IL108689A - Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid - Google Patents
Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acidInfo
- Publication number
- IL108689A IL108689A IL108689A IL10868994A IL108689A IL 108689 A IL108689 A IL 108689A IL 108689 A IL108689 A IL 108689A IL 10868994 A IL10868994 A IL 10868994A IL 108689 A IL108689 A IL 108689A
- Authority
- IL
- Israel
- Prior art keywords
- acid
- heparin
- aqueous solution
- general formula
- nucleophilic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93BO000125A IT1264101B1 (it) | 1993-03-29 | 1993-03-29 | Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL108689A0 IL108689A0 (en) | 1994-05-30 |
| IL108689A true IL108689A (en) | 1998-03-10 |
Family
ID=11338858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL108689A IL108689A (en) | 1993-03-29 | 1994-02-17 | Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5405949A (fi) |
| EP (1) | EP0618234B1 (fi) |
| JP (1) | JP2731721B2 (fi) |
| KR (1) | KR100194122B1 (fi) |
| AT (1) | ATE154039T1 (fi) |
| AU (1) | AU664939B2 (fi) |
| CA (1) | CA2114862C (fi) |
| DE (1) | DE69403537T2 (fi) |
| DK (1) | DK0618234T3 (fi) |
| ES (1) | ES2102087T3 (fi) |
| FI (1) | FI105101B (fi) |
| GR (1) | GR3024416T3 (fi) |
| IL (1) | IL108689A (fi) |
| IT (1) | IT1264101B1 (fi) |
| NO (1) | NO305994B1 (fi) |
| NZ (1) | NZ250815A (fi) |
| TW (1) | TW266215B (fi) |
| ZA (1) | ZA94970B (fi) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6255295B1 (en) | 1996-12-23 | 2001-07-03 | Nutramax Laboratories, Inc. | Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue |
| US7259152B2 (en) | 2000-06-07 | 2007-08-21 | Alfa Wasserman, Inc. | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
| CA2435637A1 (en) | 2001-01-23 | 2002-08-01 | Massachusetts Institute Of Technology | Solid- and solution -phase synthesis of heparin and other glycosaminoglycans |
| PT1427427E (pt) | 2001-09-12 | 2011-09-13 | Sigma Tau Res Switzerland Sa | Derivados de glicosaminoglicanos parcialmente dessulfatados como inibidores da heparanase, dotados de actividade antiangiogénica e destituídos de efeito anticoagulante |
| GB0216861D0 (en) * | 2002-07-19 | 2002-08-28 | Univ Birmingham | Saccharide libraries |
| KR102468224B1 (ko) * | 2016-03-09 | 2022-11-17 | 가부시키가이샤 도우사 고가쿠 겐큐쇼 | 설페이트기 및/또는 포스페이트기를 갖는 당의 제조방법 |
| CN114901702B (zh) * | 2019-12-27 | 2024-01-09 | 深圳市海普瑞药业集团股份有限公司 | 一种糖胺聚糖衍生物及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987223A (en) * | 1981-12-23 | 1991-01-22 | Choay S.A. | Derivatives of the uronic acid |
| US6174999B1 (en) * | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| IT1234508B (it) * | 1988-06-10 | 1992-05-19 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
| US5011919A (en) * | 1989-01-30 | 1991-04-30 | Ajorca S.A. | Modified heparins and obtention process |
| IT1234826B (it) * | 1989-01-30 | 1992-05-29 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
| IT1242604B (it) * | 1990-11-13 | 1994-05-16 | Alfa Wassermann Spa | Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono. |
| IT1260137B (it) * | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato |
| IT1260136B (it) * | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3 |
| BE1006134A6 (fr) * | 1992-08-25 | 1994-05-24 | Syntex Sa | Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation. |
-
1993
- 1993-03-29 IT IT93BO000125A patent/IT1264101B1/it active IP Right Grant
-
1994
- 1994-02-03 NZ NZ250815A patent/NZ250815A/en unknown
- 1994-02-03 CA CA002114862A patent/CA2114862C/en not_active Expired - Fee Related
- 1994-02-10 AU AU55085/94A patent/AU664939B2/en not_active Ceased
- 1994-02-11 ZA ZA94970A patent/ZA94970B/xx unknown
- 1994-02-17 IL IL108689A patent/IL108689A/en not_active IP Right Cessation
- 1994-02-18 TW TW083101327A patent/TW266215B/zh active
- 1994-03-07 US US08/206,980 patent/US5405949A/en not_active Expired - Lifetime
- 1994-03-18 DE DE69403537T patent/DE69403537T2/de not_active Expired - Fee Related
- 1994-03-18 EP EP94104306A patent/EP0618234B1/en not_active Expired - Lifetime
- 1994-03-18 ES ES94104306T patent/ES2102087T3/es not_active Expired - Lifetime
- 1994-03-18 AT AT94104306T patent/ATE154039T1/de not_active IP Right Cessation
- 1994-03-18 DK DK94104306.9T patent/DK0618234T3/da active
- 1994-03-25 KR KR1019940006018A patent/KR100194122B1/ko not_active IP Right Cessation
- 1994-03-28 NO NO941128A patent/NO305994B1/no not_active IP Right Cessation
- 1994-03-28 FI FI941431A patent/FI105101B/fi not_active IP Right Cessation
- 1994-03-29 JP JP6059447A patent/JP2731721B2/ja not_active Expired - Fee Related
-
1997
- 1997-08-13 GR GR970402059T patent/GR3024416T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06298805A (ja) | 1994-10-25 |
| DK0618234T3 (da) | 1997-08-25 |
| EP0618234B1 (en) | 1997-06-04 |
| CA2114862C (en) | 1999-05-25 |
| DE69403537D1 (de) | 1997-07-10 |
| GR3024416T3 (en) | 1997-11-28 |
| JP2731721B2 (ja) | 1998-03-25 |
| IL108689A0 (en) | 1994-05-30 |
| AU664939B2 (en) | 1995-12-07 |
| NO941128L (no) | 1994-09-30 |
| DE69403537T2 (de) | 1997-09-18 |
| AU5508594A (en) | 1994-10-06 |
| IT1264101B1 (it) | 1996-09-10 |
| ITBO930125A0 (it) | 1993-03-29 |
| FI941431A (fi) | 1994-09-30 |
| NO305994B1 (no) | 1999-08-30 |
| TW266215B (fi) | 1995-12-21 |
| FI105101B (fi) | 2000-06-15 |
| ITBO930125A1 (it) | 1994-09-29 |
| FI941431A0 (fi) | 1994-03-28 |
| ES2102087T3 (es) | 1997-07-16 |
| CA2114862A1 (en) | 1994-09-30 |
| KR100194122B1 (ko) | 1999-06-15 |
| EP0618234A1 (en) | 1994-10-05 |
| NO941128D0 (no) | 1994-03-28 |
| US5405949A (en) | 1995-04-11 |
| KR940021582A (ko) | 1994-10-19 |
| ZA94970B (en) | 1994-08-24 |
| ATE154039T1 (de) | 1997-06-15 |
| NZ250815A (en) | 1996-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |