IL114271A - Oxophthalazinic acid derivatives Acetic acid - Google Patents

Oxophthalazinic acid derivatives Acetic acid

Info

Publication number
IL114271A
IL114271A IL114271A IL11427190A IL114271A IL 114271 A IL114271 A IL 114271A IL 114271 A IL114271 A IL 114271A IL 11427190 A IL11427190 A IL 11427190A IL 114271 A IL114271 A IL 114271A
Authority
IL
Israel
Prior art keywords
oxo
compound
oxophthalazinyl
solution
acetic acid
Prior art date
Application number
IL114271A
Other languages
English (en)
Hebrew (he)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL114271A publication Critical patent/IL114271A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL114271A 1989-05-11 1990-05-06 Oxophthalazinic acid derivatives Acetic acid IL114271A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/350,997 US4954629A (en) 1989-05-11 1989-05-11 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
IL9430190A IL94301A (en) 1989-05-11 1990-05-06 Process for the preparation of acetic oxophetylazinyl acids, certain new compounds and pharmaceutical preparations containing them

Publications (1)

Publication Number Publication Date
IL114271A true IL114271A (en) 1998-04-05

Family

ID=23379152

Family Applications (3)

Application Number Title Priority Date Filing Date
IL9430190A IL94301A (en) 1989-05-11 1990-05-06 Process for the preparation of acetic oxophetylazinyl acids, certain new compounds and pharmaceutical preparations containing them
IL114271A IL114271A (en) 1989-05-11 1990-05-06 Oxophthalazinic acid derivatives Acetic acid
IL11427195A IL114271A0 (en) 1989-05-11 1995-06-22 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL9430190A IL94301A (en) 1989-05-11 1990-05-06 Process for the preparation of acetic oxophetylazinyl acids, certain new compounds and pharmaceutical preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11427195A IL114271A0 (en) 1989-05-11 1995-06-22 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Country Status (30)

Country Link
US (1) US4954629A (xx)
EP (1) EP0397350B1 (xx)
JP (1) JPH035479A (xx)
KR (1) KR920006419B1 (xx)
CN (1) CN1025855C (xx)
AR (1) AR246968A1 (xx)
AT (1) ATE103913T1 (xx)
AU (2) AU618898B2 (xx)
BG (1) BG50609A3 (xx)
CA (1) CA2016504C (xx)
CZ (1) CZ281213B6 (xx)
DD (1) DD294257A5 (xx)
DE (1) DE69007846T2 (xx)
DK (1) DK0397350T3 (xx)
EG (1) EG19082A (xx)
ES (1) ES2063265T3 (xx)
FI (1) FI93959C (xx)
HU (1) HU212304B (xx)
IE (1) IE62591B1 (xx)
IL (3) IL94301A (xx)
MX (2) MX167455B (xx)
NO (1) NO177708C (xx)
NZ (1) NZ233597A (xx)
PH (1) PH26567A (xx)
PL (1) PL164427B1 (xx)
PT (1) PT93985B (xx)
RO (1) RO107256B1 (xx)
RU (1) RU2014333C1 (xx)
YU (1) YU91290A (xx)
ZA (1) ZA903565B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
IL124236A (en) * 1997-05-05 2003-01-12 Pfizer Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
EP0982306A3 (en) * 1998-08-21 2000-07-05 Pfizer Products Inc. Polymorph of zopolrestat monohydrate
CN105732640B (zh) 2010-07-16 2019-01-08 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂及其用途
US8916563B2 (en) * 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
CN102558184B (zh) * 2011-12-30 2014-07-16 西南大学 酞嗪类衍生物的合成方法
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
MX2018016122A (es) * 2016-06-21 2019-08-01 Univ Columbia Inhibidores de aldosa reductasa y metodos de uso.
CN111065392A (zh) 2017-07-28 2020-04-24 应用治疗公司 用于治疗半乳糖血症的组合物和方法
CA3132136A1 (en) 2019-04-01 2020-10-08 Andrew Wasmuth Inhibitors of aldose reductase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
DE3337859A1 (de) * 1983-01-21 1984-07-26 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von benzthiazolen
CA1299178C (en) * 1985-11-07 1992-04-21 Banavara Lakshmana Mylari Heterocyclic oxophtalazinyl acetic acids
DE3684410D1 (de) * 1985-11-07 1992-04-23 Pfizer Heterocyclische oxophthalazinylessigsaeure.
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
EP0322153A3 (en) * 1987-12-21 1990-08-16 Pfizer Inc. Heterocyclic oxophtalazinyl acetic acids
WO1989006651A1 (en) * 1988-01-19 1989-07-27 Pfizer Inc. 1h-indazole-3-acetic acids as aldose reductase inhibitors
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

Also Published As

Publication number Publication date
IE901626L (en) 1990-11-11
CZ281213B6 (cs) 1996-07-17
NO177708B (no) 1995-07-31
PL285113A1 (en) 1991-07-15
IL94301A0 (en) 1991-03-10
NO902071L (no) 1990-11-12
IL114271A0 (en) 1995-10-31
AU626225B2 (en) 1992-07-23
AU618898B2 (en) 1992-01-09
AU8680691A (en) 1992-01-02
PT93985B (pt) 1996-11-29
DE69007846D1 (de) 1994-05-11
EP0397350A1 (en) 1990-11-14
ES2063265T3 (es) 1995-01-01
FI93959C (fi) 1995-06-26
RO107256B1 (ro) 1993-10-30
AU5490690A (en) 1990-11-15
HU212304B (en) 1996-05-28
IL94301A (en) 1996-01-19
EP0397350B1 (en) 1994-04-06
PT93985A (pt) 1991-01-08
US4954629A (en) 1990-09-04
NO902071D0 (no) 1990-05-10
HU902995D0 (en) 1990-09-28
NO177708C (no) 1995-11-08
PL164427B1 (pl) 1994-07-29
DD294257A5 (de) 1991-09-26
NZ233597A (en) 1992-02-25
DK0397350T3 (da) 1994-05-09
CN1025855C (zh) 1994-09-07
PH26567A (en) 1992-08-19
CA2016504C (en) 1999-07-27
EG19082A (en) 1994-07-30
FI93959B (fi) 1995-03-15
KR920006419B1 (ko) 1992-08-06
KR900018114A (ko) 1990-12-20
JPH035479A (ja) 1991-01-11
YU91290A (sh) 1992-09-07
CZ227890A3 (en) 1996-04-17
CA2016504A1 (en) 1990-11-11
FI902333A0 (fi) 1990-05-10
MX167455B (es) 1993-03-23
JPH0573753B2 (xx) 1993-10-15
MX9207687A (es) 1994-06-30
CN1047499A (zh) 1990-12-05
AR246968A1 (es) 1994-10-31
BG50609A3 (en) 1992-09-15
DE69007846T2 (de) 1994-07-28
IE62591B1 (en) 1995-02-08
ATE103913T1 (de) 1994-04-15
RU2014333C1 (ru) 1994-06-15
HUT54690A (en) 1991-03-28
ZA903565B (en) 1991-12-24

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees