IL112081A - Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them - Google Patents
Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing themInfo
- Publication number
- IL112081A IL112081A IL11208194A IL11208194A IL112081A IL 112081 A IL112081 A IL 112081A IL 11208194 A IL11208194 A IL 11208194A IL 11208194 A IL11208194 A IL 11208194A IL 112081 A IL112081 A IL 112081A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- preparation
- compositions containing
- independently
- tetrahydrofuran derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title 1
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- -1 phosphate ester Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Lubricants (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17108393A | 1993-12-21 | 1993-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL112081A0 IL112081A0 (en) | 1995-03-15 |
| IL112081A true IL112081A (en) | 2001-08-26 |
Family
ID=22622452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11208194A IL112081A (en) | 1993-12-21 | 1994-12-20 | Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0736030B1 (https=) |
| JP (1) | JP2834889B2 (https=) |
| KR (1) | KR0179990B1 (https=) |
| CN (1) | CN1064685C (https=) |
| AT (1) | ATE204875T1 (https=) |
| AU (1) | AU681753B2 (https=) |
| BR (1) | BR1100154B1 (https=) |
| CA (1) | CA2179396C (https=) |
| CO (1) | CO4520281A1 (https=) |
| CZ (1) | CZ294823B6 (https=) |
| DE (2) | DE122006000004I2 (https=) |
| DK (1) | DK0736030T3 (https=) |
| ES (1) | ES2159623T3 (https=) |
| FI (1) | FI118470B (https=) |
| FR (1) | FR06C0009I2 (https=) |
| HU (1) | HU225062B1 (https=) |
| IL (1) | IL112081A (https=) |
| LU (1) | LU91216I2 (https=) |
| MY (1) | MY130217A (https=) |
| NL (1) | NL300219I2 (https=) |
| NO (2) | NO316173B1 (https=) |
| NZ (1) | NZ278713A (https=) |
| PL (1) | PL181193B1 (https=) |
| PT (1) | PT736030E (https=) |
| SK (1) | SK283035B6 (https=) |
| TW (1) | TW377349B (https=) |
| WO (1) | WO1995017407A1 (https=) |
| ZA (1) | ZA9410142B (https=) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG48386A1 (en) * | 1994-01-24 | 1998-04-17 | Janssen Pharmaceutica Nv | Watersoluble azole antifungals |
| HUP9701690A3 (en) * | 1995-06-02 | 1998-04-28 | Schering Corp Kenilwort | Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same |
| IL118668A0 (en) * | 1995-06-19 | 1996-10-16 | Schering Corp | Tetrahydrofuran antifungals |
| US5698557A (en) * | 1995-06-19 | 1997-12-16 | Schering Corporation | Hydroxy-substituted antifungals |
| KR20000064469A (ko) * | 1995-12-20 | 2000-11-06 | 둘락 노먼 씨. | 하이드라지드의제조방법 |
| CA2255663C (en) * | 1996-05-24 | 2002-08-20 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5972381A (en) * | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| DE69730241T2 (de) * | 1996-06-28 | 2005-08-11 | Schering Corp. | Feste lösung eines fungizids mit erhöhter bioverfügbarkeit |
| US5846971A (en) * | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| CA2258683C (en) * | 1996-06-28 | 2007-07-31 | Schering Corporation | Oral composition comprising a triazole antifungal compound |
| JP2001504121A (ja) * | 1996-11-12 | 2001-03-27 | セプラコール，インク． | ２ｒ，４ｓ，ｒ，ｓ―および２ｓ，４ｒ，ｒ，ｓ―ヒドロキシイトラコナゾール―およびヒドロキシサパーコナゾール誘導体 |
| WO1998021204A1 (en) | 1996-11-12 | 1998-05-22 | Sepracor, Inc. | 2r,4s,s,s- and 2s,4r,s,s-hydroxyitraconazole |
| CN1237174A (zh) * | 1996-11-12 | 1999-12-01 | 塞普拉科公司 | 2r,4s,s,r－和2s,4r,s,r－羟基伊曲康唑 |
| AU5251398A (en) * | 1996-11-12 | 1998-06-03 | Sepracor, Inc. | (2r,4s,r,r-) and (2s,4r,r,r-)hydroxyitraconazole |
| US5684197A (en) * | 1996-12-12 | 1997-11-04 | Schering Corporation | Process for preparation of hydrazides |
| WO1998034934A1 (en) * | 1997-02-11 | 1998-08-13 | Janssen Pharmaceutica N.V. | Amino acid ester containing azole antifungals |
| US6043245A (en) * | 1997-09-25 | 2000-03-28 | Schering Corporation | Tetrahydrofuran antifungal phosphate |
