ATE720T1 - NEW PROSTAGLAND INDIVIDUALS OF THE DELTA-2,4-11-DESOXY-PGE SERIES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS. - Google Patents

NEW PROSTAGLAND INDIVIDUALS OF THE DELTA-2,4-11-DESOXY-PGE SERIES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS.

Info

Publication number
ATE720T1
ATE720T1 AT79102292T AT79102292T ATE720T1 AT E720 T1 ATE720 T1 AT E720T1 AT 79102292 T AT79102292 T AT 79102292T AT 79102292 T AT79102292 T AT 79102292T AT E720 T1 ATE720 T1 AT E720T1
Authority
AT
Austria
Prior art keywords
prostagland
desoxy
pharmaceuticals
individuals
delta
Prior art date
Application number
AT79102292T
Other languages
German (de)
Inventor
Wilhelm Dr. Bartmann
Gerhard Dr. Beck
Ulrich Dr. Lerch
Martin Dr. Bickel
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Application granted granted Critical
Publication of ATE720T1 publication Critical patent/ATE720T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5428—Acyclic unsaturated phosphonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

The present invention relates to novel prostaglandin derivatives of the formula I <IMAGE> I which are structurally related to the naturally occurring prostaglandins and in which R1 denotes (a) hydrogen or a straight-chain or branched, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon radical having up to ten carbon atoms or (b) a physiologically acceptable metal or NH4 ion or an ammonium ion which is derived from a primary, secondary or tertiary amine and R2 denotes a straight-chain, aliphatic hydrocarbon radical having up to six carbon atoms and to a process for their manufacture. The compounds of the invention are distinguished in particular by gastric acid secretion-inhibiting and ulcer-protective properties.
AT79102292T 1978-07-08 1979-07-05 NEW PROSTAGLAND INDIVIDUALS OF THE DELTA-2,4-11-DESOXY-PGE SERIES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS. ATE720T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782830079 DE2830079A1 (en) 1978-07-08 1978-07-08 NEW PROSTAGLAND DERIVATIVES OF THE DELTA 2.4-11 DESOXY-PGE SERIES
EP79102292A EP0007490B1 (en) 1978-07-08 1979-07-05 Prostaglandin compounds with a delta-2,4-11 deoxy pge structure, a process for their preparation, and their use as medicaments

Publications (1)

Publication Number Publication Date
ATE720T1 true ATE720T1 (en) 1982-03-15

Family

ID=6043884

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79102292T ATE720T1 (en) 1978-07-08 1979-07-05 NEW PROSTAGLAND INDIVIDUALS OF THE DELTA-2,4-11-DESOXY-PGE SERIES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS.

Country Status (10)

Country Link
US (1) US4258057A (en)
EP (1) EP0007490B1 (en)
JP (1) JPS5536470A (en)
AT (1) ATE720T1 (en)
AU (1) AU531714B2 (en)
CA (1) CA1156226A (en)
DE (2) DE2830079A1 (en)
ES (1) ES482128A1 (en)
IL (1) IL57738A (en)
ZA (1) ZA793388B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552898A (en) * 1982-07-14 1985-11-12 Syntex (U.S.A.) Inc. [3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties
JPS63131366U (en) * 1987-02-20 1988-08-26
IN167720B (en) * 1987-10-02 1990-12-08 Tsuneyoshi Kawate
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) * 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) * 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US20030108512A1 (en) * 2001-12-10 2003-06-12 Robert Shorr Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
WO2003099272A1 (en) * 2002-05-22 2003-12-04 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
JP2006508986A (en) * 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー Treatment of lung cells with histone deacetylase inhibitors
CA2587013A1 (en) * 2004-11-08 2006-05-18 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1414383A (en) * 1972-11-14 1975-11-19 Syntex Corp Prostatrienoic acid derivatives and process
DE2460285A1 (en) * 1973-12-25 1975-07-03 Ono Pharmaceutical Co TRANS-DELTA HIGH 2-PROSTAGLAND COMPOUNDS, PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE
US4098815A (en) * 1974-02-15 1978-07-04 Hoechst Aktiengesellschaft Novel analogues of prostanoic acids not occurring in nature
US4165437A (en) * 1976-03-12 1979-08-21 Ono Pharmaceutical Company, Ltd. Δ3 -Prostaglandin analogs
US4061670A (en) * 1976-07-19 1977-12-06 American Cyanamid Company 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners

Also Published As

Publication number Publication date
IL57738A0 (en) 1979-11-30
US4258057A (en) 1981-03-24
CA1156226A (en) 1983-11-01
EP0007490B1 (en) 1982-02-24
EP0007490A2 (en) 1980-02-06
AU531714B2 (en) 1983-09-01
DE2830079A1 (en) 1980-01-17
ZA793388B (en) 1980-06-25
IL57738A (en) 1983-05-15
AU4871479A (en) 1980-01-17
EP0007490A3 (en) 1980-05-14
DE2962192D1 (en) 1982-03-25
JPS5536470A (en) 1980-03-14
ES482128A1 (en) 1980-08-16

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee
REN Ceased due to non-payment of the annual fee