IL103493A - Use of 2 - amino - 6 -) trifluoromethoxy (benzothiazole for the preparation of the drug for the treatment of neuro-motor diseases - Google Patents
Use of 2 - amino - 6 -) trifluoromethoxy (benzothiazole for the preparation of the drug for the treatment of neuro-motor diseasesInfo
- Publication number
- IL103493A IL103493A IL10349392A IL10349392A IL103493A IL 103493 A IL103493 A IL 103493A IL 10349392 A IL10349392 A IL 10349392A IL 10349392 A IL10349392 A IL 10349392A IL 103493 A IL103493 A IL 103493A
- Authority
- IL
- Israel
- Prior art keywords
- amino
- benzothiazole
- treatment
- trifluoromethoxy
- preparing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
- Surgical Instruments (AREA)
- Percussion Or Vibration Massage (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9202696A FR2688138B1 (fr) | 1992-03-06 | 1992-03-06 | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
Publications (2)
Publication Number | Publication Date |
---|---|
IL103493A0 IL103493A0 (en) | 1993-03-15 |
IL103493A true IL103493A (en) | 1996-07-23 |
Family
ID=9427427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10349392A IL103493A (en) | 1992-03-06 | 1992-10-21 | Use of 2 - amino - 6 -) trifluoromethoxy (benzothiazole for the preparation of the drug for the treatment of neuro-motor diseases |
Country Status (22)
Country | Link |
---|---|
US (1) | US5527814A (ko) |
EP (2) | EP0558861A1 (ko) |
JP (1) | JP2713384B2 (ko) |
KR (1) | KR100190296B1 (ko) |
AT (1) | ATE149833T1 (ko) |
AU (1) | AU666150B2 (ko) |
CA (1) | CA2117466C (ko) |
CZ (1) | CZ281293B6 (ko) |
DE (1) | DE69218255T2 (ko) |
DK (1) | DK0627919T3 (ko) |
ES (1) | ES2098558T3 (ko) |
FR (1) | FR2688138B1 (ko) |
GR (1) | GR3022797T3 (ko) |
HU (1) | HU217130B (ko) |
IL (1) | IL103493A (ko) |
MX (1) | MX9206109A (ko) |
NO (1) | NO306534B1 (ko) |
RU (1) | RU2110260C1 (ko) |
SK (1) | SK279046B6 (ko) |
UA (1) | UA41879C2 (ko) |
WO (1) | WO1993017683A1 (ko) |
ZA (1) | ZA928213B (ko) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2699077B1 (fr) * | 1992-12-16 | 1995-01-13 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes. |
FR2702148B1 (fr) * | 1993-03-05 | 1995-04-07 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement du neuro-sida. |
FR2714828B1 (fr) * | 1994-01-12 | 1996-02-02 | Rhone Poulenc Rorer Sa | Application du riluzole dans le traitement des maladies mitochondriales. |
NZ320355A (en) * | 1995-10-26 | 2000-03-27 | Sanofi Sa | Use of 1-(2-naphth-2-ylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6- tetrahydropyridine for preparing drugs for treating amyotrophic lateral sclerosis |
FR2753379B1 (fr) | 1996-09-13 | 1998-10-30 | Rhone Poulenc Rorer Sa | Methode de traitement de la sclerose laterale amyotrophique |
CA2297943A1 (en) | 1997-07-25 | 1999-02-04 | Nippon Kayaku Kabushiki Kaisha | Novel compound having effect of promoting neuron differentiation |
US6417210B1 (en) | 1998-01-09 | 2002-07-09 | Mor-Research Applications Ltd. | Treatment of dyskinesias and Parkinson's disease with riluzole and levodopa |
BR9906821A (pt) * | 1998-01-09 | 2000-10-17 | Mor Research Applic Ltd | Composição farmacêutica e processo para melhorar a discinesia induzida por levodopa e discinesia tardia, e, uso de riluzol para a preparação de uma composição farmacêutica |
FR2785808B1 (fr) * | 1998-11-13 | 2002-12-06 | Aventis Laboratoire | Association riluzole et alpha-tocopherol |
EP1552831B1 (en) * | 1999-06-04 | 2009-01-07 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Use of riluzole for treating multiple sclerosis |
US6872739B1 (en) | 1999-06-04 | 2005-03-29 | Vereniging Voor Christelijk Wetenshappelikjk Onderwijs | Use of riluzole for the treatment of multiple sclerosis |
JP2001021609A (ja) * | 1999-07-07 | 2001-01-26 | Mitsubishi Electric Corp | 半導体集積回路の検査方法 |
DE19940524C2 (de) * | 1999-08-26 | 2003-06-18 | Karl-Heinz Lenzkes | Fahrzeugrad, insbesondere für Personenkraftfahrzeuge |
US6350768B1 (en) | 1999-11-24 | 2002-02-26 | Aventis Pharma S.A. | Combination of riluzole and of gabapentin and its use as a medicament |
FR2801217B1 (fr) * | 1999-11-24 | 2002-12-06 | Aventis Pharma Sa | Association de riluzole et de gabapentine et son utilisation comme medicament |
US6964982B2 (en) * | 2000-04-20 | 2005-11-15 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
IL136687A0 (en) * | 2000-06-12 | 2001-06-14 | Mor Research Applic Ltd | Pharmaceutical composition for the treatment of multiple sclerosis |
US6933310B1 (en) | 2000-10-24 | 2005-08-23 | Mitsubishi Pharma Corporation | Therapeutic agent for amyotrophic lateral sclerosis (ALS) |
AU3932902A (en) * | 2000-11-22 | 2002-06-03 | Allergan Sales Inc | A high-throughput screen for identifying channel blockers that selectively distinguish transient from persistent sodium channels |
US6479458B1 (en) | 2001-11-08 | 2002-11-12 | Allergan, Inc. | Targeting the reverse mode of the Na+/Ca2+ exchanger for the treatment of optic neuropathy associated with glaucoma and ischemic optic neuropathy |
US7361478B2 (en) * | 2001-11-20 | 2008-04-22 | Allergan, Inc. | High-throughput screen for identifying selective persistent sodium channels channel blockers |
KR20040066890A (ko) * | 2001-12-11 | 2004-07-27 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 근위축성 측삭 경화증 치료를 위한 프라미펙솔의 용도 |
US6927303B2 (en) * | 2002-06-19 | 2005-08-09 | Neurotech Co., Ltd. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
AU2003290838A1 (en) * | 2002-11-15 | 2004-06-15 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis |
MX2007014797A (es) * | 2005-05-25 | 2008-02-15 | Choongwae Pharma Corp | Proceso de preparacion del compuesto tetrafluorobencilanilina y sus sales farmaceuticamente aprobadas. |
US20070298129A1 (en) * | 2005-08-24 | 2007-12-27 | Neurotech Pharmaceuticals Co., Ltd. | Compounds and compositions for treating neuronal death or neurological dysfunction |
US20070049565A1 (en) * | 2005-08-24 | 2007-03-01 | Neurotech Pharmaceuticals Co., Ltd. | Combination of cell necrosis inhibitor and lithium for treating neuronal death or neurological dysfunction |
CA2661448A1 (en) | 2005-08-25 | 2007-03-01 | Steven Michael Weiss | Reducing myocardial damage and the incidence of arrhythmia arising from loss, reduction or interruption in coronary blood flow |
US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
ATE537826T1 (de) | 2006-05-16 | 2012-01-15 | Knopp Neurosciences Inc | Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung |
JP5110536B2 (ja) | 2006-07-19 | 2012-12-26 | 学校法人日本医科大学 | 筋萎縮性側索硬化症治療薬 |
US20100099700A1 (en) * | 2006-09-20 | 2010-04-22 | David Hung | Hydrogenated pyrido (4,3-b) indoles for treating amyotrophic lateral sclerosis (als) |
US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
EP2137171A4 (en) | 2007-03-14 | 2010-05-19 | Knopp Neurosciences Inc | SYNTHESIS OF BENZOTHIAZOLE DIAMINES SUBSTITUTED AND PURIFIED FROM THE CHIRAL PERSPECTIVE |
KR100852962B1 (ko) * | 2007-11-12 | 2008-08-20 | 주식회사 뉴로테크 | 2-하이드록시-5-페닐알킬아미노벤조산 유도체 및 이의 염의제조방법 |
BRPI0910338A2 (pt) * | 2008-04-03 | 2020-08-18 | F. Hoffmann-La Roche Ag | uso de variantes peguiladas de igf-i para o tratamento de distúbios neuromusculares |
US20110190356A1 (en) | 2008-08-19 | 2011-08-04 | Knopp Neurosciences Inc. | Compositions and Methods of Using (R)- Pramipexole |
EP2228054A1 (en) | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Riluzole aqueous suspensions |
EP2228055A1 (en) | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Riluzole liquid emulsions |
JP2012530723A (ja) * | 2009-06-19 | 2012-12-06 | ノップ ニューロサイエンシーズ、インク. | 筋萎縮性側索硬化症を治療するための組成物及び方法 |
JP2011121949A (ja) | 2009-12-14 | 2011-06-23 | Kyoto Univ | 筋萎縮性側索硬化症の予防および治療用医薬組成物 |
EP2611437B1 (en) | 2010-09-02 | 2017-03-29 | Kyoto University | Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US10357497B2 (en) * | 2012-06-23 | 2019-07-23 | Biohaven Pharmaceutical Holding Company Limited | Pro-drugs of riluzole and their method of use for the treatment of amyotrophic lateral sclerosis |
EP2882429B1 (en) | 2012-08-07 | 2024-04-10 | The General Hospital Corporation | Potassium-channel openers for use in treating amyotrophic lateral sclerosis (ALS) |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
RS61539B1 (sr) | 2013-07-12 | 2021-04-29 | Knopp Biosciences Llc | Lečenje povišenih nivoa eozinofila i/ili bazofila |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
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US20150210679A1 (en) * | 2014-01-28 | 2015-07-30 | Northwestern University | Small molecule inhibitors of superoxide dismutase expression |
WO2016114322A1 (ja) | 2015-01-13 | 2016-07-21 | 国立大学法人京都大学 | 筋萎縮性側索硬化症の予防及び/又は治療剤 |
