IE37511B1 - Dopamine derivatives - Google Patents
Dopamine derivativesInfo
- Publication number
- IE37511B1 IE37511B1 IE563/73A IE56373A IE37511B1 IE 37511 B1 IE37511 B1 IE 37511B1 IE 563/73 A IE563/73 A IE 563/73A IE 56373 A IE56373 A IE 56373A IE 37511 B1 IE37511 B1 IE 37511B1
- Authority
- IE
- Ireland
- Prior art keywords
- methoxylated
- prepared
- hydrogen
- compounds
- methyl
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- UMYZWICEDUEWIM-UHFFFAOYSA-N 1-(3,4-dimethoxyphenyl)propan-2-one Chemical compound COC1=CC=C(CC(C)=O)C=C1OC UMYZWICEDUEWIM-UHFFFAOYSA-N 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- ANOUKFYBOAKOIR-UHFFFAOYSA-N 3,4-dimethoxyphenylethylamine Chemical compound COC1=CC=C(CCN)C=C1OC ANOUKFYBOAKOIR-UHFFFAOYSA-N 0.000 abstract 2
- LYUQWQRTDLVQGA-UHFFFAOYSA-N 3-phenylpropylamine Chemical class NCCCC1=CC=CC=C1 LYUQWQRTDLVQGA-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract 2
- WUAXWQRULBZETB-UHFFFAOYSA-N homoveratric acid Chemical compound COC1=CC=C(CC(O)=O)C=C1OC WUAXWQRULBZETB-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000005932 reductive alkylation reaction Methods 0.000 abstract 2
- 230000002829 reductive effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 2
- KWTSXDURSIMDCE-UHFFFAOYSA-N 1-phenylpropan-2-amine Chemical class CC(N)CC1=CC=CC=C1 KWTSXDURSIMDCE-UHFFFAOYSA-N 0.000 abstract 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- XMZQWZJMTBCUFT-UHFFFAOYSA-N 3-bromopropylbenzene Chemical class BrCCCC1=CC=CC=C1 XMZQWZJMTBCUFT-UHFFFAOYSA-N 0.000 abstract 1
- WECUIGDEWBNQJJ-UHFFFAOYSA-N 4-phenylbutan-2-amine Chemical class CC(N)CCC1=CC=CC=C1 WECUIGDEWBNQJJ-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical class NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- AKGGYBADQZYZPD-UHFFFAOYSA-N benzylacetone Chemical class CC(=O)CCC1=CC=CC=C1 AKGGYBADQZYZPD-UHFFFAOYSA-N 0.000 abstract 1
- 229910000085 borane Inorganic materials 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000005217 methyl ethers Chemical class 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- QCCDLTOVEPVEJK-UHFFFAOYSA-N phenylacetone Chemical class CC(=O)CC1=CC=CC=C1 QCCDLTOVEPVEJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000007925 phenylethylamine derivatives Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24346672A | 1972-04-12 | 1972-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE37511B1 true IE37511B1 (en) | 1977-08-03 |
Family
ID=22918877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE563/73A IE37511B1 (en) | 1972-04-12 | 1973-04-10 | Dopamine derivatives |
Country Status (31)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH585693A5 (enrdf_load_stackoverflow) * | 1974-02-08 | 1977-03-15 | Ciba Geigy Ag | |
| US4342692A (en) * | 1980-10-20 | 1982-08-03 | Usv Pharmaceutical Corporation | Pyrrolidines |
| ZA825227B (en) * | 1981-07-22 | 1984-03-28 | Syntex Inc | Substituted pyrrolidine cardiovascular system regulators antihypertensives |
| JPS6061523A (ja) * | 1983-09-16 | 1985-04-09 | Shionogi & Co Ltd | 経口用ドブタミン製剤 |
| ZA881076B (en) * | 1987-02-24 | 1989-10-25 | Lilly Co Eli | Dobutamine salts |
| JPH0383364U (enrdf_load_stackoverflow) * | 1989-12-18 | 1991-08-23 | ||
| WO1992020645A1 (en) * | 1991-05-20 | 1992-11-26 | Tsumura & Co. | Phellodendrine analogs and allergy type iv suppressor containing the same as active ingredient |
| DE69404063T2 (de) * | 1993-04-13 | 1998-01-22 | Duphar Int Res | Herstellung von Dobutamin Verbindungen |
| EP0620208B1 (en) * | 1993-04-13 | 1997-07-09 | Duphar International Research B.V | Production of dobutamine compounds |
| ES2535975T3 (es) | 2002-10-03 | 2015-05-19 | Novaremed Ltd. | Compuestos para su uso en el tratamiento de enfermedades autoinmunitarias, enfermedades inmunoalérgicas y rechazo de trasplantes de órganos o tejidos |
| AU2005225239B2 (en) * | 2002-10-03 | 2012-06-14 | Novaremed Ltd | Compounds for treating AIDS and other diseases |
| GB0804213D0 (en) | 2008-03-06 | 2008-04-16 | New Era Biotech Ltd | A method of printing or preventing pain |
| EP2458983B1 (en) | 2009-07-31 | 2015-07-08 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| US8802734B2 (en) | 2009-09-09 | 2014-08-12 | Novaremed Limited | Method of treating or preventing pain |
| RU2014111079A (ru) * | 2011-08-25 | 2015-09-27 | Когнишн Терапьютикс, Инк. | Композиции и способы для лечения нейродегенеративного заболевания |
| WO2015116923A1 (en) | 2014-01-31 | 2015-08-06 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
| CN110869011B (zh) | 2017-05-15 | 2024-01-05 | 考格尼申治疗股份有限公司 | 用于治疗神经退行性疾病的组合物 |
| CN114524734B (zh) * | 2021-12-27 | 2024-04-26 | 嘉实（湖南）医药科技有限公司 | 一种盐酸多巴酚丁胺的制备方法 |
| CN117326958B (zh) * | 2023-09-21 | 2025-07-11 | 锦州奥鸿药业有限责任公司 | 一种高纯度盐酸多巴酚丁胺的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2276619A (en) * | 1942-03-17 | N-phentlaliphatic-dihtoroxyphentnl |
-
1973
- 1973-03-28 ZA ZA732136A patent/ZA732136B/xx unknown
- 1973-04-09 DE DE2317710A patent/DE2317710C2/de not_active Expired
- 1973-04-09 CY CY963A patent/CY963A/xx unknown
- 1973-04-09 GB GB1683573A patent/GB1392674A/en not_active Expired
- 1973-04-10 IE IE563/73A patent/IE37511B1/xx unknown
- 1973-04-10 FR FR7312845A patent/FR2182947B1/fr not_active Expired
- 1973-04-10 SE SE7305032A patent/SE399064B/xx unknown
- 1973-04-11 KR KR7300573A patent/KR790000113B1/ko not_active Expired
- 1973-04-11 DK DK196773A patent/DK142750C/da not_active IP Right Cessation
- 1973-04-11 YU YU00976/73A patent/YU36483B/xx unknown
- 1973-04-11 BG BG023268A patent/BG23001A3/xx unknown
- 1973-04-11 CH CH1112475A patent/CH580563A5/xx not_active IP Right Cessation
- 1973-04-11 CA CA168,428A patent/CA1018188A/en not_active Expired
- 1973-04-11 NL NLAANVRAGE7305097,A patent/NL174459C/xx not_active IP Right Cessation
- 1973-04-11 AT AT318773A patent/AT323719B/de not_active IP Right Cessation
- 1973-04-11 SU SU1908277A patent/SU496719A3/ru active
- 1973-04-11 BE BE1004956A patent/BE798051A/xx not_active IP Right Cessation
- 1973-04-11 AU AU54385/73A patent/AU472734B2/en not_active Expired
- 1973-04-11 CH CH517473A patent/CH569691A5/xx not_active IP Right Cessation
- 1973-04-12 DD DD73170118A patent/DD107670B3/de unknown
- 1973-04-12 HU HUEI552A patent/HU167597B/hu unknown
- 1973-04-12 PL PL1973183808A patent/PL94207B1/pl unknown
- 1973-04-12 IL IL42016A patent/IL42016A/en unknown
- 1973-04-12 HU HUEI469A patent/HU166213B/hu unknown
- 1973-04-12 CS CS77171A patent/CS190448B2/cs unknown
- 1973-04-12 JP JP48041750A patent/JPS5825656B2/ja not_active Expired
- 1973-04-12 PL PL1973161874A patent/PL90695B1/pl unknown
- 1973-04-12 PH PH14508A patent/PH11041A/en unknown
- 1973-04-12 AR AR247523A patent/AR203822A1/es active
- 1973-04-12 ES ES413639A patent/ES413639A1/es not_active Expired
- 1973-04-12 CS CS732601A patent/CS190406B2/cs unknown
- 1973-04-12 RO RO7374457A patent/RO65105A/ro unknown
- 1973-04-12 RO RO7383749A patent/RO70892A/ro unknown
-
1978
- 1978-08-10 KE KE2870A patent/KE2870A/xx unknown
- 1978-09-07 HK HK501/78A patent/HK50178A/xx unknown
- 1978-12-30 MY MY381/78A patent/MY7800381A/xx unknown
-
1979
- 1979-12-28 YU YU3212/79A patent/YU37113B/xx unknown
-
1982
- 1982-08-27 JP JP57149025A patent/JPS58131945A/ja active Granted
Also Published As
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