IE922311A1 - 2-(4-hydroxypiperidino)-1-alkanol derivatives as¹antiischemic agents - Google Patents

2-(4-hydroxypiperidino)-1-alkanol derivatives as¹antiischemic agents

Info

Publication number
IE922311A1
IE922311A1 IE231192A IE922311A IE922311A1 IE 922311 A1 IE922311 A1 IE 922311A1 IE 231192 A IE231192 A IE 231192A IE 922311 A IE922311 A IE 922311A IE 922311 A1 IE922311 A1 IE 922311A1
Authority
IE
Ireland
Prior art keywords
carbons
alkyl
hydroxy
hydrogen
chloro
Prior art date
Application number
IE231192A
Other languages
English (en)
Inventor
Willard Mckowan Welch Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE922311A1 publication Critical patent/IE922311A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IE231192A 1991-07-17 1992-07-16 2-(4-hydroxypiperidino)-1-alkanol derivatives as¹antiischemic agents IE922311A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73157791A 1991-07-17 1991-07-17

Publications (1)

Publication Number Publication Date
IE922311A1 true IE922311A1 (en) 1993-01-27

Family

ID=24940103

Family Applications (1)

Application Number Title Priority Date Filing Date
IE231192A IE922311A1 (en) 1991-07-17 1992-07-16 2-(4-hydroxypiperidino)-1-alkanol derivatives as¹antiischemic agents

Country Status (22)

Country Link
EP (1) EP0594729A1 (fi)
JP (1) JP2571904B2 (fi)
KR (1) KR0165003B1 (fi)
CN (1) CN1043759C (fi)
AU (1) AU655840B2 (fi)
BR (1) BR9206272A (fi)
CA (1) CA2113568A1 (fi)
CZ (1) CZ284133B6 (fi)
EG (1) EG20048A (fi)
FI (2) FI940192A (fi)
HU (1) HUT70528A (fi)
IE (1) IE922311A1 (fi)
IL (1) IL102473A (fi)
MX (1) MX9204190A (fi)
NO (1) NO180445C (fi)
NZ (1) NZ243580A (fi)
PL (1) PL169884B1 (fi)
PT (1) PT100689B (fi)
RU (1) RU2065859C1 (fi)
TW (1) TW201732B (fi)
WO (1) WO1993002052A1 (fi)
ZA (1) ZA925306B (fi)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
NZ255074A (en) * 1992-10-30 1996-10-28 Pfizer 6-[2-(4-hydroxy-4-(4-substituted phenyl)piperidino)-1-hydroxypropyl]-3,4-dihydro-2(1h)-quinolones
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
EP1182193A4 (en) * 1999-04-09 2002-09-11 Mochida Pharm Co Ltd REMEDIES FOR NEUROGENIC PAIN
EP1235572A2 (en) 1999-10-29 2002-09-04 MERCK SHARP & DOHME LTD. Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
EA005974B1 (ru) 2001-02-23 2005-08-25 Мерк Энд Ко., Инк. N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
AU2002338334B8 (en) 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
ATE522502T1 (de) 2002-11-25 2011-09-15 Mochida Pharm Co Ltd Therapeutisches mittel gegen atemwegserkrankungen,das ein 4-hydroxypiperidinderivat als wirkstoff enthält
WO2005035523A1 (en) * 2003-10-08 2005-04-21 Pfizer Japan Inc. Fused lactam compounds
TWI409289B (zh) 2010-09-02 2013-09-21 Taiwan Union Technology Corp 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
US5306723A (en) * 1990-05-10 1994-04-26 Pfizer Inc. Neuroprotective indolone and related derivatives

Also Published As

Publication number Publication date
EP0594729A1 (en) 1994-05-04
PL169884B1 (pl) 1996-09-30
IL102473A0 (en) 1993-01-14
NO180445C (no) 1997-04-23
FI981956A0 (fi) 1998-09-11
WO1993002052A1 (en) 1993-02-04
BR9206272A (pt) 1995-04-11
EG20048A (en) 1997-03-27
FI940192A0 (fi) 1994-01-14
PT100689A (pt) 1993-10-29
RU2065859C1 (ru) 1996-08-27
CA2113568A1 (en) 1993-02-04
KR0165003B1 (en) 1999-01-15
IL102473A (en) 1997-07-13
NO940144D0 (no) 1994-01-14
AU2322592A (en) 1993-02-23
NO180445B (no) 1997-01-13
TW201732B (fi) 1993-03-11
FI940192A (fi) 1994-01-14
AU655840B2 (en) 1995-01-12
ZA925306B (en) 1994-01-17
CN1043759C (zh) 1999-06-23
CN1068566A (zh) 1993-02-03
HUT70528A (en) 1995-10-30
MX9204190A (es) 1993-01-01
JPH06504293A (ja) 1994-05-19
CZ284133B6 (cs) 1998-08-12
NZ243580A (en) 1994-10-26
NO940144L (no) 1994-01-14
FI981956A (fi) 1998-09-11
HU9400136D0 (en) 1994-05-30
PT100689B (pt) 1999-06-30
JP2571904B2 (ja) 1997-01-16
CZ400892A3 (en) 1994-03-16

Similar Documents

Publication Publication Date Title
IE922311A1 (en) 2-(4-hydroxypiperidino)-1-alkanol derivatives as¹antiischemic agents
CA2226292C (en) Substituted benzolactam compounds as substance p antagonists
US5432175A (en) Pyridine and pyridine N-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
EP1499589B1 (fr) Derives de n-¬phenyl(piperidin-2-yl)methyl|benzamide, leur preparation et leur application en therapeutique
US20110092529A1 (en) 1,2,4-Triazole Derivatives and Their Use as Oxytocin Antagonists
BG100487A (bg) 3-(5-тетразолил-бензил)амино-пиперидинови производни, методи за получаването им и фармацевтични състави с тях, използувани както при метод за лечение, така и за производство на лекарства с приложениепри лечение на състояния, в които са посредници тахикинините
EP0464604B1 (en) 1-Indolylalkyl-4-(alkoxy-pyrimidinyl)piperazines
JP2000512296A (ja) セロトニン再取込み阻害
US20070185078A1 (en) Substituted triazole derivatives as oxytocin antagonists
EP0319429B1 (en) 9-Acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
CA2354606C (en) Azabicycloalkane derivatives and therapeutic uses thereof
JPH10510536A (ja) ２−置換された１，２，５−チアジアゾリジン−３−オン１，１−ジオキシド及びそれらの組成物
US20230056365A1 (en) PROCESS FOR MAKING CRYSTALLINE 2-(3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-1-(CYCLOPROPYLSULFONYL)AZETIDIN-3-YL)ACETONITRILE
JPH04261157A (ja) 置換−４−アミノ−３−ピリジノール、その製造法および医薬としてのその使用
EP0612730A1 (en) O-aryl ethers of morphinans
CA1266270A (en) Imidazolidinedione derivatives
US6255322B1 (en) 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
JPH037280A (ja) 新規ベンゾチオピラニルアミン
JP2956788B2 (ja) スピロイソインドリン化合物、その製造方法、それを含有する神経症を治療するための医薬およびそれを製造するための中間体
JPH07133274A (ja) ピロール誘導体
EP0639568A1 (en) Piperidine compounds, their preparation and use in the treatment of neurodegenerative disorders
JP2000026297A (ja) 緑内障および虚血性網膜症の治療方法
KR20030036834A (ko) 5-페닐벤질아민 화합물, 그의 제법 및 그의 합성 중간체
US5512566A (en) Tricyclic compounds having affinity for the 5-HT1A receptor
JPH10510534A (ja) ２−（２，３，５，６−テトラフルオロ−４−ピリジル）−１，２，５−チアジアゾリジン−３−オン＝１，１−ジオキシド並びにその組成物及び使用方法

Legal Events

Date Code Title Description
FA9A Application withdrawn section 33(1)