IE910745A1 - Glycinamide derivatives, their preparation, pharmaceutical¹compositions containing them, and their use - Google Patents
Glycinamide derivatives, their preparation, pharmaceutical¹compositions containing them, and their useInfo
- Publication number
- IE910745A1 IE910745A1 IE074591A IE74591A IE910745A1 IE 910745 A1 IE910745 A1 IE 910745A1 IE 074591 A IE074591 A IE 074591A IE 74591 A IE74591 A IE 74591A IE 910745 A1 IE910745 A1 IE 910745A1
- Authority
- IE
- Ireland
- Prior art keywords
- quinolyl
- alk
- radical
- tert
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9002890A FR2659324B1 (fr) | 1990-03-07 | 1990-03-07 | N-heterocyclyl glycinamides, leur preparation et les medicaments les contenant. |
FR9003838A FR2659966B1 (fr) | 1990-03-26 | 1990-03-26 | Derives de n-aralkyl glycinamide, leur preparation et les medicaments les contenant. |
FR9011651A FR2667066B2 (fr) | 1990-03-07 | 1990-09-21 | N-heterocyclyl glycinamides, leur preparation et les medicaments les contenant. |
Publications (1)
Publication Number | Publication Date |
---|---|
IE910745A1 true IE910745A1 (en) | 1991-09-11 |
Family
ID=27252167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE074591A IE910745A1 (en) | 1990-03-07 | 1991-03-06 | Glycinamide derivatives, their preparation, pharmaceutical¹compositions containing them, and their use |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0518961A1 (de) |
JP (1) | JPH05504968A (de) |
AU (1) | AU650261B2 (de) |
CA (1) | CA2074357A1 (de) |
HU (1) | HU210581B (de) |
IE (1) | IE910745A1 (de) |
IL (1) | IL97475A0 (de) |
NZ (1) | NZ237339A (de) |
PT (1) | PT96970A (de) |
WO (1) | WO1991013874A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696475B2 (en) | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
US6706749B2 (en) | 1998-10-22 | 2004-03-16 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658518B1 (fr) * | 1990-02-19 | 1992-04-30 | Rhone Poulenc Sante | N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant. |
FR2695641B1 (fr) * | 1992-09-11 | 1994-11-25 | Rhone Poulenc Rorer Sa | (Amino-3 phényl)-1 éthanesulfonate d'hydroquinine optiquement actif, sa préparation et son utilisation. |
CA2183731C (en) * | 1994-02-22 | 2000-03-21 | Alan J. Bitonti | Novel indole derivatives useful to treat estrogen-related neoplasms and disorders |
FR2723739B1 (fr) * | 1994-08-19 | 1997-02-14 | Sanofi Sa | Derives de glycinamide, procedes pour leur preparation et medicaments les contenant. |
DK0832065T3 (da) * | 1995-06-06 | 2001-11-19 | Pfizer | Substituerede N-(indol-2-carbonyl)glycinamider og derivater som glycogenphosphorylaseinhibitorer |
KR100241643B1 (ko) | 1995-06-06 | 2000-03-02 | 디. 제이. 우드 | 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체 |
SK72096A3 (en) | 1995-06-06 | 1997-11-05 | Pfizer | Indole-2-carboxamides, glycogen phosphorylase inhibitors and pharmauceutical compositions |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
US7074805B2 (en) | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
ES2319886T3 (es) * | 2002-02-20 | 2009-05-14 | Abbott Laboratories | Compuestos azabiciclicos condensados que inhiben el sutipo 1 del receptor valinoide (vr1). |
US6933311B2 (en) | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
TW200824687A (en) | 2006-08-25 | 2008-06-16 | Abbott Lab | Compounds that inhibit TRPV1 and uses thereof |
CN101563318A (zh) | 2006-12-20 | 2009-10-21 | 艾博特公司 | 作为trpv1香草素受体拮抗剂用于治疗疼痛的n-(5,6,7,8-四氢萘-1-基)脲衍生物以及相关化合物 |
CA2719018A1 (en) | 2008-03-20 | 2009-09-24 | Abbott Laboratories | Methods for making central nervous system agents that are trpv1 antagonists |
CN114181133B (zh) * | 2021-11-24 | 2023-04-28 | 上海应用技术大学 | 一种甘氨酸衍生乙酰胺化合物的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0166355A2 (de) * | 1984-06-26 | 1986-01-02 | Merck & Co. Inc. | Substituierte Aminophenyl- und Acylaminophenyl-Verbindungen und deren pharmazeutische Zusammensetzungen |
US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
FR2624698A1 (fr) * | 1987-12-18 | 1989-06-23 | Bernard Lyon I Universite Clau | Derives heterocycliques de n-carbamoyl-, n-thiocarbamoyl- ou n-amidino-aminomalonyl ou aminosuccinyl amides utiles comme agents edulcorants |
EP0336356A3 (de) * | 1988-04-05 | 1991-09-25 | Abbott Laboratories | Tryptophan-Derivate, verwendbar als CCK-Gegner |
CA1326108C (en) * | 1988-04-12 | 1994-01-11 | Sun Hyuk Kim | Cck antagonists |
FR2658518B1 (fr) * | 1990-02-19 | 1992-04-30 | Rhone Poulenc Sante | N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant. |
FR2667864B2 (fr) * | 1990-03-07 | 1994-08-05 | Rhone Poulenc Sante | Derives de n-phenyl glycinamides, leur preparation et les medicaments les contenant. |
-
1991
- 1991-03-05 JP JP3505782A patent/JPH05504968A/ja active Pending
- 1991-03-05 AU AU74541/91A patent/AU650261B2/en not_active Ceased
- 1991-03-05 EP EP91905834A patent/EP0518961A1/de not_active Withdrawn
- 1991-03-05 HU HU9202864A patent/HU210581B/hu not_active IP Right Cessation
- 1991-03-05 WO PCT/FR1991/000175 patent/WO1991013874A1/fr not_active Application Discontinuation
- 1991-03-05 CA CA002074357A patent/CA2074357A1/fr not_active Abandoned
- 1991-03-06 IE IE074591A patent/IE910745A1/en unknown
- 1991-03-06 NZ NZ237339A patent/NZ237339A/en unknown
- 1991-03-07 PT PT96970A patent/PT96970A/pt not_active Application Discontinuation
- 1991-03-07 IL IL97475A patent/IL97475A0/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696475B2 (en) | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
US6706749B2 (en) | 1998-10-22 | 2004-03-16 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
Also Published As
Publication number | Publication date |
---|---|
HU210581B (en) | 1995-05-29 |
JPH05504968A (ja) | 1993-07-29 |
HUT61731A (en) | 1993-03-01 |
WO1991013874A1 (fr) | 1991-09-19 |
AU650261B2 (en) | 1994-06-16 |
CA2074357A1 (fr) | 1991-09-08 |
IL97475A0 (en) | 1992-06-21 |
AU7454191A (en) | 1991-10-10 |
EP0518961A1 (de) | 1992-12-23 |
HU9202864D0 (en) | 1992-11-30 |
NZ237339A (en) | 1992-10-28 |
PT96970A (pt) | 1991-10-31 |
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