FR2156486A1 - Oxazolyl oxy or thio acetic acids - analgesics antipyretics and anti-inflammatories - Google Patents

Oxazolyl oxy or thio acetic acids - analgesics antipyretics and anti-inflammatories

Info

Publication number
FR2156486A1
FR2156486A1 FR7138043A FR7138043A FR2156486A1 FR 2156486 A1 FR2156486 A1 FR 2156486A1 FR 7138043 A FR7138043 A FR 7138043A FR 7138043 A FR7138043 A FR 7138043A FR 2156486 A1 FR2156486 A1 FR 2156486A1
Authority
FR
France
Prior art keywords
antipyretics
inflammatories
analgesics
oxazolyl
oxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7138043A
Other languages
French (fr)
Other versions
FR2156486B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7138043A priority Critical patent/FR2156486A1/en
Publication of FR2156486A1 publication Critical patent/FR2156486A1/en
Application granted granted Critical
Publication of FR2156486B1 publication Critical patent/FR2156486B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/46—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Title cpds of formula (I) and their salts with metal and bases, and their esters with 1-4C alcohols, where X = O or S, R1 = H or phenyl, opt. substd. by F, Cl, Br or 1-3C alkoxy, R2 = H, alkyl or phenyl opt. substd. by F, Cl, Br or 1-3C alkoxy, R3 = H or 1-3C alkyl. Cpds. (I) may be prepd. by the reaction of a sodio deriv. of a hydroxy or mercapto acetic ester with a 2-chlorooxazole, followed, if desired, by hydrolysis of the ester. In an example the sodio deriv. of 2-mercapto ethyl acetate was reacted with 2-chloro-4,5-diphenyl oxazole, and the prod. hydrolysed with NaOH to give a 51% yield of (I, R1 = R2 = phenyl, R3 = H, X = S).
FR7138043A 1971-10-22 1971-10-22 Oxazolyl oxy or thio acetic acids - analgesics antipyretics and anti-inflammatories Granted FR2156486A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7138043A FR2156486A1 (en) 1971-10-22 1971-10-22 Oxazolyl oxy or thio acetic acids - analgesics antipyretics and anti-inflammatories

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7138043A FR2156486A1 (en) 1971-10-22 1971-10-22 Oxazolyl oxy or thio acetic acids - analgesics antipyretics and anti-inflammatories

Publications (2)

Publication Number Publication Date
FR2156486A1 true FR2156486A1 (en) 1973-06-01
FR2156486B1 FR2156486B1 (en) 1975-11-28

Family

ID=9084769

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7138043A Granted FR2156486A1 (en) 1971-10-22 1971-10-22 Oxazolyl oxy or thio acetic acids - analgesics antipyretics and anti-inflammatories

Country Status (1)

Country Link
FR (1) FR2156486A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2281115A1 (en) * 1974-08-06 1976-03-05 Serono Lab 2-THIOL-4,5-DIPHENYLOXAZOLE SUBSTITUTES FOR SULFUR AND COMPOSITIONS CONTAINING THEM
US4477681A (en) * 1977-05-17 1984-10-16 Merck Patent Gesellschaft Mit Beschrankter Haftung Photosensitive hydroxyalkylphenones
US4547394A (en) * 1982-01-30 1985-10-15 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of hydroxyalkylphenones as initiators for radiation curing of aqueous prepolymer dispersions
EP0223177A1 (en) * 1985-11-13 1987-05-27 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones
LT4870B (en) 1998-09-17 2001-12-27 Bristol-Myers Squibb Company AN aP2 INHIBITOR AND COMBINATION FOR TREATING ATHEROSCLEROSIS
WO2004065374A1 (en) * 2003-01-17 2004-08-05 Astellas Pharma Inc. Oxazole derivatives as inhibitors of cyclooxygenase
US7358254B2 (en) 2001-07-13 2008-04-15 Bristol-Myers Squibb Company Method for treating atherosclerosis employing an aP2 inhibitor and combination
US7390824B1 (en) 1999-09-07 2008-06-24 Bristol-Myers Squibb Company Method for treating diabetes employing an aP2 inhibitor and combination

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB643681A (en) * 1947-11-10 1950-09-27 Ilford Ltd Improvements in or relating to dyestuffs and pigments derived from thiazolyl-2 thioglycollic acids
BE645890A (en) * 1963-03-29 1964-09-28

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB643681A (en) * 1947-11-10 1950-09-27 Ilford Ltd Improvements in or relating to dyestuffs and pigments derived from thiazolyl-2 thioglycollic acids
BE645890A (en) * 1963-03-29 1964-09-28

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2281115A1 (en) * 1974-08-06 1976-03-05 Serono Lab 2-THIOL-4,5-DIPHENYLOXAZOLE SUBSTITUTES FOR SULFUR AND COMPOSITIONS CONTAINING THEM
JPS5143756A (en) * 1974-08-06 1976-04-14 Serono Lab 22 chiooru 4 55 jifueniruokisazooru ss judotaino seiho
US4477681A (en) * 1977-05-17 1984-10-16 Merck Patent Gesellschaft Mit Beschrankter Haftung Photosensitive hydroxyalkylphenones
US4721734A (en) * 1977-05-17 1988-01-26 Merck Patent Gesellschaft Mit Beschrankter Haftung Photosensitive hydroxylalkylphenones
US4547394A (en) * 1982-01-30 1985-10-15 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of hydroxyalkylphenones as initiators for radiation curing of aqueous prepolymer dispersions
EP0223177A1 (en) * 1985-11-13 1987-05-27 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones
US4728661A (en) * 1985-11-13 1988-03-01 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones
LT4870B (en) 1998-09-17 2001-12-27 Bristol-Myers Squibb Company AN aP2 INHIBITOR AND COMBINATION FOR TREATING ATHEROSCLEROSIS
LT4871B (en) 1998-09-17 2001-12-27 Bristol-Myers Squibb Company AN aP2 INHIBITOR AND COMBINATION FOR TREATING DIABETES
US7390824B1 (en) 1999-09-07 2008-06-24 Bristol-Myers Squibb Company Method for treating diabetes employing an aP2 inhibitor and combination
US7358254B2 (en) 2001-07-13 2008-04-15 Bristol-Myers Squibb Company Method for treating atherosclerosis employing an aP2 inhibitor and combination
WO2004065374A1 (en) * 2003-01-17 2004-08-05 Astellas Pharma Inc. Oxazole derivatives as inhibitors of cyclooxygenase

Also Published As

Publication number Publication date
FR2156486B1 (en) 1975-11-28

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