FR2146161A1 - Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics - Google Patents

Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics

Info

Publication number
FR2146161A1
FR2146161A1 FR7126844A FR7126844A FR2146161A1 FR 2146161 A1 FR2146161 A1 FR 2146161A1 FR 7126844 A FR7126844 A FR 7126844A FR 7126844 A FR7126844 A FR 7126844A FR 2146161 A1 FR2146161 A1 FR 2146161A1
Authority
FR
France
Prior art keywords
antiinflammatories
antipyretics
analgesics
thiazolyl
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7126844A
Other languages
French (fr)
Other versions
FR2146161B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7126844A priority Critical patent/FR2146161A1/en
Publication of FR2146161A1 publication Critical patent/FR2146161A1/en
Application granted granted Critical
Publication of FR2146161B1 publication Critical patent/FR2146161B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Title cpds are of formula (I), and their esters and salts: (where R1=either 2-thienyl, which may be substd by Cl, or phenyl substd by 1 or 2 F, Cl, or Br atoms or by 1 alkoxy or alkylthio(==3C) R2=H, or phenyl opt. substd by F, Cl or alkoxy(=3C) R3=H or alkyl (=3C) and are prepd by reaction of a thiol or Cl substd thiazole (II) with a Cl, Br or SH subst. ester (III), of (II) and (III) contg a thiol gp opt followed by hydrolysis of the ester gps.
FR7126844A 1971-07-22 1971-07-22 Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics Granted FR2146161A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7126844A FR2146161A1 (en) 1971-07-22 1971-07-22 Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7126844A FR2146161A1 (en) 1971-07-22 1971-07-22 Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics

Publications (2)

Publication Number Publication Date
FR2146161A1 true FR2146161A1 (en) 1973-03-02
FR2146161B1 FR2146161B1 (en) 1974-09-06

Family

ID=9080736

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7126844A Granted FR2146161A1 (en) 1971-07-22 1971-07-22 Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics

Country Status (1)

Country Link
FR (1) FR2146161A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061425A2 (en) * 1981-03-18 1982-09-29 Ciba-Geigy Ag Thiazole derivatives, processes for their preparation, medicaments containing them and their use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061425A2 (en) * 1981-03-18 1982-09-29 Ciba-Geigy Ag Thiazole derivatives, processes for their preparation, medicaments containing them and their use
EP0061425A3 (en) * 1981-03-18 1982-12-15 Ciba-Geigy Ag Thiazole derivatives, processes for their preparation, medicaments containing them and their use
US4451471A (en) * 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same

Also Published As

Publication number Publication date
FR2146161B1 (en) 1974-09-06

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Legal Events

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ST Notification of lapse