiseurs de dissolution |
JP2007513143A (ja) * | 2003-12-04 | 2007-05-24 | ファイザー・プロダクツ・インク | 押出機を使用して好ましくはポロクサマーおよびグリセリドを含む多粒子アジスロマイシン組成物を製造するための噴霧凝固法 |
CA2547239A1 (fr) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Formes posologiques multiparticulaires d'azithromycine obtenues par des procedes se deroulant en milieu liquide |
BRPI0417348A (pt) * | 2003-12-04 | 2007-03-13 | Pfizer Prod Inc | processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo |
ATE399536T1 (de) * | 2003-12-04 | 2008-07-15 | Pfizer Prod Inc | Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten |
CA2550983C (fr) * | 2003-12-24 | 2013-09-17 | Advancis Pharmaceutical Corporation | Absorption amelioree de formes de dosage a liberation modifiee |
CN100435847C (zh) * | 2004-05-13 | 2008-11-26 | 宝龄富锦生技股份有限公司 | 含有难溶解性主药之持续释放配方 |
US20050260263A1 (en) * | 2004-05-18 | 2005-11-24 | Panion & Bf Biotech Inc. | Sustained release formulation for sparingly soluble main drugs |
CA2572223C (fr) | 2004-06-25 | 2014-08-12 | The Johns Hopkins University | Inhibiteurs d'angiogenese |
JP2008505124A (ja) * | 2004-07-02 | 2008-02-21 | アドバンシス ファーマスーティカル コーポレイション | パルス送達用錠剤 |
CN1322866C (zh) * | 2004-10-12 | 2007-06-27 | 广州贝氏药业有限公司 | 一种多单元缓释制剂 |
DE102005042875A1 (de) * | 2004-12-23 | 2006-09-21 | Grünenthal GmbH | Schnell freisetzende Darreichungsformen für Antibiotika |
WO2007008537A2 (fr) * | 2005-07-07 | 2007-01-18 | Elan Pharma International, Limited | Formulations de clarithromycine nanoparticulaires |
US20070128272A1 (en) * | 2005-12-07 | 2007-06-07 | Zerbe Horst G | Multi-vitamin and mineral supplement |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
US20070190145A1 (en) * | 2006-01-27 | 2007-08-16 | Eurand, Inc. | Drug delivery systems comprising weakly basic selective serotonin 5-ht3 blocking agent and organic acids |
KR20140088230A (ko) * | 2006-01-27 | 2014-07-09 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 약물과 유기산을 포함하는 약물 전달 시스템 |
US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
EP2030613A1 (fr) * | 2007-08-17 | 2009-03-04 | Abbott GmbH & Co. KG | Préparation de compositions avec essentiellement des antibiotiques macrolides intégrés non cristallins |
PT2234607E (pt) * | 2007-12-28 | 2011-09-30 | Acraf | Formulação de libertação lenta com base numa associação de glicogénio e alginato |
US8133506B2 (en) * | 2008-03-12 | 2012-03-13 | Aptalis Pharmatech, Inc. | Drug delivery systems comprising weakly basic drugs and organic acids |
CN102239149B (zh) | 2008-10-06 | 2015-05-13 | 约翰·霍普金斯大学 | 喹啉化合物作为血管新生、人类甲硫氨酰氨肽酶、以及sirt1的抑制剂,以及治疗病症的方法 |
RU2542110C2 (ru) * | 2009-05-29 | 2015-02-20 | Тетра Лаваль Холдингз Энд Файнэнс С.А. | Упаковочный материал, содержащий намагничиваемые участки |
US20110003005A1 (en) * | 2009-07-06 | 2011-01-06 | Gopi Venkatesh | Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions |
CN102470108A (zh) * | 2009-07-07 | 2012-05-23 | 桑诺维恩药品公司 | 非pH依赖型制剂(6-(5-氯-2-吡啶基)-5-[(4-甲基-1-哌嗪基)羰氧基]-7-氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪) |
EP2283824B1 (fr) | 2009-07-30 | 2017-04-19 | Special Products Line S.p.A. | Compositions et formules basées sur des matrices gonflables pour la libération prolongée de médicaments, comme clarithromycin, faiblement solubles |
US20120219625A1 (en) * | 2009-09-02 | 2012-08-30 | Bernard Charles Sherman | Clarithromycin extended-release tablet |
CN102106807B (zh) * | 2009-12-29 | 2013-03-27 | 上海中西制药有限公司 | 一种固体制剂的制备方法及所得固体制剂 |
US9011912B2 (en) | 2010-10-07 | 2015-04-21 | Abon Pharmaceuticals, Llc | Extended-release oral dosage forms for poorly soluble amine drugs |
MX354210B (es) | 2010-12-16 | 2018-02-16 | Celgene Corp | Formas farmaceuticas orales de liberacion controlada de farmacos escasamente solubles y los usos de estas. |
US9532977B2 (en) | 2010-12-16 | 2017-01-03 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
DE102013202703B4 (de) | 2013-02-20 | 2020-03-12 | Siemens Healthcare Gmbh | Vorrichtung und Verfahren zur Kollisionserkennung bei einem medizintechnischen Gerät |
CA2908434C (fr) | 2013-04-07 | 2021-12-28 | The Broad Institute, Inc. | Compositions et procedes s'appliquant a des vaccins personnalises contre les neoplasies |
WO2015077717A1 (fr) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions et méthodes pour diagnostiquer, évaluer et traiter un cancer au moyen d'un état de méthylation d'adn |
US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
EP3082853A2 (fr) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Polythérapie comprenant un vaccin à base de néoantigènes |
EP3234193B1 (fr) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Biomarqueurs moléculaires pour l'immunothérapie d'un cancer |
US10993997B2 (en) | 2014-12-19 | 2021-05-04 | The Broad Institute, Inc. | Methods for profiling the t cell repertoire |
EP3297660A2 (fr) | 2015-05-20 | 2018-03-28 | The Broad Institute Inc. | Néo-antigènes partagés |
US10383825B2 (en) | 2015-08-13 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | Calcium alginate dosage formulations, and methods of making and using thereof |
WO2017083348A1 (fr) | 2015-11-11 | 2017-05-18 | Celgene Corporation | Formes pharmaceutiques orales à libération contrôlée de médicaments faiblement solubles et leurs utilisations |
US20190346442A1 (en) | 2016-04-18 | 2019-11-14 | The Broad Institute, Inc. | Improved hla epitope prediction |
US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
KR20200018438A (ko) * | 2017-05-11 | 2020-02-19 | 스테디메드 리미티드 | 향상된 용해도의 약물-함유 제형 |
WO2020072700A1 (fr) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Lignées d'allèles uniques d'alh |
US20220062394A1 (en) | 2018-12-17 | 2022-03-03 | The Broad Institute, Inc. | Methods for identifying neoantigens |
CN111184699A (zh) * | 2020-04-09 | 2020-05-22 | 河北大学 | 一种硝苯地平控释胶囊及其制备方法 |
EP4158014A2 (fr) | 2020-05-26 | 2023-04-05 | Dionis Therapeutics, Inc. | Bibliothèques de mini-protéomes artificiels d'acide nucléique |
EP4426829A1 (fr) | 2021-11-01 | 2024-09-11 | Dana-Farber Cancer Institute, Inc. | Bibliothèques de mini-protéomes artificiels d'acide nucléique sélectionnées biologiquement |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4296140A (en) * | 1977-03-08 | 1981-10-20 | Tri/Valley Growers | Molded gelled pimiento body |
GB1566609A (en) * | 1977-03-10 | 1980-05-08 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions containing cholestyramine and alginic acid |
US4289751A (en) * | 1979-06-29 | 1981-09-15 | Merck & Co., Inc. | Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof |
JPS60163823A (ja) * | 1984-02-03 | 1985-08-26 | Taisho Pharmaceut Co Ltd | 経口投与製剤 |
DE3583799D1 (de) * | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
US5498424A (en) * | 1994-11-30 | 1996-03-12 | Klein; Ira | Method of treating obesity |
-
1995
- 1995-12-19 US US08/574,877 patent/US5705190A/en not_active Expired - Lifetime
-
1996
- 1996-11-25 AT AT96940616T patent/ATE170744T1/de not_active IP Right Cessation
- 1996-11-25 CN CN96199104A patent/CN1131027C/zh not_active Expired - Lifetime
- 1996-11-25 HU HU9800516A patent/HUP9800516A3/hu not_active Application Discontinuation
- 1996-11-25 DK DK96940616T patent/DK0799028T3/da active
- 1996-11-25 IL IL12127596A patent/IL121275A/xx not_active IP Right Cessation
- 1996-11-25 DE DE69600620T patent/DE69600620T2/de not_active Revoked
- 1996-11-25 RO RO97-01337A patent/RO117501B1/ro unknown
- 1996-11-25 NZ NZ323332A patent/NZ323332A/en not_active IP Right Cessation
- 1996-11-25 EP EP96940616A patent/EP0799028B1/fr not_active Revoked
- 1996-11-25 CZ CZ19972212A patent/CZ289158B6/cs not_active IP Right Cessation
- 1996-11-25 CA CA002209714A patent/CA2209714C/fr not_active Expired - Lifetime
- 1996-11-25 ES ES96940616T patent/ES2122810T3/es not_active Expired - Lifetime
- 1996-11-25 TR TR1998/00777T patent/TR199800777T2/xx unknown
- 1996-11-25 WO PCT/US1996/018960 patent/WO1997022335A1/fr not_active Application Discontinuation
- 1996-11-25 JP JP52281897A patent/JP3292732B2/ja not_active Expired - Lifetime
- 1996-11-25 RU RU97112089A patent/RU2142793C1/ru active
- 1996-11-25 DE DE29624506U patent/DE29624506U1/de not_active Expired - Lifetime
- 1996-11-25 AU AU10252/97A patent/AU701268B2/en not_active Expired
- 1996-11-25 PL PL96321363A patent/PL186696B1/pl unknown
- 1996-11-25 UA UA97073814A patent/UA40663C2/uk unknown
- 1996-11-25 KR KR1019970705229A patent/KR100632187B1/ko not_active IP Right Cessation
- 1996-12-02 ZA ZA9610110A patent/ZA9610110B/xx unknown
- 1996-12-11 TW TW085115321A patent/TW429154B/zh not_active IP Right Cessation
- 1996-12-17 AR ARP960105735A patent/AR004391A1/es unknown
-
1999
- 1999-04-26 HK HK99101812A patent/HK1016873A1/xx not_active IP Right Cessation
-
2004
- 2004-09-03 AT AT0065504U patent/AT7918U1/de not_active IP Right Cessation
-
2005
- 2005-11-02 IT IT000383T patent/ITMI20050383U1/it unknown
- 2005-11-08 PT PT103379A patent/PT103379B/pt active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL121275A (en) | Controlled release formulation for poorly soluble basic drugs | |
GB9519363D0 (en) | Pharmaceutical formulation | |
EP1124543A4 (fr) | Formulation a liberation regulee pour medicaments solubles a l'eau | |
EG23826A (en) | Pharmaceutical formulations | |
AU2827095A (en) | Controlled release oral drug delivery system | |
IL116673A0 (en) | A pharmaceutical composition containing a benzimidazole derivative and processes for the preparation thereof | |
AP9600883A0 (en) | Pharmaceutical formulations | |
ZA965368B (en) | A pharmaceutical formulation | |
IL130737A0 (en) | Emulsion vehicle for poorly soluble drugs | |
EP0862431A4 (fr) | Preparation pharmaceutique | |
ZA96124B (en) | A pharmaceutical formulation | |
AU7578598A (en) | Controlled release dosage forms containing water soluble drugs | |
AU5775398A (en) | Site-specific controlled release dosage formulation for mesalamine | |
NO996161D0 (no) | En kontrollert frigjoerende formulering for tungt loeselige basiske legemidler | |
GB9508823D0 (en) | Drug Derivatives | |
GB9523566D0 (en) | Pharmaceutical formulation | |
IL132986A0 (en) | Rapamycin formulation for oral administration | |
ZA96526B (en) | Novel pharmaceutical formulation | |
ZA964372B (en) | A pharmaceutical formulation | |
ZA965367B (en) | A pharmaceutical formulation | |
HRP970325B1 (en) | Controlled release formulation for poorly soluble basic drugs | |
ZA96122B (en) | A pharmaceutical formulation | |
ZA96392B (en) | Pharmaceutical formulations | |
AU7799198A (en) | Method for preparing pharmaceutical formulation | |
AU3749595A (en) | Method for preparing controlled release pharmaceutical forms |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |