IE851484L - N-methyl-methylthio-2-nitroethenamine - Google Patents

N-methyl-methylthio-2-nitroethenamine

Info

Publication number
IE851484L
IE851484L IE851484A IE148485A IE851484L IE 851484 L IE851484 L IE 851484L IE 851484 A IE851484 A IE 851484A IE 148485 A IE148485 A IE 148485A IE 851484 L IE851484 L IE 851484L
Authority
IE
Ireland
Prior art keywords
reaction
formula
nitromethane
compound
methyl
Prior art date
Application number
IE851484A
Other versions
IE58606B1 (en
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IE851484L publication Critical patent/IE851484L/en
Publication of IE58606B1 publication Critical patent/IE58606B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Catalysts (AREA)
  • Electromechanical Clocks (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula (II> <IMAGE> in which R1 is C1-4 alkyl, preferably methyl, are prepared by reaction of a compound of formula (I> <IMAGE> where Q is hydrogen or a cation derived from a suitable base with a suitable alkylating agent such as an alkyl halide or a dialkyl sulphate. The compound of formula (II) may be converted into a histamine H2-antagonist containing an -NHC(=CHNO2)NHCH3 end group, e.g. ranitidine, by reaction with an appropriate amine. The compound of formula (I) (compounds where Q is H or alkali metal are said to be novel) may be prepared by reaction of methyl isothiocyanate with the carbanion of nitromethane (preferably generated in situ by reaction of nitromethane with a suitable base) in the presence of dimethyl sulphoxide as solvent, Q representing the cation derived from the base used to produce the carbanion of nitromethane. [GB2160204A]
IE148485A 1984-06-15 1985-06-14 Preparation of amine derivatives IE58606B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848415254A GB8415254D0 (en) 1984-06-15 1984-06-15 Amine derivatives

Publications (2)

Publication Number Publication Date
IE851484L true IE851484L (en) 1986-01-15
IE58606B1 IE58606B1 (en) 1993-10-20

Family

ID=10562466

Family Applications (1)

Application Number Title Priority Date Filing Date
IE148485A IE58606B1 (en) 1984-06-15 1985-06-14 Preparation of amine derivatives

Country Status (22)

Country Link
JP (2) JPH0643382B2 (en)
KR (1) KR870002019B1 (en)
AT (1) AT395974B (en)
BE (1) BE902655A (en)
CA (1) CA1256454A (en)
CH (1) CH667871A5 (en)
DE (1) DE3521456A1 (en)
DK (1) DK170067B1 (en)
ES (1) ES8705359A1 (en)
FI (1) FI82239C (en)
FR (1) FR2565972B1 (en)
GB (2) GB8415254D0 (en)
HU (1) HU198179B (en)
IE (1) IE58606B1 (en)
IL (1) IL75523A (en)
IT (1) IT1209960B (en)
NL (1) NL8501727A (en)
NO (1) NO162461C (en)
PT (1) PT80643B (en)
SE (1) SE462913B (en)
SG (1) SG92590G (en)
ZA (1) ZA854502B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8907700D0 (en) * 1989-04-05 1989-05-17 Fine Organics Ltd Preparation of substituted ethenes
DE68910308D1 (en) * 1989-05-10 1993-12-02 Council Scient Ind Res Process for the preparation of 1-amino-substituted 1-thio-substituted 2-nitro alkenes.
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
YU52598A (en) * 1998-11-19 2001-05-28 D.D. Zdravlje- sektor za istraživanje i razvoj Procedure for synthesis of n-[2[[[5-[ (dialkylamino)methyl] -2-furanil]methyl]thi0]etyl]-n'-alkyl-2-nitro 1,1 alkendiamine and its hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1554153A (en) * 1975-05-15 1979-10-17 Smith Kline French Lab Process for making 2-amino-2-alkylthionitroethylenes
GB1565966A (en) 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives

Also Published As

Publication number Publication date
DK270585A (en) 1985-12-16
DE3521456A1 (en) 1986-01-09
IT8548213A0 (en) 1985-06-13
JPH06102656B2 (en) 1994-12-14
JPH06211824A (en) 1994-08-02
SE8502973D0 (en) 1985-06-14
FI852366L (en) 1985-12-16
FI82239B (en) 1990-10-31
FR2565972A1 (en) 1985-12-20
IT1209960B (en) 1989-08-30
NL194440C (en) 2002-04-04
NL194440B (en) 2001-12-03
HUT38305A (en) 1986-05-28
NO162461C (en) 1990-01-03
GB8415254D0 (en) 1984-07-18
ES544214A0 (en) 1987-05-01
PT80643A (en) 1985-07-01
PT80643B (en) 1987-11-30
DK270585D0 (en) 1985-06-14
ATA178085A (en) 1992-09-15
NO162461B (en) 1989-09-25
GB2160204A (en) 1985-12-18
JPH0643382B2 (en) 1994-06-08
HU198179B (en) 1989-08-28
CH667871A5 (en) 1988-11-15
JPS6117557A (en) 1986-01-25
GB8515195D0 (en) 1985-07-17
ES8705359A1 (en) 1987-05-01
ZA854502B (en) 1986-02-26
SE462913B (en) 1990-09-17
CA1256454A (en) 1989-06-27
AT395974B (en) 1993-04-26
FI852366A0 (en) 1985-06-14
SG92590G (en) 1991-01-18
FI82239C (en) 1991-02-11
DK170067B1 (en) 1995-05-15
KR870002019B1 (en) 1987-11-30
IL75523A (en) 1990-12-23
KR860000255A (en) 1986-01-27
IL75523A0 (en) 1985-10-31
NO852418L (en) 1985-12-16
GB2160204B (en) 1988-09-01
NL8501727A (en) 1986-01-02
IE58606B1 (en) 1993-10-20
BE902655A (en) 1985-12-16
SE8502973L (en) 1985-12-16
DE3521456C2 (en) 1993-04-29
FR2565972B1 (en) 1989-05-19

Similar Documents

Publication Publication Date Title
ES2005745A6 (en) Process for the preparation of aryl-piperidine carbinols.
KR860003215A (en) Method for preparing 4-phenylpyrrole derivative
IE810210L (en) Preparing proline derivatives.
DK557281A (en) PROCEDURE FOR INTRODUCING ALCOXY AND ARALKYLOXY GROUPS IN ORGANIC COMPOUNDS
IE851484L (en) N-methyl-methylthio-2-nitroethenamine
ATE720T1 (en) NEW PROSTAGLAND INDIVIDUALS OF THE DELTA-2,4-11-DESOXY-PGE SERIES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS.
US3406202A (en) Preparation of aniline thioethers
EP0055626B1 (en) Process for the preparation of a furan derivative
ES8307236A1 (en) Process for the preparation of a furan derivative.
JPS5622761A (en) Novel 2,2&#39;-bis(4-cumylphenol)derivative
EP0094612A3 (en) Novel alkyloxazolylacetic acid derivative, processes for preparation and pharmaceutical compositions containing same
ES485801A1 (en) Process for preparing cyclo-1,3,2-oxazaphosphoryl derivatives
US4256663A (en) 19-Hydroxy-19-methyl-6a-carba-PGI2 amides
JPS5762252A (en) Preparation of aromatic thiol
GB2002350A (en) Preparation of tetramisole intermediate
JPS56135443A (en) Preparation of phenol
JPS56147769A (en) Preparation of n-substituted piperidinol derivative
JPS5782374A (en) Preparation of pyrazole derivative
JPS5448743A (en) Preparation of benzoin ether
JPS552621A (en) Preparation of n-alkyl-benzoxa(or thia)zolone derivative
JPS57209255A (en) Amino derivative of cyclopentenone
JPS5461153A (en) Inositolsulfate ammonium salt and its preparation
JPS5748969A (en) Preparation of 1-alkyl-3-methylpyrazole type compound
IE822733L (en) m-HYDROXYPHENYL SUBSTITUTED COMPOUNDS
JPS57102856A (en) Preparation of oxime compound

Legal Events

Date Code Title Description
MM4A Patent lapsed