ID27833A - METODA UNTUK MENGOBATI ATEROSKLEROSIS DENGAN MENGGUNAKAN INHIBITOR aP2 DAN KOMBINASINYA - Google Patents

METODA UNTUK MENGOBATI ATEROSKLEROSIS DENGAN MENGGUNAKAN INHIBITOR aP2 DAN KOMBINASINYA

Info

Publication number
ID27833A
ID27833A IDW20010626A ID20010626A ID27833A ID 27833 A ID27833 A ID 27833A ID W20010626 A IDW20010626 A ID W20010626A ID 20010626 A ID20010626 A ID 20010626A ID 27833 A ID27833 A ID 27833A
Authority
ID
Indonesia
Prior art keywords
aterosclelerosis
inhibitors
combinations
treatment
methods
Prior art date
Application number
IDW20010626A
Other languages
English (en)
Indonesian (id)
Inventor
Jeffry A Robl
Rex A Parker
Scott A Biller
Haris Jamil
Bruce L Jacobson
Krishna Kudukula
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22280975&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID27833(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ID27833A publication Critical patent/ID27833A/id

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
IDW20010626A 1998-09-17 1999-09-13 METODA UNTUK MENGOBATI ATEROSKLEROSIS DENGAN MENGGUNAKAN INHIBITOR aP2 DAN KOMBINASINYA ID27833A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10067798P 1998-09-17 1998-09-17

Publications (1)

Publication Number Publication Date
ID27833A true ID27833A (id) 2001-04-26

Family

ID=22280975

Family Applications (2)

Application Number Title Priority Date Filing Date
IDW20010626A ID27833A (id) 1998-09-17 1999-09-13 METODA UNTUK MENGOBATI ATEROSKLEROSIS DENGAN MENGGUNAKAN INHIBITOR aP2 DAN KOMBINASINYA
IDW20010624A ID28450A (id) 1998-09-17 1999-09-13 METODA UNTUK MENGOBATI DIABETES DENGAN MENGGUNAKAN INHIBITOR aP2 DAN KOMBINASINYA

Family Applications After (1)

Application Number Title Priority Date Filing Date
IDW20010624A ID28450A (id) 1998-09-17 1999-09-13 METODA UNTUK MENGOBATI DIABETES DENGAN MENGGUNAKAN INHIBITOR aP2 DAN KOMBINASINYA

Country Status (30)

Country Link
US (1) US20020035064A1 (fr)
EP (2) EP1121129B1 (fr)
JP (2) JP2002524518A (fr)
KR (2) KR20010075150A (fr)
CN (2) CN1319012A (fr)
AT (1) ATE406898T1 (fr)
AU (2) AU755563B2 (fr)
BG (2) BG105431A (fr)
BR (2) BR9913831A (fr)
CA (2) CA2344300A1 (fr)
CO (2) CO5130025A1 (fr)
CZ (2) CZ2001964A3 (fr)
DE (1) DE69939481D1 (fr)
EE (2) EE200100155A (fr)
ES (1) ES2311306T3 (fr)
GE (2) GEP20033044B (fr)
HU (2) HUP0104108A2 (fr)
ID (2) ID27833A (fr)
IL (2) IL141786A0 (fr)
LT (2) LT4870B (fr)
LV (2) LV12686B (fr)
NO (2) NO20011351L (fr)
NZ (2) NZ510207A (fr)
PE (2) PE20001047A1 (fr)
PL (2) PL346660A1 (fr)
SK (1) SK3202001A3 (fr)
TR (2) TR200100774T2 (fr)
UY (2) UY25713A1 (fr)
WO (2) WO2000015229A1 (fr)
ZA (2) ZA200207430B (fr)

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AU2005201289B2 (en) * 1999-02-12 2008-04-17 President And Fellows Of Harvard College Inhibiting formation of atherosclerotic lesions
DE60041246D1 (de) * 1999-02-12 2009-02-12 Harvard College Hemmung der bildung von atherosklerotischen wunden mittels afabp antisens nukleinsäuren
US6548529B1 (en) * 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
CA2396596A1 (fr) 2000-01-28 2001-08-02 Bristol-Myers Squibb Company Inhibiteurs de tetrahydropyrimidone de la proteine de liaison de l'acide gras et procede correspondant
WO2002040448A1 (fr) * 2000-11-20 2002-05-23 Bristol-Myers Squibb Company Derives de pyridones utilises en tant qu'inhibiteurs ap2
US20040143015A1 (en) * 2001-03-12 2004-07-22 Villhauer Edwin Bernard Combination of organic compounds
WO2003006023A1 (fr) 2001-07-13 2003-01-23 Bristol-Myers Squibb Company Inhibiteurs pyrazinones inhibant une proteine de liaison aux acides gras et procede
WO2003007888A2 (fr) * 2001-07-20 2003-01-30 Adipogenix, Inc. Composes de modulation d'accumulation de graisse
EP1443919A4 (fr) 2001-11-16 2006-03-22 Bristol Myers Squibb Co Inhibiteurs doubles de la proteine de liaison des acides gras des adipocytes et de la proteine de liaison des acides gras des keratinocytes
ATE490244T1 (de) 2003-01-27 2010-12-15 Merck Sharp & Dohme Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren
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WO2005087234A1 (fr) * 2004-03-05 2005-09-22 The Trustees Of The University Of Pennsylvania Traitement a faibles effets secondaires contre des affections liees a l'hyperlipidemie et l'hypercholesterolemie
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CN101300232A (zh) 2005-07-26 2008-11-05 默克公司 合成取代的吡唑的方法
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AU2007254827A1 (en) * 2006-06-02 2007-12-13 San Diego State University Research Foundation Compositions and methods for ameliorating hyperlipidemia
WO2008079398A1 (fr) * 2006-12-21 2008-07-03 Aegerion Pharmaceuticals, Inc. Procédés de traitement de l'obésité à l'aide d'une combinaison comprenant un inhibiteur de mtp et un inhibiteur de l'absorption du cholestérol
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AU2010221182B2 (en) * 2009-03-05 2016-07-28 President And Fellows Of Harvard College Secreted aP2 and methods of inhibiting same
JP6514282B2 (ja) * 2014-03-24 2019-05-15 花王株式会社 Ｇｉｐ上昇抑制剤の評価又は選択方法
JP6223376B2 (ja) * 2014-03-24 2017-11-01 花王株式会社 Ｇｉｐ上昇抑制剤の評価又は選択方法
WO2016176656A2 (fr) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Anticorps anti-ap2 et agents de liaison à l'antigène utilisables en vue du traitement d'affections métaboliques
CN109642908B (zh) * 2016-06-27 2022-08-16 哈佛学院院长及董事 可用于治疗代谢病症的化合物
CA3066733A1 (fr) 2017-06-09 2018-12-13 President And Fellows Of Harvard College Procede d'identification de composes utiles pour traiter une lipogenese deregulee, le diabete et autres troubles apparentes

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Also Published As

Publication number Publication date
ZA200207433B (en) 2003-10-27
NO20011352L (no) 2001-05-11
NO20011351D0 (no) 2001-03-16
NZ510209A (en) 2003-07-25
BR9913831A (pt) 2001-05-29
LT2001023A (en) 2001-08-27
UY25714A1 (es) 2001-08-27
BG105431A (en) 2001-12-29
CO5130025A1 (es) 2002-02-27
CA2344309A1 (fr) 2000-03-23
PL346660A1 (en) 2002-02-25
ZA200207430B (en) 2003-09-16
JP2002524518A (ja) 2002-08-06
EE200100154A (et) 2002-12-16
CZ2001964A3 (cs) 2002-01-16
AU6143799A (en) 2000-04-03
EE04356B1 (et) 2004-10-15
EP1113801A1 (fr) 2001-07-11
CO5130026A1 (es) 2002-02-27
BG105432A (en) 2001-12-29
HUP0104240A2 (hu) 2002-03-28
LT4870B (lt) 2001-12-27
US20020035064A1 (en) 2002-03-21
TR200100774T2 (tr) 2001-12-21
EP1121129B1 (fr) 2008-09-03
NO20011352D0 (no) 2001-03-16
EP1121129A1 (fr) 2001-08-08
DE69939481D1 (de) 2008-10-16
UY25713A1 (es) 2001-08-27
AU754488B2 (en) 2002-11-14
EE200100155A (et) 2002-08-15
KR20010075150A (ko) 2001-08-09
LV12687A (en) 2001-07-20
IL141786A0 (en) 2002-03-10
IL141785A0 (en) 2002-03-10
ATE406898T1 (de) 2008-09-15
BR9913833A (pt) 2001-05-29
CN1317970A (zh) 2001-10-17
TR200100773T2 (tr) 2001-07-23
LV12686A (en) 2001-07-20
CZ2001965A3 (cs) 2002-02-13
EP1121129A4 (fr) 2002-10-16
ES2311306T3 (es) 2009-02-01
WO2000015230A1 (fr) 2000-03-23
LT4871B (lt) 2001-12-27
LV12686B (lv) 2001-10-20
PE20001047A1 (es) 2000-12-24
SK3202001A3 (en) 2002-04-04
PL346661A1 (en) 2002-02-25
EP1113801A4 (fr) 2002-10-02
GEP20033045B (en) 2003-08-25
AU755563B2 (en) 2002-12-12
WO2000015229A1 (fr) 2000-03-23
ID28450A (id) 2001-05-24
PE20001056A1 (es) 2000-12-24
LV12687B (lv) 2001-10-20
GEP20033044B (en) 2003-08-25
LT2001022A (en) 2001-08-27
CA2344300A1 (fr) 2000-03-23
NO20011351L (no) 2001-05-11
CN1319012A (zh) 2001-10-24
HUP0104108A2 (hu) 2002-03-28
AU6387799A (en) 2000-04-03
JP2002524517A (ja) 2002-08-06
KR20010079842A (ko) 2001-08-22
NZ510207A (en) 2003-08-29

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