CA2074357A1 - Derives de glycinamide, leur preparation et les medicaments les contenant - Google Patents

Derives de glycinamide, leur preparation et les medicaments les contenant

Info

Publication number
CA2074357A1
CA2074357A1 CA002074357A CA2074357A CA2074357A1 CA 2074357 A1 CA2074357 A1 CA 2074357A1 CA 002074357 A CA002074357 A CA 002074357A CA 2074357 A CA2074357 A CA 2074357A CA 2074357 A1 CA2074357 A1 CA 2074357A1
Authority
CA
Canada
Prior art keywords
alk
alkyl
phenyl
tert
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002074357A
Other languages
English (en)
French (fr)
Inventor
Jean-Dominique Bourzat
Marc Capet
Claude Cotrel
Claude Guyon
Franco Manfre
Gerard Roussel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9002890A external-priority patent/FR2659324B1/fr
Priority claimed from FR9003838A external-priority patent/FR2659966B1/fr
Priority claimed from FR9011651A external-priority patent/FR2667066B2/fr
Application filed by Individual filed Critical Individual
Publication of CA2074357A1 publication Critical patent/CA2074357A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002074357A 1990-03-07 1991-03-05 Derives de glycinamide, leur preparation et les medicaments les contenant Abandoned CA2074357A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
FR9002890A FR2659324B1 (fr) 1990-03-07 1990-03-07 N-heterocyclyl glycinamides, leur preparation et les medicaments les contenant.
FR90/02890 1990-03-07
FR9003838A FR2659966B1 (fr) 1990-03-26 1990-03-26 Derives de n-aralkyl glycinamide, leur preparation et les medicaments les contenant.
FR90/03838 1990-03-26
FR90/11651 1990-09-21
FR9011651A FR2667066B2 (fr) 1990-03-07 1990-09-21 N-heterocyclyl glycinamides, leur preparation et les medicaments les contenant.
PCT/FR1991/000175 WO1991013874A1 (fr) 1990-03-07 1991-03-05 Derives de glycinamide, leur preparation et les medicaments les contenant

Publications (1)

Publication Number Publication Date
CA2074357A1 true CA2074357A1 (fr) 1991-09-08

Family

ID=27252167

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002074357A Abandoned CA2074357A1 (fr) 1990-03-07 1991-03-05 Derives de glycinamide, leur preparation et les medicaments les contenant

Country Status (10)

Country Link
EP (1) EP0518961A1 (de)
JP (1) JPH05504968A (de)
AU (1) AU650261B2 (de)
CA (1) CA2074357A1 (de)
HU (1) HU210581B (de)
IE (1) IE910745A1 (de)
IL (1) IL97475A0 (de)
NZ (1) NZ237339A (de)
PT (1) PT96970A (de)
WO (1) WO1991013874A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658518B1 (fr) * 1990-02-19 1992-04-30 Rhone Poulenc Sante N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant.
FR2695641B1 (fr) * 1992-09-11 1994-11-25 Rhone Poulenc Rorer Sa (Amino-3 phényl)-1 éthanesulfonate d'hydroquinine optiquement actif, sa préparation et son utilisation.
JP3536258B2 (ja) * 1994-02-22 2004-06-07 メレルファーマスーティカルズ インコーポレイテッド エストロゲンに関連する新生物及び病気の処置に有用な新規なインドール誘導体類
FR2723739B1 (fr) * 1994-08-19 1997-02-14 Sanofi Sa Derives de glycinamide, procedes pour leur preparation et medicaments les contenant.
MX9709875A (es) * 1995-06-06 1998-03-31 Pfizer N-(indol-2-carbonil)-glicinamidas substituidas y derivados como inhibidores de glicogeno fosforilasa, composiciones que las contienen y uso de las mismas.
ATE205477T1 (de) 1995-06-06 2001-09-15 Pfizer Substituierte n-(indol-2-carbonyl)-amide und derivate als glycogen phosphorylase inhibitoren
MY114711A (en) 1995-06-06 2002-12-31 Pfizer Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents
US6696475B2 (en) 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
NZ510098A (en) 1998-10-22 2003-09-26 Neurosearch As Substituted phenyl derivatives, pharmaceuticals thereof and their use as blockers of the chloride channel
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
ATE420644T1 (de) * 2002-02-20 2009-01-15 Abbott Lab Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1)
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
CN101541758A (zh) 2006-08-25 2009-09-23 艾博特公司 抑制trpv1的吲唑衍生物及其用途
MX2009006730A (es) 2006-12-20 2009-06-30 Abbott Lab Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor.
JP2011515414A (ja) 2008-03-20 2011-05-19 アボット・ラボラトリーズ Ｔｒｐｖ１アンタゴニストである中枢神経系薬剤を作製する方法
CN114181133B (zh) * 2021-11-24 2023-04-28 上海应用技术大学 一种甘氨酸衍生乙酰胺化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166355A2 (de) * 1984-06-26 1986-01-02 Merck & Co. Inc. Substituierte Aminophenyl- und Acylaminophenyl-Verbindungen und deren pharmazeutische Zusammensetzungen
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
FR2624698A1 (fr) * 1987-12-18 1989-06-23 Bernard Lyon I Universite Clau Derives heterocycliques de n-carbamoyl-, n-thiocarbamoyl- ou n-amidino-aminomalonyl ou aminosuccinyl amides utiles comme agents edulcorants
JPH03503650A (ja) * 1988-04-05 1991-08-15 アボツト・ラボラトリーズ Ｃｃｋアンタゴニストとしてのトリプトファン誘導体
CA1326108C (en) * 1988-04-12 1994-01-11 Sun Hyuk Kim Cck antagonists
FR2658518B1 (fr) * 1990-02-19 1992-04-30 Rhone Poulenc Sante N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant.
FR2667864B2 (fr) * 1990-03-07 1994-08-05 Rhone Poulenc Sante Derives de n-phenyl glycinamides, leur preparation et les medicaments les contenant.

Also Published As

Publication number Publication date
IE910745A1 (en) 1991-09-11
PT96970A (pt) 1991-10-31
JPH05504968A (ja) 1993-07-29
EP0518961A1 (de) 1992-12-23
IL97475A0 (en) 1992-06-21
NZ237339A (en) 1992-10-28
HU9202864D0 (en) 1992-11-30
HU210581B (en) 1995-05-29
AU7454191A (en) 1991-10-10
WO1991013874A1 (fr) 1991-09-19
HUT61731A (en) 1993-03-01
AU650261B2 (en) 1994-06-16

Similar Documents

Publication Publication Date Title
CA2074357A1 (fr) Derives de glycinamide, leur preparation et les medicaments les contenant
FR2678938A1 (fr) Derives de pyrrolidine, leur preparation et les medicaments les contenant.
CA2152184A1 (fr) Derives de thiazolidine, leur preparation et les medicaments les contenant
EP0514442B1 (de) N-phenyl-n-acetamidoglycinamide, ihre herstellung und medikamente, die sie enthalten
EP0611766A1 (de) Polysubstituierte 2-Amidothiazole-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Zusammenstellungen die sie enthalten und ihre Anwendung für die Bereitung eines Arzneimittels
CA2074375A1 (fr) Derives de n-phenyl glycinamide, leur preparation et les medicaments les contenant
EP0766696A1 (de) Thiazolidinderivate, ihre herstellung und medikamente, die sie enthalten
WO2007068815A2 (fr) Derives heterocycliques, leur preparation et leur application en therapeutique.
CA1250286A (fr) Procede pour la preparation de derives ortho- condenses du pyrrole et les derives ainsi obtenus
EP0397556B1 (de) N-Phenylamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP0520016B1 (de) Harnstoffderivate, ihre herstellung und deren enthaltende arzneimittel
EP0374041A1 (de) 2-Benzothiazolamin-Derivate enthaltende Arzneimittel, Verbindungen und ihre Herstellung
FR2662695A1 (fr) Amino-2 polyfluoroalcoxy-6 benzoselenazoles, leur preparation et les medicaments les contenant.
EP0375510B1 (de) 2-Imino-6-polyfluoralkoxy-benzothiazol-Derivate, Verfahren zu deren Herstellung und Arzneimittel, die sie enthalten
EP2234966B1 (de) Azetidinderivate, ihre herstellung und ihre therapeutische anwendung
WO1994015915A1 (fr) N-acyl pyrrolidines et des medicaments pour le traitement ou la prevention des desordres lies a la ckk et la gastrine
EP0516729B1 (de) N-phenyl-n-alkoxycarbonylalkyl-glycinamide, ihre herstellung und sie enthaltende medikamente
FR2640624A1 (fr) Medicaments a base de derives de la benzothiazolamine-2, nouveaux derives et leur preparation
EP1299103B1 (de) 4,5-dihydro-2-thiazolylaminderivate und ihre verwendung als no-synthase inhibitoren
FR2659334A1 (fr) Derives de n-phenyl glycinamide, leur preparation et les medicaments les contenant.
FR2659966A1 (fr) Derives de n-aralkyl glycinamide, leur preparation et les medicaments les contenant.
FR2649703A1 (fr) Derives d'imino-2 polyfluoroalcoxy-6 benzothiazole, leurs procedes de preparation et les medicaments les contenant
FR2721314A1 (fr) Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2658196A1 (fr) N-phenyl n-acetamido glycinamides leur preparation et les medicaments les contenant.
FR2667863A2 (fr) N-phenyl n-acetamido glycinamides, leur preparation et les medicaments les contenant.

Legal Events

Date Code Title Description
FZDE Discontinued