SE8502973D0 - PREPARATION OF AMINE DERIVATIVES - Google Patents

PREPARATION OF AMINE DERIVATIVES

Info

Publication number
SE8502973D0
SE8502973D0 SE8502973A SE8502973A SE8502973D0 SE 8502973 D0 SE8502973 D0 SE 8502973D0 SE 8502973 A SE8502973 A SE 8502973A SE 8502973 A SE8502973 A SE 8502973A SE 8502973 D0 SE8502973 D0 SE 8502973D0
Authority
SE
Sweden
Prior art keywords
reaction
formula
nitromethane
compound
carbanion
Prior art date
Application number
SE8502973A
Other languages
Swedish (sv)
Other versions
SE462913B (en
SE8502973L (en
Inventor
J F Seager
R Dansey
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SE8502973D0 publication Critical patent/SE8502973D0/en
Publication of SE8502973L publication Critical patent/SE8502973L/en
Publication of SE462913B publication Critical patent/SE462913B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Catalysts (AREA)
  • Electromechanical Clocks (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula (II> <IMAGE> in which R1 is C1-4 alkyl, preferably methyl, are prepared by reaction of a compound of formula (I> <IMAGE> where Q is hydrogen or a cation derived from a suitable base with a suitable alkylating agent such as an alkyl halide or a dialkyl sulphate. The compound of formula (II) may be converted into a histamine H2-antagonist containing an -NHC(=CHNO2)NHCH3 end group, e.g. ranitidine, by reaction with an appropriate amine. The compound of formula (I) (compounds where Q is H or alkali metal are said to be novel) may be prepared by reaction of methyl isothiocyanate with the carbanion of nitromethane (preferably generated in situ by reaction of nitromethane with a suitable base) in the presence of dimethyl sulphoxide as solvent, Q representing the cation derived from the base used to produce the carbanion of nitromethane.
SE8502973A 1984-06-15 1985-06-14 PROCEDURE FOR PREPARING AMINERIVATE AND USING THEREOF FOR PREPARATION OF HISTAMIN-H? 712 ANTAGONIST RANITIDIN SE462913B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848415254A GB8415254D0 (en) 1984-06-15 1984-06-15 Amine derivatives

Publications (3)

Publication Number Publication Date
SE8502973D0 true SE8502973D0 (en) 1985-06-14
SE8502973L SE8502973L (en) 1985-12-16
SE462913B SE462913B (en) 1990-09-17

Family

ID=10562466

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8502973A SE462913B (en) 1984-06-15 1985-06-14 PROCEDURE FOR PREPARING AMINERIVATE AND USING THEREOF FOR PREPARATION OF HISTAMIN-H? 712 ANTAGONIST RANITIDIN

Country Status (22)

Country Link
JP (2) JPH0643382B2 (en)
KR (1) KR870002019B1 (en)
AT (1) AT395974B (en)
BE (1) BE902655A (en)
CA (1) CA1256454A (en)
CH (1) CH667871A5 (en)
DE (1) DE3521456A1 (en)
DK (1) DK170067B1 (en)
ES (1) ES8705359A1 (en)
FI (1) FI82239C (en)
FR (1) FR2565972B1 (en)
GB (2) GB8415254D0 (en)
HU (1) HU198179B (en)
IE (1) IE58606B1 (en)
IL (1) IL75523A (en)
IT (1) IT1209960B (en)
NL (1) NL8501727A (en)
NO (1) NO162461C (en)
PT (1) PT80643B (en)
SE (1) SE462913B (en)
SG (1) SG92590G (en)
ZA (1) ZA854502B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU9203905D0 (en) * 1989-04-05 1993-04-28 Glaxo Group Ltd Method for producing ranitidine
EP0396830B1 (en) * 1989-05-10 1993-10-27 Council of Scientific and Industrial Research An improved process for the preparation of 1-substituted amino-1-substituted thio-2-nitro alkenes
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
YU52598A (en) * 1998-11-19 2001-05-28 D.D. Zdravlje- sektor za istraživanje i razvoj Procedure for synthesis of n-[2[[[5-[ (dialkylamino)methyl] -2-furanil]methyl]thi0]etyl]-n'-alkyl-2-nitro 1,1 alkendiamine and its hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1554153A (en) * 1975-05-15 1979-10-17 Smith Kline French Lab Process for making 2-amino-2-alkylthionitroethylenes
GB1565966A (en) 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives

Also Published As

Publication number Publication date
JPH0643382B2 (en) 1994-06-08
SE462913B (en) 1990-09-17
BE902655A (en) 1985-12-16
PT80643B (en) 1987-11-30
IL75523A (en) 1990-12-23
NL194440B (en) 2001-12-03
JPH06211824A (en) 1994-08-02
IE851484L (en) 1986-01-15
JPS6117557A (en) 1986-01-25
ES8705359A1 (en) 1987-05-01
CH667871A5 (en) 1988-11-15
FI82239B (en) 1990-10-31
FR2565972A1 (en) 1985-12-20
DK270585D0 (en) 1985-06-14
IE58606B1 (en) 1993-10-20
NO852418L (en) 1985-12-16
IT8548213A0 (en) 1985-06-13
SE8502973L (en) 1985-12-16
FR2565972B1 (en) 1989-05-19
ZA854502B (en) 1986-02-26
ES544214A0 (en) 1987-05-01
GB2160204A (en) 1985-12-18
HU198179B (en) 1989-08-28
KR860000255A (en) 1986-01-27
NL8501727A (en) 1986-01-02
DE3521456C2 (en) 1993-04-29
PT80643A (en) 1985-07-01
AT395974B (en) 1993-04-26
ATA178085A (en) 1992-09-15
CA1256454A (en) 1989-06-27
IT1209960B (en) 1989-08-30
KR870002019B1 (en) 1987-11-30
NO162461C (en) 1990-01-03
NO162461B (en) 1989-09-25
GB2160204B (en) 1988-09-01
DK170067B1 (en) 1995-05-15
DE3521456A1 (en) 1986-01-09
SG92590G (en) 1991-01-18
IL75523A0 (en) 1985-10-31
JPH06102656B2 (en) 1994-12-14
FI852366A0 (en) 1985-06-14
HUT38305A (en) 1986-05-28
NL194440C (en) 2002-04-04
GB8515195D0 (en) 1985-07-17
FI82239C (en) 1991-02-11
GB8415254D0 (en) 1984-07-18
DK270585A (en) 1985-12-16
FI852366L (en) 1985-12-16

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