IL101700A - בנזואיזותיאזול ובנזואיזוקסזול-3- קרבוקסאמדים, שיטה להכנתם והשימוש בהם כתרופות - Google Patents

בנזואיזותיאזול ובנזואיזוקסזול-3- קרבוקסאמדים, שיטה להכנתם והשימוש בהם כתרופות

Info

Publication number
IL101700A
IL101700A IL10170092A IL10170092A IL101700A IL 101700 A IL101700 A IL 101700A IL 10170092 A IL10170092 A IL 10170092A IL 10170092 A IL10170092 A IL 10170092A IL 101700 A IL101700 A IL 101700A
Authority
IL
Israel
Prior art keywords
carboxamide
benzisothiazole
compound
methyl
hydrogen
Prior art date
Application number
IL10170092A
Other languages
English (en)
Other versions
IL101700A0 (en
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of IL101700A0 publication Critical patent/IL101700A0/xx
Publication of IL101700A publication Critical patent/IL101700A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Luminescent Compositions (AREA)
  • External Artificial Organs (AREA)
  • Flanged Joints, Insulating Joints, And Other Joints (AREA)
IL10170092A 1991-04-29 1992-04-27 בנזואיזותיאזול ובנזואיזוקסזול-3- קרבוקסאמדים, שיטה להכנתם והשימוש בהם כתרופות IL101700A (he)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90/002891A US5143923B1 (en) 1991-04-29 1991-04-29 Benzoisothiazole-and benzisoxazole-3-carboxamides

Publications (2)

Publication Number Publication Date
IL101700A0 IL101700A0 (en) 1992-12-30
IL101700A true IL101700A (he) 1995-11-27

Family

ID=24783602

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10170092A IL101700A (he) 1991-04-29 1992-04-27 בנזואיזותיאזול ובנזואיזוקסזול-3- קרבוקסאמדים, שיטה להכנתם והשימוש בהם כתרופות

Country Status (21)

Country Link
US (1) US5143923B1 (he)
EP (1) EP0511610B1 (he)
JP (1) JP2656189B2 (he)
KR (1) KR100215345B1 (he)
AT (1) ATE142628T1 (he)
AU (1) AU644054B2 (he)
CA (1) CA2067404C (he)
CZ (1) CZ282764B6 (he)
DE (1) DE69213544T2 (he)
DK (1) DK0511610T3 (he)
ES (1) ES2094843T3 (he)
FI (1) FI921875A (he)
GR (1) GR3021211T3 (he)
HU (1) HU214032B (he)
IE (1) IE77036B1 (he)
IL (1) IL101700A (he)
MX (1) MX9201963A (he)
NO (1) NO180488C (he)
NZ (1) NZ242479A (he)
PL (2) PL168870B1 (he)
RU (1) RU2039057C1 (he)

Families Citing this family (32)

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US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
GB9302622D0 (en) * 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
GB9603457D0 (he) * 1996-02-19 1996-04-17 Merck & Co Inc
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
US5952351A (en) * 1995-02-23 1999-09-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
ES2253748T3 (es) * 1995-02-28 2006-06-01 H. Lundbeck A/S Compuestos 4-aminotetrahidro bencisoxazol o isotiazol.
DE69618050T2 (de) * 1995-03-17 2002-07-11 Aventis Pharmaceuticals Inc., Cincinnati Substituierte Benzylthienylpiperazine, ihre Anwendung als Arzneimittel und Verfahren für ihre Herstellung
GB9716101D0 (en) * 1997-07-30 1997-10-01 Pharmacia & Upjohn Spa Fused heterocyclic compounds
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
CA2350722A1 (en) * 1998-11-17 2000-05-25 Leyi Gong 4-aroyl-piperidin-ccr-3 receptor antagonists iii
EP1131290B1 (en) 1998-11-20 2008-02-20 F. Hoffmann-La Roche Ag Piperidine ccr-3 receptor antagonists
PL350904A1 (en) 1999-03-26 2003-02-10 Astrazeneca Ab Novel compounds
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
RU2269523C2 (ru) 2000-04-28 2006-02-10 Акадиа Фармасьютикалз, Инк. Мускариновые агонисты
GB0013060D0 (en) * 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
GB0021670D0 (en) * 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
DE60208157T2 (de) 2001-02-16 2006-08-10 Aventis Pharmaceuticals Inc. Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden
GB0117899D0 (en) * 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
SE0102809D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab Novel compounds
US7605259B2 (en) * 2002-09-14 2009-10-20 University Of North Texas Health Science Center At Fort Worth Structurally rigid dopamine d3 receptor selective ligands and process for making them
PL375981A1 (en) * 2002-09-17 2005-12-12 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain
MXPA06004304A (es) * 2003-10-24 2006-06-05 Hoffmann La Roche Antagonistas del receptor ccr-3.
US20160296146A9 (en) * 2006-06-29 2016-10-13 Fred Wood Apparatus-Mounted Vein Contrast Enchancer

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US2626260A (en) * 1951-09-05 1953-01-20 Sterling Drug Inc Nitrobenzisoxazoles
US3145215A (en) * 1961-12-19 1964-08-18 Sterling Drug Inc Indazole derivatives
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
US4021552A (en) * 1975-06-27 1977-05-03 A. H. Robins Company, Incorporated 10-[ω-(BENZOYLPIPERIDINYL)ALKYL]PHENOTHIAZINES
US4327103A (en) * 1980-07-07 1982-04-27 Hoechst-Roussel Pharmaceuticals Incorporated 3-{3-[4-(4-Fluorobenzoyl)piperidyl]propyl}-2-methyl indole
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
IL66866A (en) * 1982-04-09 1987-08-31 Hoechst Roussel Pharma 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
CH667657A5 (de) * 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
JPS61219950A (ja) * 1985-03-26 1986-09-30 Fuji Photo Film Co Ltd 熱現像感光材料
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
EP0498466B1 (en) * 1985-04-27 2002-07-24 F. Hoffmann-La Roche Ag Indazole-3-carboxamide and -3-carboxylic acid derivatives
FR2616149B1 (fr) * 1987-06-04 1990-10-19 Adir Nouveau derive de l'acide benzo (b) thiophene - 7 carboxylique, son procede de preparation et les compositions pharmaceutiques qui le contiennent
DE3827253A1 (de) * 1987-08-20 1989-03-02 Sandoz Ag Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
IL90279A (he) * 1988-05-24 1995-03-30 American Home Prod תולדות פיפראזיניל קרבוקסאמיד, הכנתןותכשירי רוקחות המכילים אותן
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use

Also Published As

Publication number Publication date
IL101700A0 (en) 1992-12-30
US5143923A (en) 1992-09-01
HU9201414D0 (en) 1992-07-28
NO180488B (no) 1997-01-20
RU2039057C1 (ru) 1995-07-09
EP0511610A1 (en) 1992-11-04
CZ282764B6 (cs) 1997-10-15
CA2067404A1 (en) 1992-10-30
HUT62889A (en) 1993-06-28
HU214032B (en) 1997-12-29
ES2094843T3 (es) 1997-02-01
NO921654L (no) 1992-10-30
AU644054B2 (en) 1993-12-02
JP2656189B2 (ja) 1997-09-24
MX9201963A (es) 1992-11-01
ATE142628T1 (de) 1996-09-15
KR100215345B1 (ko) 1999-08-16
EP0511610B1 (en) 1996-09-11
FI921875A (fi) 1992-10-30
PL168090B1 (pl) 1996-01-31
US5143923B1 (en) 1993-11-02
CS129892A3 (en) 1992-11-18
PL168870B1 (pl) 1996-04-30
IE921379A1 (en) 1992-11-04
IE77036B1 (en) 1997-11-19
NZ242479A (en) 1995-02-24
GR3021211T3 (en) 1996-12-31
NO180488C (no) 1997-04-30
FI921875A0 (fi) 1992-04-27
KR920019784A (ko) 1992-11-20
DK0511610T3 (he) 1997-06-16
PL294358A1 (en) 1993-08-09
CA2067404C (en) 2003-08-19
DE69213544T2 (de) 1997-02-27
JPH05132472A (ja) 1993-05-28
DE69213544D1 (de) 1996-10-17
AU1518792A (en) 1992-11-05
NO921654D0 (no) 1992-04-28

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Legal Events

Date Code Title Description
FF Patent granted
HC Change of name of proprietor(s)
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees