ES2122810T3 - Formulacion de liberacion controlada para medicamentos basicos poco solubles. - Google Patents
Formulacion de liberacion controlada para medicamentos basicos poco solubles.Info
- Publication number
- ES2122810T3 ES2122810T3 ES96940616T ES96940616T ES2122810T3 ES 2122810 T3 ES2122810 T3 ES 2122810T3 ES 96940616 T ES96940616 T ES 96940616T ES 96940616 T ES96940616 T ES 96940616T ES 2122810 T3 ES2122810 T3 ES 2122810T3
- Authority
- ES
- Spain
- Prior art keywords
- controlled release
- release formulation
- little soluble
- basic medicines
- medicines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
SE DESCRIBE UNA COMPOSICION FARMACEUTICA SOLIDA, ORAL DE LIBERACION CONTROLADA, PARA UN REGIMEN DE ADMINISTRACION DIARIA REDUCIDA DONDE EL PRINCIPIO ACTIVO ES UN FARMACO BASICO POCO SOLUBLE. LA FORMULACION INCLUYE EL USO DE UNA SAL DE ALGINATO SOLUBLE EN AGUA, UNA SAL COMPLEJO DE ACIDO ALGINICO Y UN ACIDO CARBOXILICO ORGANICO MEZCLADO CON EL FARMACO TERAPEUTICO. TAMBIEN SE DESCRIBE UNA FORMA ESPECIFICA DE ADMINISTRACION UNA VEZ AL DIA PARA CLARITROMICINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/574,877 US5705190A (en) | 1995-12-19 | 1995-12-19 | Controlled release formulation for poorly soluble basic drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2122810T3 true ES2122810T3 (es) | 1998-12-16 |
Family
ID=24298013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96940616T Expired - Lifetime ES2122810T3 (es) | 1995-12-19 | 1996-11-25 | Formulacion de liberacion controlada para medicamentos basicos poco solubles. |
Country Status (27)
Country | Link |
---|---|
US (1) | US5705190A (es) |
EP (1) | EP0799028B1 (es) |
JP (1) | JP3292732B2 (es) |
KR (1) | KR100632187B1 (es) |
CN (1) | CN1131027C (es) |
AR (1) | AR004391A1 (es) |
AT (2) | ATE170744T1 (es) |
AU (1) | AU701268B2 (es) |
CA (1) | CA2209714C (es) |
CZ (1) | CZ289158B6 (es) |
DE (2) | DE69600620T2 (es) |
DK (1) | DK0799028T3 (es) |
ES (1) | ES2122810T3 (es) |
HK (1) | HK1016873A1 (es) |
HU (1) | HUP9800516A3 (es) |
IL (1) | IL121275A (es) |
IT (1) | ITMI20050383U1 (es) |
NZ (1) | NZ323332A (es) |
PL (1) | PL186696B1 (es) |
PT (1) | PT103379B (es) |
RO (1) | RO117501B1 (es) |
RU (1) | RU2142793C1 (es) |
TR (1) | TR199800777T2 (es) |
TW (1) | TW429154B (es) |
UA (1) | UA40663C2 (es) |
WO (1) | WO1997022335A1 (es) |
ZA (1) | ZA9610110B (es) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA41995C2 (uk) * | 1994-05-06 | 2001-10-15 | Пфайзер Інк. | Лікарська форма азитроміцину з контрольованим вивільненням ( варіанти ), спосіб її введення, спосіб її виготовлення і спосіб лікування інфекційних захворювань ссавців з її використанням ( варіанти ) |
TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
US20050064033A1 (en) * | 1997-04-11 | 2005-03-24 | Notario Gerard F. | Extended release formulations of erythromycin derivatives |
US6551616B1 (en) * | 1997-04-11 | 2003-04-22 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
US6010718A (en) * | 1997-04-11 | 2000-01-04 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
SI20108B (en) * | 1997-06-11 | 2001-12-31 | Abbott Lab | A controlled release formulation for poorly soluble basic drugs |
US6156771A (en) * | 1997-08-28 | 2000-12-05 | Rubin; Walter | Method for alleviation of lower gastrointestinal disorders in a human patient |
WO1999049863A1 (fr) * | 1998-03-26 | 1999-10-07 | Fujisawa Pharmaceutical Co., Ltd. | Preparations a liberation prolongee |
EE05054B1 (et) * | 1998-08-21 | 2008-08-15 | Novartis Ag | 5-HT4 agonisti v?i antagonisti peroraalne ravimkoostis ja selle kasutamine meditsiinis |
IT1313610B1 (it) | 1999-08-09 | 2002-09-09 | S I F I Societa Ind Farmaceuti | Processo per la preparazione di formulazioni acquose per uso oftalmico |
TR200000054A2 (tr) * | 2000-01-05 | 2001-08-21 | Sanovel İlaç San. Ve Ti̇c. Anoni̇m Şi̇rketi̇ | Klaritromisin içeren sürekli salım sağlayan tablet formülasyonları. |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
CZ20023167A3 (cs) * | 2000-02-29 | 2003-10-15 | Teva Pharmaceutical Industries Ltd. | Způsob přípravy klaritromycinu a klaritromycinového meziproduktu, v podstatě prostého oximu a farmaceutický prostředek, který jej obsahuje |
AU2001263812B2 (en) * | 2000-03-28 | 2004-09-23 | Sandoz Ag | Granulated particles with masked taste |
DE10031043A1 (de) * | 2000-06-26 | 2002-02-14 | Bayer Ag | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
IN192748B (es) * | 2000-08-29 | 2004-05-15 | Ranbaxy Lab Ltd | |
US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
US6673369B2 (en) | 2001-08-29 | 2004-01-06 | Ranbaxy Laboratories Limited | Controlled release formulation |
HUP0500791A2 (en) * | 2001-08-29 | 2006-09-28 | Ranbaxy Lab Ltd | Controlled release formulation of clarithromycin or tinidazol |
US6642276B2 (en) * | 2001-10-01 | 2003-11-04 | M/S Ind-Swift Limited | Controlled release macrolide pharmaceutical formulations |
US20030091627A1 (en) * | 2001-10-31 | 2003-05-15 | Vinay Sharma | Rate-controlled delivery of macrolides |
US7037523B2 (en) * | 2001-11-02 | 2006-05-02 | Wockhardt Limited | Controlled release compositions for macrolide antimicrobial agents |
US20030181488A1 (en) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
EP1485078B1 (en) * | 2002-03-15 | 2012-09-26 | Cypress Bioscience, Inc. | Milnacipran for the treatment of irritable bowel syndrome |
AU2003245504A1 (en) * | 2002-06-14 | 2003-12-31 | Andrx Corporation | Pharmaceutical compositions for drugs having ph-dependentsolubility |
US20060083759A1 (en) * | 2002-07-17 | 2006-04-20 | Aleksander Resman | Stabilization of the profile of release of active substances from a formulation |
SI21300A (sl) * | 2002-10-08 | 2004-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Farmacevtske formulacije z alginati |
US20040132826A1 (en) * | 2002-10-25 | 2004-07-08 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
US20060003004A1 (en) * | 2002-10-25 | 2006-01-05 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
GB0230034D0 (en) * | 2002-12-23 | 2003-01-29 | Biochemie Gmbh | Organic compounds |
AU2004207578B2 (en) * | 2003-01-28 | 2007-06-28 | Collegium Pharmaceutical, Inc. | Multiparticulate compositions of milnacipran for oral administration |
US20040185097A1 (en) * | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
NZ543395A (en) * | 2003-05-06 | 2008-04-30 | Nirmal Mulye | Controlled release formulation of erythromycin derivatives |
US7063862B2 (en) * | 2003-06-03 | 2006-06-20 | Biokey, Inc. | Pharmaceutical composition and method for treating |
CA2675724C (en) * | 2003-06-16 | 2012-12-04 | Andrx Pharmaceuticals, Llc | Oral extended-release composition |
US20050053658A1 (en) * | 2003-09-09 | 2005-03-10 | Venkatesh Gopi M. | Extended release systems for macrolide antibiotics |
US8313776B2 (en) * | 2003-07-21 | 2012-11-20 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
JP2006528185A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
US8313775B2 (en) * | 2003-07-21 | 2012-11-20 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
WO2005016311A1 (en) * | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
JP2007502294A (ja) * | 2003-08-12 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
EP1658034A4 (en) * | 2003-08-29 | 2011-06-22 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
JP2007513869A (ja) * | 2003-09-15 | 2007-05-31 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
CA2540104A1 (en) * | 2003-09-30 | 2005-04-07 | Solubest Ltd. | Water soluble nanoparticles comprising inclusion complexes |
RU2006119453A (ru) * | 2003-12-04 | 2007-12-20 | Пфайзер Продактс Инк. (Us) | Получение посредством основанных на применении жидкостей способов лекарственные формы азитромицина с большим количеством частиц |
WO2005053639A2 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Controlled release multiparticulates formed with dissolution enhancers |
WO2005053656A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride |
WO2005053651A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate compositions with improved stability |
WO2005053652A1 (en) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride |
US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
CA2547773A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride |
WO2005053655A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Method for making pharmaceutical multiparticulates |
WO2005062898A2 (en) * | 2003-12-24 | 2005-07-14 | Advancis Pharmaceutical Corporation | Enhanced absorption of modified release dosage forms |
CN100435847C (zh) * | 2004-05-13 | 2008-11-26 | 宝龄富锦生技股份有限公司 | 含有难溶解性主药之持续释放配方 |
US20050260263A1 (en) * | 2004-05-18 | 2005-11-24 | Panion & Bf Biotech Inc. | Sustained release formulation for sparingly soluble main drugs |
CA2572223C (en) | 2004-06-25 | 2014-08-12 | The Johns Hopkins University | Angiogenesis inhibitors |
JP2008505124A (ja) * | 2004-07-02 | 2008-02-21 | アドバンシス ファーマスーティカル コーポレイション | パルス送達用錠剤 |
CN1322866C (zh) * | 2004-10-12 | 2007-06-27 | 广州贝氏药业有限公司 | 一种多单元缓释制剂 |
DE102005042875A1 (de) * | 2004-12-23 | 2006-09-21 | Grünenthal GmbH | Schnell freisetzende Darreichungsformen für Antibiotika |
US20070015719A1 (en) * | 2005-07-07 | 2007-01-18 | Elan Pharma International Limited | Nanoparticulate clarithromycin formulations |
US20070128272A1 (en) * | 2005-12-07 | 2007-06-07 | Zerbe Horst G | Multi-vitamin and mineral supplement |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
BRPI0707324A2 (pt) * | 2006-01-27 | 2011-05-03 | Eurand Inc | sistemas de fornecimento de fármaco compreendendo agente de bloqueio de serotonina 5-ht3 seletivo fracamente básico e ácidos orgánicos |
NZ569984A (en) * | 2006-01-27 | 2011-06-30 | Eurand Inc | Drug delivery systems comprising weakly basic drugs and organic acids |
US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
EP2030613A1 (en) * | 2007-08-17 | 2009-03-04 | Abbott GmbH & Co. KG | Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics |
PT2234607E (pt) * | 2007-12-28 | 2011-09-30 | Acraf | Formulação de libertação lenta com base numa associação de glicogénio e alginato |
US8133506B2 (en) * | 2008-03-12 | 2012-03-13 | Aptalis Pharmatech, Inc. | Drug delivery systems comprising weakly basic drugs and organic acids |
US8729097B2 (en) | 2008-10-06 | 2014-05-20 | The Johns Hopkins University | Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and SIRT1, and methods of treating disorders |
WO2010138054A1 (en) * | 2009-05-29 | 2010-12-02 | Tetra Laval Holdings & Finance S.A. | Packaging material comprising magnetisable portions |
US20110003005A1 (en) * | 2009-07-06 | 2011-01-06 | Gopi Venkatesh | Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions |
EP2451444A1 (en) * | 2009-07-07 | 2012-05-16 | Sunovion Pharmaceuticals Inc. | Formulations of 6- (5-chloro-2-pyridyl) - 5- [ (4-methyl-1-piperazinyl) carbonyloxy]- 7-0x0-6, 7- dihydro- 5h- phyrrolo [3, 4-b]pyrazine |
EP2283824B1 (en) | 2009-07-30 | 2017-04-19 | Special Products Line S.p.A. | Compositions and formulations based on swellable matrices for sustained release of poorly soluble drugs such as clarithromycin |
WO2011026234A1 (en) * | 2009-09-02 | 2011-03-10 | Bernard Charles Sherman | Clarithromycin extended-release tablet |
CN102106807B (zh) | 2009-12-29 | 2013-03-27 | 上海中西制药有限公司 | 一种固体制剂的制备方法及所得固体制剂 |
US9011912B2 (en) | 2010-10-07 | 2015-04-21 | Abon Pharmaceuticals, Llc | Extended-release oral dosage forms for poorly soluble amine drugs |
WO2012083017A2 (en) | 2010-12-16 | 2012-06-21 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
US9532977B2 (en) | 2010-12-16 | 2017-01-03 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
DE102013202703B4 (de) | 2013-02-20 | 2020-03-12 | Siemens Healthcare Gmbh | Vorrichtung und Verfahren zur Kollisionserkennung bei einem medizintechnischen Gerät |
BR112015025460B1 (pt) | 2013-04-07 | 2024-01-02 | The Broad Institute, Inc. | Método para a produção de uma vacina personalizada contra a neoplasia para um indivíduo diagnosticado como tendo uma neoplasia, vacina personalizada e uso da mesma |
WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
CA2934073A1 (en) | 2013-12-20 | 2015-06-25 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
EP3234193B1 (en) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molecular biomarkers for cancer immunotherapy |
EP3757211A1 (en) | 2014-12-19 | 2020-12-30 | The Broad Institute, Inc. | Methods for profiling the t-cell-receptor repertoire |
RU2020132040A (ru) | 2015-05-20 | 2020-10-12 | Те Брод Инститьют Инк. | Общие неоантигены |
WO2017027778A1 (en) * | 2015-08-13 | 2017-02-16 | Temple University-Of The Commonwealth System Of Higher Education | Calcium alginate dosage formulations, and methods of making and using thereof |
EP3373916A1 (en) | 2015-11-11 | 2018-09-19 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
WO2017184590A1 (en) | 2016-04-18 | 2017-10-26 | The Broad Institute Inc. | Improved hla epitope prediction |
WO2018140391A1 (en) | 2017-01-24 | 2018-08-02 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
WO2018207188A1 (en) * | 2017-05-11 | 2018-11-15 | Steadymed, Ltd. | Enhanced solubility drug-containing formulations |
WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
US20220062394A1 (en) | 2018-12-17 | 2022-03-03 | The Broad Institute, Inc. | Methods for identifying neoantigens |
CN111184699A (zh) * | 2020-04-09 | 2020-05-22 | 河北大学 | 一种硝苯地平控释胶囊及其制备方法 |
KR20230029673A (ko) | 2020-05-26 | 2023-03-03 | 디오니스 테라퓨틱스, 아이엔씨. | 핵산 인공 미니-프로테옴 라이브러리 |
WO2023076733A1 (en) | 2021-11-01 | 2023-05-04 | Dana-Farber Cancer Institute, Inc. | Biologically selected nucleic acid artificial mini-proteome libraries |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4296140A (en) * | 1977-03-08 | 1981-10-20 | Tri/Valley Growers | Molded gelled pimiento body |
GB1566609A (en) * | 1977-03-10 | 1980-05-08 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions containing cholestyramine and alginic acid |
US4289751A (en) * | 1979-06-29 | 1981-09-15 | Merck & Co., Inc. | Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof |
JPS60163823A (ja) * | 1984-02-03 | 1985-08-26 | Taisho Pharmaceut Co Ltd | 経口投与製剤 |
ATE66143T1 (de) * | 1985-01-11 | 1991-08-15 | Abbott Lab | Feste zubereitung mit langsamer freisetzung. |
US5498424A (en) * | 1994-11-30 | 1996-03-12 | Klein; Ira | Method of treating obesity |
-
1995
- 1995-12-19 US US08/574,877 patent/US5705190A/en not_active Expired - Lifetime
-
1996
- 1996-11-25 DK DK96940616T patent/DK0799028T3/da active
- 1996-11-25 PL PL96321363A patent/PL186696B1/pl unknown
- 1996-11-25 RU RU97112089A patent/RU2142793C1/ru active
- 1996-11-25 EP EP96940616A patent/EP0799028B1/en not_active Revoked
- 1996-11-25 RO RO97-01337A patent/RO117501B1/ro unknown
- 1996-11-25 AU AU10252/97A patent/AU701268B2/en not_active Expired
- 1996-11-25 AT AT96940616T patent/ATE170744T1/de not_active IP Right Cessation
- 1996-11-25 NZ NZ323332A patent/NZ323332A/en not_active IP Right Cessation
- 1996-11-25 DE DE69600620T patent/DE69600620T2/de not_active Revoked
- 1996-11-25 JP JP52281897A patent/JP3292732B2/ja not_active Expired - Lifetime
- 1996-11-25 CA CA002209714A patent/CA2209714C/en not_active Expired - Lifetime
- 1996-11-25 KR KR1019970705229A patent/KR100632187B1/ko not_active IP Right Cessation
- 1996-11-25 CN CN96199104A patent/CN1131027C/zh not_active Expired - Lifetime