| PE120799A1 (es) * | 1997-09-25 | 1999-12-01 | Schering Corp | Fosfato de tetrahidrofurano antifungal |
| WO1999018111A1 (en) * | 1997-10-07 | 1999-04-15 | Schering Corporation | Crystalline antifungal glycine ester polymorph |
| KR100626109B1 (ko) * | 1997-10-07 | 2006-09-20 | 쉐링 코포레이션 | 항진균성 결정성 다형체 및 이를 포함하는 약제학적 조성물 |
| US6713481B1 (en) * | 1997-10-17 | 2004-03-30 | David R. Andrews | Crystalline antifungal polymorph |
| US5883097A (en) * | 1998-04-16 | 1999-03-16 | Schering Corporation | Soluble azole antifungal salt |
| EP0957101A1 (en) * | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| US6147077A (en) * | 1999-04-29 | 2000-11-14 | Sepracor Inc. | 2R,4S-hydroxyitraconazole isomers |
| AU768491B2 (en) | 1999-05-04 | 2003-12-11 | Janssen Pharmaceutica N.V. | Antifungal ethers |
| US6362172B2 (en) | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6448401B1 (en) | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
| EP1372394A1 (en) | 2001-04-03 | 2004-01-02 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US7446107B2 (en) | 2002-02-15 | 2008-11-04 | Transform Pharmaceuticals, Inc. | Crystalline forms of conazoles and methods of making and using the same |
| US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| WO2004000284A1 (en) | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
| CA2477923C (en) | 2002-03-01 | 2021-02-23 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| EP1511490A4 (en) | 2002-05-31 | 2009-03-11 | Transform Pharmaceuticals Inc | NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| ITMI20032020A1 (it) | 2003-10-17 | 2005-04-18 | Italfarmaco Spa | Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici |
| KR101289115B1 (ko) * | 2004-08-13 | 2013-07-23 | 엠에스디 인터내셔널 홀딩즈 게엠베하 | 항생제인 트리아졸 및 코르티코스테로이드를 포함하는약제학적 제형 |
| JO2691B1 (en) * | 2005-05-03 | 2013-03-03 | ايساي آر آند دي مانجمنت كو.، ليمتد | Monolysine salts for azole compounds |
| EP2130540A1 (en) * | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| WO2011003992A1 (en) | 2009-07-09 | 2011-01-13 | Sandoz Ag | A crystalline form of posaconazole |
| WO2011158248A2 (en) * | 2010-05-12 | 2011-12-22 | Glenmark Generics Limited | Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole |
| JP5955837B2 (ja) | 2010-05-19 | 2016-07-20 | サンド・アクチエンゲゼルシヤフト | ポサコナゾール及びポサコナゾール中間体の精製 |
| EP2571847B1 (en) * | 2010-05-19 | 2016-09-21 | Sandoz AG | Process for the preparation of chiral hydrazides |
| AU2011254657B2 (en) * | 2010-05-19 | 2016-02-04 | Sandoz Ag | Preparation of posaconazole intermediates |
| CN102906087B (zh) * | 2010-05-19 | 2016-03-23 | 桑多斯股份公司 | 制备手性三唑酮的方法 |
| HUE056581T2 (hu) | 2010-06-29 | 2022-02-28 | Merck Sharp & Dohme | Szubsztituált béta-ciklodextrinnel stabilizált pozakonazol intravénás oldat formulációk |
| CA2838051C (en) | 2011-06-16 | 2019-09-24 | Sandoz Ag | Process for the preparation of a chiral compound |
| EP2789610A1 (en) | 2013-04-10 | 2014-10-15 | Sandoz Ag | Purification of Posaconazole Intermediates |
| CA2919290A1 (en) * | 2013-07-25 | 2015-01-29 | Sandoz Ag | Improved process for the preparation of crystalline form iv of posaconazole |
| ITMI20132114A1 (it) | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| CN105287403A (zh) * | 2014-08-02 | 2016-02-03 | 陕西合成药业股份有限公司 | 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途 |
| CN104370894A (zh) * | 2014-10-21 | 2015-02-25 | 江苏恒盛药业有限公司 | 无定型泊沙康唑的制备工艺 |
| EP3227277B1 (en) | 2014-12-05 | 2020-02-05 | Pulmocide Limited | Antimycotic compound |
| KR102653821B1 (ko) * | 2015-05-21 | 2024-04-02 | 풀모사이드 리미티드 | 항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염. |
| CN106317032A (zh) * | 2015-06-15 | 2017-01-11 | 重庆圣华曦药业股份有限公司 | 一种制备高纯度的泊沙康唑的方法 |
| CN106432338A (zh) * | 2015-08-08 | 2017-02-22 | 陕西合成药业股份有限公司 | 泊沙康唑衍生物、合成和在长效制剂中的用途 |
| AU2016325733B2 (en) * | 2015-09-23 | 2020-04-09 | Biocon Limited | Crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole |
| CN105606736A (zh) * | 2016-01-27 | 2016-05-25 | 重庆华邦制药有限公司 | 分离测定泊沙康唑中间体z1及其有关物质的方法 |
| KR20180115329A (ko) * | 2016-03-04 | 2018-10-22 | 저장 아우선 파마슈티칼 씨오., 엘티디. | 포사코나졸, 조성물, 중간체, 제조방법 및 그의 용도 |
| CN105949278B (zh) * | 2016-03-30 | 2019-12-06 | 南京曼杰生物科技有限公司 | 一种取代的四氢呋喃水溶性衍生物及其应用 |
| WO2017032908A1 (en) | 2016-07-08 | 2017-03-02 | Synthon B.V. | Pharmaceutical composition comprising amorphous posaconazole |
| US11185548B2 (en) | 2016-12-23 | 2021-11-30 | Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| CN106967054A (zh) * | 2017-03-30 | 2017-07-21 | 成都绿林科技有限公司 | 一种泊沙康唑的制备方法 |
| CN106883221A (zh) * | 2017-04-17 | 2017-06-23 | 兰州大学 | 一种无定形泊沙康唑及其制备方法 |
| CN108341754A (zh) * | 2018-03-12 | 2018-07-31 | 扬子江药业集团有限公司 | 泊沙康唑杂质及其制备方法和用途 |
| CN110938093B (zh) * | 2018-09-21 | 2022-08-19 | 华创合成制药股份有限公司 | 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途 |
| CN112778369B (zh) * | 2019-11-05 | 2024-01-26 | 华创合成制药股份有限公司 | 一种三唑类衍生物及其制备方法和用途 |
| GB201917867D0 (en) | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| CN113666915B (zh) * | 2021-08-27 | 2022-08-16 | 江苏海洋大学 | 一种泊沙康唑中间体的制备方法 |
| CN114315811B (zh) * | 2021-11-19 | 2024-04-30 | 江苏恒盛药业有限公司 | 一种三氮唑类似物化合物及其制备方法和应用 |
| CN120794964A (zh) * | 2025-07-03 | 2025-10-17 | 广州绿十字制药股份有限公司 | 泊沙康唑脂肪酸酯、泊沙康唑脂肪酸酯脂肪乳及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| CA1292472C (en) * | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| DE3852477T2 (de) * | 1987-11-20 | 1995-05-04 | Schering Corp | Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte. |
| US5039676A (en) * | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| IL103558A0 (en) * | 1991-10-30 | 1993-03-15 | Schering Corp | Tri-substituted tetrahydrofuran antifungals |
-
1994
- 1994-12-20 PL PL94315169A patent/PL181193B1/pl unknown
- 1994-12-20 PT PT95906620T patent/PT736030E/pt unknown
- 1994-12-20 NZ NZ278713A patent/NZ278713A/en not_active IP Right Cessation
- 1994-12-20 CZ CZ19961805A patent/CZ294823B6/cs not_active IP Right Cessation
- 1994-12-20 JP JP7517469A patent/JP2834889B2/ja not_active Expired - Lifetime
- 1994-12-20 AU AU15127/95A patent/AU681753B2/en not_active Expired
- 1994-12-20 CO CO94057442A patent/CO4520281A1/es unknown
- 1994-12-20 CA CA002179396A patent/CA2179396C/en not_active Expired - Lifetime
- 1994-12-20 SK SK826-96A patent/SK283035B6/sk not_active IP Right Cessation
- 1994-12-20 TW TW083111949A patent/TW377349B/zh not_active IP Right Cessation
- 1994-12-20 AT AT95906620T patent/ATE204875T1/de active
- 1994-12-20 CN CN94195025A patent/CN1064685C/zh not_active Expired - Lifetime
- 1994-12-20 EP EP95906620A patent/EP0736030B1/en not_active Expired - Lifetime
- 1994-12-20 HU HU9601709A patent/HU225062B1/hu active Protection Beyond IP Right Term
- 1994-12-20 WO PCT/US1994/014236 patent/WO1995017407A1/en not_active Ceased
- 1994-12-20 MY MYPI94003426A patent/MY130217A/en unknown
- 1994-12-20 DE DE1994628125 patent/DE122006000004I2/de active Active
- 1994-12-20 IL IL11208194A patent/IL112081A/xx active Protection Beyond IP Right Term
- 1994-12-20 ZA ZA9410142A patent/ZA9410142B/xx unknown
- 1994-12-20 ES ES95906620T patent/ES2159623T3/es not_active Expired - Lifetime
- 1994-12-20 DK DK95906620T patent/DK0736030T3/da active
- 1994-12-20 DE DE69428125T patent/DE69428125T2/de not_active Expired - Lifetime
-
1996
- 1996-06-20 FI FI962577A patent/FI118470B/fi not_active IP Right Cessation
- 1996-06-20 NO NO19962616A patent/NO316173B1/no not_active IP Right Cessation
- 1996-06-21 KR KR1019960703319A patent/KR0179990B1/ko not_active Expired - Lifetime
-
1997
- 1997-03-06 BR BR1100154A patent/BR1100154B1/pt unknown
-
2006
- 2006-01-27 LU LU91216C patent/LU91216I2/en unknown
- 2006-02-01 NL NL300219C patent/NL300219I2/nl unknown
- 2006-02-10 NO NO2006002C patent/NO2006002I2/no unknown
- 2006-03-13 FR FR06C0009C patent/FR06C0009I2/fr active Active
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