IL119698A - New 9 -]) Loacil (Amido [-6-dimethyl-6-intermediates of deoxytetracyclines - Google Patents

New 9 -]) Loacil (Amido [-6-dimethyl-6-intermediates of deoxytetracyclines

Info

Publication number
IL119698A
IL119698A IL11969893A IL11969893A IL119698A IL 119698 A IL119698 A IL 119698A IL 11969893 A IL11969893 A IL 11969893A IL 11969893 A IL11969893 A IL 11969893A IL 119698 A IL119698 A IL 119698A
Authority
IL
Israel
Prior art keywords
amino
alkyl
group
dioxo
methyl
Prior art date
Application number
IL11969893A
Other languages
English (en)
Hebrew (he)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL119698A publication Critical patent/IL119698A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/18—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
IL11969893A 1992-08-13 1993-08-12 New 9 -]) Loacil (Amido [-6-dimethyl-6-intermediates of deoxytetracyclines IL119698A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/928,590 US5442059A (en) 1992-08-13 1992-08-13 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
IL106672A IL106672A (en) 1992-08-13 1993-08-12 9-] Amido) Converted glycyl ([- 6-dimethyl-6-dioxytetracyclines

Publications (1)

Publication Number Publication Date
IL119698A true IL119698A (en) 1998-09-24

Family

ID=25456487

Family Applications (3)

Application Number Title Priority Date Filing Date
IL106672A IL106672A (en) 1992-08-13 1993-08-12 9-] Amido) Converted glycyl ([- 6-dimethyl-6-dioxytetracyclines
IL11969893A IL119698A (en) 1992-08-13 1993-08-12 New 9 -]) Loacil (Amido [-6-dimethyl-6-intermediates of deoxytetracyclines
IL11969896A IL119698A0 (en) 1992-08-13 1996-11-26 Novel 9- ([haloacyl) amido]-6-demethyl-6-deoxytetracycline intermediates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL106672A IL106672A (en) 1992-08-13 1993-08-12 9-] Amido) Converted glycyl ([- 6-dimethyl-6-dioxytetracyclines

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11969896A IL119698A0 (en) 1992-08-13 1996-11-26 Novel 9- ([haloacyl) amido]-6-demethyl-6-deoxytetracycline intermediates

Country Status (28)

Country Link
US (3) US5442059A (zh)
EP (1) EP0582829B1 (zh)
JP (1) JP3633640B2 (zh)
KR (1) KR100309541B1 (zh)
CN (1) CN1033971C (zh)
AT (1) ATE205472T1 (zh)
AU (1) AU680616B2 (zh)
BR (1) BR1100987A (zh)
CA (1) CA2103845C (zh)
CZ (1) CZ288174B6 (zh)
DE (1) DE69330733T2 (zh)
DK (1) DK0582829T3 (zh)
ES (1) ES2161220T3 (zh)
FI (1) FI116055B (zh)
HK (1) HK1009960A1 (zh)
HU (3) HU212265B (zh)
IL (3) IL106672A (zh)
MX (1) MX9304756A (zh)
NO (1) NO304884B1 (zh)
NZ (1) NZ248342A (zh)
PH (1) PH30006A (zh)
PL (3) PL174108B1 (zh)
PT (1) PT582829E (zh)
RU (1) RU2123999C1 (zh)
SG (1) SG52326A1 (zh)
SK (1) SK281974B6 (zh)
TW (1) TW269678B (zh)
ZA (1) ZA935890B (zh)

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US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
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EP2327686A3 (en) * 1999-09-14 2012-08-22 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
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Also Published As

Publication number Publication date
PH30006A (en) 1996-10-29
ZA935890B (en) 1994-03-11
PL174108B1 (pl) 1998-06-30
IL106672A (en) 1998-02-22
MX9304756A (es) 1994-02-28
CZ157493A3 (en) 1994-03-16
KR100309541B1 (ko) 2002-08-31
CA2103845A1 (en) 1994-02-14
IL119698A0 (en) 1997-02-18
HUT71594A (en) 1996-01-29
NO304884B1 (no) 1999-03-01
ATE205472T1 (de) 2001-09-15
SG52326A1 (en) 1998-09-28
HUT66660A (en) 1994-12-28
CZ288174B6 (en) 2001-05-16
JPH06199758A (ja) 1994-07-19
HU9302335D0 (en) 1993-10-28
DE69330733D1 (de) 2001-10-18
BR1100987A (pt) 1999-12-07
PT582829E (pt) 2002-01-30
EP0582829B1 (en) 2001-09-12
HU211501A9 (en) 1995-11-28
HU215445B (hu) 2000-12-28
CA2103845C (en) 2005-05-17
NO932873D0 (no) 1993-08-12
EP0582829A1 (en) 1994-02-16
PL174073B1 (pl) 1998-06-30
AU680616B2 (en) 1997-08-07
NZ248342A (en) 1995-07-26
US5495030A (en) 1996-02-27
DE69330733T2 (de) 2002-07-04
HK1009960A1 (en) 1999-06-11
JP3633640B2 (ja) 2005-03-30
CN1087899A (zh) 1994-06-15
US5567692A (en) 1996-10-22
HU9401974D0 (en) 1994-09-28
ES2161220T3 (es) 2001-12-01
RU2123999C1 (ru) 1998-12-27
HU212265B (en) 1996-04-29
IL106672A0 (en) 1993-12-08
FI933568A (fi) 1994-02-14
US5442059A (en) 1995-08-15
SK84893A3 (en) 1994-06-08
PL173448B1 (pl) 1998-03-31
CN1033971C (zh) 1997-02-05
DK0582829T3 (da) 2001-10-15
AU4461193A (en) 1994-02-17
TW269678B (zh) 1996-02-01
PL300068A1 (en) 1994-02-21
NO932873L (no) 1994-02-14
SK281974B6 (sk) 2001-09-11
FI933568A0 (fi) 1993-08-12
FI116055B (fi) 2005-09-15
KR940003908A (ko) 1994-03-14

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