- 1996-11-25 WO PCT/US1996/018960 patent/WO1997022335A1/en not_active Application Discontinuation
- 1996-11-25 CZ CZ19972212A patent/CZ289158B6/cs not_active IP Right Cessation
- 1996-11-25 IL IL12127596A patent/IL121275A/xx not_active IP Right Cessation
- 1996-11-25 DE DE29624506U patent/DE29624506U1/de not_active Expired - Lifetime
- 1996-11-25 UA UA97073814A patent/UA40663C2/uk unknown
- 1996-11-25 HU HU9800516A patent/HUP9800516A3/hu not_active Application Discontinuation
- 1996-11-25 ES ES96940616T patent/ES2122810T3/es not_active Expired - Lifetime
- 1996-11-25 TR TR1998/00777T patent/TR199800777T2/xx unknown
- 1996-12-02 ZA ZA9610110A patent/ZA9610110B/xx unknown
- 1996-12-11 TW TW085115321A patent/TW429154B/zh not_active IP Right Cessation
- 1996-12-17 AR ARP960105735A patent/AR004391A1/es unknown
-
1999
- 1999-04-26 HK HK99101812A patent/HK1016873A1/xx not_active IP Right Cessation
-
2004
- 2004-09-03 AT AT0065504U patent/AT7918U1/de not_active IP Right Cessation
-
2005
- 2005-11-02 IT IT000383T patent/ITMI20050383U1/it unknown
- 2005-11-08 PT PT103379A patent/PT103379B/pt active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2122810T3 (es) | Formulacion de liberacion controlada para medicamentos basicos poco solubles. | |
US6221377B1 (en) | Administration media for analgesic, anti-inflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs | |
DE69735093D1 (de) | ARZNEIMITTEL ZUR GESTEUERTEN FREISETZUNG VON beta LACTAM ANTIBIOTIKA | |
BR0112532A (pt) | Composição farmacêutica oral, sistema galênico e uso da composição | |
ATE99927T1 (de) | Pharmazeutische formulierungen. | |
CO4750658A1 (es) | Formulaciones farmaceuticas y procedimientos que comprenden amoxicilina y una sal de acido clavulanico | |
EP1243267A3 (en) | Amoxycillin and clavulanate containing pharmaceutical formulation | |
ES2189803T3 (es) | Procedimiento. | |
CA2326517A1 (en) | New galenic preparations of meloxicam for oral administration | |
IT8767796A0 (it) | Forma farmaceutica di dosaggio per somministrazione orale con erogazione controllata di un ingrediente attivo | |
EA200700049A1 (ru) | Препаративные формы оральных лекарственных форм мемантина с модифицированным высвобождением | |
HUP0203733A2 (en) | Flat medicinal preparation for transmucosal administration of oxycodon or a comparable active ingredient in the oral cavity, for use in pain therapy and in addiction therapy | |
PT706401E (pt) | Sistema para administracao de farmacos | |
DK0754034T3 (da) | Brusende farmaceutiske formuleringer indeholdende biologisk nedbrydelige mikrokapsler med kontrolleret afgivelse | |
ES2160821T3 (es) | Uso de una composicion que comprende amoxicilina y acido clavulanico para la produccion de un medicamento para el tratamiento de infecciones bacterianas en pacientes pediatricos. | |
ATE430561T1 (de) | Chronotherapeutische diltiazem formulierungen und deren verabreichung | |
US4911931A (en) | Pharmaceutical combination for treatment of bone-wasting diseases | |
DE60117712D1 (de) | Pharmazeutische zusammensetzung für die kontrollierte freisetzung eines beta-lactam-antibiotikums | |
Schneider et al. | Evaluation of an oral prolonged-release antibiotic formulation | |
WO2000026185A3 (en) | Omeprazole solution and method of using same | |
MXPA05010010A (es) | Regimen de dosificacion de farmaco anti-inflamatorio no-esteroideo. | |
ATE296115T1 (de) | Ortsspezifische arzneimittel verabreichung | |
WO2002056867A3 (en) | Extended release pharmaceutical compositions containing beta-lactam antibiotics | |
GT199700078A (es) | Formulacion de liberacion controlada para farmacos basicos escasamente solubles | |
YU25297A (en) | A controlled release formulation for poorly soluble basic drugs |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 799028 Country of ref document: ES |