US11911369B2 (en) * | 2015-03-03 | 2024-02-27 | Biohaven Therapeutics Ltd. | Prodrugs of riluzole and their method of use |
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US10322114B2 (en) | 2017-07-31 | 2019-06-18 | Above And Beyond Nb, Llc | Formulation of a riluzole solution with beta-cyclodextrins |
US20210071258A1 (en) | 2017-09-01 | 2021-03-11 | Juno Therapeutics, Inc. | Gene expression and assessment of risk of developing toxicity following cell therapy |
WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
WO2020097155A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
PT3886894T (pt) | 2018-11-30 | 2024-05-02 | Juno Therapeutics Inc | Métodos para dosagem e tratamento de malignidades de células b em terapia celular adotiva |
SG11202105502RA (en) | 2018-11-30 | 2021-06-29 | Juno Therapeutics Inc | Methods for treatment using adoptive cell therapy |
AU2020395318A1 (en) | 2019-12-06 | 2022-06-09 | Juno Therapeutics, Inc. | Methods related to toxicity and response associated with cell therapy for treating B cell malignancies |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2492258A1 (fr) * | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
US4826860A (en) * | 1987-03-16 | 1989-05-02 | Warner-Lambert Company | Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents |
FR2619713B1 (fr) * | 1987-08-25 | 1990-08-31 | Rhone Poulenc Sante | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement des troubles du sommeil et de la depression |
US4918090A (en) * | 1988-01-25 | 1990-04-17 | Warner-Lambert Company | Substituted 2-aminbenzothiazoles and derivatives useful as cerebrovascular agents |
DE68903484T2 (de) * | 1988-12-15 | 1993-03-18 | Rhone Poulenc Sante | 2-imino-6-polyfluoralkoxy-benzothiazol-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten. |
US5236940A (en) * | 1988-12-15 | 1993-08-17 | Rhone-Poulenc Sante | Pharmaceutical compositions, 2-benzothiazolamine derivatives, and their preparation |
FR2649702B1 (fr) * | 1989-07-13 | 1991-11-22 | Rhone Poulenc Sante | Derives d'alkylimino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant |
FR2662160B1 (fr) * | 1990-05-18 | 1992-07-24 | Rhone Poulenc Sante | Derives d'alkylthio-3 propyl-3 benzothiazoline leur preparation et les medicaments les contenant. |
FR2663029B1 (fr) * | 1990-06-07 | 1992-07-31 | Rhone Poulenc Sante | Derives de benzothiazole, leur preparation et les medicaments les contenant. |
-
1992
- 1992-03-06 FR FR9202696A patent/FR2688138B1/fr not_active Expired - Fee Related
- 1992-10-21 IL IL10349392A patent/IL103493A/en not_active IP Right Cessation
- 1992-10-22 RU RU94041223A patent/RU2110260C1/ru active
- 1992-10-22 JP JP5515371A patent/JP2713384B2/ja not_active Expired - Lifetime
- 1992-10-22 AU AU29482/92A patent/AU666150B2/en not_active Expired
- 1992-10-22 DK DK92923852.5T patent/DK0627919T3/da active
- 1992-10-22 CA CA002117466A patent/CA2117466C/fr not_active Expired - Lifetime
- 1992-10-22 UA UA94085678A patent/UA41879C2/uk unknown
- 1992-10-22 EP EP92402878A patent/EP0558861A1/fr active Pending
- 1992-10-22 SK SK1047-94A patent/SK279046B6/sk not_active IP Right Cessation
- 1992-10-22 KR KR1019940703081A patent/KR100190296B1/ko not_active IP Right Cessation
- 1992-10-22 HU HU9402558A patent/HU217130B/hu unknown
- 1992-10-22 AT AT92923852T patent/ATE149833T1/de active
- 1992-10-22 WO PCT/FR1992/000992 patent/WO1993017683A1/fr active IP Right Grant
- 1992-10-22 ES ES92923852T patent/ES2098558T3/es not_active Expired - Lifetime
- 1992-10-22 EP EP92923852A patent/EP0627919B1/fr not_active Expired - Lifetime
- 1992-10-22 DE DE69218255T patent/DE69218255T2/de not_active Expired - Lifetime
- 1992-10-22 CZ CZ942120A patent/CZ281293B6/cs not_active IP Right Cessation
- 1992-10-23 MX MX9206109A patent/MX9206109A/es unknown
- 1992-10-23 ZA ZA928213A patent/ZA928213B/xx unknown
-
1994
- 1994-09-02 NO NO19943256A patent/NO306534B1/no not_active IP Right Cessation
- 1994-10-21 US US08/327,343 patent/US5527814A/en not_active Expired - Lifetime
-
1997
- 1997-03-13 GR GR960403093T patent/GR3022797T3/el unknown
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Legal Events
Date | Code | Title | Description |
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FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |